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Gupta N, Ochiai H, Hoshino Y, Klein S, Zustin J, Ramjiawan RR, Kitahara S, Maimon N, Bazou D, Chiang S, Li S, Schanne DH, Jain RK, Munn LL, Huang P, Kozin SV, Duda DG

Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models.

Cancers (Basel). 2023;15(4):ePub - PMID: 36831366 - PMCID: PMC9954510 - DOI: 10.3390/cancers15041021

Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev I

Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.

Oncotarget. 2017;8(65):108292-108302 - PMID: 29312532 - PMCID: PMC5752445 - DOI: 10.18632/oncotarget.22660

Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.

J Natl Cancer Inst. 2015;107(4):ePub - PMID: 25710962 - PMCID: PMC4402365 - DOI: 10.1093/jnci/djv017

Babykutty S, Heishi T, Tsukada K, Huang Y, Kozin S, Conner D, Lin Q, Kucherlapati R, Jain RK, Fukumura D

Restoring perivascular nitric oxide gradients normalizes breast cancer vasculature.

Nitric Oxide. 2014;42C:115 - PMID: 25519573

Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.

Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516

Kozin SV, Duda DG, Munn LL, Jain RK

Neovascularization After Irradiation: What is the Source of Newly Formed Vessels in Recurring Tumors?

J Natl Cancer Inst. 2012;104(12):899-905 - PMID: 22572994 - PMCID: PMC3379722 - DOI: 10.1093/jnci/djs239

Kozin SV, Duda DG, Munn LL, Jain RK

Is vasculogenesis crucial for the regrowth of irradiated tumours?

Nat Rev Cancer. 2011;11(7):532 - PMID: 21701514 - PMCID: PMC4790119 - DOI: 10.1038/nrc2007-c1

Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK

CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?

Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636

Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG

Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.

Cancer Res. 2010;70(14):5679-85 - PMID: 20631066 - PMCID: PMC2918387 - DOI: 10.1158/0008-5472.CAN-09-4446

Kozin SV, Niemierko A, Huang P, Silva J, Doppke KP, Suit HD

Inter- and intramouse heterogeneity of radiation response for a growing paired organ.

Radiat Res. 2008;170(2):264-7 - PMID: 18666813 - DOI: 10.1667/RR1262.1

Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D

Perivascular nitric oxide gradients normalize tumor vasculature.

Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730

Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y

Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.

Cancer Res. 2007;67(11):5076-82 - PMID: 17545583 - DOI: 10.1158/0008-5472.CAN-06-3664

Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK

Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.

Semin Oncol. 2006;33(5 Suppl 10):S35-40 - PMID: 17145523 - PMCID: PMC2686124 - DOI: 10.1053/j.seminoncol.2006.08.007

Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

Cancer Cell. 2004;6(6):553-63 - PMID: 15607960 - DOI: 10.1016/j.ccr.2004.10.011

Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.

Cancer Res. 2004;64(11):3731-6 - PMID: 15172975 - DOI: 10.1158/0008-5472.CAN-04-0074

Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.

Nature. 2004;428(6980):328-32 - PMID: 15029197 - DOI: 10.1038/nature02329

Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.

Nat Med. 2004;10(2):145-7 - PMID: 14745444 - PMCID: PMC2693485 - DOI: 10.1038/nm988

Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.

Cancer Res. 2001;61(1):39-44 - PMID: 11196192

Sergey Kozin

Sergey Kozin

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