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Glioma subtypes determine how the dangerous brain tumors spread, evade anti-angiogenic treatment

Molecular signatures of anti-angiogenic resistant cells could provide new treatment targets.

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They haven’t seen each other in about a year and a half, but once they’ve shaken hands, their conversation immediately turns to science. When your work has the potential to save millions of lives, that’s what you do.

Rakesh K. Jain, COE74M, 76PhD, has spent decades working on some of the world’s most pressing health problems, and has  come to be regarded as one of America’s most accomplished scientists. Arup K. Chakraborty, COE88PhD, is tackling one of the world’s most elusive challenges: creating a vaccine for the human immunodeficiency virus (HIV), the causative agent of AIDS.

Read the full story at University of Delaware ...

If confirmed in human patients, findings could indicate the need to treat lymph node metastases

A study by Massachusetts General Hospital (MGH) investigators finds that, in mouse models, cancer cells from metastatic lymph nodes can escape into the circulation by invading nodal blood vessels, leading to the development of metastases in other parts of the body. Their report appearing in the March 23 issue of Science adds evidence to the debate regarding the role of lymph node metastases in the spread of cancer. 

Article in Science ...

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2


Bacterial toxins kill lymphatic muscle cells, raising risk of recurrent infection

Cancer drug targets molecular pathway contributing to tumor progression, radiation-induced hearing loss