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Current SARS-CoV-2 vaccines are effective at preventing COVID-19 or limiting disease severity in healthy individuals, but effectiveness is lower among patients with cancer or immunosuppression. A team led by Drs. Jain, Stylianopoulos and Munn predict vaccine effectiveness over time by building a mathematical framework to account for vaccination-induced immunity. A booster dose of both mRNA vaccines can induce a robust enhancement of both antibody levels and numbers of pertinent types of adaptive immune cells, which is predicted to provide sufficient protection for more than 1 y in healthy patients. However, the model suggests that for immunosuppressed people or patients with cancer receiving an immunosuppressive treatment, the booster effect may wane and should be given boosters on a more frequent basis.

press release