Fukumura Lab
Gomes-Santos IL, Kumar AS, Hausmann F, Meyer MN, Shiferaw SZ, Amoozgar Z, Jain RK, Fukumura D
Exercise intensity governs tumor control in mice with breast cancer.
Front Immunol. 2024;15:1339232 - PMID: 38495879 - PMCID: PMC10940460 - DOI: 10.3389/fimmu.2024.1339232
Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Sassi S, Bardeesy N, Ho WJ, Jain RK, Duda DG
Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
Cancer Immunol Res. 2024;12(4):400-412 - PMID: 38260999 - PMCID: PMC10985468 - DOI: 10.1158/2326-6066.CIR-23-0486
Jain R, Krishnan S, Lee S, Amoozgar Z, Subudhi S, Kumar A, Posada J, Lindeman N, Lei P, Duquette M, Roberge S, Huang P, Andersson P, Datta M, Munn L, Fukumura D
Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma.
Res Sq. 2023;:ePub - PMID: 38234841 - PMCID: PMC10793505 - DOI: 10.21203/rs.3.rs-3707472/v1
Dong X, Ren J, Amoozgar Z, Lee S, Datta M, Roberge S, Duquette M, Fukumura D, Jain RK
Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice.
J Immunother Cancer. 2023;11(3):ePub - PMID: 36898734 - PMCID: PMC10008211 - DOI: 10.1136/jitc-2022-005583
Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin S, Matsui A, Pu Z, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Bardeesy N, Ho WJ, Jain RK, Duda DG
Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
bioRxiv. 2023;:ePub - PMID: 36747853 - PMCID: PMC9901023 - DOI: 10.1101/2023.01.26.525680
Boucher Y, Posada JM, Subudhi S, Kumar AS, Rosario SR, Gu L, Kumra H, Mino-Kenudson M, Talele NP, Duda DG, Fukumura D, Wo JY, Clark JW, Ryan DP, Fernandez-Del Castillo C, Hong TS, Pittet MJ, Jain RK
Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer.
Clin Cancer Res. 2023;29(8):1605-1619 - PMID: 36749873 - PMCID: PMC10106451 - DOI: 10.1158/1078-0432.CCR-22-1630
Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S
Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy.
FASEB J. 2022;36(10):e22521 - PMID: 36052742 - PMCID: PMC9574655 - DOI: 10.1096/fj.202200033R
Ho WW, Pittet MJ, Fukumura D, Jain RK
The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy.
Cancer Cell. 2022;40(7):701-702 - PMID: 35714604 - PMCID: PMC10894502 - DOI: 10.1016/j.ccell.2022.05.016
Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK
Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.
Clin Cancer Res. 2022;28(14):3076-3090 - PMID: 35584239 - PMCID: PMC9355624 - DOI: 10.1158/1078-0432.CCR-22-0486
Agrud A, Subburaju S, Goel P, Ren J, Kumar AS, Caldarone BJ, Dai W, Chavez J, Fukumura D, Jain RK, Kloner RA, Vasudevan A
Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.
Sci Rep. 2022;12(1):4922 - PMID: 35318369 - PMCID: PMC8941104 - DOI: 10.1038/s41598-022-08806-9
Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118
Amoozgar Z, Kloepper J, Ren J, Tay RE, Kazer SW, Kiner E, Krishnan S, Posada JM, Ghosh M, Mamessier E, Wong C, Ferraro GB, Batista A, Wang N, Badeaux M, Roberge S, Xu L, Huang P, Shalek AK, Fukumura D, Kim HJ, Jain RK
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Nat Commun. 2021;12(1):2582 - PMID: 33976133 - PMCID: PMC8113440 - DOI: 10.1038/s41467-021-22885-8
Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D
Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade.
Cancer Immunol Res. 2021;9(7):765-778 - PMID: 33839688 - PMCID: PMC8295193 - DOI: 10.1158/2326-6066.CIR-20-0499
Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen IX, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain, RK, Vander Heiden MG
Fatty acid synthesis is required for breast cancer brain metastasis
Nature Cancer. 2021;:ePub
Krishnan S, Amoozgar Z, Fukumura D, Jain RK
Implications of a granulocyte-high glioblastoma microenvironment in immune suppression and therapy resistance†.
J Pathol. 2021;254(2):105-108 - PMID: 33534142 - PMCID: PMC8262382 - DOI: 10.1002/path.5637
Subburaju S, Kaye S, Choi YK, Baruah J, Datta D, Ren J, Kumar AS, Szabo G, Fukumura D, Jain RK, Elkhal A, Vasudevan A
NAD+-mediated rescue of prenatal forebrain angiogenesis restores postnatal behavior.
Sci Adv. 2020;6(41):ePub - PMID: 33036972 - PMCID: PMC7546698 - DOI: 10.1126/sciadv.abb9766
Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massague J, Neman J, Sibson NR, Steeg PS, Thorsen F, Young LS, Varešlija D, Vultur A, Weis-Garcia F, Winkler F
Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines.
Cancer Res. 2020;80(20):4314-4323 - PMID: 32641416 - PMCID: PMC7572582 - DOI: 10.1158/0008-5472.CAN-20-0291
Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M
Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Nat Biotechnol. 2020;38(4):420-425 - PMID: 32042168 - PMCID: PMC7456461 - DOI: 10.1038/s41587-019-0404-8
Rowlands CJ, Bruns OT, Franke D, Fukamura D, Jain RK, Bawendi MG, So PTC
Increasing the penetration depth of temporal focusing multiphoton microscopy for neurobiological applications.
J Phys D Appl Phys. 2019;52(26):264001 - PMID: 33191950 - PMCID: PMC7655118 - DOI: 10.1088/1361-6463/ab16b4
Shvedova M, Litvak MM, Roberts JD, Fukumura D, Suzuki T, Şencan İ, Li G, Reventun P, Buys ES, Kim HH, Sakadžić S, Ayata C, Huang PL, Feil R, Atochin DN
cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice.
J Cereb Blood Flow Metab. 2019;39(12):2379-2391 - PMID: 31423931 - PMCID: PMC6893979 - DOI: 10.1177/0271678X19870583
Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Nat Biomed Eng. 2019;3(3):230-245 - PMID: 30948807 - PMCID: PMC6452896 - DOI: 10.1038/s41551-018-0334-7
Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N
Retraction Note: A homing system targets therapeutic T cells to brain cancer.
Nature. 2019;567(7746):132 - PMID: 30787441 - PMCID: PMC6497143 - DOI: 10.1038/s41586-019-0967-z
Askoxylakis V, Ferraro GB, Badeaux M, Kodack DP, Kirst I, Shankaraiah RC, Wong CSF, Duda DG, Fukumura D, Jain RK
Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.
NPJ Breast Cancer. 2019;5:4 - PMID: 30675514 - PMCID: PMC6333771 - DOI: 10.1038/s41523-018-0100-8
Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N
A homing system targets therapeutic T cells to brain cancer.
Nature. 2018;561(7723):331-337 - PMID: 30185905 - PMCID: PMC6402337 - DOI: 10.1038/s41586-018-0499-y
Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK
Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Proc Natl Acad Sci U S A. 2018;115(37):E8717-E8726 - PMID: 30150398 - PMCID: PMC6140479 - DOI: 10.1073/pnas.1807105115
Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW
Consensus guidelines for the use and interpretation of angiogenesis assays.
Angiogenesis. 2018;21(3):425-532 - PMID: 29766399 - PMCID: PMC6237663 - DOI: 10.1007/s10456-018-9613-x
Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT
Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green.
Proc Natl Acad Sci U S A. 2018;115(17):4465-4470 - PMID: 29626132 - PMCID: PMC5924901 - DOI: 10.1073/pnas.1718917115
Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK
Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Sci Transl Med. 2018;10(432):ePub - PMID: 29540614 - PMCID: PMC5936748 - DOI: 10.1126/scitranslmed.aag0945
Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Nat Rev Clin Oncol. 2018;15(5):325-340 - PMID: 29508855 - PMCID: PMC5921900 - DOI: 10.1038/nrclinonc.2018.29
Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N
Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.
J Immunol. 2018;200(8):3000-3007 - PMID: 29500245 - PMCID: PMC5893394 - DOI: 10.4049/jimmunol.1700407
Rowlands CJ, Park D, Bruns OT, Piatkevich KD, Fukumura D, Jain RK, Bawendi MG, Boyden ES, So PT
Wide-field three-photon excitation in biological samples.
Light Sci Appl. 2017;6:e16255 - PMID: 29152380 - PMCID: PMC5687557 - DOI: 10.1038/lsa.2016.255
Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Wei H, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MG
Next-generation in vivo optical imaging with short-wave infrared quantum dots.
Nat Biomed Eng. 2017;1:ePub - PMID: 29119058 - PMCID: PMC5673283 - DOI: 10.1038/s41551-017-0056
Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, Amoozgar Z, Seano G, Ferraro GB, Chatterjee S, Xu L, Fukumura D, Duda DG, Jain RK
A cerebellar window for intravital imaging of normal and disease states in mice.
Nat Protoc. 2017;12(11):2251-2262 - PMID: 28981123 - PMCID: PMC5918134 - DOI: 10.1038/nprot.2017.101
Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D
Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Proc Natl Acad Sci U S A. 2017;114(39):10455-10460 - PMID: 28900008 - PMCID: PMC5625928 - DOI: 10.1073/pnas.1710754114
Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
J Clin Invest. 2017;127(8):3039-3051 - PMID: 28691930 - PMCID: PMC5531423 - DOI: 10.1172/JCI93182
Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, Wong CSF, Kloepper J, Das R, Tam A, Tanboon J, Duda DG, Miller CR, Siegel MB, Anders CK, Sanders M, Estrada MV, Schlegel R, Arteaga CL, Brachtel E, Huang A, Fukumura D, Engelman JA, Jain RK
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
Sci Transl Med. 2017;9(391):ePub - PMID: 28539475 - PMCID: PMC5917603 - DOI: 10.1126/scitranslmed.aal4682
David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram Shankaraiah, Z. Alexander Cao, Rakesh R. Ramjiawan, Divya Bezwada, Bhushankumar Patel, Yongchul Song, Carlotta Costa, Kamila Naxerova, Christina S. F. Wong, Jonas Kloepper, Rita Das, Angela Tam, Jantima Tanboon, Dan G. Duda, C. Ryan Miller, Marni B. Siegel, Carey K. Anders, Melinda Sanders, Monica V. Estrada, Robert Schlegel, Carlos L. Arteaga, Elena Brachtel, Alan Huang, Dai Fukumura, Jeffrey A. Engelman, Rakesh K. Jain
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Science Translational Medicine. 2017;9(391):eaal4682
Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK
Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy.
Cancer Discov. 2016;6(8):852-69 - PMID: 27246539 - PMCID: PMC4972679 - DOI: 10.1158/2159-8290.CD-15-1177
Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK
Solid stress and elastic energy as measures of tumour mechanopathology.
Nat Biomed Eng. 2016;1:ePub - PMID: 28966873 - PMCID: PMC5621647 - DOI: 10.1038/s41551-016-0004
Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK
Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27908927 - PMCID: PMC5131752 - DOI: 10.1101/cshperspect.a031195
Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
Sci Transl Med. 2016;8(360):360ra135 - PMID: 27733559 - PMCID: PMC5457741 - DOI: 10.1126/scitranslmed.aaf5219
Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK
Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27663981 - PMCID: PMC5131751 - DOI: 10.1101/cshperspect.a027094
Meijer EF, Baish JW, Padera TP, Fukumura D
Measuring Vascular Permeability In Vivo.
Methods Mol Biol. 2016;1458:71-85 - PMID: 27581015 - PMCID: PMC5435480 - DOI: 10.1007/978-1-4939-3801-8_6
Patil MD, Bhaumik J, Babykutty S, Banerjee UC, Fukumura D
Arginine dependence of tumor cells: targeting a chink in cancer's armor.
Oncogene. 2016;35(38):4957-72 - PMID: 27109103 - PMCID: PMC5457742 - DOI: 10.1038/onc.2016.37
Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Proc Natl Acad Sci U S A. 2016;113(16):4470-5 - PMID: 27044097 - PMCID: PMC4843449 - DOI: 10.1073/pnas.1525349113
Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Proc Natl Acad Sci U S A. 2016;113(16):4476-81 - PMID: 27044098 - PMCID: PMC4843473 - DOI: 10.1073/pnas.1525360113
Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam T, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop I, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D
PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity.
Clin Cancer Res. 2016;22(12):2993-3004 - PMID: 26861455 - PMCID: PMC4911258 - DOI: 10.1158/1078-0432.CCR-15-1839
Fukumura D, Incio J, Shankaraiah R, Jain RK
Obesity and cancer: an angiogenic and inflammatory link.
Microcirculation. 2016;23(3):191-206 - PMID: 26808917 - PMCID: PMC4818678 - DOI: 10.1111/micc.12270
Park KR, Monsky WL, Lee CG, Song CH, Kim DH, Jain RK, Fukumura D
Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability.
Radiat Res. 2016;185(2):182-189 - PMID: 26771172 - PMCID: PMC4761451 - DOI: 10.1667/RR14190.1
Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE
A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.
Sci Transl Med. 2016;8(320):320ra4 - PMID: 26738797 - PMCID: PMC4794335 - DOI: 10.1126/scitranslmed.aad0293
Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
PLoS One. 2015;10(12):e0141392 - PMID: 26641266 - PMCID: PMC4671732 - DOI: 10.1371/journal.pone.0141392
Samuel R, Duda DG, Fukumura D, Jain RK
Vascular diseases await translation of blood vessels engineered from stem cells.
Sci Transl Med. 2015;7(309):309rv6 - PMID: 26468328 - PMCID: PMC4799660 - DOI: 10.1126/scitranslmed.aaa1805
Jain RK, Fukumura D, Duda DG
From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey.
Cancer J. 2015;21(4):235-236 - PMID: 26222072 - PMCID: PMC4791947 - DOI: 10.1097/PPO.0000000000000136
Lemon CM, Karnas E, Han X, Bruns OT, Kempa TJ, Fukumura D, Bawendi MG, Jain RK, Duda DG, Nocera DG
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.
J Am Chem Soc. 2015;137(31):9832-42 - PMID: 26149349 - PMCID: PMC4750386 - DOI: 10.1021/jacs.5b04765
Jain RK, Fukumura D, Duda DG
Lessons From 30 Years of Teaching About the Microenvironment of Tumors.
Cancer J. 2015;21(3):137 - PMID: 26049690 - PMCID: PMC4792516 - DOI: 10.1097/PPO.0000000000000119
Choi JW, Kim P, Kim JK, Kim YR, Fukumura D, Yun SH
Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis.
Theranostics. 2015;5(7):724-32 - PMID: 25897337 - PMCID: PMC4402496 - DOI: 10.7150/thno.10734
Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.
J Natl Cancer Inst. 2015;107(4):ePub - PMID: 25710962 - PMCID: PMC4402365 - DOI: 10.1093/jnci/djv017
Kodack DP, Askoxylakis V, Ferraro GB, Fukumura D, Jain RK
Emerging Strategies for Treating Brain Metastases from Breast Cancer.
Cancer Cell. 2015;27(2):163-175 - PMID: 25670078 - PMCID: PMC4325273 - DOI: 10.1016/j.ccell.2015.01.001
Stylianopoulos T, Economides EA, Baish JW, Fukumura D, Jain RK
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors.
Ann Biomed Eng. 2015;43(9):2291-300 - PMID: 25670323 - PMCID: PMC4519365 - DOI: 10.1007/s10439-015-1276-9
Han HS, Niemeyer E, Huang Y, Kamoun WS, Martin JD, Bhaumik J, Chen Y, Roberge S, Cui J, Martin MR, Fukumura D, Jain RK, Bawendi MG, Duda DG
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice.
Proc Natl Acad Sci U S A. 2015;112(5):1350-5 - PMID: 25605916 - PMCID: PMC4321304 - DOI: 10.1073/pnas.1421632111
Babykutty S, Heishi T, Tsukada K, Huang Y, Kozin S, Conner D, Lin Q, Kucherlapati R, Jain RK, Fukumura D
Restoring perivascular nitric oxide gradients normalizes breast cancer vasculature.
Nitric Oxide. 2014;42C:115 - PMID: 25519573
Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R
Correlative intravital imaging of cGMP signals and vasodilation in mice.
Front Physiol. 2014;5:394 - PMID: 25352809 - PMCID: PMC4196583 - DOI: 10.3389/fphys.2014.00394
Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG
Magneto-fluorescent core-shell supernanoparticles.
Nat Commun. 2014;5:5093 - PMID: 25298155 - PMCID: PMC4264679 - DOI: 10.1038/ncomms6093
Jain RK, Fukumura D, Duda DG
Modes of neovascularization in tumors and clinical translation of antiangiogenic therapy.
In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (Editor: LM McManus & RN Mitchell). Elsevier Press, Oxford. 2014;:(in press)
Chung E, Yeon C, Jain RK, Fukumura D
Uncovering tumor biology by intravital microscopy.
In: Comprehensive Biomedical Physics, Volume: IV 'Optical molecular imaging' (Editor: Kiessling Alves & Anders Brahme). Elsevier Press. 2014;:(in press)
Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK
Benefits of Vascular Normalization Are Dose and Time Dependent--Letter.
Cancer Res. 2013;73(23):7144-6 - PMID: 24265277 - PMCID: PMC3876035 - DOI: 10.1158/0008-5472.CAN-13-1989
Huang Y, Goel S, Duda DG, Fukumura D, Jain RK
Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
Cancer Res. 2013;73(10):2943-8 - PMID: 23440426 - PMCID: PMC3655127 - DOI: 10.1158/0008-5472.CAN-12-4354
Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK
Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164
Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Proc Natl Acad Sci U S A. 2013;110(31):12774-9 - PMID: 23861493 - PMCID: PMC3732948 - DOI: 10.1073/pnas.1310675110
Jain RK, Munn LL, Fukumura D
Measuring Interstitial pH and pO2 in Mouse Tumors.
Cold Spring Harb Protoc. 2013;2013(7):675-7 - PMID: 23818669 - DOI: 10.1101/pdb.prot075713
Jain RK, Munn LL, Fukumura D
Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.
Cold Spring Harb Protoc. 2013;2013(7):678-80 - PMID: 23818670 - DOI: 10.1101/pdb.prot075721
Thunemann M, Wen L, Hillenbrand M, Vachaviolos IA, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R
Transgenic Mice for cGMP Imaging.
Circ Res. 2013;113(4):365-71 - PMID: 23801067 - PMCID: PMC3896241 - DOI: 10.1161/CIRCRESAHA.113.301063
Jain RK, Munn LL, Fukumura D
Measuring leukocyte-endothelial interactions in mice.
Cold Spring Harb Protoc. 2013;2013(6):561-3 - PMID: 23734020 - DOI: 10.1101/pdb.prot075085
Jain RK, Munn LL, Fukumura D
Measuring vascular permeability in mice.
Cold Spring Harb Protoc. 2013;2013(5):444-6 - PMID: 23637370 - DOI: 10.1101/pdb.prot074344
Jain RK, Munn LL, Fukumura D
Measuring angiogenesis and hemodynamics in mice.
Cold Spring Harb Protoc. 2013;2013(4):354-8 - PMID: 23547161 - DOI: 10.1101/pdb.prot073916
Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Cell. 2013;152(5):1065-76 - PMID: 23452854 - PMCID: PMC3587980 - DOI: 10.1016/j.cell.2013.01.036
Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG
Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
Nat Mater. 2013;12(5):445-51 - PMID: 23377294 - PMCID: PMC3677691 - DOI: 10.1038/nmat3539
Jain RK, Munn LL, Fukumura D
Lung window preparation in mice.
Cold Spring Harb Protoc. 2013;2013(1):ePub - PMID: 23282642 - DOI: 10.1101/pdb.prot072678
Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK
Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.
Intravital. 2012;1(1):ePub - PMID: 24353926 - PMCID: PMC3864876 - DOI: 10.4161/intv.21557
Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Proc Natl Acad Sci U S A. 2012;109(43):17561-6 - PMID: 23045683 - PMCID: PMC3491458 - DOI: 10.1073/pnas.1215397109
Jain RK, Munn LL, Fukumura D
Pancreatic tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209145 - DOI: 10.1101/pdb.prot072363
Jain RK, Munn LL, Fukumura D
Liver tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209146 - DOI: 10.1101/pdb.prot072371
Jain RK, Munn LL, Fukumura D
Lymphangiography of the mouse tail.
Cold Spring Harb Protoc. 2012;2012(11):1177-8 - PMID: 23118364 - DOI: 10.1101/pdb.prot072108
Jain RK, Munn LL, Fukumura D
Lymphangiography of the mouse ear.
Cold Spring Harb Protoc. 2012;2012(11):1179-80 - PMID: 23118365 - DOI: 10.1101/pdb.prot072116
Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Proc Natl Acad Sci U S A. 2012;109(45):E3119-27 - PMID: 23071298 - PMCID: PMC3494882 - DOI: 10.1073/pnas.1216078109
Jain RK, Munn LL, Fukumura D
Mammary fat pad chamber preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1113-4 - PMID: 23028075 - DOI: 10.1101/pdb.prot071506
Jain RK, Munn LL, Fukumura D
Mammary fat pad tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1115-6 - PMID: 23028076 - DOI: 10.1101/pdb.prot071514
Jain RK, Munn LL, Fukumura D
Corneal pocket assay in rabbits.
Cold Spring Harb Protoc. 2012;2012(9):1017-8 - PMID: 22949714 - DOI: 10.1101/pdb.prot070052
Jain RK, Munn LL, Fukumura D
Rabbit ear chambers.
Cold Spring Harb Protoc. 2012;2012(7):813-14 - PMID: 22753607 - DOI: 10.1101/pdb.prot070045
Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK
An isolated tumor perfusion model in mice.
Nat Protoc. 2012;7(4):749-55 - PMID: 22441293 - PMCID: PMC3375334 - DOI: 10.1038/nprot.2012.030
Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG
Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Nat Protoc. 2012;7(4):756-62 - PMID: 22441294 - PMCID: PMC3380105 - DOI: 10.1038/nprot.2012.031
Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D
A transient parabiosis skin transplantation model in mice.
Nat Protoc. 2012;7(4):763-70 - PMID: 22441295 - PMCID: PMC3375333 - DOI: 10.1038/nprot.2012.032
Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D
Multistage nanoparticles for improved delivery into tumor tissue.
Methods Enzymol. 2012;508:109-30 - PMID: 22449923 - PMCID: PMC3774840 - DOI: 10.1016/B978-0-12-391860-4.00006-9
Vakoc BJ, Fukumura D, Jain RK, Bouma BE
Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.
Nat Rev Cancer. 2012;12(5):363-8 - PMID: 22475930 - PMCID: PMC3560400 - DOI: 10.1038/nrc3235
Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Nat Nanotechnol. 2012;7(6):383-8 - PMID: 22484912 - PMCID: PMC3370066 - DOI: 10.1038/nnano.2012.45
Goel S, Fukumura D, Jain RK
Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology.
Proc Natl Acad Sci U S A. 2012;109(20):E1214 - PMID: 22550180 - PMCID: PMC3356659 - DOI: 10.1073/pnas.1203794109
Jain RK, Munn LL, Fukumura D, Melder RJ
In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553
Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK
Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Angew Chem Int Ed Engl. 2011;50(48):11417-20 - PMID: 22113800 - PMCID: PMC3260125 - DOI: 10.1002/anie.201104449
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Normalization of the vasculature for treatment of cancer and other diseases.
Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010
Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D
Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Proc Natl Acad Sci U S A. 2011;108(6):2426-31 - PMID: 21245339 - PMCID: PMC3038705 - DOI: 10.1073/pnas.1018382108
Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK
Scaling rules for diffusive drug delivery in tumor and normal tissues.
Proc Natl Acad Sci U S A. 2011;108(5):1799-803 - PMID: 21224417 - PMCID: PMC3033252 - DOI: 10.1073/pnas.1018154108
Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 2011;108(9):3725-30 - PMID: 21321210 - PMCID: PMC3048115 - DOI: 10.1073/pnas.1100446108
Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK
CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636
Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L
PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Clin Cancer Res. 2011;17(11):3638-48 - PMID: 21459800 - PMCID: PMC3107920 - DOI: 10.1158/1078-0432.CCR-10-2456
Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK
The biology of brain metastases-translation to new therapies.
Nat Rev Clin Oncol. 2011;8(6):344-56 - PMID: 21487419 - PMCID: PMC3259742 - DOI: 10.1038/nrclinonc.2011.58
Huang P, Westmoreland SV, Jain RK, Fukumura D
Spontaneous nonthymic tumors in SCID mice.
Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755
Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP
Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108
Jain RK, Munn LL, Fukumura D
Intravital microscopy of normal and diseased tissues in the mouse.
In: Live Cell Imaging: A Laboratory Manual, 2nd Edition, (R. D. Goldman, J. R. Swedlow and D. L. Specter, Eds.), CSH Press, Cold Spring Harbor, NY. 2010;Chapter 26:475-521
Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH
In vivo wide-area cellular imaging by side-view endomicroscopy.
Nat Methods. 2010;7(4):303-5 - PMID: 20228814 - PMCID: PMC2849759 - DOI: 10.1038/nmeth.1440
Fukumura D, Duda DG, Munn LL, Jain RK
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x
Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK
Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Biophys J. 2010;99(5):1342-9 - PMID: 20816045 - PMCID: PMC2931749 - DOI: 10.1016/j.bpj.2010.06.016
Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK
Malignant cells facilitate lung metastasis by bringing their own soil.
Proc Natl Acad Sci U S A. 2010;107(50):21677-82 - PMID: 21098274 - PMCID: PMC3003109 - DOI: 10.1073/pnas.1016234107
Brown E, Munn LL, Fukumura D, Jain RK
In vivo imaging of tumors.
Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452
Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL
Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Nat Methods. 2010;7(8):655-60 - PMID: 20581828 - PMCID: PMC2921873 - DOI: 10.1038/nmeth.1475
Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D
Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073
Choi B, Bouma B, Fukumura D, Jain RK
Optical methods in vascular biology and medicine.
J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696
Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG
Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
J Am Chem Soc. 2010;132(2):472-83 - PMID: 20025223 - PMCID: PMC2871316 - DOI: 10.1021/ja908137d
Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG
InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
J Am Chem Soc. 2010;132(2):470-1 - PMID: 20025222 - PMCID: PMC2862004 - DOI: 10.1021/ja908250r
Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG
A nanoparticle size series for in vivo fluorescence imaging.
Angew Chem Int Ed Engl. 2010;49(46):8649-52 - PMID: 20886481 - PMCID: PMC3035057 - DOI: 10.1002/anie.201003142
Jain RK, Tam J, Au P, Fukumura D
Angiogenesis in Development, Disease and Regeneration.
In: Santin M, editor. Strategies in Regenerative Medicine: Integrating Biology with Materials Design. Springer, New York. 2009;Chapter 6:ePub
Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D
Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Cancer Res. 2009;69(7):2801-8 - PMID: 19318557 - PMCID: PMC2670480 - DOI: 10.1158/0008-5472.CAN-08-4051
Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK
Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo.
Am J Pathol. 2009;175(1):294-302 - PMID: 19477947 - PMCID: PMC2708815 - DOI: 10.2353/ajpath.2009.080887
Tam J, Fukumura D, Jain RK
A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Cell Metab. 2009;9(1):52-63 - PMID: 19117546 - PMCID: PMC2643084 - DOI: 10.1016/j.cmet.2008.11.005
Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971
Dawson MR, Duda DG, Fukumura D, Jain RK
VEGFR1-activity-independent metastasis formation.
Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254
Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK
VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
PLoS One. 2009;4(9):e6525 - PMID: 19763275 - PMCID: PMC2744279 - DOI: 10.1371/journal.pone.0006525
Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK
Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
PLoS One. 2009;4(12):e8316 - PMID: 20016816 - PMCID: PMC2789383 - DOI: 10.1371/journal.pone.0008316
Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK
Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
J Cell Physiol. 2009;219(2):430-7 - PMID: 19170073 - PMCID: PMC2665001 - DOI: 10.1002/jcp.21686
Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D, Jain RK
Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.
PLoS One. 2009;4(3):e4974 - PMID: 19333381 - PMCID: PMC2659427 - DOI: 10.1371/journal.pone.0004974
Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK
Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
J Clin Oncol. 2009;27(15):2542-52 - PMID: 19332720 - PMCID: PMC2739611 - DOI: 10.1200/JCO.2008.19.9356
Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA
Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.
Opt Lett. 2009;34(13):2066-8 - PMID: 19572001 - PMCID: PMC2872111 - DOI: 10.1364/ol.34.002066
Jain RK, Booth MF, Padera TP, Munn LL, Fukumura D, Brown E
Applications of nonlinear intravital microscopy in tumor biology.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 29:735-756
Fukumura D, Jain RK
Imaging angiogenesis and the microenvironment.
APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x
Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK
Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182
Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D
Perivascular nitric oxide gradients normalize tumor vasculature.
Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730
Huang P, Duda DG, Jain RK, Fukumura D
Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079
Jain RK, Lahdenranta J, Fukumura D
Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
PLoS Med. 2008;5(1):e24 - PMID: 18232729 - PMCID: PMC2214795 - DOI: 10.1371/journal.pmed.0050024
Au P, Tam J, Fukumura D, Jain RK
Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Blood. 2008;111(9):4551-8 - PMID: 18256324 - PMCID: PMC2343592 - DOI: 10.1182/blood-2007-10-118273
Jain RK, Fukumura D, Munn LL, Brown E
Tumor Angiogenesis and Blood Flow.
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:199-201
Jain RK, Fukumura D, Munn LL, Brown E
Optical Microscopy in Small Animal Research
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:183-187
Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK
Data do not support benefits of anti-VEGFR3 therapy
Cancer Research. 2007;67:5055
Fukumura D, Jain RK
Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
J Cell Biochem. 2007;101(4):937-49 - PMID: 17171643 - DOI: 10.1002/jcb.21187
Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE
Influence of tumor cell and stroma sensitivity on tumor response to radiation.
Cancer Res. 2007;67(9):4016-21 - PMID: 17483312 - DOI: 10.1158/0008-5472.CAN-06-4498
Fukumura D, Jain RK
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
Microvasc Res. 2007;74(2-3):72-84 - PMID: 17560615 - PMCID: PMC2100036 - DOI: 10.1016/j.mvr.2007.05.003
Au P, Tam J, Fukumura D, Jain RK
Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11
Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.
Nat Biotechnol. 2007;25(3):317-8 - PMID: 17322871 - DOI: 10.1038/nbt1287
Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK
Anti-VEGFR-3 therapy and lymph node metastasis [corrected].
Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935
Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655
Fukumura D, Kashiwagi S, Jain RK
The role of nitric oxide in tumour progression.
Nat Rev Cancer. 2006;6(7):521-34 - PMID: 16794635 - DOI: 10.1038/nrc1910
Cochran DM, Fukumura D, Ancukiewicz M, Carmeliet P, Jain RK
Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Ann Biomed Eng. 2006;34(8):1247-58 - PMID: 16832606 - DOI: 10.1007/s10439-006-9134-4
Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D
Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Cancer Res. 2006;66(8):3971-7 - PMID: 16618713 - DOI: 10.1158/0008-5472.CAN-04-3085
Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK
Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392
Brown EB, Munn LL, Fukumura D, Jain RK
A Practical Guide to in vivo Imaging of Tumors.
In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 92:695-700
Jain RK, Au P, Tam J, Duda DG, Fukumura D
Engineering vascularized tissue.
Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821
Hagendoorn J, Padera TP, Fukumura D, Jain RK
Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003
Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
J Clin Invest. 2005;115(7):1816-27 - PMID: 15951843 - PMCID: PMC1143589 - DOI: 10.1172/JCI24015
Huang P, McKee TD, Jain RK, Fukumura D
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003
Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Nat Med. 2005;11(6):678-82 - PMID: 15880117 - PMCID: PMC2686110 - DOI: 10.1038/nm1247
Jain RK, Brown EB, Munn LL, Fukumura D
Intravital microscopy of normal and diseased tissues in the mouse.
In: Live Cell Imaging: A Laboratory Manual (Editors: R. D. Goldman and D. L. Spector). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 2004;Chapter 24:435-466
Xu L, Pathak PS, Fukumura D
Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells.
Clin Cancer Res. 2004;10(2):701-7 - PMID: 14760093 - DOI: 10.1158/1078-0432.ccr-0953-03
Gohongi T, Todoroki T, Fukumura D, Jain RK
Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Oncol Rep. 2004;11(4):803-7 - PMID: 15010876
Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK
Tissue engineering: creation of long-lasting blood vessels.
Nature. 2004;428(6979):138-9 - PMID: 15014486 - DOI: 10.1038/428138a
Duda DG, Fukumura D, Jain RK
Role of eNOS in neovascularization: NO for endothelial progenitor cells.
Trends Mol Med. 2004;10(4):143-5 - PMID: 15162796 - DOI: 10.1016/j.molmed.2004.02.001
Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK
Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Cancer Cell. 2004;6(6):553-63 - PMID: 15607960 - DOI: 10.1016/j.ccr.2004.10.011
Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK
Differential transplantability of tumor-associated stromal cells.
Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268
Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK
Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.
Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24
Dolmans DE, Fukumura D, Jain RK
Photodynamic therapy for cancer.
Nat Rev Cancer. 2003;3(5):380-7 - PMID: 12724736 - DOI: 10.1038/nrc1071
Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D
Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts.
Clin Cancer Res. 2003;9(11):4221-6 - PMID: 14519649
Forbes NS, Munn LL, Fukumura D, Jain RK
Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Cancer Res. 2003;63(17):5188-93 - PMID: 14500342
Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD
Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer Res. 2003;63(4):747-51 - PMID: 12591719
Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK
Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.
Circ Res. 2003;93(9):e88-97 - PMID: 14525808 - PMCID: PMC2755542 - DOI: 10.1161/01.RES.0000099243.20096.FA
Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK
Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Cancer Res. 2002;62(7):2151-6 - PMID: 11929837
Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK
Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Clin Cancer Res. 2002;8(4):1008-13 - PMID: 11948107
Jain RK, Munn LL, Fukumura D
Dissecting tumour pathophysiology using intravital microscopy.
Nat Rev Cancer. 2002;2(4):266-76 - PMID: 12001988 - DOI: 10.1038/nrc778
Dolmans DE, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D
Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.
Cancer Res. 2002;62(15):4289-94 - PMID: 12154031
Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Cancer Res. 2002;62(23):6831-6 - PMID: 12460895
Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Nature. 2002;416(6878):279-80 - PMID: 11907566 - DOI: 10.1038/416279b
Jain RK, Munn LL, Fukumura D
Transparent Window Models and Intravital Microscopy: Imaging Gene Expression
Physiological Function and Drug Delivery in Tumors, In: Tumor Models in Cancer Research, B. Teicher, Ed., Humana Press, Inc., Totowa, NJ. 2001;Chapter 34:647-671
Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nat Med. 2001;7(7):864-8 - PMID: 11433354 - DOI: 10.1038/89997
Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D
Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Lab Invest. 2001;81(10):1439-51 - PMID: 11598156 - DOI: 10.1038/labinvest.3780357
Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105
Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045
Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.
Proc Natl Acad Sci U S A. 2001;98(5):2604-9 - PMID: 11226286 - PMCID: PMC30185 - DOI: 10.1073/pnas.041359198
Hartford AC, Gohongi T, Fukumura D, Jain RK
Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
Cancer Res. 2000;60(8):2128-31 - PMID: 10786673
Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK
Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer Res. 2000;60(16):4556-60 - PMID: 10969807
Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer Res. 2000;60(22):6248-52 - PMID: 11103778
Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA
Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.
Microcirculation. 1999;5(2-3):153-71 - PMID: 9789256
Suzuki M, Mori M, Fukumura D, Suzuki H, Miura S, Ishii H
Omeprazole attenuates neutrophil-endothelial cell adhesive interaction induced by extracts of Helicobacter pylori.
J Gastroenterol Hepatol. 1999;14(1):27-31 - PMID: 10029274 - DOI: 10.1046/j.1440-1746.1999.01809.x
Swartz MA, Kristensen CA, Melder RJ, Roberge S, Calautti E, Fukumura D, Jain RK
Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.
Br J Cancer. 1999;81(5):756-9 - PMID: 10555742 - PMCID: PMC2374305 - DOI: 10.1038/sj.bjc.6690760
Monsky WL, Fukumura D, Gohongi T, Ancukiewcz M, Weich HA, Torchilin VP, Yuan F, Jain RK
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Cancer Res. 1999;59(16):4129-35 - PMID: 10463618
Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK
Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nat Med. 1999;5(10):1203-8 - PMID: 10502827 - DOI: 10.1038/13524
Jain RK, Munn LL, Fukumura D, Melder RJ
In Vitro and In Vivo Quantification of Adhesion Between Leukocytes and Vascular Endothelium.
In: Methods in Molecular Medicine - Methods in Tissue Engineering, J.R. Morgan and M.L. Yarmush, Eds., Humana Press, Totowa. 1998;:553-575
Fukumura D, Jain RK
Role of nitric oxide in angiogenesis and microcirculation in tumors.
Cancer Metastasis Rev. 1998;17(1):77-89 - PMID: 9544424 - DOI: 10.1023/a:1005908805527
Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK
Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.
J Invest Dermatol. 1998;111(1):1-6 - PMID: 9665379 - DOI: 10.1046/j.1523-1747.1998.00262.x
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E, Keshet E
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature. 1998;394(6692):485-90 - PMID: 9697772 - DOI: 10.1038/28867
Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B
Tumor induction of VEGF promoter activity in stromal cells.
Cell. 1998;94(6):715-25 - PMID: 9753319 - DOI: 10.1016/s0092-8674(00)81731-6
Suzuki M, Mori M, Miura S, Suematsu M, Fukumura D, Kimura H, Ishii H
Omeprazole attenuates oxygen-derived free radical production from human neutrophils.
Free Radic Biol Med. 1997;21(5):727-31 - PMID: 8891677 - DOI: 10.1016/0891-5849(96)00180-3
Tanaka S, Miura S, Kimura H, Ohkubo N, Tsuzuki Y, Fukumura D, Serizawa H, Kurose I, Mori M, Ishii H
Amelioration of chronic inflammation by ingestion of elemental diet in a rat model of granulomatous enteritis.
Dig Dis Sci. 1997;42(2):408-19 - PMID: 9052527 - DOI: 10.1023/a:1018890624384
Higuchi H, Kurose I, Fukumura D, Yan HJ, Saito H, Miura S, Hokari R, Watanabe N, Zeki S, Yoshida M, Kitajima M, Granger DN, Ishii H
Active oxidants mediate IFN-alpha-induced microvascular alterations in rat mesentery.
J Immunol. 1997;158(10):4893-900 - PMID: 9144506
Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
Science. 1997;276(5317):1423-5 - PMID: 9162011 - DOI: 10.1126/science.276.5317.1423
Fukumura D, Yuan F, Monsky WL, Chen Y, Jain RK
Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
Am J Pathol. 1997;151(3):679-88 - PMID: 9284816 - PMCID: PMC1857859
Horie Y, Kato S, Ohki E, Hamamatsu H, Fukumura D, Kurose I, Suzuki H, Suematsu M, Miura S, Ishii H
Effect of lipopolysaccharides on erythrocyte flow velocity in rat liver.
J Gastroenterol. 1997;32(6):783-90 - PMID: 9430017 - DOI: 10.1007/BF02936955
Fukumura D, Yuan F, Endo M, Jain RK
Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.
Am J Pathol. 1997;150(2):713-25 - PMID: 9033284 - PMCID: PMC1858293
Yoshida M, Fukumura D, Wakabayashi G, Otani Y, Oshima A, Shimazu M, Kubota T, Kumai K, Kurose I, Miura S
Gastric microcirculatory disturbance and behaviour of leucocytes after thermal injury: intravital observation of arteriovenous shunting channels in the gastric submucosal layer.
J Gastroenterol Hepatol. 1996;10(4):365-70 - PMID: 8527699 - DOI: 10.1111/j.1440-1746.1995.tb01585.x
Miura S, Fukumura D, Shiozaki H, Suzuki M, Kurose I, Suematsu M, Tsuchiya M, Ishii H
Bile acid-induced depolarization of mitochondrial membrane potential preceding cell injury in cultured gastric mucosal cells.
J Gastroenterol Hepatol. 1996;10(6):621-6 - PMID: 8580403 - DOI: 10.1111/j.1440-1746.1995.tb01360.x
Suzuki H, Miura S, Imaeda H, Suzuki M, Han JY, Mori M, Fukumura D, Tsuchiya M, Ishii H
Enhanced levels of chemiluminescence and platelet activating factor in urease-positive gastric ulcers.
Free Radic Biol Med. 1996;20(3):449-54 - PMID: 8720917 - DOI: 10.1016/0891-5849(96)02048-5
Fukumura D, Kurose I, Miura S, Serizawa H, Sekizuka E, Nagata H, Tsuchiya M, Ishii H
Role of endothelin-1 in repeated electrical stimulation-induced microcirculatory disturbance and mucosal damage in rat stomach.
J Gastroenterol Hepatol. 1996;11(3):279-85 - PMID: 8742927 - DOI: 10.1111/j.1440-1746.1996.tb00076.x
Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ
Leukocyte-endothelial adhesion and angiogenesis in tumors.
Cancer Metastasis Rev. 1996;15(2):195-204 - PMID: 8842491 - DOI: 10.1007/BF00437472
Fukumura D, Yonei Y, Kurose I, Saito H, Ohishi T, Higuchi H, Miura S, Kato S, Kimura H, Ebinuma H, Ishi H
Role in nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicity in vitro and ex vivo.
Hepatology. 1996;24(1):141-9 - PMID: 8707254 - DOI: 10.1053/jhep.1996.v24.pm0008707254
Saito H, Kurose I, Ebinuma H, Fukumura D, Higuchi H, Atsukawa K, Tada S, Kimura H, Yonei Y, Masuda T, Miura S, Ishii H
Kupffer cell-mediated cytotoxicity against hepatoma cells occurs through production of nitric oxide and adhesion via ICAM-1/CD18.
Int Immunol. 1996;8(7):1165-72 - PMID: 8757962 - DOI: 10.1093/intimm/8.7.1165
Miura S, Fukumura D, Kurose I, Higuchi H, Kimura H, Tsuzuki Y, Shigematsu T, Han JY, Tsuchiya M, Ishii H
Roles of ET-1 in endotoxin-induced microcirculatory disturbance in rat small intestine.
Am J Physiol. 1996;271(3 Pt 1):G461-9 - PMID: 8843771 - DOI: 10.1152/ajpgi.1996.271.3.G461
Kurose I, Higuchi H, Yonei Y, Ebinuma H, Watanabe N, Hokari R, Fukumura D, Miura S, Takaishi M, Saito H, Nakatsumi RC, Ishii H
Rat Kupffer cell-derived nitric oxide suppresses proliferation and induces apoptosis of syngeneic hepatoma cells.
Gastroenterology. 1996;111(4):1058-70 - PMID: 8831602 - DOI: 10.1016/s0016-5085(96)70075-6
Kurose I, Miura S, Higuchi H, Watanabe N, Kamegaya Y, Takaishi M, Tomita K, Fukumura D, Kato S, Ishii H
Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles for tumor necrosis factor alpha.
Hepatology. 1996;24(5):1185-92 - PMID: 8903396 - DOI: 10.1002/hep.510240534
Fukumura D, Miura S, Kurose I, Higuchi H, Suzuki H, Ebinuma H, Han JY, Watanabe N, Wakabayashi G, Kitajima M, Ishii H
IL-1 is an important mediator for microcirculatory changes in endotoxin-induced intestinal mucosal damage.
Dig Dis Sci. 1996;41(12):2482-92 - PMID: 9011462 - DOI: 10.1007/BF02100147
Miura S, Fukumura D, Kurose I, Kimura H, Suzuki M, Morishita T, Nagata H, Tsuchiya M, Ishii H
Spatial heterogeneity of mucosal blood flow during ischemia-reperfusion injury of rat stomach investigated by laser Doppler perfusion imaging.
J Gastroenterol. 1995;30(3):279-86 - PMID: 7647892 - DOI: 10.1007/BF02347500
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Cancer Res. 1995;55(17):3752-6 - PMID: 7641188
Miura S, Tsuzuki Y, Fukumura D, Serizawa H, Suematsu M, Kurose I, Imaeda H, Kimura H, Nagata H, Tsuchiya M
Intravital demonstration of sequential migration process of lymphocyte subpopulations in rat Peyer's patches.
Gastroenterology. 1995;109(4):1113-23 - PMID: 7557076 - DOI: 10.1016/0016-5085(95)90569-3
Fukumura D, Kurose I, Miura S, Tsuchiya M, Ishii H
Oxidative stress in gastric mucosal injury: role of platelet-activating factor-activated granulocytes.
J Gastroenterol. 1995;30(5):565-71 - PMID: 8574326 - DOI: 10.1007/BF02367780
Kurose I, Miura S, Saito H, Tada S, Fukumura D, Higuchi H, Ishii H
Rat Kupffer cell-derived nitric oxide modulates induction of lymphokine-activated killer cell.
Gastroenterology. 1995;109(6):1958-68 - PMID: 7498662 - DOI: 10.1016/0016-5085(95)90764-5
Fukumura D, Salehi HA, Witwer B, Tuma RF, Melder RJ, Jain RK
Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.
Cancer Res. 1995;55(21):4824-9 - PMID: 7585514
Kurose I, Miura S, Fukumura D, Suzuki M, Nagata H, Sekizuka E, Morishita T, Tsuchiya M
Attenuating effect of antithrombin III on the fibrinolytic activation and microvascular derangement in rat gastric mucosa.
Thromb Haemost. 1994;71(1):119-23 - PMID: 8165629
Yonei Y, Kurose I, Fukumura D, Saito H, Miura S, Tsukada N, Oda M, Tsuchiya M
Evidence of direct interaction between Kupffer cells and colon cancer cells: an ultrastructural study of the co-culture.
Liver. 1994;14(1):37-44 - PMID: 8177028 - DOI: 10.1111/j.1600-0676.1994.tb00005.x
Tashiro H, Miura S, Kurose I, Fukumura D, Suzuki H, Suematsu M, Yoshioka M, Tsuchiya M, Kai A, Kudoh Y
Verotoxin induces hemorrhagic lesions in rat small intestine. Temporal alteration of vasoactive substances.
Dig Dis Sci. 1994;39(6):1230-8 - PMID: 8200255 - DOI: 10.1007/BF02093788
Suzuki M, Miura S, Mori M, Kai A, Suzuki H, Fukumura D, Suematsu M, Tsuchiya M
Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants.
Gut. 1994;35(10):1375-8 - PMID: 7959190 - PMCID: PMC1375008 - DOI: 10.1136/gut.35.10.1375
Miura S, Imaeda H, Shiozaki H, Kurose I, Fukumura D, Tashiro H, Serizawa H, Suematsu M, Sekizuka E, Tsuchiya M
Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid.
Am J Physiol. 1993;264(5 Pt 1):G828-34 - PMID: 8498509 - DOI: 10.1152/ajpgi.1993.264.5.G828
Kurose I, Suematsu M, Miura S, Fukumura D, Sekizuka E, Nagata H, Oshio C, Tsuchiya M
Oxyradical generation from leukocytes during endotoxin-induced microcirculatory disturbance in rat mesentery--attenuating effect of cetraxate.
Toxicol Appl Pharmacol. 1993;120(1):37-44 - PMID: 8511781 - DOI: 10.1006/taap.1993.1084
Kurose I, Fukumura D, Miura S, Suematsu M, Suzuki M, Sekizuka E, Nagata H, Morishita T, Tsuchiya M
Fluorographic study on the oxidative stress in the process of gastric mucosal injury: attenuating effect of vitamin E.
J Gastroenterol Hepatol. 1993;8(3):254-8 - PMID: 8518396 - DOI: 10.1111/j.1440-1746.1993.tb01196.x
Kurose I, Miura S, Fukumura D, Yonei Y, Saito H, Tada S, Suematsu M, Tsuchiya M
Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst.
Cancer Res. 1993;53(11):2676-82 - PMID: 8388320
Kurose I, Fukumura D, Miura S, Sekizuka E, Nagata H, Suematsu M, Tsuchiya M
Nitric oxide mediates vasoactive effects of endothelin-3 on rat mesenteric microvascular beds in vivo.
Angiology. 1993;44(6):483-90 - PMID: 8503515 - DOI: 10.1177/000331979304400609
Kurose I, Kato S, Ishii H, Fukumura D, Miura S, Suematsu M, Tsuchiya M
Nitric oxide mediates lipopolysaccharide-induced alteration of mitochondrial function in cultured hepatocytes and isolated perfused liver.
Hepatology. 1993;18(2):380-8 - PMID: 8340067
Kurose I, Miura S, Fukumura D, Tsuchiya M
Mechanisms of endothelin-induced macromolecular leakage in microvascular beds of rat mesentery.
Eur J Pharmacol. 1993;250(1):85-94 - PMID: 8119327 - DOI: 10.1016/0014-2999(93)90624-q
Kurose I, Miura S, Suematsu M, Serizawa H, Fukumura D, Asako H, Hibi T, Tsuchiya M
Tissue-type plasminogen activator of colonic mucosa in ulcerative colitis. Evidence of endothelium-derived fibrinolytic activation.
Dig Dis Sci. 1992;37(2):307-11 - PMID: 1735352 - DOI: 10.1007/BF01308189
Saito H, Fukumura D, Kurose I, Suematsu M, Tada S, Kagawa T, Miura S, Morizane T, Tsuchiya M
Visualization of oxidative processes at the cellular level during neutrophil-mediated cytotoxicity against a human hepatoma cell line, HCC-M.
Int J Cancer. 1992;51(1):124-9 - PMID: 1314229 - DOI: 10.1002/ijc.2910510122
Kurose I, Miura S, Fukumura D, Tashiro H, Imaeda H, Shiozaki H, Suematsu M, Nagata H, Sekizuka E, Tsuchiya M
Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1.
Gut. 1992;33(7):868-71 - PMID: 1644323 - PMCID: PMC1379395 - DOI: 10.1136/gut.33.7.868
Shimmura S, Tsubota K, Oguchi Y, Fukumura D, Suematsu M, Tsuchiya M
Oxiradical-dependent photoemission induced by a phacoemulsification probe.
Invest Ophthalmol Vis Sci. 1992;33(10):2904-7 - PMID: 1326494
Liu YY, Miura S, Suzuki H, Kurose I, Fukumura D, Suzuki M, Suematsu M, Tsuchiya M
Quantitative analysis of mesenteric microcirculatory disturbances induced by autonomic nervous irritation.
Keio J Med. 1992;41(3):128-33 - PMID: 1434306 - DOI: 10.2302/kjm.41.128
Suzuki M, Miura S, Suematsu M, Fukumura D, Kurose I, Suzuki H, Kai A, Kudoh Y, Ohashi M, Tsuchiya M
Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury.
Am J Physiol. 1992;263(5 Pt 1):G719-25 - PMID: 1443147 - DOI: 10.1152/ajpgi.1992.263.5.G719
Miura S, Kurose I, Fukumura D, Suematsu M, Sekizuka E, Tashiro H, Serizawa H, Asako H, Tsuchiya M
Ischemic bowel necrosis induced by endothelin-1: an experimental model in rats.
Digestion. 1991;48(3):163-72 - PMID: 1916037 - DOI: 10.1159/000200689
Kurose I, Saito H, Suematsu M, Fukumura D, Miura S, Morizane T, Tsuchiya M
Kupffer cell-mediated oxidative stress on colon cancer cell line visualized by digital imaging fluorescence microscopy.
Cancer Lett. 1991;59(3):201-9 - PMID: 1913616 - DOI: 10.1016/0304-3835(91)90142-5
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