Within the wider field of clinical anesthesia I specializes in the surgical anesthesia of patients with the complication of pulmonary hypertension. Such patients have a high perioperative mortality rate, and it is often very difficult for them to be anesthetized. In this respect, We has professional knowledge and skills in intensive care, in the main because Kyorin University accepts many pulmonary hypertension patients. We have extensive clinical experience of this kind of anesthesia, which we have performed routinely. In daily clinical practice, we have hardly worked in the surgical ICU and operating rooms. Therefore, our clinical focus is on sepsis conditions and on the peripheral circulatory environment under severe disease states.
The theme of basic research is endothelial cell disorder; we have created our own murine hemorrhagic model and has striven to elucidate the endothelial cell function by observing the peripheral circulation of mice. In particular, we focus on the physiological role of the glycocalyx gel layer. we are devoting our efforts toward the elucidation of its mechanism and to the improvement of endothelial cell function of severe pathology.
In January 2022, I came to the steel. lab at MGH and started my research. I am just starting out, but I will do my best. The following are my research results so far.My publication
・Shingo Mitsuda, Kohji Uzawa, Marie Sawa, Tadao Ando, Takahiro Yoshikawa, Hideki Miyao, Tomoko Yorozu, Akira Ushiyama. Vascular endothelial glycocalyx plays a role in the obesity paradox according to intravital observation. Front Cardiovasc Med. 2021 Nov 2;8:727888. PMID: 34796208
・Uzawa K, Seki H, Yorozu T. Residual paralysis caused by 50 mg rocuronium after reversal with 4 mg/kg sugammadex: a case report. BMC Anesthesiol. 2021 May 20;21(1): 154. PMID: 34016059
・Uzawa K, Ushiyama A, Mitsuda S, Ando T, Sawa M, Miyao H, Yorozu T. The protective effect of hydroxyethyl starch solution on the glycocalyx layer in an acute hemorrhage mouse model. J Anesth. 2019 Oct 15. PMID:31617003
・Jimbo I, Uzawa K, Tokumine J, Mitsuda S, Watanabe K, Yorozu T. Ultrasonographic identification of the cricothyroid membrane in a patient with a difficult airway as a result of cervical hematoma caused by hemophilia: a case report. BMC Anesthesiol. 2019 Jul 9;19(1):124. PMID:31288737
・Okano H, Uzawa K, Watanabe K, Motoyasu A, Tokumine J, Lefor AK, Yorozu T. Ultrasound-guided identification of the cricothyroid membrane in a patient with a difficult airway: a case report. BMC Emerg Med. 2018 Feb 8;18(1):5. PMID:29422029
・Kohji Uzawa, Joho Tokumine, Akihiro Suzuki. Utility of ultrasound in airway assessment and management. J Jpn Soc of Intensive Care Med 2017;24: 55-6.
・Kohji Uzawa, Tokumine J, Lefor AK, Takagi T, Watanabe K, Yorozu T. Difficult Airway Due to an Undiagnosed Subglottic Tumor: A Case Report. Medicine (Baltimore). 2016 Apr; 95(15) PMID: 27082606
・Kohyama T, Moriyama K, Kanai R, Kotani M, Kohji Uzawa, Satoh T, Yorozu T. Accuracy of Pulse Oximeters in Detecting Hypoxemia in Patients with Chronic Thromboembolic Pulmonary Hypertension. PLoS One. 2015 Oct 28;10(10): PMID: 26509896
・Kohji Uzawa, Masako Hakone, Harumasa Nakazawa, Hiroyuki Yasuda, Kiyosi Moriyama, Tomoko Yorozu. Spinal Anesthesia Using a Low Dose of Isobaric Bupivacaine in a Patient with Pulmonary Artery Hypertension and Mixed Obstructive and Restrictive Lung Disease Undergoing Repeated Femoral Fracture Surgery. MASUI 2014.2.
・Kohji Uzawa, Kiyoshi Moriyama, Mariko Kotani, Tomoki Kohyama, Yuuki Ohashi, Hiroyuki Yasuda, Yasuhide Iwao, Tomoko Yorozu Long-term ventilatory support to stabilize a flail chest in a patient with multiple myeloma J Jpn Soc Intensive Care Med 2012; 19: 207-210.
・Moriyama K, Kohji Uzawa, Iijima T,et al. Scheduled perioperative switch from oral sildenafil to intravenous epoprostenol in a patient with Eisenmenger syndrome undergoing a sigmoidectomy. J Clin Anesth. 2012 Sep: P487-9.