Xingjian Zhang

Research Fellow

Xingjian Zhang

Research Fellow

Dr. Xingjian Zhang is a Research Fellow at Harvard Medical School and Massachusetts General Hospital, working under the co-mentorship of Dr. Rakesh Jain and Dr. Lance Munn. His research focuses on addressing critical challenges in immuno-oncology from a biophysical perspective. Dr. Zhang specializes in engineering immune cells to overcome the biophysical barriers of the tumor microenvironment, which contribute to cancer immune evasion. His goal is to improve immunotherapy for solid tumors, providing better treatment options and survival outcomes for patients resistant to current therapies.

*Awardee of the 2025 Mass General Neurosicence Transformative Scholar Awards

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Publications

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O'Melia MJ, Menzel L, Lei PJ, Zhou H, Zhang X, Contreras-Alvarado N, Rajotte JJ, Liu L, Nikmaneshi MR, Baish JW, Ubellacker JM, Boland GM, Cohen S, Padera TP, Munn LL

Overcoming impaired antigen presentation in tumor-draining lymph nodes facilitates immunotherapy.
J Immunother Cancer. 2025;13(12):ePub - PMID: 41469140 - PMCID: PMC12766806 - DOI: 10.1136/jitc-2025-013364