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Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - DOI: 10.1038/s41588-022-01134-8
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A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.

Clin Cancer Res. 2022;28(18):3950-3957 - PMID: 35833850 - PMCID: PMC9481695 - DOI: 10.1158/1078-0432.CCR-22-1169
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The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy.

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Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.

Clin Cancer Res. 2022;28(14):3076-3090 - PMID: 35584239 - PMCID: PMC9355624 - DOI: 10.1158/1078-0432.CCR-22-0486
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Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.

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Increased CD8+ T-Cell Infiltration and Efficacy for Multikinase Inhibitors after PD-1 Blockade in Hepatocellular Carcinoma.

J Natl Cancer Inst. 2022;114(9):1301-1305 - PMID: 35288743 - PMCID: PMC9468280 - DOI: 10.1093/jnci/djac051
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Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55α Complex the Answer?

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Nat Protoc. 2020;15(8):2321-2340 - PMID: 32681151 - DOI: 10.1038/s41596-020-0328-2
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Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines.

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Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma: The GEMCAD 1402 Randomized Clinical Trial.

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Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.

Am Soc Clin Oncol Educ Book. 2019;39:165-174 - PMID: 31099649 - PMCID: PMC6596289 - DOI: 10.1200/EDBK_237987
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Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?

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Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.

Proc Natl Acad Sci U S A. 2019;116(7):2662-2671 - PMID: 30700544 - PMCID: PMC6377457 - DOI: 10.1073/pnas.1818322116
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Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.

Proc Natl Acad Sci U S A. 2019;116(10):4558-4566 - PMID: 30700545 - PMCID: PMC6410779 - DOI: 10.1073/pnas.1815515116
Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L

A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.

Nat Protoc. 2019;14(2):541-555 - PMID: 30617350 - PMCID: PMC6571021 - DOI: 10.1038/s41596-018-0105-7
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Clin Cancer Res. 2019;25(7):2024-2026 - PMID: 30630829 - PMCID: PMC6445672 - DOI: 10.1158/1078-0432.CCR-18-3724
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Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.

Proc Natl Acad Sci U S A. 2019;116(6):2210-2219 - PMID: 30659155 - PMCID: PMC6369817 - DOI: 10.1073/pnas.1818357116
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Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.

NPJ Breast Cancer. 2019;5:4 - PMID: 30675514 - PMCID: PMC6333771 - DOI: 10.1038/s41523-018-0100-8
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Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.

Sci Rep. 2018;8(1):17062 - PMID: 30459364 - PMCID: PMC6244161 - DOI: 10.1038/s41598-018-34820-x
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Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.

Nat Rev Cancer. 2018;18(11):720 - PMID: 30337715 - PMCID: PMC6357229 - DOI: 10.1038/s41568-018-0072-x
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Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study.

Transl Cancer Res. 2018;7(Suppl 1):S16-S20 - PMID: 30175050 - PMCID: PMC6117158 - DOI: 10.21037/tcr.2017.12.17
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A homing system targets therapeutic T cells to brain cancer.

Nature. 2018;561(7723):331-337 - PMID: 30185905 - PMCID: PMC6402337 - DOI: 10.1038/s41586-018-0499-y
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Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.

Proc Natl Acad Sci U S A. 2018;115(37):E8717-E8726 - PMID: 30150398 - PMCID: PMC6140479 - DOI: 10.1073/pnas.1807105115
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Phase I and biomarker study of plerixafor and bevacizumab in recurrent high-grade glioma.

Clin Cancer Res. 2018;24(19):4643-4649 - PMID: 29941486 - DOI: 10.1158/1078-0432.CCR-18-1025
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Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.

Int J Radiat Oncol Biol Phys. 2018;101(5):1222-1225 - PMID: 29859792 - PMCID: PMC6050125 - DOI: 10.1016/j.ijrobp.2018.04.026
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Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis. 2018;21(3):425-532 - PMID: 29766399 - PMCID: PMC6237663 - DOI: 10.1007/s10456-018-9613-x
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Quantifying solid stress and elastic energy from excised or in situ tumors.

Nat Protoc. 2018;13(5):1091-1105 - PMID: 29674756 - PMCID: PMC6546092 - DOI: 10.1038/nprot.2018.020
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A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

Cancer Cell. 2018;33(5):874-889.e7 - PMID: 29681511 - PMCID: PMC6211172 - DOI: 10.1016/j.ccell.2018.03.020
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Understanding the tumor immune microenvironment (TIME) for effective therapy.

Nat Med. 2018;24(5):541-550 - PMID: 29686425 - PMCID: PMC5998822 - DOI: 10.1038/s41591-018-0014-x
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Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green.

Proc Natl Acad Sci U S A. 2018;115(17):4465-4470 - PMID: 29626132 - PMCID: PMC5924901 - DOI: 10.1073/pnas.1718917115
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Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.

Trends Cancer. 2018;4(4):292-319 - PMID: 29606314 - PMCID: PMC5930008 - DOI: 10.1016/j.trecan.2018.02.005
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Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.

Trends Cancer. 2018;4(4):258-259 - PMID: 29606306 - PMCID: PMC6161778 - DOI: 10.1016/j.trecan.2018.02.010
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A Physical View of Cancer.

Trends Cancer. 2018;4(4):257 - PMID: 29606305 - PMCID: PMC6296379 - DOI: 10.1016/j.trecan.2018.03.001
Pinter M, Kwanten WJ, Jain RK

Renin-angiotensin system inhibitors to mitigate cancer treatment-related adverse events.

Clin Cancer Res. 2018;24(16):3803-3812 - PMID: 29610292 - PMCID: PMC6095804 - DOI: 10.1158/1078-0432.CCR-18-0236
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Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.

Sci Transl Med. 2018;10(432):ePub - PMID: 29540614 - PMCID: PMC5936748 - DOI: 10.1126/scitranslmed.aag0945
Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.

Nat Rev Clin Oncol. 2018;15(5):325-340 - PMID: 29508855 - PMCID: PMC5921900 - DOI: 10.1038/nrclinonc.2018.29
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Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

J Immunol. 2018;200(8):3000-3007 - PMID: 29500245 - PMCID: PMC5893394 - DOI: 10.4049/jimmunol.1700407
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Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.

Proc Natl Acad Sci U S A. 2018;115(9):E2077-E2084 - PMID: 29440379 - PMCID: PMC5834719 - DOI: 10.1073/pnas.1719966115
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Origins of lymphatic and distant metastases in human colorectal cancer.

Science. 2017;357(6346):55-60 - PMID: 28684519 - PMCID: PMC5536201 - DOI: 10.1126/science.aai8515
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Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma.

Clin Cancer Res. 2017;23(19):5959-5969 - PMID: 28600474 - PMCID: PMC5856249 - DOI: 10.1158/1078-0432.CCR-17-0256
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Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.

Oncotarget. 2017;8(65):108292-108302 - PMID: 29312532 - PMCID: PMC5752445 - DOI: 10.18632/oncotarget.22660
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Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival.

NPJ Precis Oncol. 2017;1:ePub - PMID: 29202103 - PMCID: PMC5708878 - DOI: 10.1038/s41698-017-0020-3
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Use of inhibitors of the renin-angiotensin system is associated with longer survival in patients with hepatocellular carcinoma.

United European Gastroenterol J. 2017;5(7):987-996 - PMID: 29163965 - PMCID: PMC5676550 - DOI: 10.1177/2050640617695698
Rowlands CJ, Park D, Bruns OT, Piatkevich KD, Fukumura D, Jain RK, Bawendi MG, Boyden ES, So PT

Wide-field three-photon excitation in biological samples.

Light Sci Appl. 2017;6:e16255 - PMID: 29152380 - PMCID: PMC5687557 - DOI: 10.1038/lsa.2016.255
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Next-generation in vivo optical imaging with short-wave infrared quantum dots.

Nat Biomed Eng. 2017;1:ePub - PMID: 29119058 - PMCID: PMC5673283 - DOI: 10.1038/s41551-017-0056
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Engineering and physical sciences in oncology: challenges and opportunities.

Nat Rev Cancer. 2017;17(11):659-675 - PMID: 29026204 - PMCID: PMC5683724 - DOI: 10.1038/nrc.2017.83
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A cerebellar window for intravital imaging of normal and disease states in mice.

Nat Protoc. 2017;12(11):2251-2262 - PMID: 28981123 - PMCID: PMC5918134 - DOI: 10.1038/nprot.2017.101
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Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy.

Sci Transl Med. 2017;9(410):ePub - PMID: 28978752 - PMCID: PMC5928511 - DOI: 10.1126/scitranslmed.aan5616
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Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.

Proc Natl Acad Sci U S A. 2017;114(39):10455-10460 - PMID: 28900008 - PMCID: PMC5625928 - DOI: 10.1073/pnas.1710754114
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YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.

Dev Cell. 2017;42(5):462-478.e7 - PMID: 28867486 - DOI: 10.1016/j.devcel.2017.08.002
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Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

J Clin Invest. 2017;127(8):3039-3051 - PMID: 28691930 - PMCID: PMC5531423 - DOI: 10.1172/JCI93182
Askoxylakis V, Arvanitis CD, Wong CSF, Ferraro GB, Jain RK

Emerging Strategies for Delivering Antiangiogenic Therapies to Primary and Metastatic Brain Tumors.

Adv Drug Deliv Rev. 2017;119:159-174 - PMID: 28648712 - DOI: 10.1016/j.addr.2017.06.011
Askoxylakis V, Kodack DP, Ferraro GB, Jain RK

Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?

Breast Cancer Res Treat. 2017;165(2):467-468 - PMID: 28643019 - DOI: 10.1007/s10549-017-4351-0
Levin VA, Chan J, Datta M, Yee JL, Jain RK

Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.

J Neurooncol. 2017;134(2):325-330 - PMID: 28631191 - DOI: 10.1007/s11060-017-2528-3
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The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.

Sci Transl Med. 2017;9(391):ePub - PMID: 28539475 - PMCID: PMC5917603 - DOI: 10.1126/scitranslmed.aal4682
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The brain microenvironment mediates resistance in luminal breast cancer to
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Science Translational Medicine. 2017;9(391):eaal4682
De Palma M, Jain RK

CD4(+) T Cell Activation and Vascular Normalization: Two Sides of the Same Coin?

Immunity. 2017;46(5):773-775 - PMID: 28514684 - DOI: 10.1016/j.immuni.2017.04.015
Chen Y, Liu YC, Sung YC, Ramjiawan RR, Lin TT, Chang CC, Jeng KS, Chang CF, Liu CH, Gao DY, Hsu FF, Duyverman AM, Kitahara S, Huang P, Dima S, Popescu I, Flaherty KT, Zhu AX, Bardeesy N, Jain RK, Benes CH, Duda DG

Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.

Sci Rep. 2017;7:44123 - PMID: 28276530 - PMCID: PMC5343435 - DOI: 10.1038/srep44123
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A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma.

Cancer. 2017;123(11):1979-1988 - PMID: 28192597 - PMCID: PMC5444988 - DOI: 10.1002/cncr.30571
Mpekris F, Baish JW, Stylianopoulos T, Jain RK

Role of vascular normalization in benefit from metronomic chemotherapy.

Proc Natl Acad Sci U S A. 2017;114(8):1994-1999 - PMID: 28174262 - PMCID: PMC5338413 - DOI: 10.1073/pnas.1700340114
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New Directions in Anti-Angiogenic Therapy for Glioblastoma.

Neurotherapeutics. 2017;14(2):321-332 - PMID: 28083806 - PMCID: PMC5398985 - DOI: 10.1007/s13311-016-0510-y
Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I

Stress granule-associated protein G3BP2 regulates breast tumor initiation.

Proc Natl Acad Sci U S A. 2017;114(5):1033-1038 - PMID: 28096337 - PMCID: PMC5293063 - DOI: 10.1073/pnas.1525387114
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Hypoxia-induced DNA hypermethylation: another reason to normalize tumor vessels

Translational Cancer Research. 2016;5:7
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Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy.

Cancer Discov. 2016;6(8):852-69 - PMID: 27246539 - PMCID: PMC4972679 - DOI: 10.1158/2159-8290.CD-15-1177
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Solid stress and elastic energy as measures of tumour mechanopathology.

Nat Biomed Eng. 2016;1:ePub - PMID: 28966873 - PMCID: PMC5621647 - DOI: 10.1038/s41551-016-0004
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The forces of cancer

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Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds.

Sci Rep. 2016;6:37949 - PMID: 27905494 - PMCID: PMC5131361 - DOI: 10.1038/srep37949
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Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.

Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27908927 - PMCID: PMC5131752 - DOI: 10.1101/cshperspect.a031195
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Improving treatment of liver metastases by targeting nonangiogenic mechanisms.

Nat Med. 2016;22(11):1209-1210 - PMID: 27824818 - DOI: 10.1038/nm.4228
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Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma.

Transl Oncol. 2016;9(5):431-437 - PMID: 27751347 - PMCID: PMC5067928 - DOI: 10.1016/j.tranon.2016.07.004
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Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.

Sci Transl Med. 2016;8(360):360ra135 - PMID: 27733559 - PMCID: PMC5457741 - DOI: 10.1126/scitranslmed.aaf5219
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Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.

Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27663981 - PMCID: PMC5131751 - DOI: 10.1101/cshperspect.a027094
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Closing the gap between astrocytes and brain metastasis progression.

Cell Res. 2016;26(9):973-4 - PMID: 27514701 - PMCID: PMC5034114 - DOI: 10.1038/cr.2016.96
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Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.

Proc Natl Acad Sci U S A. 2016;113(16):4470-5 - PMID: 27044097 - PMCID: PMC4843449 - DOI: 10.1073/pnas.1525349113
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Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.

Proc Natl Acad Sci U S A. 2016;113(16):4476-81 - PMID: 27044098 - PMCID: PMC4843473 - DOI: 10.1073/pnas.1525360113
Blakeley JO, Ye X, Duda DG, Halpin CF, Bergner AL, Muzikansky A, Merker VL, Gerstner ER, Fayad LM, Ahlawat S, Jacobs MA, Jain RK, Zalewski C, Dombi E, Widemann BC, Plotkin SR

Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas.

J Clin Oncol. 2016;34(14):1669-75 - PMID: 26976425 - PMCID: PMC4872317 - DOI: 10.1200/JCO.2015.64.3817
Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam T, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop I, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D

PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity.

Clin Cancer Res. 2016;22(12):2993-3004 - PMID: 26861455 - PMCID: PMC4911258 - DOI: 10.1158/1078-0432.CCR-15-1839
Fukumura D, Incio J, Shankaraiah R, Jain RK

Obesity and cancer: an angiogenic and inflammatory link.

Microcirculation. 2016;23(3):191-206 - PMID: 26808917 - PMCID: PMC4818678 - DOI: 10.1111/micc.12270
Park KR, Monsky WL, Lee CG, Song CH, Kim DH, Jain RK, Fukumura D

Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability.

Radiat Res. 2016;185(2):182-189 - PMID: 26771172 - PMCID: PMC4761451 - DOI: 10.1667/RR14190.1
Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

Sci Transl Med. 2016;8(320):320ra4 - PMID: 26738797 - PMCID: PMC4794335 - DOI: 10.1126/scitranslmed.aad0293
Lee EQ, Kaley TJ, Duda DG, Schiff D, Lassman AB, Wong ET, Mikkelsen T, Purow BW, Muzikansky A, Ancukiewicz M, Huse JT, Ramkissoon S, Drappatz J, Norden AD, Beroukhim R, Weiss SE, Alexander BM, McCluskey CS, Gerard M, Smith KH, Jain RK, Batchelor TT, Ligon KL, Wen PY

A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients.

Clin Cancer Res. 2015;21(16):3610-8 - PMID: 25910950 - PMCID: PMC4790106 - DOI: 10.1158/1078-0432.CCR-14-3220
Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, Duda DG

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.

Hepatology. 2015;61(5):1591-602 - PMID: 25529917 - PMCID: PMC4406806 - DOI: 10.1002/hep.27665
Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.

PLoS One. 2015;10(12):e0141392 - PMID: 26641266 - PMCID: PMC4671732 - DOI: 10.1371/journal.pone.0141392
Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, Winer EP, Krop IE, Jain RK

Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.

Proc Natl Acad Sci U S A. 2015;112(46):14325-14330 - PMID: 26578779 - PMCID: PMC4655544 - DOI: 10.1073/pnas.1518808112
Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L

Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model.

Proc Natl Acad Sci U S A. 2015;112(47):14676-81 - PMID: 26554010 - PMCID: PMC4664377 - DOI: 10.1073/pnas.1512570112
Samuel R, Duda DG, Fukumura D, Jain RK

Vascular diseases await translation of blood vessels engineered from stem cells.

Sci Transl Med. 2015;7(309):309rv6 - PMID: 26468328 - PMCID: PMC4799660 - DOI: 10.1126/scitranslmed.aaa1805
Stylianopoulos T, Jain RK

Design considerations for nanotherapeutics in oncology.

Nanomedicine. 2015;11(8):1893-907 - PMID: 26282377 - PMCID: PMC4628869 - DOI: 10.1016/j.nano.2015.07.015
Jain RK, Fukumura D, Duda DG

From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey.

Cancer J. 2015;21(4):235-236 - PMID: 26222072 - PMCID: PMC4791947 - DOI: 10.1097/PPO.0000000000000136
Batista A, Riedemann L, Vardam T, Jain RK

Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment.

Cancer J. 2015;21(4):307-13 - PMID: 26222083 - DOI: 10.1097/PPO.0000000000000125
Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG

An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.

Nat Protoc. 2015;10(8):1264-1274 - PMID: 26203823 - PMCID: PMC4800979 - DOI: 10.1038/nprot.2015.080
Lemon CM, Karnas E, Han X, Bruns OT, Kempa TJ, Fukumura D, Bawendi MG, Jain RK, Duda DG, Nocera DG

Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.

J Am Chem Soc. 2015;137(31):9832-42 - PMID: 26149349 - PMCID: PMC4750386 - DOI: 10.1021/jacs.5b04765
Zou HY, Friboulet L, Kodack DP, Engstrom LD, Li Q, West M, Tang RW, Wang H, Tsaparikos K, Wang J, Timofeevski S, Katayama R, Dinh DM, Lam H, Lam JL, Yamazaki S, Hu W, Patel B, Bezwada D, Frias RL, Lifshits E, Mahmood S, Gainor JF, Affolter T, Lappin PB, Gukasyan H, Lee N, Deng S, Jain RK, Johnson TW, Shaw AT, Fantin VR, Smeal T

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.

Cancer Cell. 2015;28(1):70-81 - PMID: 26144315 - PMCID: PMC4504786 - DOI: 10.1016/j.ccell.2015.05.010
Duda DG, Heist RS, Sahani DV, Stylianopoulos T, Engelman JA, Jain RK

Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.

Proc Natl Acad Sci U S A. 2015;112(27):E3454 - PMID: 26080434 - PMCID: PMC4500270 - DOI: 10.1073/pnas.1507225112
Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP

Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.

J Natl Cancer Inst. 2015;107(9):ePub - PMID: 26063793 - PMCID: PMC4651102 - DOI: 10.1093/jnci/djv155
Jain RK, Fukumura D, Duda DG

Lessons From 30 Years of Teaching About the Microenvironment of Tumors.

Cancer J. 2015;21(3):137 - PMID: 26049690 - PMCID: PMC4792516 - DOI: 10.1097/PPO.0000000000000119
Gerstner ER, Ye X, Duda DG, Levine MA, Mikkelsen T, Kaley TJ, Olson JJ, Nabors BL, Ahluwalia MS, Wen PY, Jain RK, Batchelor TT, Grossman S

A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma.

Neuro Oncol. 2015;17(10):1386-92 - PMID: 26008604 - PMCID: PMC4578584 - DOI: 10.1093/neuonc/nov085
Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK

Lessons From Anti-Vascular Endothelial Growth Factor and Anti-Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma.

J Clin Oncol. 2015;33(10):1197-213 - PMID: 25713439 - PMCID: PMC4517055 - DOI: 10.1200/JCO.2014.55.9575
Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.

J Natl Cancer Inst. 2015;107(4):ePub - PMID: 25710962 - PMCID: PMC4402365 - DOI: 10.1093/jnci/djv017
Kodack DP, Askoxylakis V, Ferraro GB, Fukumura D, Jain RK

Emerging Strategies for Treating Brain Metastases from Breast Cancer.

Cancer Cell. 2015;27(2):163-175 - PMID: 25670078 - PMCID: PMC4325273 - DOI: 10.1016/j.ccell.2015.01.001
Stylianopoulos T, Economides EA, Baish JW, Fukumura D, Jain RK

Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors.

Ann Biomed Eng. 2015;43(9):2291-300 - PMID: 25670323 - PMCID: PMC4519365 - DOI: 10.1007/s10439-015-1276-9
Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery.

Proc Natl Acad Sci U S A. 2015;112(6):1827-32 - PMID: 25624495 - PMCID: PMC4330784 - DOI: 10.1073/pnas.1424563112
Han HS, Niemeyer E, Huang Y, Kamoun WS, Martin JD, Bhaumik J, Chen Y, Roberge S, Cui J, Martin MR, Fukumura D, Jain RK, Bawendi MG, Duda DG

Quantum dot/antibody conjugates for in vivo cytometric imaging in mice.

Proc Natl Acad Sci U S A. 2015;112(5):1350-5 - PMID: 25605916 - PMCID: PMC4321304 - DOI: 10.1073/pnas.1421632111
Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.

Proc Natl Acad Sci U S A. 2015;112(5):1547-52 - PMID: 25605928 - PMCID: PMC4321320 - DOI: 10.1073/pnas.1424024112
Naxerova K, Jain RK

Using tumour phylogenetics to identify the roots of metastasis in humans.

Nat Rev Clin Oncol. 2015;12(5):258-72 - PMID: 25601447 - DOI: 10.1038/nrclinonc.2014.238
Jain RK, Netti PA

Letter to the editor regarding recent article by Wu et Al. [journal of theoretical biology, 355, 194-207 (2014)].

J Theor Biol. 2014;363:453 - PMID: 25219622 - DOI: 10.1016/j.jtbi.2014.08.052
Babykutty S, Heishi T, Tsukada K, Huang Y, Kozin S, Conner D, Lin Q, Kucherlapati R, Jain RK, Fukumura D

Restoring perivascular nitric oxide gradients normalizes breast cancer vasculature.

Nitric Oxide. 2014;42C:115 - PMID: 25519573
Jain RK

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia.

Cancer Cell. 2014;26(5):605-622 - PMID: 25517747 - PMCID: PMC4269830 - DOI: 10.1016/j.ccell.2014.10.006
Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R

Correlative intravital imaging of cGMP signals and vasodilation in mice.

Front Physiol. 2014;5:394 - PMID: 25352809 - PMCID: PMC4196583 - DOI: 10.3389/fphys.2014.00394
Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG

Magneto-fluorescent core-shell supernanoparticles.

Nat Commun. 2014;5:5093 - PMID: 25298155 - PMCID: PMC4264679 - DOI: 10.1038/ncomms6093
Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.

Nat Cell Biol. 2014;16(10):931-941 - PMID: 25218639 - PMCID: PMC4564017 - DOI: 10.1038/ncb3036
Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen B, Loeffler JS, Wen PY, Sorensen AG, Jain RK

Increased perfusion due to vascular normalization improves oxygenation and survival in glioblastoma patients treated with cediranib with or without chemoradiation.

Neuro Oncol. 2014;16 Suppl 3:iii12 - PMID: 25165209 - PMCID: PMC4144509
Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK

Vessel calibre-a potential MRI biomarker of tumour response in clinical trials.

Nat Rev Clin Oncol. 2014;11(10):566-584 - PMID: 25113840 - PMCID: PMC4445139 - DOI: 10.1038/nrclinonc.2014.126
Duda DG, Ancukiewicz M, Isakoff SJ, Krop IE, Jain RK

Seeds and soil: unraveling the role of local tumor stroma in distant metastasis.

J Natl Cancer Inst. 2014;106(8):ePub - PMID: 25082335 - DOI: 10.1093/jnci/dju187
Jain RK, Fukumura D, Duda DG

Modes of neovascularization in tumors and clinical translation of antiangiogenic therapy.

In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (Editor: LM McManus & RN Mitchell). Elsevier Press, Oxford. 2014;:(in press)
Chung E, Yeon C, Jain RK, Fukumura D

Uncovering tumor biology by intravital microscopy.

In: Comprehensive Biomedical Physics, Volume: IV 'Optical molecular imaging' (Editor: Kiessling Alves & Anders Brahme). Elsevier Press. 2014;:(in press)
Jain RK, Duda DG

Molecular Pathophysiology of Tumors.

In: Principles and Practice of Radiation Oncology, 6th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2014;Chapter 4:(in press)
Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure.

Cancer Cell. 2014;26(1):14-15 - PMID: 25026209 - PMCID: PMC4381566 - DOI: 10.1016/j.ccr.2014.06.003
Jain RK, Martin JD, Stylianopoulos T

The role of mechanical forces in tumor growth and therapy.

Annu Rev Biomed Eng. 2014;16:321-46 - PMID: 25014786 - PMCID: PMC4109025 - DOI: 10.1146/annurev-bioeng-071813-105259
Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG

A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma.

Int J Radiat Oncol Biol Phys. 2014;89(4):830-8 - PMID: 24867540 - PMCID: PMC4791180 - DOI: 10.1016/j.ijrobp.2014.03.034
Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK

Hypermutable DNA chronicles the evolution of human colon cancer.

Proc Natl Acad Sci U S A. 2014;111(18):E1889-98 - PMID: 24753616 - PMCID: PMC4020055 - DOI: 10.1073/pnas.1400179111
Jain RK

An indirect way to tame cancer

Sci Am. 2014;310(2):46-53 - PMID: 24640331 - DOI: 10.1038/scientificamerican0214-46
Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK

Benefits of Vascular Normalization Are Dose and Time Dependent--Letter.

Cancer Res. 2013;73(23):7144-6 - PMID: 24265277 - PMCID: PMC3876035 - DOI: 10.1158/0008-5472.CAN-13-1989
Huang Y, Goel S, Duda DG, Fukumura D, Jain RK

Vascular normalization as an emerging strategy to enhance cancer immunotherapy.

Cancer Res. 2013;73(10):2943-8 - PMID: 23440426 - PMCID: PMC3655127 - DOI: 10.1158/0008-5472.CAN-12-4354
Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.

Proc Natl Acad Sci U S A. 2013;110(47):19059-64 - PMID: 24190997 - PMCID: PMC3839699 - DOI: 10.1073/pnas.1318022110
Stylianopoulos T, Jain RK

Combining two strategies to improve perfusion and drug delivery in solid tumors.

Proc Natl Acad Sci U S A. 2013;110(46):18632-7 - PMID: 24167277 - PMCID: PMC3832007 - DOI: 10.1073/pnas.1318415110
Chauhan VP, Jain RK

Strategies for advancing cancer nanomedicine.

Nat Mater. 2013;12(11):958-62 - PMID: 24150413 - PMCID: PMC4120281 - DOI: 10.1038/nmat3792
Zhu AX, Finn RS, Mulcahy M, Gurtler J, Sun W, Schwartz JD, Dalal RP, Joshi A, Hozak RR, Xu Y, Ancukiewicz M, Jain RK, Nugent F, Duda DG, Stuart K

A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2 in Patients with Advanced Hepatocellular Cancer.

Clin Cancer Res. 2013;19(23):6614-23 - PMID: 24088738 - PMCID: PMC4795808 - DOI: 10.1158/1078-0432.CCR-13-1442
Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.

Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516
Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG

Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.

Nat Med. 2013;19(9):1178-83 - PMID: 23955713 - PMCID: PMC3769525 - DOI: 10.1038/nm.3289
Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, Mason W, Mikkelsen T, Phuphanich S, Ashby LS, Degroot J, Gattamaneni R, Cher L, Rosenthal M, Payer F, Jürgensmeier JM, Jain RK, Sorensen AG, Xu J, Liu Q, van den Bent M

Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma.

J Clin Oncol. 2013;31(26):3212-3218 - PMID: 23940216 - PMCID: PMC4021043 - DOI: 10.1200/JCO.2012.47.2464
Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.

J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164
Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK

Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.

Proc Natl Acad Sci U S A. 2013;110(31):12774-9 - PMID: 23861493 - PMCID: PMC3732948 - DOI: 10.1073/pnas.1310675110
Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, Dietrich J, Stemmer-Rachamimov AO, Batchelor TT, Jain RK

Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.

Neuro Oncol. 2013;15(8):1079-87 - PMID: 23828240 - PMCID: PMC3714160 - DOI: 10.1093/neuonc/not082
Sahani DV, Jiang T, Hayano K, Duda DG, Catalano OA, Ancukiewicz M, Jain RK, Zhu AX

Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy.

J Hematol Oncol. 2013;6(1):51 - PMID: 23842041 - PMCID: PMC3722053 - DOI: 10.1186/1756-8722-6-51
Jain RK, Munn LL, Fukumura D

Measuring Interstitial pH and pO2 in Mouse Tumors.

Cold Spring Harb Protoc. 2013;2013(7):675-7 - PMID: 23818669 - DOI: 10.1101/pdb.prot075713
Jain RK, Munn LL, Fukumura D

Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.

Cold Spring Harb Protoc. 2013;2013(7):678-80 - PMID: 23818670 - DOI: 10.1101/pdb.prot075721
Thunemann M, Wen L, Hillenbrand M, Vachaviolos IA, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R

Transgenic Mice for cGMP Imaging.

Circ Res. 2013;113(4):365-71 - PMID: 23801067 - PMCID: PMC3896241 - DOI: 10.1161/CIRCRESAHA.113.301063
Jain RK, Munn LL, Fukumura D

Measuring leukocyte-endothelial interactions in mice.

Cold Spring Harb Protoc. 2013;2013(6):561-3 - PMID: 23734020 - DOI: 10.1101/pdb.prot075085
Jain RK

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers.

J Clin Oncol. 2013;31(17):2205-18 - PMID: 23669226 - PMCID: PMC3731977 - DOI: 10.1200/JCO.2012.46.3653
Duda DG, Munn LL, Jain RK

Can We Identify Predictive Biomarkers for Antiangiogenic Therapy of Cancer Using Mathematical Modeling?

J Natl Cancer Inst. 2013;105(11):762-5 - PMID: 23670727 - PMCID: PMC3672078 - DOI: 10.1093/jnci/djt114
Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK

Co-evolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse.

Cancer Res. 2013;73(13):3833-3841 - PMID: 23633490 - PMCID: PMC3702668 - DOI: 10.1158/0008-5472.CAN-12-4521
Jain RK, Munn LL, Fukumura D

Measuring vascular permeability in mice.

Cold Spring Harb Protoc. 2013;2013(5):444-6 - PMID: 23637370 - DOI: 10.1101/pdb.prot074344
Jain RK, Munn LL, Fukumura D

Measuring angiogenesis and hemodynamics in mice.

Cold Spring Harb Protoc. 2013;2013(4):354-8 - PMID: 23547161 - DOI: 10.1101/pdb.prot073916
Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.

Cell. 2013;152(5):1065-76 - PMID: 23452854 - PMCID: PMC3587980 - DOI: 10.1016/j.cell.2013.01.036
Prabhakar U, Blakey DC, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST, Gabizon A, Grodzinski P

Challenges and key considerations of the enhanced permeability and retention effect (EPR) for nanomedicine drug delivery in oncology.

Cancer Res. 2013;73(8):2412-2417 - PMID: 23423979 - PMCID: PMC3916009 - DOI: 10.1158/0008-5472.CAN-12-4561
Zhu AX, Ancukiewicz M, Supko JG, Sahani DV, Blaszkowsky LS, Meyerhardt JA, Abrams TA, Jackson McCleary N, Bhargava P, Muzikansky A, Sheehan S, Regan E, Vasudev E, Knowles M, Fuchs CS, Ryan DP, Jain RK, Duda DG

Efficacy, safety, pharmacokinetics and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: A phase II study.

Clin Cancer Res. 2013;19(6):1557-66 - PMID: 23362324 - PMCID: PMC3609423 - DOI: 10.1158/1078-0432.CCR-12-3041
Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG

Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.

Nat Mater. 2013;12(5):445-51 - PMID: 23377294 - PMCID: PMC3677691 - DOI: 10.1038/nmat3539
Jain RK, Munn LL, Fukumura D

Lung window preparation in mice.

Cold Spring Harb Protoc. 2013;2013(1):ePub - PMID: 23282642 - DOI: 10.1101/pdb.prot072678
Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG, Nocera DG

A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.

Chem Sci. 2012;3(10):2980-2985 - PMID: 26413260 - PMCID: PMC4582792 - DOI: 10.1039/C2SC20212C
Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG and Nocera DG

A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.

Chemical Science. 2012;:ePub
Jain RK

Delivery of molecular and cellular medicine to solid tumors.

Adv Drug Deliv Rev. 2012;64(Suppl):353-365 - PMID: 24511174 - PMCID: PMC3914635 - DOI: 10.1016/j.addr.2012.09.011
Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK

Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.

Intravital. 2012;1(1):ePub - PMID: 24353926 - PMCID: PMC3864876 - DOI: 10.4161/intv.21557
Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK

Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.

Annu Rev Chem Biomol Eng. 2012;2:281-98 - PMID: 22432620 - DOI: 10.1146/annurev-chembioeng-061010-114300
Jain RK, Munn LL, Fukumura D

Pancreatic tumor preparation in mice.

Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209145 - DOI: 10.1101/pdb.prot072363
Jain RK, Munn LL, Fukumura D

Liver tumor preparation in mice.

Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209146 - DOI: 10.1101/pdb.prot072371
Jain RK, Munn LL, Fukumura D

Lymphangiography of the mouse tail.

Cold Spring Harb Protoc. 2012;2012(11):1177-8 - PMID: 23118364 - DOI: 10.1101/pdb.prot072108
Jain RK, Munn LL, Fukumura D

Lymphangiography of the mouse ear.

Cold Spring Harb Protoc. 2012;2012(11):1179-80 - PMID: 23118365 - DOI: 10.1101/pdb.prot072116
Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK

Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.

Proc Natl Acad Sci U S A. 2012;109(45):E3119-27 - PMID: 23071298 - PMCID: PMC3494882 - DOI: 10.1073/pnas.1216078109
Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.

Proc Natl Acad Sci U S A. 2012;109(43):17561-6 - PMID: 23045683 - PMCID: PMC3491458 - DOI: 10.1073/pnas.1215397109
Jain RK, Munn LL, Fukumura D

Mammary fat pad chamber preparation in mice.

Cold Spring Harb Protoc. 2012;2012(10):1113-4 - PMID: 23028075 - DOI: 10.1101/pdb.prot071506
Jain RK, Munn LL, Fukumura D

Mammary fat pad tumor preparation in mice.

Cold Spring Harb Protoc. 2012;2012(10):1115-6 - PMID: 23028076 - DOI: 10.1101/pdb.prot071514
Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L

TGF-? blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.

Proc Natl Acad Sci U S A. 2012;109(41):16618-23 - PMID: 22996328 - PMCID: PMC3478596 - DOI: 10.1073/pnas.1117610109
Jain RK

Delivery of molecular and cellular medicine to solid tumors.

Adv Drug Deliv Rev. 2012;:ePub - PMID: 22983334
Jain RK, Munn LL, Fukumura D

Corneal pocket assay in rabbits.

Cold Spring Harb Protoc. 2012;2012(9):1017-8 - PMID: 22949714 - DOI: 10.1101/pdb.prot070052
Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.

Proc Natl Acad Sci U S A. 2012;109(38):15101-8 - PMID: 22932871 - PMCID: PMC3458380 - DOI: 10.1073/pnas.1213353109
Kozin SV, Duda DG, Munn LL, Jain RK

Neovascularization After Irradiation: What is the Source of Newly Formed Vessels in Recurring Tumors?

J Natl Cancer Inst. 2012;104(12):899-905 - PMID: 22572994 - PMCID: PMC3379722 - DOI: 10.1093/jnci/djs239
Goel S, Wong AH, Jain RK

Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.

Cold Spring Harb Perspect Med. 2012;2(3):a006486 - PMID: 22393532 - PMCID: PMC3282493 - DOI: 10.1101/cshperspect.a006486
Jain RK, Carmeliet P

SnapShot: Tumor angiogenesis.

Cell. 2012;149(6):1408-1408.e1 - PMID: 22682256 - DOI: 10.1016/j.cell.2012.05.025
Meyerhardt JA, Ancukiewicz M, Abrams TA, Schrag D, Enzinger PC, Chan JA, Kulke MH, Wolpin BM, Goldstein M, Blaszkowsky L, Zhu AX, Elliott M, Regan E, Jain RK, Duda DG

Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.

PLoS One. 2012;7(6):e38231 - PMID: 22701615 - PMCID: PMC3373492 - DOI: 10.1371/journal.pone.0038231
Jain RK, Munn LL, Fukumura D

Rabbit ear chambers.

Cold Spring Harb Protoc. 2012;2012(7):813-14 - PMID: 22753607 - DOI: 10.1101/pdb.prot070045
Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK

Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.

Neoplasia. 2012;14(2):84-94 - PMID: 22431917 - PMCID: PMC3306254 - DOI: 10.1593/neo.111600
Saylor PJ, Kozak KR, Smith MR, Ancukiewicz MA, Efstathiou JA, Zietman AL, Jain RK, Duda DG

Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.

Oncologist. 2012;17(2):212-9 - PMID: 22302227 - PMCID: PMC3286170 - DOI: 10.1634/theoncologist.2011-0321
Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK

Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).

PLoS One. 2012;7(2):e26331 - PMID: 22347360 - PMCID: PMC3274514 - DOI: 10.1371/journal.pone.0026331
Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK

An isolated tumor perfusion model in mice.

Nat Protoc. 2012;7(4):749-55 - PMID: 22441293 - PMCID: PMC3375334 - DOI: 10.1038/nprot.2012.030
Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG

Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.

Nat Protoc. 2012;7(4):756-62 - PMID: 22441294 - PMCID: PMC3380105 - DOI: 10.1038/nprot.2012.031
Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D

A transient parabiosis skin transplantation model in mice.

Nat Protoc. 2012;7(4):763-70 - PMID: 22441295 - PMCID: PMC3375333 - DOI: 10.1038/nprot.2012.032
Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D

Multistage nanoparticles for improved delivery into tumor tissue.

Methods Enzymol. 2012;508:109-30 - PMID: 22449923 - PMCID: PMC3774840 - DOI: 10.1016/B978-0-12-391860-4.00006-9
Vakoc BJ, Fukumura D, Jain RK, Bouma BE

Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.

Nat Rev Cancer. 2012;12(5):363-8 - PMID: 22475930 - PMCID: PMC3560400 - DOI: 10.1038/nrc3235
Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.

Nat Nanotechnol. 2012;7(6):383-8 - PMID: 22484912 - PMCID: PMC3370066 - DOI: 10.1038/nnano.2012.45
Goel S, Fukumura D, Jain RK

Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology.

Proc Natl Acad Sci U S A. 2012;109(20):E1214 - PMID: 22550180 - PMCID: PMC3356659 - DOI: 10.1073/pnas.1203794109
Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL

Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.

Blood. 2011;118(17):4740-9 - PMID: 21835951 - PMCID: PMC3208287 - DOI: 10.1182/blood-2011-02-338426
Jain A, Munn LL

Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.

Lab Chip. 2011;11(17):2941-7 - PMID: 21773633 - PMCID: PMC3743538 - DOI: 10.1039/c1lc20401g
Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D

Multistage nanoparticle delivery system for deep penetration into tumor tissue.

Proc Natl Acad Sci U S A. 2011;108(6):2426-31 - PMID: 21245339 - PMCID: PMC3038705 - DOI: 10.1073/pnas.1018382108
Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK

Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.

Angew Chem Int Ed Engl. 2011;50(48):11417-20 - PMID: 22113800 - PMCID: PMC3260125 - DOI: 10.1002/anie.201104449
Dawson MR, Chae SS, Jain RK, Duda DG

Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.

Am J Cancer Res. 2011;1(2):144-54 - PMID: 21822499 - PMCID: PMC3150110
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK

Normalization of the vasculature for treatment of cancer and other diseases.

Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010
Kozin SV, Duda DG, Munn LL, Jain RK

Is vasculogenesis crucial for the regrowth of irradiated tumours?

Nat Rev Cancer. 2011;11(7):532 - PMID: 21701514 - PMCID: PMC4790119 - DOI: 10.1038/nrc2007-c1
Zhu AX, Duda DG, Sahani DV, Jain RK

HCC and angiogenesis: possible targets and future directions.

Nat Rev Clin Oncol. 2011;8(5):292-301 - PMID: 21386818 - PMCID: PMC3266719 - DOI: 10.1038/nrclinonc.2011.30
Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.

Proc Natl Acad Sci U S A. 2011;108(7):2909-14 - PMID: 21282607 - PMCID: PMC3041115 - DOI: 10.1073/pnas.1018892108
Jain RK, Munn LL, Fukumura D, Melder RJ

In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.

Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553
Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG

Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.

PLoS One. 2011;6(3):e17228 - PMID: 21390238 - PMCID: PMC3048404 - DOI: 10.1371/journal.pone.0017228
Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM

Cell-surface sensors for real-time probing of cellular environments.

Nat Nanotechnol. 2011;6(8):524-31 - PMID: 21765401 - PMCID: PMC3163485 - DOI: 10.1038/nnano.2011.101
Carmeliet P, Jain RK

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.

Nat Rev Drug Discov. 2011;10(6):417-27 - PMID: 21629292 - DOI: 10.1038/nrd3455
Carmeliet P, Jain RK

Molecular mechanisms and clinical applications of angiogenesis.

Nature. 2011;473(7347):298-307 - PMID: 21593862 - PMCID: PMC4049445 - DOI: 10.1038/nature10144
Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG

Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma.

Cancer Res. 2011;71(11):3745-52 - PMID: 21507932 - PMCID: PMC3107375 - DOI: 10.1158/0008-5472.CAN-10-2991
Emblem KE, Bjornerud A, Mouridsen K, Borra RJ, Batchelor TT, Jain RK, Sorensen AG

T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients.

J Cereb Blood Flow Metab. 2011;31(10):2054-64 - PMID: 21505476 - PMCID: PMC3208147 - DOI: 10.1038/jcbfm.2011.39
Faber AC, Corcoran RB, Ebi H, Sequist LV, Waltman BA, Chung E, Incio J, Digumarthy SR, Pollack SF, Song Y, Muzikansky A, Lifshits E, Roberge S, Coffman EJ, Benes CH, Gómez HL, Baselga J, Arteaga CL, Rivera MN, Dias-Santagata D, Jain RK, Engelman JA

BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.

Cancer Discov. 2011;1(4):352-65 - PMID: 22145099 - PMCID: PMC3229203 - DOI: 10.1158/2159-8290.CD-11-0106
di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK

Glioblastoma recurrence after cediranib therapy in patients: lack of rebound revascularization as mode of escape.

Cancer Res. 2011;71(1):19-28 - PMID: 21199795 - PMCID: PMC3074948 - DOI: 10.1158/0008-5472.CAN-10-2602
Huang Y, Snuderl M, Jain RK

Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.

Cancer Cell. 2011;19(1):1-2 - PMID: 21251607 - PMCID: PMC3037265 - DOI: 10.1016/j.ccr.2011.01.005
Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK

Dehydro-alpha-lapachone, a plant product with antivascular activity.

Proc Natl Acad Sci U S A. 2011;108(28):11596-601 - PMID: 21709229 - PMCID: PMC3136298 - DOI: 10.1073/pnas.1104225108
Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT

Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.

J Neurooncol. 2011;103(2):325-32 - PMID: 20821342 - PMCID: PMC4090923 - DOI: 10.1007/s11060-010-0390-7
Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK

Scaling rules for diffusive drug delivery in tumor and normal tissues.

Proc Natl Acad Sci U S A. 2011;108(5):1799-803 - PMID: 21224417 - PMCID: PMC3033252 - DOI: 10.1073/pnas.1018154108
Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L

TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.

Clin Cancer Res. 2011;17(6):1415-24 - PMID: 21278244 - PMCID: PMC3060297 - DOI: 10.1158/1078-0432.CCR-10-2429
Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.

Proc Natl Acad Sci U S A. 2011;108(9):3725-30 - PMID: 21321210 - PMCID: PMC3048115 - DOI: 10.1073/pnas.1100446108
Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK

CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?

Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636
Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L

PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.

Clin Cancer Res. 2011;17(11):3638-48 - PMID: 21459800 - PMCID: PMC3107920 - DOI: 10.1158/1078-0432.CCR-10-2456
Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK

The biology of brain metastases-translation to new therapies.

Nat Rev Clin Oncol. 2011;8(6):344-56 - PMID: 21487419 - PMCID: PMC3259742 - DOI: 10.1038/nrclinonc.2011.58
Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y

Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.

Cancer Res. 2011;71(13):4527-38 - PMID: 21571860 - DOI: 10.1158/0008-5472.CAN-10-4376
Huang P, Westmoreland SV, Jain RK, Fukumura D

Spontaneous nonthymic tumors in SCID mice.

Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755
Horowitz NS, Penson RT, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Cohen KS, Berlin S, Krasner CN, Moses MA, Jain RK

Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.

Clin Ovarian Cancer Other Gynecol Malig. 2011;4(1):26-33 - PMID: 21833345 - PMCID: PMC3151740 - DOI: 10.1016/j.cloc.2011.04.003
Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP

Impaired lymphatic contraction associated with immunosuppression.

Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108
Jain RK, Munn LL, Fukumura D

Intravital microscopy of normal and diseased tissues in the mouse.

In: Live Cell Imaging: A Laboratory Manual, 2nd Edition, (R. D. Goldman, J. R. Swedlow and D. L. Specter, Eds.), CSH Press, Cold Spring Harbor, NY. 2010;Chapter 26:475-521
Liao S, Padera TP, Jain RK

Notch leads lymphatics and links them to blood vessels.

Arterioscler Thromb Vasc Biol. 2010;30(9):1682-3 - PMID: 20720193 - PMCID: PMC2945915 - DOI: 10.1161/ATVBAHA.110.210633
Jain RK, Stylianopoulos T

Delivering nanomedicine to solid tumors.

Nat Rev Clin Oncol. 2010;7(11):653-64 - PMID: 20838415 - PMCID: PMC3065247 - DOI: 10.1038/nrclinonc.2010.139
Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E

Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.

Cancer Res. 2010;70(9):3483-93 - PMID: 20406973 - PMCID: PMC4785015 - DOI: 10.1158/0008-5472.CAN-09-3107
Gerstner ER, Chen PJ, Wen PY, Jain RK, Batchelor TT, Sorensen G

Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.

Neuro Oncol. 2010;12(5):466-72 - PMID: 20406897 - PMCID: PMC2940624 - DOI: 10.1093/neuonc/nop051
Finn AV, Jain RK

Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization?

JACC Cardiovasc Imaging. 2010;3(1):41-4 - PMID: 20129529 - PMCID: PMC2842010 - DOI: 10.1016/j.jcmg.2009.11.001
Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH

In vivo wide-area cellular imaging by side-view endomicroscopy.

Nat Methods. 2010;7(4):303-5 - PMID: 20228814 - PMCID: PMC2849759 - DOI: 10.1038/nmeth.1440
Fukumura D, Duda DG, Munn LL, Jain RK

Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.

Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x
Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK

Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.

Biophys J. 2010;99(5):1342-9 - PMID: 20816045 - PMCID: PMC2931749 - DOI: 10.1016/j.bpj.2010.06.016
Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK

Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.

Biophys J. 2010;99(10):3119-28 - PMID: 21081058 - PMCID: PMC2980743 - DOI: 10.1016/j.bpj.2010.08.065
Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK

Malignant cells facilitate lung metastasis by bringing their own soil.

Proc Natl Acad Sci U S A. 2010;107(50):21677-82 - PMID: 21098274 - PMCID: PMC3003109 - DOI: 10.1073/pnas.1016234107
Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK

A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.

Oncologist. 2010;15(8):845-51 - PMID: 20667969 - PMCID: PMC3078712 - DOI: 10.1634/theoncologist.2010-0030
Duda DG, Jain RK

Premetastatic lung niche: is vascular endothelial growth factor receptor 1 activation required?

Cancer Res. 2010;70(14):5670-3 - PMID: 20587530 - PMCID: PMC2919170 - DOI: 10.1158/0008-5472.CAN-10-0119
Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH

Lymphotoxin-alpha contributes to lymphangiogenesis.

Blood. 2010;116(12):2173-82 - PMID: 20566898 - PMCID: PMC2951858 - DOI: 10.1182/blood-2009-12-256065
Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK

Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.

Oncologist. 2010;15(6):577-83 - PMID: 20484123 - PMCID: PMC3061828 - DOI: 10.1634/theoncologist.2010-0029
Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG

In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.

Neuro Oncol. 2010;12(4):341-50 - PMID: 20308312 - PMCID: PMC2940602 - DOI: 10.1093/neuonc/nop032
Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK

Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.

J Clin Oncol. 2010;28(17):2817-23 - PMID: 20458050 - PMCID: PMC2903316 - DOI: 10.1200/JCO.2009.26.3988
Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG

Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.

Cancer Res. 2010;70(14):5679-85 - PMID: 20631066 - PMCID: PMC2918387 - DOI: 10.1158/0008-5472.CAN-09-4446
Brown E, Munn LL, Fukumura D, Jain RK

In vivo imaging of tumors.

Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452
Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.

Nat Methods. 2010;7(8):655-60 - PMID: 20581828 - PMCID: PMC2921873 - DOI: 10.1038/nmeth.1475
Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D

Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.

Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073
Choi B, Bouma B, Fukumura D, Jain RK

Optical methods in vascular biology and medicine.

J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696
Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG

Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.

J Am Chem Soc. 2010;132(2):472-83 - PMID: 20025223 - PMCID: PMC2871316 - DOI: 10.1021/ja908137d
Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG

InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.

J Am Chem Soc. 2010;132(2):470-1 - PMID: 20025222 - PMCID: PMC2862004 - DOI: 10.1021/ja908250r
Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG

A nanoparticle size series for in vivo fluorescence imaging.

Angew Chem Int Ed Engl. 2010;49(46):8649-52 - PMID: 20886481 - PMCID: PMC3035057 - DOI: 10.1002/anie.201003142
Jain RK, Tam J, Au P, Fukumura D

Angiogenesis in Development, Disease and Regeneration.

In: Santin M, editor. Strategies in Regenerative Medicine: Integrating Biology with Materials Design. Springer, New York. 2009;Chapter 6:ePub
Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT

The potential utility of anti-VEGF agents to normalize tumor vasculature and alleviate edema in brain and spinal cord tumor patients.

Nat Clin Pract Oncol. 2009;6:229-36
Jain A, Munn LL

Determinants of leukocyte margination in rectangular microchannels.

PLoS One. 2009;4(9):e7104 - PMID: 19768109 - PMCID: PMC2740820 - DOI: 10.1371/journal.pone.0007104
Cheng G, Tse J, Jain RK, Munn LL

Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.

PLoS One. 2009;4(2):e4632 - PMID: 19247489 - PMCID: PMC2645686 - DOI: 10.1371/journal.pone.0004632
Perentes JY, Duda DG, Jain RK

Visualizing anti-tumor immune responses in vivo.

Dis Model Mech. 2009;2(3-4):107-10 - PMID: 19259379 - PMCID: PMC2650205 - DOI: 10.1242/dmm.001842
Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D

Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.

Cancer Res. 2009;69(7):2801-8 - PMID: 19318557 - PMCID: PMC2670480 - DOI: 10.1158/0008-5472.CAN-08-4051
Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.

J Clin Oncol. 2009;27(18):3020-6 - PMID: 19470921 - PMCID: PMC2702234 - DOI: 10.1200/JCO.2008.21.1771
Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG

Biomarkers of response and resistance to antiangiogenic therapy.

Nat Rev Clin Oncol. 2009;6(6):327-38 - PMID: 19483739 - PMCID: PMC3057433 - DOI: 10.1038/nrclinonc.2009.63
Jain RK

A new target for tumor therapy.

N Engl J Med. 2009;360(25):2669-71 - PMID: 19535806 - PMCID: PMC4792114 - DOI: 10.1056/NEJMcibr0902054
Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK

Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.

Biophys J. 2009;97(1):330-6 - PMID: 19580771 - PMCID: PMC2711376 - DOI: 10.1016/j.bpj.2009.03.064
Zhu AX, Duda DG, Sahani DV, Jain RK

Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.

Cancer J. 2009;15(4):263-8 - PMID: 19672141 - PMCID: PMC4792519 - DOI: 10.1097/PPO.0b013e3181af5e35
Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK

Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo.

Am J Pathol. 2009;175(1):294-302 - PMID: 19477947 - PMCID: PMC2708815 - DOI: 10.2353/ajpath.2009.080887
Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.

J Clin Oncol. 2009;27(18):3027-35 - PMID: 19470923 - PMCID: PMC2702235 - DOI: 10.1200/JCO.2008.20.9908
Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT

VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.

Nat Rev Clin Oncol. 2009;6(4):229-36 - PMID: 19333229 - PMCID: PMC4793889 - DOI: 10.1038/nrclinonc.2009.14
Tam J, Fukumura D, Jain RK

A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.

Cell Metab. 2009;9(1):52-63 - PMID: 19117546 - PMCID: PMC2643084 - DOI: 10.1016/j.cmet.2008.11.005
Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.

Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971
Dawson MR, Duda DG, Fukumura D, Jain RK

VEGFR1-activity-independent metastasis formation.

Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254
Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK

VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.

PLoS One. 2009;4(9):e6525 - PMID: 19763275 - PMCID: PMC2744279 - DOI: 10.1371/journal.pone.0006525
Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.

Cancer Res. 2009;69(20):7905-10 - PMID: 19826039 - PMCID: PMC2859041 - DOI: 10.1158/0008-5472.CAN-09-2099
Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK

Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.

PLoS One. 2009;4(12):e8316 - PMID: 20016816 - PMCID: PMC2789383 - DOI: 10.1371/journal.pone.0008316
Jain RK, Duda DG, Sorensen AG

Emerging paradigms and potential biomarkers of response and resistance in anatiangiogenic therapy of cancer

ASCO 2009 Educational Book. 2009;:716-21
Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, Ligon KL, Aldape K, Jain RK, Stiles CD, Egorin MJ, Prados MD

Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).

Neuro Oncol. 2009;11(6):853-60 - PMID: 19293394 - PMCID: PMC2802405 - DOI: 10.1215/15228517-2009-010
Gerstner ER, Sorensen AG, Jain RK, Batchelor TT

Anti-vascular endothelial growth factor therapy for malignant glioma.

Curr Neurol Neurosci Rep. 2009;9(3):254-62 - PMID: 19348715 - PMCID: PMC4790123 - DOI: 10.1007/s11910-009-0037-2
di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.

PLoS One. 2009;4(4):e5123 - PMID: 19352490 - PMCID: PMC2662415 - DOI: 10.1371/journal.pone.0005123
Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK

Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.

J Cell Physiol. 2009;219(2):430-7 - PMID: 19170073 - PMCID: PMC2665001 - DOI: 10.1002/jcp.21686
Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D, Jain RK

Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.

PLoS One. 2009;4(3):e4974 - PMID: 19333381 - PMCID: PMC2659427 - DOI: 10.1371/journal.pone.0004974
Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK

Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.

J Clin Oncol. 2009;27(15):2542-52 - PMID: 19332720 - PMCID: PMC2739611 - DOI: 10.1200/JCO.2008.19.9356
Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E

Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.

N Engl J Med. 2009;361(4):358-67 - PMID: 19587327 - PMCID: PMC4816642 - DOI: 10.1056/NEJMoa0902579
Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA

Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.

Opt Lett. 2009;34(13):2066-8 - PMID: 19572001 - PMCID: PMC2872111 - DOI: 10.1364/ol.34.002066
Sorensen AG, Batchelor TT, Zhang WT, Chen PJ, Yeo P, Wang M, Jennings D, Wen PY, Lahdenranta J, Ancukiewicz M, di Tomaso E, Duda DG, Jain RK

A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.

Cancer Res. 2009;69(13):5296-300 - PMID: 19549889 - PMCID: PMC2824172 - DOI: 10.1158/0008-5472.CAN-09-0814
Chi AS, Sorensen AG, Jain RK, Batchelor TT

Angiogenesis as a therapeutic target in malignant gliomas.

Oncologist. 2009;14(6):621-36 - PMID: 19487335 - PMCID: PMC4790121 - DOI: 10.1634/theoncologist.2008-0272
Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.

Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295
Mok W, Stylianopoulos T, Boucher Y, Jain RK

Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.

Clin Cancer Res. 2009;15(7):2352-60 - PMID: 19318482 - PMCID: PMC2872130 - DOI: 10.1158/1078-0432.CCR-08-2082
Willett CG, Duda DG, Xu L, diTomaso E, Boucher Y, Czito B, Ancukiewicz M, Clark J, Carroll M, Lauwers G, Jain RK

Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).

J Clin Oncol. 2008;26(15_suppl):4096 - PMID: 27949464
Jain RK, Duda DG, Batchelor TT, Sorensen AG, Willett CG

Normalization of tumor vasculature and microenvironment.

In: Angiogenesis: An Integrative Approach from Science to Medicine (Editors: W. D. Figg and J. Folkman), Springer. 2008;:173-282
Jain RK, Duda DG

Vascular and interstitial biology of tumors

In: Clinical Oncology. 4th Edition, (Editors: Abeloff M, Armitage J, Niederhuber J, Kastan M, McKenna WG), Elsevier, Philadelphia. 2008;:105-24
Jain RK, Kozak K

Molecular Pathophysiology of Tumors.

In: Principles and Practice of Radiation Oncology, 5th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2008;Chapter 4:126-141
Jain RK, Booth MF, Padera TP, Munn LL, Fukumura D, Brown E

Applications of nonlinear intravital microscopy in tumor biology.

In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 29:735-756
Brown E, Majewska A, Jain RK

Photobleaching and recovery with nonlinear microscopy.

In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 26:673-688
Jain RK

Judah Folkman

Journal of Clinical Investigation. 2008;118:823
Gerstner ER, Sorensen AG, Jain RK, Batchelor TT

Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.

Curr Opin Neurol. 2008;21(6):728-35 - PMID: 18989120 - DOI: 10.1097/WCO.0b013e328318402a
Fukumura D, Jain RK

Imaging angiogenesis and the microenvironment.

APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x
Sorensen AG, Batchelor TT, Wen PY, Zhang WT, Jain RK

Response criteria for glioma.

Nat Clin Pract Oncol. 2008;5(11):634-44 - PMID: 18711427 - PMCID: PMC4795821 - DOI: 10.1038/ncponc1204
Padera TP, Jain RK

VEGFR3: a new target for antiangiogenesis therapy?

Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014
Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.

Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182
Nagano S, Perentes JY, Jain RK, Boucher Y

Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.

Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193
Jain RK

Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.

Nat Rev Cancer. 2008;8(4):309-16 - PMID: 18337733 - DOI: 10.1038/nrc2346
Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DG

A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.

Nat Protoc. 2008;3(3):388-97 - PMID: 18323810 - PMCID: PMC2676340 - DOI: 10.1038/nprot.2007.537
Jones RC, Capen D, Petersen B, Jain RK, Duda DG

A protocol for a lung neovascularization model in rodents.

Nat Protoc. 2008;3(3):378-87 - PMID: 18323809 - PMCID: PMC2676330 - DOI: 10.1038/nprot.2007.536
Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D

Perivascular nitric oxide gradients normalize tumor vasculature.

Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730
Jain RK

Taming vessels to treat cancer.

Sci Am. 2008;298(1):56-63 - PMID: 18225696 - DOI: 10.1038/scientificamerican0108-56
Huang P, Duda DG, Jain RK, Fukumura D

Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.

Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079
Jain RK, Lahdenranta J, Fukumura D

Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.

PLoS Med. 2008;5(1):e24 - PMID: 18232729 - PMCID: PMC2214795 - DOI: 10.1371/journal.pmed.0050024
Au P, Tam J, Fukumura D, Jain RK

Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.

Blood. 2008;111(9):4551-8 - PMID: 18256324 - PMCID: PMC2343592 - DOI: 10.1182/blood-2007-10-118273
Jain RK, Fukumura D, Munn LL, Brown E

Tumor Angiogenesis and Blood Flow.

In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:199-201
Jain RK, Fukumura D, Munn LL, Brown E

Optical Microscopy in Small Animal Research

In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:183-187
Jain RK, Batchelor TT, Duda DG, Willett CG

Normalization of tumor vasculature and microenvironment.

In: Antiangiogenic Agents in Cancer Therapy. (Editors: Beverly Teicher and Lee Ellis), Humana Press. 2007;:261-76
Jain RK, Duda DG

Normalization of tumor vasculature and microenvironment by antiangiogenic therapy.

In: Angiogenesis: Mechanisms and Cancer Therapy (Editors: Dieter Marm and Norbert E. Fusenig), Springer-Verlag, Berlin. 2007;:577-92
Jain RK, Duda DG

Angiogenesis in Solid Tumors

In: Antiangiogenic Cancer Therapy (Editors: James L. Abbruzzese, Darren W. Davis and Roy S. Herbst), CRC Press, Boca Raton. 2007;:43-90
Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Data do not support benefits of anti-VEGFR3 therapy

Cancer Research. 2007;67:5055
Willett CG, Duda DG, Jain RK

Surrogate biomarkers for anti-angiogenic therapy for advanced colorectal cancer.

Current Colorectal Cancer Reports. 2007;3:94-98
Jain RK, Munn LL

Vascular normalization as rationale for combining chemotherapy with antiangiogenic agents

PPO Updates. 2007;21:1-7
Duda DG, Cohen KS, Au P, Scadden DT, Willett CG, Jain RK

Detection of circulating endothelial cells: CD146- based magnetic separation enrichment or flow cytometric assay?

J Clin Oncol. 2007;25:e3-e5
Fukumura D, Jain RK

Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.

J Cell Biochem. 2007;101(4):937-49 - PMID: 17171643 - DOI: 10.1002/jcb.21187
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Cancer Cell. 2007;11(1):83-95 - PMID: 17222792 - PMCID: PMC2748664 - DOI: 10.1016/j.ccr.2006.11.021
Tyrrell JA, di Tomaso E, Fuja D, Tong R, Kozak K, Jain RK, Roysam B

Robust 3-D modeling of vasculature imagery using superellipsoids.

IEEE Trans Med Imaging. 2007;26(2):223-37 - PMID: 17304736 - DOI: 10.1109/TMI.2006.889722
Duda DG, Cohen KS, Scadden DT, Jain RK

A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.

Nat Protoc. 2007;2(4):805-10 - PMID: 17446880 - PMCID: PMC2686125 - DOI: 10.1038/nprot.2007.111
Bockhorn M, Jain RK, Munn LL

Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?

Lancet Oncol. 2007;8(5):444-8 - PMID: 17466902 - PMCID: PMC2712886 - DOI: 10.1016/S1470-2045(07)70140-7
Fukumura D, Jain RK

Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.

Microvasc Res. 2007;74(2-3):72-84 - PMID: 17560615 - PMCID: PMC2100036 - DOI: 10.1016/j.mvr.2007.05.003
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT

Angiogenesis in brain tumours.

Nat Rev Neurosci. 2007;8(8):610-22 - PMID: 17643088 - DOI: 10.1038/nrn2175
Jain RK, Finn AV, Kolodgie FD, Gold HK, Virmani R

Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization.

Nat Clin Pract Cardiovasc Med. 2007;4(9):491-502 - PMID: 17712362 - DOI: 10.1038/ncpcardio0979
Au P, Tam J, Fukumura D, Jain RK

Small blood vessel engineering.

Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11
Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK

Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.

Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643
Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT

Antiangiogenic agents for the treatment of glioblastoma.

Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895
Mok W, Boucher Y, Jain RK

Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.

Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107
Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK

Targeted therapy in rectal cancer.

Oncology (Williston Park). 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim - PMID: 17910311 - PMCID: PMC2686129
Sun C, Jain RK, Munn LL

Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.

Ann Biomed Eng. 2007;35(12):2121-9 - PMID: 17846892 - PMCID: PMC2752713 - DOI: 10.1007/s10439-007-9377-8
Xu L, Jain RK

Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma.

Mol Cancer Res. 2007;5(9):873-80 - PMID: 17704140 - DOI: 10.1158/1541-7786.MCR-06-0141
Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.

Nat Clin Pract Oncol. 2007;4(5):316-21 - PMID: 17464339 - PMCID: PMC2686127 - DOI: 10.1038/ncponc0813
Jain RK, Tong RT, Munn LL

Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.

Cancer Res. 2007;67(6):2729-35 - PMID: 17363594 - PMCID: PMC3022341 - DOI: 10.1158/0008-5472.CAN-06-4102
Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB

Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma.

J Soc Integr Oncol. 2007;5(1):11-7 - PMID: 17309809 - DOI: 10.2310/7200.2006.033
Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.

Nat Biotechnol. 2007;25(3):317-8 - PMID: 17322871 - DOI: 10.1038/nbt1287
Duda DG, Batchelor TT, Willett CG, Jain RK

VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.

Trends Mol Med. 2007;13(6):223-30 - PMID: 17462954 - PMCID: PMC2686126 - DOI: 10.1016/j.molmed.2007.04.001
Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Anti-VEGFR-3 therapy and lymph node metastasis [corrected].

Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935
Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y

Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.

Cancer Res. 2007;67(11):5076-82 - PMID: 17545583 - DOI: 10.1158/0008-5472.CAN-06-3664
Duda DG, Jain RK, Willett CG

Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.

J Clin Oncol. 2007;25(26):4033-42 - PMID: 17827451 - PMCID: PMC2686120 - DOI: 10.1200/JCO.2007.11.3985
Jain RK, Xu L

alphaPlGF: a new kid on the antiangiogenesis block.

Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023
Jain RK

Seminal findings and an allergy to black flies.

In: Reflections from the Frontiers, Explorations for the Future: Gordon Research Conferences, 1931-2006 (Editors: Arthur A. Daemmrich, Nancy Ryan Gray and Leah Shaper), Gordon Research Conferences and Chemical Heritage Foundation, Philadelphia. 2006;:70-71
Jain RK, Duda DG, Clark JW, Loeffler JS

Lessons from phase III clinical trials on anti-VEGF therapy for cancer.

Nat Clin Pract Oncol. 2006;3(1):24-40 - PMID: 16407877 - DOI: 10.1038/ncponc0403
McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK

Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.

Cancer Res. 2006;66(5):2509-13 - PMID: 16510565 - DOI: 10.1158/0008-5472.CAN-05-2242
Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK

Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.

Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655
Reddy ST, Berk DA, Jain RK, Swartz MA

A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.

J Appl Physiol. 2006;101(4):1162-9 - PMID: 16763103 - DOI: 10.1152/japplphysiol.00389.2006
Fukumura D, Kashiwagi S, Jain RK

The role of nitric oxide in tumour progression.

Nat Rev Cancer. 2006;6(7):521-34 - PMID: 16794635 - DOI: 10.1038/nrc1910
Cochran DM, Fukumura D, Ancukiewicz M, Carmeliet P, Jain RK

Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.

Ann Biomed Eng. 2006;34(8):1247-58 - PMID: 16832606 - DOI: 10.1007/s10439-006-9134-4
Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH

Platelet-derived growth factor receptor-beta in Gorham's disease.

Nat Clin Pract Oncol. 2006;3(12):693-7 - PMID: 17139320 - PMCID: PMC2693369 - DOI: 10.1038/ncponc0660
Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.

Proc Natl Acad Sci U S A. 2006;103(4):855-60 - PMID: 16418262 - PMCID: PMC1348013 - DOI: 10.1073/pnas.0510412103
Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK

Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.

J Clin Oncol. 2006;24(9):1449-53 - PMID: 16549839 - PMCID: PMC2718681 - DOI: 10.1200/JCO.2005.04.2861
Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D

Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.

Cancer Res. 2006;66(8):3971-7 - PMID: 16618713 - DOI: 10.1158/0008-5472.CAN-04-3085
Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK

Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.

Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392
Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK

Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.

Semin Oncol. 2006;33(5 Suppl 10):S35-40 - PMID: 17145523 - PMCID: PMC2686124 - DOI: 10.1053/j.seminoncol.2006.08.007
Brown EB, Munn LL, Fukumura D, Jain RK

A Practical Guide to in vivo Imaging of Tumors.

In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 92:695-700
Brown E, Majewska A, Jain RK

FRAP and Multiphoton FRAP.

In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 56:429-438
Jain RK

Antiangiogenic therapy for cancer: current and emerging concepts.

Oncology (Williston Park). 2005;19(4 Suppl 3):7-16 - PMID: 15934498
di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL

Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.

Cancer Res. 2005;65(13):5740-9 - PMID: 15994949 - DOI: 10.1158/0008-5472.CAN-04-4552
Jain RK, Au P, Tam J, Duda DG, Fukumura D

Engineering vascularized tissue.

Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821
Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Héligon C, Terclavers S, Ciesiolka M, Kälin R, Man WY, Senn I, Wyns S, Lupu F, Brändli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P

A genetic Xenopus laevis tadpole model to study lymphangiogenesis.

Nat Med. 2005;11(9):998-1004 - PMID: 16116431 - DOI: 10.1038/nm1285
Hagendoorn J, Padera TP, Fukumura D, Jain RK

Molecular regulation of microlymphatic formation and function: role of nitric oxide.

Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003
Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B

A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.

Microvasc Res. 2005;70(3):165-78 - PMID: 16239015 - DOI: 10.1016/j.mvr.2005.08.005
Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.

J Clin Oncol. 2005;23(31):8136-9 - PMID: 16258121 - DOI: 10.1200/JCO.2005.02.5635
Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D

NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.

J Clin Invest. 2005;115(7):1816-27 - PMID: 15951843 - PMCID: PMC1143589 - DOI: 10.1172/JCI24015
Huang P, McKee TD, Jain RK, Fukumura D

Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.

Comp Med. 2005;55(3):236-43 - PMID: 16089171
Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN

Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.

J Clin Oncol. 2005;23(9):1951-61 - PMID: 15774788 - DOI: 10.1200/JCO.2005.08.119
Jain RK

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.

Science. 2005;307(5706):58-62 - PMID: 15637262 - DOI: 10.1126/science.1104819
Duda DG, Jain RK

Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.

J Clin Invest. 2005;115(3):596-8 - PMID: 15765145 - PMCID: PMC1052004 - DOI: 10.1172/JCI24511
Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y

Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.

Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682
Xu L, Tong R, Cochran DM, Jain RK

Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.

Cancer Res. 2005;65(13):5711-9 - PMID: 15994946 - DOI: 10.1158/0008-5472.CAN-04-4313
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P

Genetic evidence for a tumor suppressor role of HIF-2alpha.

Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003
Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.

Nat Med. 2005;11(6):678-82 - PMID: 15880117 - PMCID: PMC2686110 - DOI: 10.1038/nm1247
Jain RK

Vascular and Interstitial Biology of Tumors.

In: Clinical Oncology, 3rd Edition (Editors: M. Abeleff, J. Armitage, J. Niederhuber, M. Kastan and G. McKenna), Elsevier, Philadelphia, PA. 2004;Chapter 9:153-172
Jain RK, Brown EB, Munn LL, Fukumura D

Intravital microscopy of normal and diseased tissues in the mouse.

In: Live Cell Imaging: A Laboratory Manual (Editors: R. D. Goldman and D. L. Spector). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 2004;Chapter 24:435-466
Jain RK

Correspondence: Recognition of tumor blood vessel normalization as a new antiangiogenic concept.

Nature Medicine. 2004;10:329-330
Chan YT, Zimmer JP, Stroh M, Steckel JS, Jain RK, Bawendi MG

Incorporation of luminescent nanocrystals into monodisperse core-shell silica microspheres.

Advanced Materials. 2004;16:23-24
Willett CG, Duda DG, Fischman A, Jain RK

Correspondence: PET concerns in bevacizumab treatment

Nature Medicine. 2004;10:561
Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK

Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.

Nat Med. 2004;10(2):203-7 - PMID: 14716306 - DOI: 10.1038/nm981
Gohongi T, Todoroki T, Fukumura D, Jain RK

Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.

Oncol Rep. 2004;11(4):803-7 - PMID: 15010876
Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK

Tissue engineering: creation of long-lasting blood vessels.

Nature. 2004;428(6979):138-9 - PMID: 15014486 - DOI: 10.1038/428138a
Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.

Nature. 2004;428(6980):328-32 - PMID: 15029197 - DOI: 10.1038/nature02329
Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LL

Differential gene expression in metastasizing cells shed from kidney tumors.

Cancer Res. 2004;64(7):2469-73 - PMID: 15059900 - DOI: 10.1158/0008-5472.can-03-0256
Brown EB, Boucher Y, Nasser S, Jain RK

Measurement of macromolecular diffusion coefficients in human tumors.

Microvasc Res. 2004;67(3):231-6 - PMID: 15121448 - DOI: 10.1016/j.mvr.2004.02.001
Duda DG, Fukumura D, Jain RK

Role of eNOS in neovascularization: NO for endothelial progenitor cells.

Trends Mol Med. 2004;10(4):143-5 - PMID: 15162796 - DOI: 10.1016/j.molmed.2004.02.001
Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK

Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.

Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752
Jain RK, Stroh M

Zooming in and out with quantum dots.

Nat Biotechnol. 2004;22(8):959-60 - PMID: 15286644 - DOI: 10.1038/nbt0804-959
Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

Cancer Cell. 2004;6(6):553-63 - PMID: 15607960 - DOI: 10.1016/j.ccr.2004.10.011
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.

Nat Med. 2004;10(2):145-7 - PMID: 14745444 - PMCID: PMC2693485 - DOI: 10.1038/nm988
Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK

Differential transplantability of tumor-associated stromal cells.

Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.

Cancer Res. 2004;64(11):3731-6 - PMID: 15172975 - DOI: 10.1158/0008-5472.CAN-04-0074
Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK

Pathology: cancer cells compress intratumour vessels.

Nature. 2004;427(6976):695 - PMID: 14973470 - DOI: 10.1038/427695a
Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK

Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.

Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24
Jain RK

Molecular Pathophysiology of Tumors

In: Principles and Practice of Radiation Oncology, 4th Edition (Editors: C. A. Parez, L. W. Brady, E. C. Halperin, and R. Schmidt-Ullrich), Lippincott, Williams & Wilkins, New York. 2003;Chapter 4:163-179
Netti PA, Jain RK

Interstitial Transport in Solid Tumors

In: Cancer Modeling and Simulation (Editor: L Preziosi), Chapman & Hall, Boca Raton, FL. 2003;Chapter 3:51-74
Netti PA, Travascio F, Jain RK

Coupled Macromolecular Transport and Gel Mechanics: Poroviscoelastic Approach.

AIChE Journal. 2003;49:1580-1596
Jain RK

Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy.

Cold Spring Harb Symp Quant Biol. 2003;67:239-48 - PMID: 12858546 - DOI: 10.1101/sqb.2002.67.239
Mollica F, Jain RK, Netti PA

A model for temporal heterogeneities of tumor blood flow.

Microvasc Res. 2003;65(1):56-60 - PMID: 12535873 - DOI: 10.1016/s0026-2862(02)00012-2
Dolmans DE, Fukumura D, Jain RK

Photodynamic therapy for cancer.

Nat Rev Cancer. 2003;3(5):380-7 - PMID: 12724736 - DOI: 10.1038/nrc1071
Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.

Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879
Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK

A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.

Blood. 2003;102(7):2555-61 - PMID: 12775571 - DOI: 10.1182/blood-2003-02-0365
Jain RK

Molecular regulation of vessel maturation.

Nat Med. 2003;9(6):685-93 - PMID: 12778167 - DOI: 10.1038/nm0603-685
Jain RK, Duda DG

Role of bone marrow-derived cells in tumor angiogenesis and treatment.

Cancer Cell. 2003;3(6):515-6 - PMID: 12842078 - DOI: 10.1016/s1535-6108(03)00138-7
Padera TP, Stoll BR, So PT, Jain RK

Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.

Mol Imaging. 2003;1(1):9-15 - PMID: 12920856 - DOI: 10.1162/15353500200200004
Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B

Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.

Microvasc Res. 2003;66(2):113-25 - PMID: 12935769 - DOI: 10.1016/s0026-2862(03)00039-6
Jain RK, Booth MF

What brings pericytes to tumor vessels?

J Clin Invest. 2003;112(8):1134-6 - PMID: 14561696 - PMCID: PMC213497 - DOI: 10.1172/JCI20087
Roose T, Netti PA, Munn LL, Boucher Y, Jain RK

Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.

Microvasc Res. 2003;66(3):204-12 - PMID: 14609526 - DOI: 10.1016/s0026-2862(03)00057-8
Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y

Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.

Clin Cancer Res. 2003;9(15):5508-13 - PMID: 14654530
Padera TP, Boucher Y, Jain RK

Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.

Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026
Jain RK, Padera TP

Development. Lymphatics make the break.

Science. 2003;299(5604):209-10 - PMID: 12522236 - DOI: 10.1126/science.1081345
Forbes NS, Munn LL, Fukumura D, Jain RK

Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.

Cancer Res. 2003;63(17):5188-93 - PMID: 14500342
Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD

Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.

Cancer Res. 2003;63(4):747-51 - PMID: 12591719
Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK

Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.

Circ Res. 2003;93(9):e88-97 - PMID: 14525808 - PMCID: PMC2755542 - DOI: 10.1161/01.RES.0000099243.20096.FA
Davies Cde L, Berk DA, Pluen A, Jain RK

Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.

Br J Cancer. 2002;86(10):1639-44 - PMID: 12085216 - PMCID: PMC2746604 - DOI: 10.1038/sj.bjc.6600270
Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM

Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.

Am J Pathol. 2002;160(3):985-1000 - PMID: 11891196 - PMCID: PMC1867175 - DOI: 10.1016/S0002-9440(10)64920-6
Jain RK, Fenton BT

Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?

J Natl Cancer Inst. 2002;94(6):417-21 - PMID: 11904313 - DOI: 10.1093/jnci/94.6.417
Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK

Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.

Neoplasia. 2002;4(1):3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209
Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK

Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.

Cancer Res. 2002;62(7):2151-6 - PMID: 11929837
Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK

Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.

Clin Cancer Res. 2002;8(4):1008-13 - PMID: 11948107
Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.

Clin Cancer Res. 2002;8(4):1284-91 - PMID: 11948144
Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK

Solid stress facilitates spheroid formation: potential involvement of hyaluronan.

Br J Cancer. 2002;86(6):947-53 - PMID: 11953828 - PMCID: PMC2364140 - DOI: 10.1038/sj.bjc.6600158
Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK

Lymphatic metastasis in the absence of functional intratumor lymphatics.

Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420
Jain RK, Munn LL, Fukumura D

Dissecting tumour pathophysiology using intravital microscopy.

Nat Rev Cancer. 2002;2(4):266-76 - PMID: 12001988 - DOI: 10.1038/nrc778
Jain RK, Padera TP

Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.

J Natl Cancer Inst. 2002;94(11):785-7 - PMID: 12048260 - DOI: 10.1093/jnci/94.11.785
Dolmans DE, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D

Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.

Cancer Res. 2002;62(15):4289-94 - PMID: 12154031
Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK

Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.

Biophys J. 2002;83(3):1650-60 - PMID: 12202388 - PMCID: PMC1302261 - DOI: 10.1016/S0006-3495(02)73933-7
Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LL

Red blood cells augment leukocyte rolling in a virtual blood vessel.

Biophys J. 2002;83(4):1834-41 - PMID: 12324405 - PMCID: PMC1302276 - DOI: 10.1016/S0006-3495(02)73948-9
Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL

Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.

Cancer Res. 2002;62(23):6831-6 - PMID: 12460895
Jain RK

Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.

Semin Oncol. 2002;29(6 Suppl 16):3-9 - PMID: 12516032 - DOI: 10.1053/sonc.2002.37265
Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RK

Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.

Neoplasia. 2002;4(5):449-63 - PMID: 12192604 - PMCID: PMC1661679 - DOI: 10.1038/sj.neo.7900260
Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK

Tumour biology: herceptin acts as an anti-angiogenic cocktail.

Nature. 2002;416(6878):279-80 - PMID: 11907566 - DOI: 10.1038/416279b
Chung HW, Chung HJ

Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683-3688, 2000.

Cancer Res. 2001;61(22):8347-50 - PMID: 11719469
Jain RK, Munn LL, Fukumura D

Transparent Window Models and Intravital Microscopy: Imaging Gene Expression

Physiological Function and Drug Delivery in Tumors, In: Tumor Models in Cancer Research, B. Teicher, Ed., Humana Press, Inc., Totowa, NJ. 2001;Chapter 34:647-671
Jain RK

In Memoriam: Pietro M. Gullino (1919-2001)

Cancer Research. 2001;61:8930-8931
Baish JW, Jain RK

Correspondence Regarding Fractals and Cancer.

Cancer Research. 2001;61:8347-8351
Jain RK, Carmeliet PF

Vessels of death or life.

Sci Am. 2001;285(6):38-45 - PMID: 11759584 - DOI: 10.1038/scientificamerican1201-38
Jain RK, Forbes NS

Can engineered bacteria help control cancer?

Proc Natl Acad Sci U S A. 2001;98(26):14748-50 - PMID: 11752416 - PMCID: PMC64926 - DOI: 10.1073/pnas.261606598
Jain RK

Transport of molecules, particles, and cells in solid tumors.

Annu Rev Biomed Eng. 2001;1:241-63 - PMID: 11701489 - DOI: 10.1146/annurev.bioeng.1.1.241
Jain RK

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.

Nat Med. 2001;7(9):987-9 - PMID: 11533692 - DOI: 10.1038/nm0901-987
Jain RK

Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.

J Control Release. 2001;74(1-3):7-25 - PMID: 11489479 - DOI: 10.1016/s0168-3659(01)00306-6
Jain RK

Clearing the smoke on nicotine and angiogenesis.

Nat Med. 2001;7(7):775-7 - PMID: 11433337 - DOI: 10.1038/89889
Jain RK

Delivery of molecular and cellular medicine to solid tumors.

Adv Drug Deliv Rev. 2001;46(1-3):149-68 - PMID: 11259838 - DOI: 10.1016/s0169-409x(00)00131-9
Yuan J, Melder RJ, Jain RK, Munn LL

Lateral view flow system for studies of cell adhesion and deformation under flow conditions.

Biotechniques. 2001;30(2):388-94 - PMID: 11233608 - PMCID: PMC2752719 - DOI: 10.2144/01302rr02
Dull RO, Yuan J, Chang YS, Tarbell J, Jain RK, Munn LL

Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.

Microvasc Res. 2001;61(2):203-10 - PMID: 11254400 - DOI: 10.1006/mvre.2000.2298
Melder RJ, Kristensen CA, Munn LL, Jain RK

Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery.

Biorheology. 2001;38(2-3):151-9 - PMID: 11381172
Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher Y

Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.

Microvasc Res. 2001;62(1):26-42 - PMID: 11421658 - DOI: 10.1006/mvre.2001.2311
Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.

Nat Med. 2001;7(7):864-8 - PMID: 11433354 - DOI: 10.1038/89997
Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D

Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.

Lab Invest. 2001;81(10):1439-51 - PMID: 11598156 - DOI: 10.1038/labinvest.3780357
Patan S, Munn LL, Tanda S, Roberge S, Jain RK, Jones RC

Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.

Circ Res. 2001;89(8):723-31 - PMID: 11597996 - DOI: 10.1161/hh2001.097870
Patan S, Tanda S, Roberge S, Jones RC, Jain RK, Munn LL

Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation.

Circ Res. 2001;89(8):732-9 - PMID: 11597997 - PMCID: PMC2752899 - DOI: 10.1161/hh2001.097872
Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.

Cancer Res. 2001;61(1):39-44 - PMID: 11196192
Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.

Proc Natl Acad Sci U S A. 2001;98(8):4628-33 - PMID: 11274375 - PMCID: PMC31885 - DOI: 10.1073/pnas.081626898
Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK

Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.

Cancer Res. 2001;61(6):2404-8 - PMID: 11289105
Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

Cancer Res. 2001;61(16):6020-4 - PMID: 11507045
Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA

A potential murine model for flap-related investigations.

Plast Reconstr Surg. 2001;107(6):1504-8 - PMID: 11335827 - DOI: 10.1097/00006534-200105000-00032
Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK

LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.

Cancer Res. 2001;61(22):8079-84 - PMID: 11719431
Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.

Proc Natl Acad Sci U S A. 2001;98(5):2604-9 - PMID: 11226286 - PMCID: PMC30185 - DOI: 10.1073/pnas.041359198
Jain RK

Delivery of Biologic Molecules and Cells to Tumors

In: Biologic Therapy of Cancer: Principles and Practice, S. Rosenberg, Ed., Lippincott, Williams and Watkins, Philadelphia. 2000;:865-874
Carmeliet P, Jain RK

Angiogenesis in cancer and other diseases.

Nature. 2000;407(6801):249-57 - PMID: 11001068 - DOI: 10.1038/35025220
Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK

Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.

Cancer Res. 2000;60(16):4324-7 - PMID: 10969769
Baish JW, Jain RK

Fractals and cancer.

Cancer Res. 2000;60(14):3683-8 - PMID: 10919633
Helmlinger G, Endo M, Ferrara N, Hlatky L, Jain RK

Formation of endothelial cell networks.

Nature. 2000;405(6783):139-41 - PMID: 10821260 - DOI: 10.1038/35012132
Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK

Role of extracellular matrix assembly in interstitial transport in solid tumors.

Cancer Res. 2000;60(9):2497-503 - PMID: 10811131
Dellian M, Yuan F, Trubetskoy VS, Torchilin VP, Jain RK

Vascular permeability in a human tumour xenograft: molecular charge dependence.

Br J Cancer. 2000;82(9):1513-8 - PMID: 10789717 - PMCID: PMC2363402 - DOI: 10.1054/bjoc.1999.1171
Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, Jain RK, McDonald DM

Openings between defective endothelial cells explain tumor vessel leakiness.

Am J Pathol. 2000;156(4):1363-80 - PMID: 10751361 - PMCID: PMC1876882 - DOI: 10.1016/S0002-9440(10)65006-7
Ramanujan S, Koenig GC, Padera TP, Stoll BR, Jain RK

Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.

Cancer Res. 2000;60(5):1442-8 - PMID: 10728711
Jain RK, Munn LL

Leaky vessels? Call Ang1!

Nat Med. 2000;6(2):131-2 - PMID: 10655092 - DOI: 10.1038/72212
Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JM

Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.

Microvasc Res. 2000;59(2):265-77 - PMID: 10684732 - DOI: 10.1006/mvre.1999.2225
Melder RJ, Yuan J, Munn LL, Jain RK

Erythrocytes enhance lymphocyte rolling and arrest in vivo.

Microvasc Res. 2000;59(2):316-22 - PMID: 10684738 - DOI: 10.1006/mvre.1999.2223
Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL

Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.

Proc Natl Acad Sci U S A. 2000;97(26):14608-13 - PMID: 11121063 - PMCID: PMC18966 - DOI: 10.1073/pnas.97.26.14608
McDonald DM, Munn L, Jain RK

Vasculogenic mimicry: how convincing, how novel, and how significant?

Am J Pathol. 2000;156(2):383-8 - PMID: 10666365 - PMCID: PMC1850027 - DOI: 10.1016/S0002-9440(10)64740-2
Somasundaran P, Simpson S, Jain RK, Ivanov I, Raghuraman V

Investigation of Thin Aqueous Films on Silica Using a Modified Interferometric Technique.

J Colloid Interface Sci. 2000;225(1):243-246 - PMID: 10767167 - DOI: 10.1006/jcis.2000.6735
Hartford AC, Gohongi T, Fukumura D, Jain RK

Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.

Cancer Res. 2000;60(8):2128-31 - PMID: 10786673
Stohrer M, Boucher Y, Stangassinger M, Jain RK

Oncotic pressure in solid tumors is elevated.

Cancer Res. 2000;60(15):4251-5 - PMID: 10945638
Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK

Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.

Cancer Res. 2000;60(16):4556-60 - PMID: 10969807
Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

Cancer Res. 2000;60(19):5565-70 - PMID: 11034104
Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK

Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.

Cancer Res. 2000;60(22):6248-52 - PMID: 11103778
Kaur A, Hale CL, Ramanujan S, Jain RK, Johnson RP

Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.

J Virol. 2000;74(18):8413-24 - PMID: 10954541 - PMCID: PMC116352 - DOI: 10.1128/jvi.74.18.8413-8424.2000
Somasundaran P, Simpson S, Ivanov I, Jain RK, Sarkar D

Thinning and Rupture of Aqueous Surfactant Films on Silica

Langmuir. 1999;15:7658-7661
Kristensen CA, Hamberg LM, Hunter GJ, Roberge S, Kierstead D, Wolf GL, Jain RK

Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy.

Neoplasia. 1999;1(6):518-25 - PMID: 10935499 - PMCID: PMC1508121 - DOI: 10.1038/sj.neo.7900063
Heijn M, Roberge S, Jain RK

Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.

Cancer Res. 1999;59(17):4458-63 - PMID: 10485498
Endo M, Jain RK, Witwer B, Brown D

Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.

Microvasc Res. 1999;58(2):89-98 - PMID: 10458924 - DOI: 10.1006/mvre.1999.2158
Jain RK

Understanding barriers to drug delivery: high resolution in vivo imaging is key.

Clin Cancer Res. 1999;5(7):1605-6 - PMID: 10430057
Moulton KS, Melder RJ, Dharnidharka VR, Hardin-Young J, Jain RK, Briscoe DM

Angiogenesis in the huPBL-SCID model of human transplant rejection.

Transplantation. 1999;67(12):1626-31 - PMID: 10401773 - DOI: 10.1097/00007890-199906270-00020
Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK

Return of lymphatic function after flap transfer for acute lymphedema.

Ann Surg. 1999;229(3):421-7 - PMID: 10077056 - PMCID: PMC1191709 - DOI: 10.1097/00000658-199903000-00017
Kristensen CA, Askenasy N, Jain RK, Koretsky AP

Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.

Br J Cancer. 1999;79(2):278-85 - PMID: 9888469 - PMCID: PMC2362210 - DOI: 10.1038/sj.bjc.6690045
Lichtenbeld HC, Ferarra N, Jain RK, Munn LL

Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.

Microvasc Res. 1999;57(3):357-62 - PMID: 10329263 - DOI: 10.1006/mvre.1998.2140
Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA

Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.

Microcirculation. 1999;5(2-3):153-71 - PMID: 9789256
Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK

Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.

Proc Natl Acad Sci U S A. 1999;96(6):3137-42 - PMID: 10077650 - PMCID: PMC15908 - DOI: 10.1073/pnas.96.6.3137
Swartz MA, Kristensen CA, Melder RJ, Roberge S, Calautti E, Fukumura D, Jain RK

Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.

Br J Cancer. 1999;81(5):756-9 - PMID: 10555742 - PMCID: PMC2374305 - DOI: 10.1038/sj.bjc.6690760
Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK

Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.

J Biomech. 1999;32(12):1297-307 - PMID: 10569708 - DOI: 10.1016/s0021-9290(99)00125-6
Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK

Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.

Cancer Res. 1999;59(15):3776-82 - PMID: 10446995
Monsky WL, Fukumura D, Gohongi T, Ancukiewcz M, Weich HA, Torchilin VP, Yuan F, Jain RK

Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.

Cancer Res. 1999;59(16):4129-35 - PMID: 10463618
Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK

Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.

Nat Med. 1999;5(10):1203-8 - PMID: 10502827 - DOI: 10.1038/13524
Pluen A, Netti PA, Jain RK, Berk DA

Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.

Biophys J. 1999;77(1):542-52 - PMID: 10388779 - PMCID: PMC1300351 - DOI: 10.1016/S0006-3495(99)76911-0
Berlin K, Jain RK, Richert C

Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins.

Biotechnol Bioeng. 1998;61(2):107-18 - PMID: 10099504 - DOI: 10.1002/(sici)1097-0290(199821)61:2<107::aid-bit5>3.0.co;2-q
Jain RK

Delivery of Monoclonal Antibodies to the Tumor Cell

In: Monoclonal Antibody-Based Therapy of Cancer, M.L. Grossbard, Ed., Marcel Dekker, Inc., New York. 1998;:23-52
Jain RK, Munn LL, Fukumura D, Melder RJ

In Vitro and In Vivo Quantification of Adhesion Between Leukocytes and Vascular Endothelium.

In: Methods in Molecular Medicine - Methods in Tissue Engineering, J.R. Morgan and M.L. Yarmush, Eds., Humana Press, Totowa. 1998;:553-575
Jain RK

Microcirculation and Transport Phenomena in Tumours

In: Connective Tissue Biology: Integration and Reductionism. Eds. R.K. Reed and K. Rubin, Portland Press Ltd, London. 1998;71:269-293
Sckell A, Safabakhsh N, Dellian M, Jain RK

Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice.

Cancer Res. 1998;58(24):5866-9 - PMID: 9865747
Jain RK

Delivery of molecular and cellular medicine to solid tumors.

J Control Release. 1998;53(1-3):49-67 - PMID: 9741913 - DOI: 10.1016/s0168-3659(97)00237-x
Baish JW, Jain RK

Cancer, angiogenesis and fractals.

Nat Med. 1998;4(9):984 - PMID: 9734370 - DOI: 10.1038/1952
Jain RK, Safabakhsh N, Sckell A, Chen Y, Jiang P, Benjamin L, Yuan F, Keshet E

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor.

Proc Natl Acad Sci U S A. 1998;95(18):10820-5 - PMID: 9724788 - PMCID: PMC27979 - DOI: 10.1073/pnas.95.18.10820
Jain RK

The next frontier of molecular medicine: delivery of therapeutics.

Nat Med. 1998;4(6):655-7 - PMID: 9623964 - DOI: 10.1038/nm0698-655
Jain RK

Integrative pathophysiology of solid tumors: role in detection and treatment.

Cancer J Sci Am. 1998;4 Suppl 1:S48-57 - PMID: 9619271
Rosenzweig M, DeMaria MA, Harper DM, Friedrich S, Jain RK, Johnson RP

Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques.

Proc Natl Acad Sci U S A. 1998;95(11):6388-93 - PMID: 9600975 - PMCID: PMC27734 - DOI: 10.1073/pnas.95.11.6388
Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R

Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.

Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01
Hunter GJ, Hamberg LM, Choi N, Jain RK, McCloud T, Fischman AJ

Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism.

Clin Cancer Res. 1998;4(4):949-55 - PMID: 9563889
Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.

Proc Natl Acad Sci U S A. 1998;95(8):4607-12 - PMID: 9539785 - PMCID: PMC22537 - DOI: 10.1073/pnas.95.8.4607
Zhu H, Jain RK, Baxter LT

Tumor pretargeting for radioimmunodetection and radioimmunotherapy.

J Nucl Med. 1998;39(1):65-76 - PMID: 9443740
Fukumura D, Jain RK

Role of nitric oxide in angiogenesis and microcirculation in tumors.

Cancer Metastasis Rev. 1998;17(1):77-89 - PMID: 9544424 - DOI: 10.1023/a:1005908805527
Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK

Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.

J Invest Dermatol. 1998;111(1):1-6 - PMID: 9665379 - DOI: 10.1046/j.1523-1747.1998.00262.x
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E, Keshet E

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.

Nature. 1998;394(6692):485-90 - PMID: 9697772 - DOI: 10.1038/28867
Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B

Tumor induction of VEGF promoter activity in stromal cells.

Cell. 1998;94(6):715-25 - PMID: 9753319 - DOI: 10.1016/s0092-8674(00)81731-6
Boucher Y, Brekken C, Netti PA, Baxter LT, Jain RK

Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.

Br J Cancer. 1998;78(11):1442-8 - PMID: 9836476 - PMCID: PMC2063228 - DOI: 10.1038/bjc.1998.705
Jain RK

Tumor Microcirculation: Role in Drug and Nutrient Delivery

In: Advances in Blood Substitutes, Eds, R.M. Winslow, K. D. Vandegriff, and M. Intaglietta, Birkhuser, Boston. 1997;:46-70
Jain RK

Delivery of Molecular Medicine to Solid Tumors

In: Microcirculation Annual 1997, M. Tsuchiya, M. Asano and N. Sato, Eds, Nihon-Igakukan, Tokyo. 1997;13:1-5
Jain RK

Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection and Treatment

In: Tumor Angiogenesis, R. Bicknell, C. Lewis and N. Ferrara, Eds, Oxford University Press, Oxford. 1997;:45-59
Jain RK

Tumor Microcirculation: Role in Delivery of Molecular and Cellular Medicine

In: The Biology of Tumors, Proceedings of the Ninth Annual Pezcoller Symposium on the Biology of Tumors, Rovereto, Italy. 1997;:319-345
Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK

Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors

AIChE Journal. 1997;43:818-834
Kristensen CA, Roberge S, Jain RK

Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.

Clin Cancer Res. 1997;3(3):319-24 - PMID: 10026014
Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK

Fractal characteristics of tumor vascular architecture during tumor growth and regression.

Microcirculation. 1997;4(4):395-402 - PMID: 9431507 - DOI: 10.3109/10739689709146803
Jain RK, Schlenger K, Höckel M, Yuan F

Quantitative angiogenesis assays: progress and problems.

Nat Med. 1997;3(11):1203-8 - PMID: 9359693 - DOI: 10.1038/nm1197-1203
Griffon-Etienne G, Boucher Y, Jain RK, Suit HD

Effects of needle insertion in tumors on interstitial fluid pressure.

Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037
Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CG, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, Suit HD

Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.

J Surg Oncol. 1997;66(1):30-8 - PMID: 9290690 - DOI: 10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o
Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK

Solid stress inhibits the growth of multicellular tumor spheroids.

Nat Biotechnol. 1997;15(8):778-83 - PMID: 9255794 - DOI: 10.1038/nbt0897-778
Leunig M, Yuan F, Gerweck LE, Jain RK

Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice.

Int J Microcirc Clin Exp. 1997;17(1):1-9 - PMID: 9176719 - DOI: 10.1159/000179199
Baish JW, Netti PA, Jain RK

Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.

Microvasc Res. 1997;53(2):128-41 - PMID: 9143544 - DOI: 10.1006/mvre.1996.2005
Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK

Geometric resistance and microvascular network architecture of human colorectal carcinoma.

Microcirculation. 1997;4(1):25-33 - PMID: 9110281 - DOI: 10.3109/10739689709148315
Jain RK

The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.

Microcirculation. 1997;4(1):1-23 - PMID: 9110280 - DOI: 10.3109/10739689709148314
Briscoe DM, Ganz P, Alexander SI, Melder RJ, Jain RK, Cotran RS, Lichtman AH

The problem of chronic rejection: influence of leukocyte-endothelial interactions.

Kidney Int Suppl. 1997;58:S22-7 - PMID: 9067938
Berk DA, Yuan F, Leunig M, Jain RK

Direct in vivo measurement of targeted binding in a human tumor xenograft.

Proc Natl Acad Sci U S A. 1997;94(5):1785-90 - PMID: 9050856 - PMCID: PMC19994 - DOI: 10.1073/pnas.94.5.1785
Helmlinger G, Yuan F, Dellian M, Jain RK

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.

Nat Med. 1997;3(2):177-82 - PMID: 9018236 - DOI: 10.1038/nm0297-177
Boucher Y, Salehi H, Witwer B, Harsh GR, Jain RK

Interstitial fluid pressure in intracranial tumours in patients and in rodents.

Br J Cancer. 1997;75(6):829-36 - PMID: 9062403 - PMCID: PMC2063404 - DOI: 10.1038/bjc.1997.148
Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.

Science. 1997;276(5317):1423-5 - PMID: 9162011 - DOI: 10.1126/science.276.5317.1423
Fukumura D, Yuan F, Monsky WL, Chen Y, Jain RK

Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.

Am J Pathol. 1997;151(3):679-88 - PMID: 9284816 - PMCID: PMC1857859
Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJ

Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.

Am J Pathol. 1997;150(6):2099-112 - PMID: 9176401 - PMCID: PMC1858325
Jain RK

Delivery of molecular and cellular medicine to solid tumors.

Adv Drug Deliv Rev. 1997;26(2-3):71-90 - PMID: 10837535 - DOI: 10.1016/s0169-409x(97)00027-6
Melder RJ, Koenig GC, Munn LL, Jain RK

Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.

Nat Immun. 1997;15(2-3):154-63 - PMID: 9162265
Fukumura D, Yuan F, Endo M, Jain RK

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

Am J Pathol. 1997;150(2):713-25 - PMID: 9033284 - PMCID: PMC1858293
Zhu H, Baxter LT, Jain RK

Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.

J Nucl Med. 1997;38(5):731-41 - PMID: 9170438
Jain RK

Solid Tumor Barriers to Anticancer Drugs.

Cope. 1996;12:22-23
Saltzman WM, Jain RK

Drug Delivery: Barriers to Drug Transport and the Design of Novel Therapeutic Agents.

Molecular Medicine Today. 1996;1:4
Kristjansen PE, Brown TJ, Shipley LA, Jain RK

Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.

Clin Cancer Res. 1996;2(2):359-67 - PMID: 9816179
Lichtenbeld HC, Yuan F, Michel CC, Jain RK

Perfusion of single tumor microvessels: application to vascular permeability measurement.

Microcirculation. 1996;3(4):349-57 - PMID: 9086446 - DOI: 10.3109/10739689609148307
Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK

Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.

Microvasc Res. 1996;51(3):327-46 - PMID: 8992232 - DOI: 10.1006/mvre.1996.0031
Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.

Proc Natl Acad Sci U S A. 1996;93(25):14765-70 - PMID: 8962129 - PMCID: PMC26210 - DOI: 10.1073/pnas.93.25.14765
Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS

Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.

Biophys J. 1996;71(5):2656-68 - PMID: 8913603 - PMCID: PMC1233752 - DOI: 10.1016/S0006-3495(96)79457-2
Dellian M, Helmlinger G, Yuan F, Jain RK

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.

Br J Cancer. 1996;74(8):1206-15 - PMID: 8883406 - PMCID: PMC2075944 - DOI: 10.1038/bjc.1996.518
Jain RK

1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.

Ann Biomed Eng. 1996;24(4):457-73 - PMID: 8841721 - DOI: 10.1007/BF02648108
Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.

Acta Orthop Scand. 1996;67(4):383-8 - PMID: 8792744 - DOI: 10.3109/17453679609002336
Zhu H, Melder RJ, Baxter LT, Jain RK

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.

Cancer Res. 1996;56(16):3771-81 - PMID: 8706023
Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.

Am J Pathol. 1996;149(1):59-71 - PMID: 8686763 - PMCID: PMC1865247
Nozue M, Lee I, Manning JM, Manning LR, Jain RK

Oxygenation in tumors by modified hemoglobins.

J Surg Oncol. 1996;62(2):109-14 - PMID: 8649036 - DOI: 10.1002/(SICI)1096-9098(199606)62:2<109::AID-JSO6>3.0.CO;2-C
Jain RK

Delivery of molecular medicine to solid tumors.

Science. 1996;271(5252):1079-80 - PMID: 8599082 - DOI: 10.1126/science.271.5252.1079
Leunig M, Yuan F, Gerweck LE, Berk DA, Jain RK

Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.

Res Exp Med (Berl). 1996;195(5):275-88 - PMID: 8578003 - DOI: 10.1007/BF02576798
Nozue M, Lee I, Hartford A, Tanda S, Suit H, Jain R

pO(2) measurement in murine tumors by Eppendorf 'Histograph'.

Int J Oncol. 1996;9(5):955-62 - PMID: 21541601 - DOI: 10.3892/ijo.9.5.955
Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK

Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.

Cancer Res. 1996;56(5):964-68 - PMID: 8640786
Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ

Leukocyte-endothelial adhesion and angiogenesis in tumors.

Cancer Metastasis Rev. 1996;15(2):195-204 - PMID: 8842491 - DOI: 10.1007/BF00437472
Kristensen CA, Nozue M, Boucher Y, Jain RK

Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.

Br J Cancer. 1996;74(4):533-6 - PMID: 8761366 - PMCID: PMC2074665 - DOI: 10.1038/bjc.1996.397
Boucher Y, Leunig M, Jain RK

Tumor angiogenesis and interstitial hypertension.

Cancer Res. 1996;56(18):4264-6 - PMID: 8797602
Munn LL, Melder RJ, Jain RK

Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.

Biophys J. 1996;71(1):466-78 - PMID: 8804629 - PMCID: PMC1233497 - DOI: 10.1016/S0006-3495(96)79248-2
Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK

During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.

Nat Med. 1996;2(9):992-7 - PMID: 8782456 - DOI: 10.1038/nm0996-992
Patan S, Munn LL, Jain RK

Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.

Microvasc Res. 1996;51(2):260-72 - PMID: 8778579 - DOI: 10.1006/mvre.1996.0025
Skalak R, Zargaryan S, Jain RK, Netti PA, Hoger A

Compatibility and the genesis of residual stress by volumetric growth.

J Math Biol. 1996;34(8):889-914 - PMID: 8858855 - DOI: 10.1007/BF01834825
Johnson EM, Berk DA, Jain RK, Deen WM

Hindered diffusion in agarose gels: test of effective medium model.

Biophys J. 1996;70(2):1017-23 - PMID: 8789119 - PMCID: PMC1225002 - DOI: 10.1016/S0006-3495(96)79645-5
Berk DA, Swartz MA, Leu AJ, Jain RK

Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching.

Am J Physiol. 1996;270(1 Pt 2):H330-7 - PMID: 8769769 - DOI: 10.1152/ajpheart.1996.270.1.H330
Swartz MA, Berk DA, Jain RK

Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory.

Am J Physiol. 1996;270(1 Pt 2):H324-9 - PMID: 8769768 - DOI: 10.1152/ajpheart.1996.270.1.H324
Baxter LT, Jain RK

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.

Br J Cancer. 1996;73(4):447-56 - PMID: 8595158 - PMCID: PMC2074453 - DOI: 10.1038/bjc.1996.80
Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK

Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.

Microvasc Res. 1996;52(1):27-46 - PMID: 8812751 - DOI: 10.1006/mvre.1996.0041
Jain RK, Janda KD, Saltzman WM

Drug discovery and delivery.

Mol Med Today. 1995;1(1):4 - PMID: 9415129 - DOI: 10.1016/1357-4310(95)80005-0
Melder RJ, Salehi HA, Jain RK

Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.

Microvasc Res. 1995;50(1):35-44 - PMID: 7476578 - DOI: 10.1006/mvre.1995.1036
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

Cancer Res. 1995;55(17):3752-6 - PMID: 7641188
Boucher Y, Lee I, Jain RK

Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.

Microvasc Res. 1995;50(2):175-82 - PMID: 8538498 - DOI: 10.1006/mvre.1995.1051
Zlotecki RA, Baxter LT, Boucher Y, Jain RK

Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.

Microvasc Res. 1995;50(3):429-43 - PMID: 8583955 - DOI: 10.1006/mvre.1995.1069
Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK

Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.

Cancer Res. 1995;55(22):5451-8 - PMID: 7585615
Gazit Y, Berk DA, Leunig M, Baxter LT, Jain RK

Scale-invariant behavior and vascular network formation in normal and tumor tissue.

Phys Rev Lett. 1995;75(12):2428-2431 - PMID: 10059301 - DOI: 10.1103/PhysRevLett.75.2428
Munn LL, Koenig GC, Jain RK, Melder RJ

Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.

Biotechniques. 1995;19(4):622-6, 628-31 - PMID: 8777057
Yamada S, Mayadas TN, Yuan F, Wagner DD, Hynes RO, Melder RJ, Jain RK

Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin.

Blood. 1995;86(9):3487-92 - PMID: 7579454
Baxter LT, Zhu H, Mackensen DG, Butler WF, Jain RK

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.

Cancer Res. 1995;55(20):4611-22 - PMID: 7553638
Yamada S, Melder RJ, Leunig M, Ohkubo C, Jain RK

Leukocyte rolling increases with age.

Blood. 1995;86(12):4707-8 - PMID: 8541569
Melder RJ, Munn LL, Yamada S, Ohkubo C, Jain RK

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.

Biophys J. 1995;69(5):2131-8 - PMID: 8580357 - PMCID: PMC1236447 - DOI: 10.1016/S0006-3495(95)80087-1
Fukumura D, Salehi HA, Witwer B, Tuma RF, Melder RJ, Jain RK

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.

Cancer Res. 1995;55(21):4824-9 - PMID: 7585514
Johnson EM, Berk DA, Jain RK, Deen WM

Diffusion and partitioning of proteins in charged agarose gels.

Biophys J. 1995;68(4):1561-8 - PMID: 7787041 - PMCID: PMC1282050 - DOI: 10.1016/S0006-3495(95)80328-0
Jain RK

Tumor Microcirculation: Role in Cancer Diagnosis and Treatment

In: Progress in Microcirculation Research, H. Niimi, et al, Eds., Pergamon Press, Tarrytown. 1994;:29-36
Jain RK

Transport Phenomena in Tumors

Advances in Chemical Engineering. 1994;20:129-200
Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.

Br J Cancer. 1994;69(1):101-3 - PMID: 8286189 - PMCID: PMC1968758 - DOI: 10.1038/bjc.1994.15
Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK

Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.

J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684 - DOI: 10.1093/jnci/86.4.293
Baxter LT, Zhu H, Mackensen DG, Jain RK

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

Cancer Res. 1994;54(6):1517-28 - PMID: 8137258
Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313 - DOI: 10.1073/pnas.91.6.2081
Jain RK

Barriers to drug delivery in solid tumors.

Sci Am. 1994;271(1):58-65 - PMID: 8066425 - DOI: 10.1038/scientificamerican0794-58
Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

Cancer Res. 1994;54(13):3352-6 - PMID: 8012948
Hamberg LM, Kristjansen PE, Hunter GJ, Wolf GL, Jain RK

Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.

Cancer Res. 1994;54(23):6032-6 - PMID: 7954440
Leu AJ, Berk DA, Yuan F, Jain RK

Flow velocity in the superficial lymphatic network of the mouse tail.

Am J Physiol. 1994;267(4 Pt 2):H1507-13 - PMID: 7943396 - DOI: 10.1152/ajpheart.1994.267.4.H1507
Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK

A method for labeling cells for positron emission tomography (PET) studies.

J Immunol Methods. 1994;175(1):79-87 - PMID: 7930641 - DOI: 10.1016/0022-1759(94)90333-6
Melder RJ, Jain RK

Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.

J Immunol Methods. 1994;175(1):69-77 - PMID: 7930640 - DOI: 10.1016/0022-1759(94)90332-8
Martin GR, Jain RK

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.

Cancer Res. 1994;54(21):5670-4 - PMID: 7923215
Kristjansen PE, Roberge S, Lee I, Jain RK

Tissue-isolated human tumor xenografts in athymic nude mice.

Microvasc Res. 1994;48(3):389-402 - PMID: 7731400 - DOI: 10.1006/mvre.1994.1063
Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.

Lab Invest. 1994;71(2):300-7 - PMID: 7521447
Melder RJ, Jain RK

Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells.

Cell Biophys. 1994;20(2-3):161-76 - PMID: 1285298 - DOI: 10.1007/BF02823656
Lee I, Boucher Y, Demhartner TJ, Jain RK

Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.

Br J Cancer. 1994;69(3):492-6 - PMID: 8123479 - PMCID: PMC1968875 - DOI: 10.1038/bjc.1994.89
Lee I, Demhartner TJ, Boucher Y, Jain RK, Intaglietta M

Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.

Microvasc Res. 1994;48(1):1-12 - PMID: 7990716 - DOI: 10.1006/mvre.1994.1034
Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

Cancer Res. 1994;54(17):4564-8 - PMID: 8062241
Munn LL, Melder RJ, Jain RK

Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.

Biophys J. 1994;67(2):889-95 - PMID: 7948702 - PMCID: PMC1225432 - DOI: 10.1016/S0006-3495(94)80550-8
Melder RJ, Jain RK

Delivery of Effector Cells to Tumors

In: '93 Recent Advances in Cancer Research, J.G. Park, Ed., Seoul National University, Seoul. 1993;:202-217
Jain RK

Physiological Resistance to the Treatment of Solid Tumors

In: Drug Resistance in Oncology, B. Teicher, Ed., M. Dekker, New York. 1993;Chapter 4:87-105
Jain RK, Baxter LT

Extravasation and Interstitial Transport in Tumors

In: Biological Barriers to Protein Delivery, K.L. Audus and T.J. Raub, Eds., Plenum Press, New York. 1993;Chapter 15:441-465
Eskey CJ, Koretsky AP, Domach MM, Jain RK

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.

Proc Natl Acad Sci U S A. 1993;90(7):2646-50 - PMID: 8464871 - PMCID: PMC46152 - DOI: 10.1073/pnas.90.7.2646
Yuan F, Leunig M, Berk DA, Jain RK

Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.

Microvasc Res. 1993;45(3):269-89 - PMID: 8321142 - DOI: 10.1006/mvre.1993.1024
Berk DA, Yuan F, Leunig M, Jain RK

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.

Biophys J. 1993;65(6):2428-36 - PMID: 8312481 - PMCID: PMC1225983 - DOI: 10.1016/S0006-3495(93)81326-2
Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK

Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.

Cancer Res. 1993;53(24):5867-71 - PMID: 8261395
Martin GR, Jain RK

Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.

Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048
Zlotecki RA, Boucher Y, Lee I, Baxter LT, Jain RK

Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.

Cancer Res. 1993;53(11):2466-8 - PMID: 8495405
Kristjansen PE, Boucher Y, Jain RK

Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.

Cancer Res. 1993;53(20):4764-6 - PMID: 8402656
Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, Messmer K

Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.

Cancer Res. 1992;52(2):487-90 - PMID: 1728421
Kaufman EN, Jain RK

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.

Cancer Res. 1992;52(15):4157-67 - PMID: 1638531
Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, Jain RK

Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

Cancer Res. 1992;52(7):1993-5 - PMID: 1551128
Eskey CJ, Koretsky AP, Domach MM, Jain RK

2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.

Cancer Res. 1992;52(21):6010-9 - PMID: 1394226
Baxter LT, Yuan F, Jain RK

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.

Cancer Res. 1992;52(20):5838-44 - PMID: 1394212
Kaufman EN, Jain RK

In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching.

J Immunol Methods. 1992;155(1):1-17 - PMID: 1383343 - DOI: 10.1016/0022-1759(92)90265-u
Lee I, Boucher Y, Jain RK

Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.

Cancer Res. 1992;52(11):3237-40 - PMID: 1534273
Boucher Y, Jain RK

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

Cancer Res. 1992;52(18):5110-4 - PMID: 1516068
Less JR, Posner MC, Boucher Y, Borochovitz D, Wolmark N, Jain RK

Interstitial hypertension in human breast and colorectal tumors.

Cancer Res. 1992;52(22):6371-4 - PMID: 1423283
Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, Jain RK

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

Cancer Res. 1992;52(23):6553-60 - PMID: 1384965
Ward KA, Jain RK

Blood Flow Response to Hyperglycemia.

In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Sevick EM, Jain RK

Viscous Resistance to Blood Flow in the Tumor Microcirculation: Clinical Implications.

In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Baxter LT, Jain RK

Vascular and Interstitial Transport in Tumors

In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Jain RK

Parameters Governing Tumor Blood Flow

In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Ward KA, DiPette DJ, Held TN, Jain RK

Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.

Cancer Res. 1991;51(13):3612-6 - PMID: 2054796
Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.

Microvasc Res. 1991;41(2):252-72 - PMID: 2051960 - DOI: 10.1016/0026-2862(91)90026-8
Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.

Microvasc Res. 1991;41(1):5-23 - PMID: 2051954 - DOI: 10.1016/0026-2862(91)90003-t
Sasaki A, Melder RJ, Whiteside TL, Herberman RB, Jain RK

Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.

J Natl Cancer Inst. 1991;83(6):433-7 - PMID: 1999850 - DOI: 10.1093/jnci/83.6.433
Sevick EM, Jain RK

Measurement of capillary filtration coefficient in a solid tumor.

Cancer Res. 1991;51(4):1352-5 - PMID: 1997172
Jain RK

Therapeutic implications of tumor physiology.

Curr Opin Oncol. 1991;3(6):1105-8 - PMID: 1843113 - DOI: 10.1097/00001622-199112000-00020
Jain RK

Haemodynamic and transport barriers to the treatment of solid tumours.

Int J Radiat Biol. 1991;60(1-2):85-100 - PMID: 1678003 - DOI: 10.1080/09553009114551621
Kaufman EN, Jain RK

Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime.

Biophys J. 1991;60(3):596-610 - PMID: 1932550 - PMCID: PMC1260103 - DOI: 10.1016/S0006-3495(91)82089-6
Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK

Interstitial hypertension in superficial metastatic melanomas in humans.

Cancer Res. 1991;51(24):6691-4 - PMID: 1742743
Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK

Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.

Cancer Res. 1991;51(24):6695-8 - PMID: 1742744
Yuan F, Baxter LT, Jain RK

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

Cancer Res. 1991;51(12):3119-30 - PMID: 2039991
Sevick EM, Jain RK

Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.

Cancer Res. 1991;51(10):2727-30 - PMID: 2021951
Less JR, Skalak TC, Sevick EM, Jain RK

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.

Cancer Res. 1991;51(1):265-73 - PMID: 1988088
Ohkubo C, Bigos D, Jain RK

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.

Cancer Res. 1991;51(5):1561-3 - PMID: 1997196
Herberman RB, Basse P, Jain RK, Melder RJ, Goldfarb RH, Ernstoff MS, Kirkwood JM, Whiteside TL

Approaches to immunotherapy with defined populations of IL-2 cultured NK cells, immune T Cells or tumor infiltrating lymphocytes.

In: Biology and Clinical Applications of IL-2, R.C. Rees, Ed., Oxford University Press, London. 1990;Chapter 12:111-119
Jain RK

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.

Cancer Res. 1990;50(3 Suppl):814s-819s - PMID: 2404582
Clauss MA, Jain RK

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.

Cancer Res. 1990;50(12):3487-92 - PMID: 2340499
Jain RK

Vascular and interstitial barriers to delivery of therapeutic agents in tumors.

Cancer Metastasis Rev. 1990;9(3):253-66 - PMID: 2292138 - DOI: 10.1007/BF00046364
Kaufman EN, Jain RK

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.

Biophys J. 1990;58(4):873-85 - PMID: 2248992 - PMCID: PMC1281033 - DOI: 10.1016/S0006-3495(90)82432-2
Jain RK

Tumor physiology and antibody delivery.

Front Radiat Ther Oncol. 1990;24:32-46; discussion 64-8 - PMID: 2187763
Boucher Y, Baxter LT, Jain RK

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

Cancer Res. 1990;50(15):4478-84 - PMID: 2369726
Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.

Microvasc Res. 1990;40(2):246-63 - PMID: 2250603 - DOI: 10.1016/0026-2862(90)90023-k
Jain RK, Stock RJ, Chary SR, Rueter M

Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.

Microvasc Res. 1990;39(1):77-93 - PMID: 2314308 - DOI: 10.1016/0026-2862(90)90060-5
Chary SR, Jain RK

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.

Proc Natl Acad Sci U S A. 1989;86(14):5385-9 - PMID: 2748592 - PMCID: PMC297627 - DOI: 10.1073/pnas.86.14.5385
Sevick EM, Jain RK

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.

Cancer Res. 1989;49(13):3506-12 - PMID: 2731172
Jain RK

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.

J Natl Cancer Inst. 1989;81(8):570-6 - PMID: 2649688 - DOI: 10.1093/jnci/81.8.570
Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.

Microvasc Res. 1989;37(1):77-104 - PMID: 2646512 - DOI: 10.1016/0026-2862(89)90074-5
Sevick EM, Jain RK

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.

Cancer Res. 1989;49(13):3513-9 - PMID: 2731173
Sasaki A, Jain RK, Maghazachi AA, Goldfarb RH, Herberman RB

Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.

Cancer Res. 1989;49(14):3742-6 - PMID: 2500233
Maldarelli C, Jain RK

Stability of thin films: characterization and applications in industrial and biological systems.

Thin Liquid Films, I.B. Ivanov, Ed., M. Dekker, New York. 1988;:497-568
Jain RK

Transvascular and interstitial transport in tumors

Vascular Endothelium in Health and Disease, S. Chien (Ed.), Elsevier, Amsterdam . 1988;:215-220
Jain RK

Transport of molecules across tumor vasculature.

Cancer Metastasis Rev. 1988;6(4):559-93 - PMID: 3327633 - DOI: 10.1007/BF00047468
Ward KA, Jain RK

Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia.

Int J Hyperthermia. 1988;4(3):223-50 - PMID: 3290346 - DOI: 10.3109/02656738809051100
Jain RK

Determinants of tumor blood flow: a review.

Cancer Res. 1988;48(10):2641-58 - PMID: 3282647
DiPette DJ, Ward KA, Jain RK, Kerr NE, Schwarzenberger K

Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.

Cancer Res. 1988;48(6):1476-80 - PMID: 3345521
Jain RK, Baxter LT

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

Cancer Res. 1988;48(24 Pt 1):7022-32 - PMID: 3191477
Baxter LT, Jain RK

Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.

Microvasc Res. 1988;36(1):108-15 - PMID: 3185299 - DOI: 10.1016/0026-2862(88)90043-x
Sevick EM, Jain RK

Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.

Cancer Res. 1988;48(5):1201-7 - PMID: 3342400
Jain RK

Tumor blood flow response to hyperthermia and pharmacological agents.

Radiation Research, E.M. Fieldman et al (eds.), Taylor and Francis, London. 1987;Volume 2:813-818
Jain RK

Interstitial transport in tumors.

Advances in Microcirculation. 1987;13:266-284
Chary SC, Jain RK

Analysis of diffusive and convective recovery after photobleaching-uniform flow field.

Chemical Engineering Commun. 1987;55:235-249
Ward-Hartley KA, Jain RK

Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.

Cancer Res. 1987;47(2):371-7 - PMID: 3791228
Traykov TT, Jain RK

Effect of glucose and galactose on red blood cell membrane deformability.

Int J Microcirc Clin Exp. 1987;6(1):35-44 - PMID: 3583577
Baxter LT, Jain RK, Svensjö E

Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.

Microvasc Res. 1987;34(3):336-48 - PMID: 2448593 - DOI: 10.1016/0026-2862(87)90066-5
Jain RK, Ward-Hartley KA

Dynamics of cancer cell interactions with microvasculature and interstitium.

Biorheology. 1987;24(2):117-25 - PMID: 3651585 - DOI: 10.3233/bir-1987-24205
Jain RK

Transport of molecules in the tumor interstitium: a review.

Cancer Res. 1987;47(12):3039-51 - PMID: 3555767
DiPette D, Ward-Hartley K, Jain RK

Effect of hyperglycemia on systemic hemodynamics and blood flow rate in normal and neoplastic tissues in rats

Cancer Res. 1986;46:6299-6304
Traykov TT, Jain RK

Effect of transmembrane potential on the deformability of RBC's suspended in carbohydrate-saline solutions.

J Colloid and Interface Science. 1986;114:273-276
Traykov TT, Jain RK

Effect of glucose, galactose, and transmembrane potential on shear elastic modulus of erythrocyte membrane.

AIChE Symposium Series. 1986;82:190-194
Gerlowski LE, Jain RK

Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.

Int J Microcirc Clin Exp. 1986;4(4):363-72 - PMID: 4086191
Jain RK, Gerlowski LE

Extravascular transport in normal and tumor tissues.

Crit Rev Oncol Hematol. 1986;5(2):115-70 - PMID: 3521923 - DOI: 10.1016/s1040-8428(86)80023-3
DiPette DJ, Ward-Hartley KA, Jain RK

Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.

Cancer Res. 1986;46(12 Pt 1):6299-304 - PMID: 3779648
Gerlowski LE, Jain RK

Microvascular permeability of normal and neoplastic tissues.

Microvasc Res. 1986;31(3):288-305 - PMID: 2423854 - DOI: 10.1016/0026-2862(86)90018-x
Jain RK

Analysis of heat transfer and temperature distributions in tissues during local and whole body hyperthermia

Heat Transfer in Medicine and Biology, A. Shitzer and R. Eberhart, Eds., Plenum Press, New York, Volume 2. 1985;Chapter 16:3-54
Ivanov B, Dimitrov DS, Somasundaran P, Jain RK

Thinning of films with deformable surfaces: diffusion-controlled surfactant transfer

Chemical Engineering Science. 1985;40:137-150
Dimitrov DS, Zhelev DV, Jain RK

Stability of membrane systems modeled as multilayered viscoelastic films.

J Theor Biol. 1985;113(2):353-77 - PMID: 3999781 - DOI: 10.1016/s0022-5193(85)80232-0
Jain RK

Transport of macromolecules in tumor microcirculation.

Biotechnol Prog. 1985;1(2):81-94 - PMID: 20568145 - DOI: 10.1002/btpr.5420010205
Jain RK

Mass and heat transfer in tumors: applications in detection and treatment

Advances in Transport Processes. 1984;3:205-339
Jain RK, Ward-Hartley KA

Tumor blood flow: characterization, modifications and role in hyperthermia

IEEE Transactions in Sonics and Ultrasonics; Special Issue on Hyperthermia. 1984;31:504-526
Dimitrov DS, Jain RK

Stability of thin viscoelastic films between permeable membranes

J Colloid and Interface Science. 1984;101:489-499
Dimitrov DS, Li J, Angelova M, Jain RK

Surface effects in preparation of cell-size liposomes.

FEBS Letters. 1984;176:398-400
Dudar TE, Jain RK

Differential response of normal and tumor microcirculation to hyperthermia.

Cancer Res. 1984;44(2):605-12 - PMID: 6692365
Peloso R, Tuma DT, Jain RK

Dielectric properties of solid tumors during normothermia and hyperthermia.

IEEE Trans Biomed Eng. 1984;31(11):725-8 - PMID: 6500596 - DOI: 10.1109/TBME.1984.325399
Dimitrov DS, Jain RK

Membrane stability.

Biochim Biophys Acta. 1984;779(4):437-68 - PMID: 6391549 - DOI: 10.1016/0304-4157(84)90020-0
Nugent LJ, Jain RK

Extravascular diffusion in normal and neoplastic tissues.

Cancer Res. 1984;44(1):238-44 - PMID: 6197161
Nugent LJ, Jain RK

Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed.

Am J Physiol. 1984;246(1 Pt 2):H129-37 - PMID: 6198927 - DOI: 10.1152/ajpheart.1984.246.1.H129
Jain RK, Shah SA, Finney PL

Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.

J Natl Cancer Inst. 1984;73(2):429-36 - PMID: 6589435 - DOI: 10.1093/jnci/73.2.429
Nugent LJ, Jain RK

Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.

Microvasc Res. 1984;28(2):270-4 - PMID: 6209533 - DOI: 10.1016/0026-2862(84)90022-0
Nugent LJ, Jain RK

Two-compartment model for plasma pharmacokinetics in individual blood vessels.

J Pharmacokinet Biopharm. 1984;12(4):451-61 - PMID: 6084709 - DOI: 10.1007/BF01062668
Jain RK

Bioheat transfer: mathematical models of thermal systems.

Hyperthermia in Cancer Therapy, F.K. Storm, Ed., G.K. Hall and Co., Boston. 1983;Chapter 2:9-46
Dudar TE, Jain RK

Mathematical models for microcirculatory changes during hyperthermia in normal and neoplastic tissues

AIChE Symposium Series 227. 1983;79:153-162
Nugent LJ, Jain RK

Interstitial diffusion of macromolecules in normal and tumor capillary beds

AIChE Symposium Series 227. 1983;79:1-10
Jain RK, Maldarelli C

Stability of thin viscoelastic films with applications to biological membrane deformation.

Annals of New York Academy of Sciences. 1983;404:89-102
Volpe BT, Jain RK

Temperature distributions and thermal response in humans. II. Simulation of whole-body, regional and localized hyperthermia in cancer patients

AIChE Symposium Series 227. 1983;79:116-123
Shah SA, Jain RK, Finney PL

Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma.

Adv Exp Med Biol. 1983;157:23-42 - PMID: 7158522 - DOI: 10.1007/978-1-4684-4388-2_4
Dudar TE, Jain RK

Microcirculatory flow changes during tissue growth.

Microvasc Res. 1983;25(1):1-21 - PMID: 6188025 - DOI: 10.1016/0026-2862(83)90040-7
Shah SA, Jain RK, Finney PL

Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.

Cancer Lett. 1983;19(3):317-23 - PMID: 6883314 - DOI: 10.1016/0304-3835(83)90101-5
Gerlowski LE, Jain RK

Physiologically based pharmacokinetic modeling: principles and applications.

J Pharm Sci. 1983;72(10):1103-27 - PMID: 6358460 - DOI: 10.1002/jps.2600721003
Shah SA, Jain RK, Finney PL

Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rats bearing W256 carcinosarcoma

Hyperthermia, H.I. Bicher and D.F. Bruley, eds., Plenum Publishing Corporation, New York. 1982;:23-42
Maldarelli C, Jain RK

The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film II. Extension of the theory to the study of the onset of small-scale cell membrane motions.

J. Colloid and Interface Science. 1982;90:263-276
Maldarelli C, Jain RK

The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. I. General formulation and a derivation of the dispersion equation.

J. Colloid and Interface Science. 1982;90:233-262
Grossmann IE, Drabbant RD, Jain RK

Incorporating toxicology in the synthesis of industrial chemical complexes

Chemical Engineering Commun. 1982;17:151-170
Townsend JG, Jain RK, Cashmore AR

In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.

J Pharm Sci. 1982;71(10):1102-5 - PMID: 7143204 - DOI: 10.1002/jps.2600711005
Gullino PM, Jain RK, Grantham FH

Temperature gradients and local perfusion in a mammary carcinoma.

J Natl Cancer Inst. 1982;68(3):519-33 - PMID: 6950181
Volpe BT, Jain RK

Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.

Med Phys. 1982;9(4):506-13 - PMID: 7110081 - DOI: 10.1118/1.595115
Nugent LJ, Jain RK

Monitoring transport in the rabbit ear chamber.

Microvasc Res. 1982;24(2):204-9 - PMID: 7176939 - DOI: 10.1016/0026-2862(82)90057-7
Jain RK, Gerlowski L, Weissbrod J, Wang J, Pierson RN, Jr

Kinetics of uptake, distribution and excretion of zinc in rats.

Annals of Biomedical Engineering. 1981;9:347-361
Zawicki DF, Jain RK, Schmid-Schoenbein GW, Chien S

Dynamics of neovascularization in normal tissue.

Microvasc Res. 1981;21(1):27-47 - PMID: 7010086 - DOI: 10.1016/0026-2862(81)90003-0
Jain RK, Weissbrod JM, Wei J

Mass transport in tumors: characterization and applications to chemotherapy.

Adv Cancer Res. 1981;33:251-310 - PMID: 7006335 - DOI: 10.1016/s0065-230x(08)60672-7
Jain RK

Heat transfer in tumors: characterization and applications to thermography and hyperthermia.

Advances in Biomedical Engineering, edited by D.O. Cooney, Marcel Dekker, Inc., New York, Part I. 1980;Chapter 2:59-91
Jain RK, Ivanov IB

Thinning and rupture of ring-shaped films

J Chemical Society, Faraday Transactions II. 1980;76:250-266
Sien HP, Jain RK

Intratumour temperature distributions during hyperthermia

J Thermal Biology. 1980;5:127-130
Jain RK, Gullino PM

Analysis of transient temperature distribution in a perfused medium Due to a spherical heat source with application to heat transfer in tumors: homogeneous and infinite medium

Chemical Engineering Commun. 1980;4:95-118
Maldarelli C, Jain RK, Ivanov IB, Ruckenstein E

Stability of symmetric and unsymmetric, thin liquid films to short and long wavelength perturbations

J Colloid and Interface Science. 1980;78:118-143
Jain RK

Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.

Ann N Y Acad Sci. 1980;335:48-66 - PMID: 6931539 - DOI: 10.1111/j.1749-6632.1980.tb50736.x
Weissbrod JM, Jain RK

Preliminary model for streptozocin metabolism in mice.

J Pharm Sci. 1980;69(6):691-4 - PMID: 6451687 - DOI: 10.1002/jps.2600690621
Chryanthopoulos GS, Jain RK

Thermal interactions between normal and neoplastic tissues in the rat, rabbit, swine, and dog during hyperthermia.

Med Phys. 1980;7(5):529-39 - PMID: 7421764 - DOI: 10.1118/1.594668
Ivanov IB, Jain RK, Somasundaran P, Traykov TT

The role of surfactants on the coalescences of emulsion droplets

Solution Chemistry of Surfactants, edited by K.A. Mittal, Plenum Press, New York. 1979;2:817-840
Jain RK, Ivanov IB, Maldarelli C, Ruckenstein E

Instability and rupture of thin liquid films

Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:140-167
Ivanov IB, Jain RK

Formation and thinning of thin liquid films

Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:120-139
Jain RK

Transient temperature distributions in an infinite perfused medium due to a time-dependent, spherical heat source

Trans. ASME J. Biomechanical Engineering. 1979;101:82-86
Tzeghai G, Jain RK

A semi-empirical model for cell kill kinetics during hyperthermia.

J Thermal Biology. 1979;4:257-258
Sien HP, Jain RK

Temperature distributions in normal and neoplastic tissues during hyperthermia: a lumped parameter model

J Thermal Biology. 1979;4:157-164
Jain RK, Wei J, Gullino PM

Pharmacokinetics of methotrexate in solid tumors.

J Pharmacokinet Biopharm. 1979;7(2):181-94 - PMID: 20218013 - DOI: 10.1007/BF01059737
Jain RK, Grantham FH, Gullino PM

Blood flow and heat transfer in Walker 256 mammary carcinoma.

J Natl Cancer Inst. 1979;62(4):927-33 - PMID: 285296
Jain RK, Maldarelli C, Ruckenstein E

Onset of microvilli in normal and neoplastic cells.

AIChE Symposium Series, Biorheology. 1978;74:120-124
Jain RK

Effect of inhomogeneities and finite boundaries on temperature distribution in a perfused medium with application to tumors

Trans. ASME J. Biomechanical Engineering. 1978;100:235-241
Weissbrod JM, Jain RK, Sirotnak FM

Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.

J Pharmacokinet Biopharm. 1978;6(6):487-503 - PMID: 731413 - DOI: 10.1007/BF01062105
Pierson RN, Price DC, Wang J, Jain RK

Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man.

Am J Physiol. 1978;235(3):F254-64 - PMID: 696835 - DOI: 10.1152/ajprenal.1978.235.3.F254
Jain RK, Wei J

Dynamics of drug transport in solid tumors: distributed parameter model

J Bioengineering. 1977;1:313-329
Jain RK, Denn MM

Short term regulation of BOD upsets in an estuary

Trans. ASME J. Dynamic Systems, Measurement and Control. 1976;98, Series G:30-31
Jain RK, Ruckenstein E

Stability of stagnant viscous films on a solid surface

J Colloid and Interface Science. 1976;54:108-116
Ruckenstein E, Jain RK

Spontaneous rupture of thin liquid films

J Chemical Society, Faraday Transactions II. 1974;70:132-147
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