Krishnan S, Lee S, Amoozgar Z, Subudhi S, Srinivasan Kumar A, Posada JM, Lindeman N, Lei P, Duquette M, Steinbuch S, Charabati M, Huang P, Andersson P, Datta M, Munn LL, Fukumura D, Jain RK

Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma.
Proc Natl Acad Sci U S A. 2025;122(38):e2414941122 - PMID: 40953263 - DOI: 10.1073/pnas.2414941122

Hadjigeorgiou AG, Munn LL, Stylianopoulos T, Jain RK

Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors.
bioRxiv. 2025;:ePub - PMID: 40894718 - PMCID: PMC12393523 - DOI: 10.1101/2025.08.20.671229

Munn LL, Jain RK

Challenges and opportunities for the next generation of computational tumor models.
PLoS Biol. 2025;23(7):e3003269 - PMID: 40700394 - PMCID: PMC12286354 - DOI: 10.1371/journal.pbio.3003269

Hale AT, Kalailingam P, Kundishora AJ, Reeves BC, Brastianos PK, Shih HA, Jain RK, Ning M, Stapleton CJ, Patel AB, Smith ER, Chapman PH, Rabinov JD, Kleinstiver BP, Musolino PL, Kahle KT

An opportune time for targeted brain arteriovenous malformation therapy.
J Neurosurg. 2025;:1-4 - PMID: 40644723 - DOI: 10.3171/2025.4.JNS25260

Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LH, Singh A, Fu J, Waterton SK, Cheng YC, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA

Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.
Immunity. 2025;58(7):1688-1705.e9 - PMID: 40592342 - PMCID: PMC12233199 - DOI: 10.1016/j.immuni.2025.06.005

Voutouri C, Munn LL, Stylianopoulos T, Jain RK

Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions.
PLoS Comput Biol. 2025;21(6):e1013163 - PMID: 40504865 - PMCID: PMC12201673 - DOI: 10.1371/journal.pcbi.1013163

Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK

Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
Clin Cancer Res. 2025;31(16):3571-3580 - PMID: 40495423 - PMCID: PMC12351280 - DOI: 10.1158/1078-0432.CCR-24-4159

Hadjigeorgiou AG, Harkos C, Mishra AK, Morad G, Johnson SB, Ajami NJ, Wargo JA, Munn LL, Stylianopoulos T, Jain RK

Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy.
Cancer Res. 2025;85(16):3139-3155 - PMID: 40439571 - PMCID: PMC12355177 - DOI: 10.1158/0008-5472.CAN-24-2232

Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR, Neurofibromatosis Clinical Trials Consortium

Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104.
J Neurooncol. 2025;173(3):751-757 - PMID: 40434540 - DOI: 10.1007/s11060-025-05020-1

Talele NP, Kumra H, Gomes-Santos IL, Ho WW, Andersson P, Siwicki M, Huang P, Duda DG, Pittet MJ, Fukumura D, Jain RK

IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity.
J Immunother Cancer. 2025;13(5):ePub - PMID: 40413022 - PMCID: PMC12104899 - DOI: 10.1136/jitc-2024-011404

Harkos C, Hadjigeorgiou AG, Voutouri C, Kumar AS, Stylianopoulos T, Jain RK

Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer.
Nat Rev Cancer. 2025;25(5):324-340 - PMID: 39972158 - DOI: 10.1038/s41568-025-00796-w

Ren J, Amoozgar Z, Uccello TP, Lei PJ, Zhao Y, Ho WW, Huang P, Kardian A, Mack SC, Duda DG, Xu L, Jain RK

Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma.
Proc Natl Acad Sci U S A. 2025;122(4):e2319474122 - PMID: 39841145 - PMCID: PMC11789170 - DOI: 10.1073/pnas.2319474122

Nia HT, Munn LL, Jain RK

Probing the physical hallmarks of cancer.
Nat Methods. 2025;22(9):1800-1818 - PMID: 39815103 - DOI: 10.1038/s41592-024-02564-4

Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK

Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
medRxiv. 2024;:ePub - PMID: 39677483 - PMCID: PMC11643154 - DOI: 10.1101/2024.11.28.24318104

Martin JD, Mpekris F, Chauhan VP, Martin MR, Walsh ME, Stuber MD, McDonald DM, Yuan F, Stylianopoulos T, Jain RK

Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport.
Drug Deliv. 2024;31(1):2430528 - PMID: 39568143 - PMCID: PMC11583359 - DOI: 10.1080/10717544.2024.2430528

Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Honeder SE, Kumar AS, Ramesh DL, Wu M, Hansen JA, Sivanand S, Riedmayr LM, Duquette M, Ali A, Henning N, Shevzov-Zebrun A, Gourgue F, Barbeau AM, Waite M, Kunchok T, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG

Site of breast cancer metastasis is independent of single nutrient levels.
bioRxiv. 2024;:ePub - PMID: 39484531 - PMCID: PMC11527034 - DOI: 10.1101/2024.10.24.616714

Linke JA, Munn LL, Jain RK

Compressive stresses in cancer: characterization and implications for tumour progression and treatment.
Nat Rev Cancer. 2024;24(11):768-791 - PMID: 39390249 - DOI: 10.1038/s41568-024-00745-z

Sun Y, Yin Z, Li S, Wu L, Zhang Y, Zhao Y, Gomes Dos Santos IL, Subudhi S, Lei P, Muzikansky A, Yuan Z, Rueda BR, Jain RK, Xu L

Losartan rewires the tumor-immune microenvironment and suppresses IGF-1 to overcome resistance to chemo-immunotherapy in ovarian cancer.
Br J Cancer. 2024;131(10):1683-1693 - PMID: 39369055 - PMCID: PMC11554678 - DOI: 10.1038/s41416-024-02863-9

Liu Z, Ma K, Jia Q, Yang Y, Fan P, Wang Y, Wang J, Sun J, Sun L, Shi H, Sun L, Zhu B, Xu W, Zhang L, Jain RK, Qin S, Huang Y

Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer
10.1136/bmjonc-2024-000473. 2024;3:e000473 - DOI: 10.1136/bmjonc-2024-000473

Banerjee S, Booth CM, Bruera E, Büchler MW, Drilon A, Fry TJ, Ghobrial IM, Gianni L, Jain RK, Kroemer G, Llovet JM, Long GV, Pantel K, Pritchard-Jones K, Scher HI, Tabernero J, Weichselbaum RR, Weller M, Wu YL

Two decades of advances in clinical oncology - lessons learned and future directions.
Nat Rev Clin Oncol. 2024;21(11):771-780 - PMID: 39354161 - PMCID: PMC12261309 - DOI: 10.1038/s41571-024-00945-4

Datta M, Via LE, Dartois V, Xu L, Barry CE, Jain RK

Leveraging insights from cancer to improve tuberculosis therapy.
Trends Mol Med. 2024;31(1):11-20 - PMID: 39142973 - PMCID: PMC11717643 - DOI: 10.1016/j.molmed.2024.07.011

Skelton WP, Masur J, Thomas J, Fallah P, Jain RK, Ravi P, Mantia C, McGregor BA, Nuzzo PV, Adib E, Zarif TE, Preston MA, Clinton TN, Li R, Steele GS, Kassouf W, Freeman D, Pond GR, Jain RK, Sonpavde GP

Impact of Angiotensin Converting Enzyme Inhibitors on Pathologic Complete Response With Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer.
Clin Genitourin Cancer. 2024;22(5):102143 - PMID: 39032202 - DOI: 10.1016/j.clgc.2024.102143

Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Munn LL, Jain RK, Stylianopoulos T

Dynamic heterogeneity in COVID-19: Insights from a mathematical model.
PLoS One. 2024;19(5):e0301780 - PMID: 38820409 - PMCID: PMC11142552 - DOI: 10.1371/journal.pone.0301780

Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell J, Vander Heiden MG

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Elife. 2024;13:ePub - PMID: 38787918 - PMCID: PMC11126308 - DOI: 10.7554/eLife.95652

Datta M, Via LE, Dartois V, Weiner DM, Zimmerman M, Kaya F, Walker AM, Fleegle JD, Raplee ID, McNinch C, Zarodniuk M, Kamoun WS, Yue C, Kumar AS, Subudhi S, Xu L, Barry CE, Jain RK

Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
Proc Natl Acad Sci U S A. 2024;121(14):e2321336121 - PMID: 38530888 - PMCID: PMC10998582 - DOI: 10.1073/pnas.2321336121

Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RK

In silico clinical studies for optimal COVID-19 vaccination schedules in patients with cancer.
Cell Rep Med. 2024;5(3):101436 - PMID: 38508146 - PMCID: PMC10982978 - DOI: 10.1016/j.xcrm.2024.101436

Gomes-Santos IL, Kumar AS, Hausmann F, Meyer MN, Shiferaw SZ, Amoozgar Z, Jain RK, Fukumura D

Exercise intensity governs tumor control in mice with breast cancer.
Front Immunol. 2024;15:1339232 - PMID: 38495879 - PMCID: PMC10940460 - DOI: 10.3389/fimmu.2024.1339232

Wolf B, Jain RK

Unraveling a hidden player in lymphovascular invasion in bladder cancer.
Cancer Cell. 2024;42(4):509-512 - PMID: 38458186 - DOI: 10.1016/j.ccell.2024.02.007

Datta M, Kennedy M, Siri S, Via LE, Baish JW, Xu L, Dartois V, Barry CE, Jain RK

Mathematical model of oxygen, nutrient, and drug transport in Tuberculosis Granulomas.
PLoS Comput Biol. 2024;20(2):e1011847 - PMID: 38335224 - PMCID: PMC10883541 - DOI: 10.1371/journal.pcbi.1011847

Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin SM, Matsui A, Hernandez A, Pu Z, Halvorsen S, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Sassi S, Bardeesy N, Ho WJ, Jain RK, Duda DG

Reprogramming the Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
Cancer Immunol Res. 2024;12(4):400-412 - PMID: 38260999 - PMCID: PMC10985468 - DOI: 10.1158/2326-6066.CIR-23-0486

Jain R, Krishnan S, Lee S, Amoozgar Z, Subudhi S, Kumar A, Posada J, Lindeman N, Lei P, Duquette M, Roberge S, Huang P, Andersson P, Datta M, Munn L, Fukumura D

Wnt inhibition alleviates resistance to immune checkpoint blockade in glioblastoma.
Res Sq. 2023;:ePub - PMID: 38234841 - PMCID: PMC10793505 - DOI: 10.21203/rs.3.rs-3707472/v1

Iorgulescu JB, Ruthen N, Ahn R, Panagioti E, Gokhale PC, Neagu M, Speranza MC, Eschle BK, Soroko KM, Piranlioglu R, Datta M, Krishnan S, Yates KB, Baker GJ, Jain RK, Suvà ML, Neuberg D, White FM, Chiocca EA, Freeman GJ, Sharpe AH, Wu CJ, Reardon DA

Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.
Front Immunol. 2023;14:1297932 - PMID: 38213329 - PMCID: PMC10782385 - DOI: 10.3389/fimmu.2023.1297932

Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell JC, Heiden MGV

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
bioRxiv. 2023;:ePub - PMID: 38187626 - PMCID: PMC10769456 - DOI: 10.1101/2023.12.24.573250

Harkos C, Stylianopoulos T, Jain RK

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes.
PLoS Comput Biol. 2023;19(12):e1011740 - PMID: 38113269 - PMCID: PMC10763956 - DOI: 10.1371/journal.pcbi.1011740

Wolf B, Weydandt L, Dornhöfer N, Hiller GGR, Höhn AK, Nel I, Jain RK, Horn LC, Aktas B

Desmoplasia in cervical cancer is associated with a more aggressive tumor phenotype.
Sci Rep. 2023;13(1):18946 - PMID: 37919378 - PMCID: PMC10622496 - DOI: 10.1038/s41598-023-46340-4

Nikmaneshi MR, Jain RK, Munn LL

Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization.
PLoS Comput Biol. 2023;19(6):e1011131 - PMID: 37289729 - PMCID: PMC10249820 - DOI: 10.1371/journal.pcbi.1011131

Plotkin SR, Allen J, Dhall G, Campian JL, Clapp DW, Fisher MJ, Jain RK, Tonsgard J, Ullrich NJ, Thomas C, Edwards LJ, Korf B, Packer R, Karajannis MA, Blakeley JO

Multicenter, prospective, phase 2 study of maintenance bevacizumab for children and adults with NF2-related schwannomatosis and progressive vestibular schwannoma.
Neuro Oncol. 2023;25(8):1498-1506 - PMID: 37010875 - PMCID: PMC10398799 - DOI: 10.1093/neuonc/noad066

Dong X, Ren J, Amoozgar Z, Lee S, Datta M, Roberge S, Duquette M, Fukumura D, Jain RK

Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice.
J Immunother Cancer. 2023;11(3):ePub - PMID: 36898734 - PMCID: PMC10008211 - DOI: 10.1136/jitc-2022-005583

Gupta N, Ochiai H, Hoshino Y, Klein S, Zustin J, Ramjiawan RR, Kitahara S, Maimon N, Bazou D, Chiang S, Li S, Schanne DH, Jain RK, Munn LL, Huang P, Kozin SV, Duda DG

Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models.
Cancers (Basel). 2023;15(4):ePub - PMID: 36831366 - PMCID: PMC9954510 - DOI: 10.3390/cancers15041021

Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin S, Matsui A, Pu Z, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Bardeesy N, Ho WJ, Jain RK, Duda DG

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
bioRxiv. 2023;:ePub - PMID: 36747853 - PMCID: PMC9901023 - DOI: 10.1101/2023.01.26.525680

Boucher Y, Posada JM, Subudhi S, Kumar AS, Rosario SR, Gu L, Kumra H, Mino-Kenudson M, Talele NP, Duda DG, Fukumura D, Wo JY, Clark JW, Ryan DP, Fernandez-Del Castillo C, Hong TS, Pittet MJ, Jain RK

Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer.
Clin Cancer Res. 2023;29(8):1605-1619 - PMID: 36749873 - PMCID: PMC10106451 - DOI: 10.1158/1078-0432.CCR-22-1630

Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, Dong X, Speranza MC, Neagu MR, Iorgulescu JB, Huang RY, Youssef G, Reardon DA, Sharpe AH, Freeman GJ, Suvà ML, Xu L, Jain RK

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models.
Proc Natl Acad Sci U S A. 2023;120(6):e2219199120 - PMID: 36724255 - PMCID: PMC9963691 - DOI: 10.1073/pnas.2219199120

Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RK

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2.
Proc Natl Acad Sci U S A. 2023;120(3):e2211132120 - PMID: 36623200 - PMCID: PMC9934028 - DOI: 10.1073/pnas.2211132120

Patel SA, Nilsson MB, Le X, Cascone T, Jain RK, Heymach JV

Molecular Mechanisms and Future Implications of VEGF/VEGFR in Cancer Therapy.
Clin Cancer Res. 2023;29(1):30-39 - PMID: 35969170 - PMCID: PMC10274152 - DOI: 10.1158/1078-0432.CCR-22-1366

Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - PMCID: PMC10290535 - DOI: 10.1038/s41588-022-01134-8

Saulnier Sholler G, Duda DG, Bergendahl G, Ebb D, Snuderl M, Laetsch TW, Michlitsch J, Hanson D, Isakoff MS, Bielamowicz K, Kraveka JM, Ferguson W, Carmeliet P, De Deene A, Gijsen L, Jain RK

A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.
Clin Cancer Res. 2022;28(18):3950-3957 - PMID: 35833850 - PMCID: PMC9481695 - DOI: 10.1158/1078-0432.CCR-22-1169

Ho WW, Pittet MJ, Fukumura D, Jain RK

The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy.
Cancer Cell. 2022;40(7):701-702 - PMID: 35714604 - PMCID: PMC10894502 - DOI: 10.1016/j.ccell.2022.05.016

Nuzzo PV, Adib E, Weise N, Curran C, Stewart T, Freeman D, Nassar AH, Abou Alaiwi S, Bakouny Z, McGregor BA, Choueiri TK, Jain RK, McKay RR, Sonpavde G

Impact of renin-angiotensin system inhibitors on outcomes in patients with metastatic renal cell carcinoma treated with immune-checkpoint inhibitors
Clin Genitourin Cancer. 2022;20(4):301-306 - PMID: 35614012 - PMCID: PMC10013974 - DOI: 10.1016/j.clgc.2022.04.012

Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK

Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.
Clin Cancer Res. 2022;28(14):3076-3090 - PMID: 35584239 - PMCID: PMC9355624 - DOI: 10.1158/1078-0432.CCR-22-0486

Agrud A, Subburaju S, Goel P, Ren J, Kumar AS, Caldarone BJ, Dai W, Chavez J, Fukumura D, Jain RK, Kloner RA, Vasudevan A

Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.
Sci Rep. 2022;12(1):4922 - PMID: 35318369 - PMCID: PMC8941104 - DOI: 10.1038/s41598-022-08806-9

Kikuchi H, Matsui A, Morita S, Amoozgar Z, Inoue K, Ruan Z, Staiculescu D, Wong JS, Huang P, Yau T, Jain RK, Duda DG

Increased CD8+ T-Cell Infiltration and Efficacy for Multikinase Inhibitors after PD-1 Blockade in Hepatocellular Carcinoma.
J Natl Cancer Inst. 2022;114(9):1301-1305 - PMID: 35288743 - PMCID: PMC9468280 - DOI: 10.1093/jnci/djac051

Mpekris F, Voutouri C, Panagi M, Baish JW, Jain RK, Stylianopoulos T

Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy
Journal of Controlled Release. 2022;345:190-199 - PMID: 35271911 - PMCID: PMC9168447 - DOI: 10.1016/j.jconrel.2022.03.008

Drobni ZD, Michielin O, Quinaglia T, Zlotoff DA, Zubiri L, Gilman HK, Supraja S, Merkely B, Muller V, Sullivan RJ, Reynolds KL, Pittet MJ, Jain RK, Neilan TG

Renin–angiotensin–aldosterone system inhibitors and survival in patients with hypertension treated with immune checkpoint inhibitors
European Journal of Cancer. 2022;163:108-118 - PMID: 35065368 - PMCID: PMC9618285 - DOI: 10.1016/j.ejca.2021.12.024

Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK

Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118

Blanc L, Ferraro GB, Tuck M, Prideaux B, Dartois V, Jain RK, Desbenoit N

Kendrick Mass Defect Variation to Decipher Isotopic Labeling in Brain Metastases Studied by Mass Spectrometry Imaging.
Anal Chem. 2021;93(49):16314-16319 - PMID: 34860501 - PMCID: PMC9841243 - DOI: 10.1021/acs.analchem.1c03916

Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, Jain RK, Clish CB, Vander Heiden MG, Golub TR

Publisher Correction: A metastasis map of human cancer cell lines.
Nature. 2021;599(7885):E7 - PMID: 34732899 - PMCID: PMC8599020 - DOI: 10.1038/s41586-021-04149-z

Wu L, Vasilijic S, Sun Y, Chen J, Landegger LD, Zhang Y, Zhou W, Ren J, Early S, Yin Z, Ho WW, Zhang N, Gao X, Lee GY, Datta M, Sagers JE, Brown A, Muzikansky A, Stemmer-Rachamimov A, Zhang L, Plotkin SR, Jain RK, Stankovic KM, Xu L

Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models.
Sci Transl Med. 2021;13(602):ePub - PMID: 34261799 - PMCID: PMC8409338 - DOI: 10.1126/scitranslmed.abd4816

Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Sci Immunol. 2021;6(61):ePub - PMID: 34215680 - PMCID: PMC8845079 - DOI: 10.1126/sciimmunol.abi7083

Boucher Y, Kumar AS, Posada JM, Gjini E, Pfaff K, Lipschitz M, Lako A, Duda DG, Rodig SJ, Hodi FS, Jain RK

Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients
NPJ Precis Oncol. 2021;5(1):62 - PMID: 34188163 - PMCID: PMC8242049 - DOI: 10.1038/s41698-021-00197-w

Subudhi S, Verma A, Patel AB, Hardin CC, Khandekar MJ, Lee H, McEvoy D, Stylianopoulos T, Munn LL, Dutta S, Jain RK

Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19.
NPJ Digit Med. 2021;4(1):87 - PMID: 34021235 - PMCID: PMC8140139 - DOI: 10.1038/s41746-021-00456-x

Jain RK, Skelton Iv WP, Pond GR, Naqvi M, Kim Y, Curran C, Freeman D, Nuzzo PV, Alaiwi SA, Nassar AH, Jain RK, Sonpavde G

Angiotensin Blockade Modulates the Activity of PD1/L1 Inhibitors in Metastatic Urothelial Carcinoma.
Clin Genitourin Cancer. 2021;19(6):540-546 - PMID: 34011489 - PMCID: PMC8526625 - DOI: 10.1016/j.clgc.2021.04.002

Amoozgar Z, Kloepper J, Ren J, Tay RE, Kazer SW, Kiner E, Krishnan S, Posada JM, Ghosh M, Mamessier E, Wong C, Ferraro GB, Batista A, Wang N, Badeaux M, Roberge S, Xu L, Huang P, Shalek AK, Fukumura D, Kim HJ, Jain RK

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Nat Commun. 2021;12(1):2582 - PMID: 33976133 - PMCID: PMC8113440 - DOI: 10.1038/s41467-021-22885-8

Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D

Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade.
Cancer Immunol Res. 2021;9(7):765-778 - PMID: 33839688 - PMCID: PMC8295193 - DOI: 10.1158/2326-6066.CIR-20-0499

Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen IX, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain, RK, Vander Heiden MG

Fatty acid synthesis is required for breast cancer brain metastasis
Nature Cancer. 2021;:ePub

Munn LL, Stylianopoulos T, Jain NK, Hardin CC, Khandekar MJ, Jain RK

Vascular normalization to improve treatment of COVID-19: Lessons from treatment of cancer.
Clin Cancer Res. 2021;27(10):2706-2711 - PMID: 33648989 - PMCID: PMC8127351 - DOI: 10.1158/1078-0432.CCR-20-4750

Li W, Li S, Chen IX, Liu Y, Ramjiawan RR, Leung CH, Gerweck LE, Fukumura D, Loeffler JS, Jain RK, Duda DG, Huang P

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.
Radiat Oncol. 2021;16(1):48 - PMID: 33663521 - PMCID: PMC7934382 - DOI: 10.1186/s13014-021-01775-9

Krishnan S, Amoozgar Z, Fukumura D, Jain RK

Implications of a granulocyte-high glioblastoma microenvironment in immune suppression and therapy resistance†.
J Pathol. 2021;254(2):105-108 - PMID: 33534142 - PMCID: PMC8262382 - DOI: 10.1002/path.5637

Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK

In silico dynamics of COVID-19 phenotypes for optimizing clinical management.
Proc Natl Acad Sci U S A. 2021;118(3):ePub - PMID: 33402434 - PMCID: PMC7826337 - DOI: 10.1073/pnas.2021642118

Nayak L, Molinaro AM, Peters KB, Clarke JL, Jordan JT, de Groot JF, Nghiemphu PL, Kaley TJ, Colman H, McCluskey C, Gaffey S, Smith T, Cote DJ, Severgnini M, Yearley JH, Zhao Q, Blumenschein WM, Duda DG, Muzikansky A, Jain RK, Wen PY, Reardon DA

Randomized phase II and biomarker study of pembrolizumab plus bevacizumab versus pembrolizumab alone for recurrent glioblastoma patients.
Clin Cancer Res. 2021;27(4):1048-1057 - PMID: 33199490 - PMCID: PMC8284901 - DOI: 10.1158/1078-0432.CCR-20-2500

Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT

Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients.
Neurooncol Adv. 2020;2(1):vdaa157 - PMID: 33392506 - PMCID: PMC7764510 - DOI: 10.1093/noajnl/vdaa157

Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, Jain RK, Clish CB, Vander Heiden MG, Golub TR

A metastasis map of human cancer cell lines.
Nature. 2020;588(7837):331-336 - PMID: 33299191 - PMCID: PMC8439149 - DOI: 10.1038/s41586-020-2969-2

Shigeta K, Matsui A, Kikuchi H, Klein S, Mamessier E, Chen IX, Aoki S, Kitahara S, Inoue K, Shigeta A, Hato T, Ramjiawan RR, Staiculescu D, Zopf D, Fiebig L, Hobbs GS, Quaas A, Dima S, Popescu I, Huang P, Munn LL, Cobbold M, Goyal L, Zhu AX, Jain RK, Duda DG

Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
J Immunother Cancer. 2020;8(2):ePub - PMID: 33234602 - PMCID: PMC7689089 - DOI: 10.1136/jitc-2020-001435

Saif M, Kwanten WJ, Carr JA, Chen IX, Posada JM, Srivastava A, Zhang J, Zheng Y, Pinter M, Chatterjee S, Softic S, Kahn CR, van Leyen K, Bruns OT, Jain RK, Bawendi MG

Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Nat Biomed Eng. 2020;4(12):1222 - PMID: 33235308 - PMCID: PMC8328147 - DOI: 10.1038/s41551-020-00664-y

Nia HT, Munn LL, Jain RK

Physical traits of cancer.
Science. 2020;370(6516):ePub - PMID: 33122355 - PMCID: PMC8274378 - DOI: 10.1126/science.aaz0868

Subburaju S, Kaye S, Choi YK, Baruah J, Datta D, Ren J, Kumar AS, Szabo G, Fukumura D, Jain RK, Elkhal A, Vasudevan A

NAD+-mediated rescue of prenatal forebrain angiogenesis restores postnatal behavior.
Sci Adv. 2020;6(41):ePub - PMID: 33036972 - PMCID: PMC7546698 - DOI: 10.1126/sciadv.abb9766

Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK

In silico dynamics of COVID-19 phenotypes for optimizing clinical management
Res Sq. 2020;:ePub - PMID: 32908974 - PMCID: PMC7480033 - DOI: 10.21203/rs.3.rs-71086/v1

Martin JD, Jain RK

Normalizing the tumor microenvironment for radiosensitization. In “Molecular Targeted Radiosensitizers: Opportunities and Challenges"
Cancer Drug Discovery and Development. 2020;Chapter 12:301-338

Martin JD, Duda DG, Jain RK

Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55α Complex the Answer?
Circ Res. 2020;127(6):724-726 - PMID: 32853096 - PMCID: PMC7462096 - DOI: 10.1161/CIRCRESAHA.120.317720

Nia HT, Datta M, Seano G, Zhang S, Ho WW, Roberge S, Huang P, Munn LL, Jain RK

In vivo compression and imaging in mouse brain to measure the effects of solid stress.
Nat Protoc. 2020;15(8):2321-2340 - PMID: 32681151 - PMCID: PMC11412114 - DOI: 10.1038/s41596-020-0328-2

Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massague J, Neman J, Sibson NR, Steeg PS, Thorsen F, Young LS, Varešlija D, Vultur A, Weis-Garcia F, Winkler F

Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines.
Cancer Res. 2020;80(20):4314-4323 - PMID: 32641416 - PMCID: PMC7572582 - DOI: 10.1158/0008-5472.CAN-20-0291

Saif M, Kwanten WJ, Carr JA, Chen IX, Posada JM, Srivastava A, Zhang J, Zheng Y, Pinter M, Chatterjee S, Softic S, Kahn CR, van Leyen K, Bruns OT, Jain RK, Bawendi MG

Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Nat Biomed Eng. 2020;4(8):801-813 - PMID: 32572196 - PMCID: PMC8310386 - DOI: 10.1038/s41551-020-0569-y

Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR, Davies MA, Vander Heiden MG, Hernando E, Mann M, Cantley LC, Pacold ME

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Cancer Discov. 2020;10(9):1352-1373 - PMID: 32571778 - PMCID: PMC7483776 - DOI: 10.1158/2159-8290.CD-19-1228

Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M

Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Nat Biotechnol. 2020;38(4):420-425 - PMID: 32042168 - PMCID: PMC7456461 - DOI: 10.1038/s41587-019-0404-8

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z

A framework for advancing our understanding of cancer-associated fibroblasts.
Nat Rev Cancer. 2020;20(3):174-186 - PMID: 31980749 - PMCID: PMC7046529 - DOI: 10.1038/s41568-019-0238-1

Flores-Toro JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Singh R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Proc Natl Acad Sci U S A. 2020;117(2):1129-1138 - PMID: 31879345 - PMCID: PMC6969504 - DOI: 10.1073/pnas.1910856117

Arvanitis CD, Ferraro GB, Jain RK

The blood-brain barrier and blood-tumour barrier in brain tumours and metastases.
Nat Rev Cancer. 2020;20(1):26-41 - PMID: 31601988 - PMCID: PMC8246629 - DOI: 10.1038/s41568-019-0205-x

Gerstner E, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T

Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma.
Clin Cancer Res. 2020;26(1):206-212 - PMID: 31558474 - PMCID: PMC7139851 - DOI: 10.1158/1078-0432.CCR-19-1739

Rowlands CJ, Bruns OT, Franke D, Fukamura D, Jain RK, Bawendi MG, So PTC

Increasing the penetration depth of temporal focusing multiphoton microscopy for neurobiological applications.
J Phys D Appl Phys. 2019;52(26):264001 - PMID: 33191950 - PMCID: PMC7655118 - DOI: 10.1088/1361-6463/ab16b4

Fernández-Martos C, Pericay C, Losa F, García-Carbonero R, Layos L, Rodríguez-Salas N, Martin-Richard M, Alonso-Orduña V, Vera R, Gallego J, Capdevila J, Salud A, Nogué M, Maurel J, Guash I, Montagut C, Lopez C, Macias I, Jain RK, Garcia-Albeniz X

Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma: The GEMCAD 1402 Randomized Clinical Trial.
JAMA Oncol. 2019;5(11):1566-1573 - PMID: 31465088 - PMCID: PMC6865228 - DOI: 10.1001/jamaoncol.2019.2294

Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER

Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
Sci Rep. 2019;9(1):8721 - PMID: 31197238 - PMCID: PMC6565804 - DOI: 10.1038/s41598-019-44365-2

Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS

Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.
JAMA Oncol. 2019;5(7):1020-1027 - PMID: 31145418 - PMCID: PMC6547247 - DOI: 10.1001/jamaoncol.2019.0892

Datta M, Coussens LM, Nishikawa H, Hodi FS, Jain RK

Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.
Am Soc Clin Oncol Educ Book. 2019;39:165-174 - PMID: 31099649 - PMCID: PMC6596289 - DOI: 10.1200/EDBK_237987

Amoozgar Z, Jain RK, Duda DG

Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?
Cancer Res. 2019;79(9):2104-2106 - PMID: 31043429 - PMCID: PMC6601607 - DOI: 10.1158/0008-5472.CAN-19-0749

Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Proc Natl Acad Sci U S A. 2019;116(22):10674-10680 - PMID: 31040208 - PMCID: PMC6561160 - DOI: 10.1073/pnas.1819889116

Cleary JM, Horick NK, McCleary NJ, Abrams TA, Yurgelun MB, Azzoli CG, Rubinson DA, Brooks GA, Chan JA, Blaszkowsky LS, Clark JW, Goyal L, Meyerhardt JA, Ng K, Schrag D, Savarese DMF, Graham C, Fitzpatrick B, Gibb KA, Boucher Y, Duda DG, Jain RK, Fuchs CS, Enzinger PC

FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial.
Cancer. 2019;125(13):2213-2221 - PMID: 30913304 - PMCID: PMC6763367 - DOI: 10.1002/cncr.32029

Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Nat Biomed Eng. 2019;3(3):230-245 - PMID: 30948807 - PMCID: PMC6452896 - DOI: 10.1038/s41551-018-0334-7

Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N

Retraction Note: A homing system targets therapeutic T cells to brain cancer.
Nature. 2019;567(7746):132 - PMID: 30787441 - PMCID: PMC6497143 - DOI: 10.1038/s41586-019-0967-z

Martin JD, Seano G, Jain RK

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.
Annu Rev Physiol. 2019;81:505-534 - PMID: 30742782 - PMCID: PMC6571025 - DOI: 10.1146/annurev-physiol-020518-114700

Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RK

Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.
Proc Natl Acad Sci U S A. 2019;116(7):2662-2671 - PMID: 30700544 - PMCID: PMC6377457 - DOI: 10.1073/pnas.1818322116

Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.
Proc Natl Acad Sci U S A. 2019;116(10):4558-4566 - PMID: 30700545 - PMCID: PMC6410779 - DOI: 10.1073/pnas.1815515116

Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L

A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.
Nat Protoc. 2019;14(2):541-555 - PMID: 30617350 - PMCID: PMC6571021 - DOI: 10.1038/s41596-018-0105-7

Nia HT, Munn LL, Jain RK

Mapping physical tumor microenvironment and drug delivery.
Clin Cancer Res. 2019;25(7):2024-2026 - PMID: 30630829 - PMCID: PMC6445672 - DOI: 10.1158/1078-0432.CCR-18-3724

Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, Yeku O, Del Carmen MG, Spriggs DR, Jain RK, Xu L

Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2019;116(6):2210-2219 - PMID: 30659155 - PMCID: PMC6369817 - DOI: 10.1073/pnas.1818357116

Askoxylakis V, Ferraro GB, Badeaux M, Kodack DP, Kirst I, Shankaraiah RC, Wong CSF, Duda DG, Fukumura D, Jain RK

Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.
NPJ Breast Cancer. 2019;5:4 - PMID: 30675514 - PMCID: PMC6333771 - DOI: 10.1038/s41523-018-0100-8

Ina Ly K, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER

Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
Sci Rep. 2018;8(1):17062 - PMID: 30459364 - PMCID: PMC6244161 - DOI: 10.1038/s41598-018-34820-x

Mitchell MJ, Jain RK, Langer R

Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.
Nat Rev Cancer. 2018;18(11):720 - PMID: 30337715 - PMCID: PMC6357229 - DOI: 10.1038/s41568-018-0072-x

Khandekar MJ, Jain R

Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study.
Transl Cancer Res. 2018;7(Suppl 1):S16-S20 - PMID: 30175050 - PMCID: PMC6117158 - DOI: 10.21037/tcr.2017.12.17

Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N

A homing system targets therapeutic T cells to brain cancer.
Nature. 2018;561(7723):331-337 - PMID: 30185905 - PMCID: PMC6402337 - DOI: 10.1038/s41586-018-0499-y

Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK

Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Proc Natl Acad Sci U S A. 2018;115(37):E8717-E8726 - PMID: 30150398 - PMCID: PMC6140479 - DOI: 10.1073/pnas.1807105115

Lee EQ, Duda DG, Muzikansky A, Gerstner E, Kuhn JG, Reardon DA, Nayak L, Norden AD, Doherty L, LaFrankie D, Stefanik J, Vardam T, Smith KH, McCluskey C, Gaffey SC, Batchelor T, Jain RK, Wen PY

Phase I and biomarker study of plerixafor and bevacizumab in recurrent high-grade glioma.
Clin Cancer Res. 2018;24(19):4643-4649 - PMID: 29941486 - DOI: 10.1158/1078-0432.CCR-18-1025

Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, Jain RK, Zhu AX, Duda DG

Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Int J Radiat Oncol Biol Phys. 2018;101(5):1222-1225 - PMID: 29859792 - PMCID: PMC6050125 - DOI: 10.1016/j.ijrobp.2018.04.026

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW

Consensus guidelines for the use and interpretation of angiogenesis assays.
Angiogenesis. 2018;21(3):425-532 - PMID: 29766399 - PMCID: PMC6237663 - DOI: 10.1007/s10456-018-9613-x

Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK

Quantifying solid stress and elastic energy from excised or in situ tumors.
Nat Protoc. 2018;13(5):1091-1105 - PMID: 29674756 - PMCID: PMC6546092 - DOI: 10.1038/nprot.2018.020

Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Cancer Cell. 2018;33(5):874-889.e7 - PMID: 29681511 - PMCID: PMC6211172 - DOI: 10.1016/j.ccell.2018.03.020

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF

Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nat Med. 2018;24(5):541-550 - PMID: 29686425 - PMCID: PMC5998822 - DOI: 10.1038/s41591-018-0014-x

Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT

Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green.
Proc Natl Acad Sci U S A. 2018;115(17):4465-4470 - PMID: 29626132 - PMCID: PMC5924901 - DOI: 10.1073/pnas.1718917115

Stylianopoulos T, Munn LL, Jain RK

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.
Trends Cancer. 2018;4(4):292-319 - PMID: 29606314 - PMCID: PMC5930008 - DOI: 10.1016/j.trecan.2018.02.005

Stylianopoulos T, Munn LL, Jain RK

Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.
Trends Cancer. 2018;4(4):258-259 - PMID: 29606306 - PMCID: PMC6161778 - DOI: 10.1016/j.trecan.2018.02.010

Jain RK, Batista A

A Physical View of Cancer.
Trends Cancer. 2018;4(4):257 - PMID: 29606305 - PMCID: PMC6296379 - DOI: 10.1016/j.trecan.2018.03.001

Pinter M, Kwanten WJ, Jain RK

Renin-angiotensin system inhibitors to mitigate cancer treatment-related adverse events.
Clin Cancer Res. 2018;24(16):3803-3812 - PMID: 29610292 - PMCID: PMC6095804 - DOI: 10.1158/1078-0432.CCR-18-0236

Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Sci Transl Med. 2018;10(432):ePub - PMID: 29540614 - PMCID: PMC5936748 - DOI: 10.1126/scitranslmed.aag0945

Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Nat Rev Clin Oncol. 2018;15(5):325-340 - PMID: 29508855 - PMCID: PMC5921900 - DOI: 10.1038/nrclinonc.2018.29

Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.
J Immunol. 2018;200(8):3000-3007 - PMID: 29500245 - PMCID: PMC5893394 - DOI: 10.4049/jimmunol.1700407

Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L

Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.
Proc Natl Acad Sci U S A. 2018;115(9):E2077-E2084 - PMID: 29440379 - PMCID: PMC5834719 - DOI: 10.1073/pnas.1719966115

Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK

Origins of lymphatic and distant metastases in human colorectal cancer.
Science. 2017;357(6346):55-60 - PMID: 28684519 - PMCID: PMC5536201 - DOI: 10.1126/science.aai8515

Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK

Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma.
Clin Cancer Res. 2017;23(19):5959-5969 - PMID: 28600474 - PMCID: PMC5856249 - DOI: 10.1158/1078-0432.CCR-17-0256

Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev I

Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.
Oncotarget. 2017;8(65):108292-108302 - PMID: 29312532 - PMCID: PMC5752445 - DOI: 10.18632/oncotarget.22660

Andronesi OC, Esmaeili M, Borra RJH, Emblem K, Gerstner ER, Pinho MC, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Ivy SP, Wen PY, Duda DG, Jain R, Rosen BR, Sorensen GA, Batchelor TT

Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival.
NPJ Precis Oncol. 2017;1:ePub - PMID: 29202103 - PMCID: PMC5708878 - DOI: 10.1038/s41698-017-0020-3

Pinter M, Weinmann A, Wörns MA, Hucke F, Bota S, Marquardt JU, Duda DG, Jain RK, Galle PR, Trauner M, Peck-Radosavljevic M, Sieghart W

Use of inhibitors of the renin-angiotensin system is associated with longer survival in patients with hepatocellular carcinoma.
United European Gastroenterol J. 2017;5(7):987-996 - PMID: 29163965 - PMCID: PMC5676550 - DOI: 10.1177/2050640617695698

Rowlands CJ, Park D, Bruns OT, Piatkevich KD, Fukumura D, Jain RK, Bawendi MG, Boyden ES, So PT

Wide-field three-photon excitation in biological samples.
Light Sci Appl. 2017;6:e16255 - PMID: 29152380 - PMCID: PMC5687557 - DOI: 10.1038/lsa.2016.255

Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Wei H, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MG

Next-generation in vivo optical imaging with short-wave infrared quantum dots.
Nat Biomed Eng. 2017;1:ePub - PMID: 29119058 - PMCID: PMC5673283 - DOI: 10.1038/s41551-017-0056

Mitchell MJ, Jain RK, Langer R

Engineering and physical sciences in oncology: challenges and opportunities.
Nat Rev Cancer. 2017;17(11):659-675 - PMID: 29026204 - PMCID: PMC5683724 - DOI: 10.1038/nrc.2017.83

Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, Amoozgar Z, Seano G, Ferraro GB, Chatterjee S, Xu L, Fukumura D, Duda DG, Jain RK

A cerebellar window for intravital imaging of normal and disease states in mice.
Nat Protoc. 2017;12(11):2251-2262 - PMID: 28981123 - PMCID: PMC5918134 - DOI: 10.1038/nprot.2017.101

Pinter M, Jain RK

Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy.
Sci Transl Med. 2017;9(410):ePub - PMID: 28978752 - PMCID: PMC5928511 - DOI: 10.1126/scitranslmed.aan5616

Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D

Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Proc Natl Acad Sci U S A. 2017;114(39):10455-10460 - PMID: 28900008 - PMCID: PMC5625928 - DOI: 10.1073/pnas.1710754114

Wang X, Freire Valls A, Schermann G, Shen Y, Moya IM, Castro L, Urban S, Solecki GM, Winkler F, Riedemann L, Jain RK, Mazzone M, Schmidt T, Fischer T, Halder G, Ruiz de Almodóvar C

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.
Dev Cell. 2017;42(5):462-478.e7 - PMID: 28867486 - DOI: 10.1016/j.devcel.2017.08.002

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
J Clin Invest. 2017;127(8):3039-3051 - PMID: 28691930 - PMCID: PMC5531423 - DOI: 10.1172/JCI93182

Askoxylakis V, Arvanitis CD, Wong CSF, Ferraro GB, Jain RK

Emerging Strategies for Delivering Antiangiogenic Therapies to Primary and Metastatic Brain Tumors.
Adv Drug Deliv Rev. 2017;119:159-174 - PMID: 28648712 - PMCID: PMC12051390 - DOI: 10.1016/j.addr.2017.06.011

Askoxylakis V, Kodack DP, Ferraro GB, Jain RK

Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?
Breast Cancer Res Treat. 2017;165(2):467-468 - PMID: 28643019 - DOI: 10.1007/s10549-017-4351-0

Levin VA, Chan J, Datta M, Yee JL, Jain RK

Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.
J Neurooncol. 2017;134(2):325-330 - PMID: 28631191 - DOI: 10.1007/s11060-017-2528-3

Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, Wong CSF, Kloepper J, Das R, Tam A, Tanboon J, Duda DG, Miller CR, Siegel MB, Anders CK, Sanders M, Estrada MV, Schlegel R, Arteaga CL, Brachtel E, Huang A, Fukumura D, Engelman JA, Jain RK

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
Sci Transl Med. 2017;9(391):ePub - PMID: 28539475 - PMCID: PMC5917603 - DOI: 10.1126/scitranslmed.aal4682

David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram Shankaraiah, Z. Alexander Cao, Rakesh R. Ramjiawan, Divya Bezwada, Bhushankumar Patel, Yongchul Song, Carlotta Costa, Kamila Naxerova, Christina S. F. Wong, Jonas Kloepper,
Rita Das, Angela Tam, Jantima Tanboon, Dan G. Duda, C. Ryan Miller, Marni B. Siegel, Carey K. Anders, Melinda Sanders, Monica V. Estrada, Robert Schlegel, Carlos L. Arteaga, Elena Brachtel, Alan Huang, Dai Fukumura, Jeffrey A. Engelman, Rakesh K. Jain

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Science Translational Medicine. 2017;9(391):eaal4682

De Palma M, Jain RK

CD4(+) T Cell Activation and Vascular Normalization: Two Sides of the Same Coin?
Immunity. 2017;46(5):773-775 - PMID: 28514684 - DOI: 10.1016/j.immuni.2017.04.015

Chen Y, Liu YC, Sung YC, Ramjiawan RR, Lin TT, Chang CC, Jeng KS, Chang CF, Liu CH, Gao DY, Hsu FF, Duyverman AM, Kitahara S, Huang P, Dima S, Popescu I, Flaherty KT, Zhu AX, Bardeesy N, Jain RK, Benes CH, Duda DG

Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.
Sci Rep. 2017;7:44123 - PMID: 28276530 - PMCID: PMC5343435 - DOI: 10.1038/srep44123

Goyal L, Zheng H, Yurgelun MB, Abrams TA, Allen JN, Cleary JM, Knowles M, Regan E, Reardon A, Khachatryan A, Jain RK, Nardi V, Borger DR, Duda DG, Zhu AX

A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma.
Cancer. 2017;123(11):1979-1988 - PMID: 28192597 - PMCID: PMC5444988 - DOI: 10.1002/cncr.30571

Mpekris F, Baish JW, Stylianopoulos T, Jain RK

Role of vascular normalization in benefit from metronomic chemotherapy.
Proc Natl Acad Sci U S A. 2017;114(8):1994-1999 - PMID: 28174262 - PMCID: PMC5338413 - DOI: 10.1073/pnas.1700340114

Wang N, Jain RK, Batchelor TT

New Directions in Anti-Angiogenic Therapy for Glioblastoma.
Neurotherapeutics. 2017;14(2):321-332 - PMID: 28083806 - PMCID: PMC5398985 - DOI: 10.1007/s13311-016-0510-y

Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I

Stress granule-associated protein G3BP2 regulates breast tumor initiation.
Proc Natl Acad Sci U S A. 2017;114(5):1033-1038 - PMID: 28096337 - PMCID: PMC5293063 - DOI: 10.1073/pnas.1525387114

Ng MR, Jain RK

Hypoxia-induced DNA hypermethylation: another reason to normalize tumor vessels
Translational Cancer Research. 2016;5:7

Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK

Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy.
Cancer Discov. 2016;6(8):852-69 - PMID: 27246539 - PMCID: PMC4972679 - DOI: 10.1158/2159-8290.CD-15-1177

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK

Solid stress and elastic energy as measures of tumour mechanopathology.
Nat Biomed Eng. 2016;1:ePub - PMID: 28966873 - PMCID: PMC5621647 - DOI: 10.1038/s41551-016-0004

Munn LL, Jain RK

The forces of cancer
In: The Scientist. 2016;30(4):ePub

Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK

Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds.
Sci Rep. 2016;6:37949 - PMID: 27905494 - PMCID: PMC5131361 - DOI: 10.1038/srep37949

Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK

Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27908927 - PMCID: PMC5131752 - DOI: 10.1101/cshperspect.a031195

Emblem KE, Jain RK

Improving treatment of liver metastases by targeting nonangiogenic mechanisms.
Nat Med. 2016;22(11):1209-1210 - PMID: 27824818 - DOI: 10.1038/nm.4228

Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR

Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma.
Transl Oncol. 2016;9(5):431-437 - PMID: 27751347 - PMCID: PMC5067928 - DOI: 10.1016/j.tranon.2016.07.004

Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
Sci Transl Med. 2016;8(360):360ra135 - PMID: 27733559 - PMCID: PMC5457741 - DOI: 10.1126/scitranslmed.aaf5219

Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK

Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27663981 - PMCID: PMC5131751 - DOI: 10.1101/cshperspect.a027094

Ferraro GB, Kodack DP, Askoxylakis V, Jain RK

Closing the gap between astrocytes and brain metastasis progression.
Cell Res. 2016;26(9):973-4 - PMID: 27514701 - PMCID: PMC5034114 - DOI: 10.1038/cr.2016.96

Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Proc Natl Acad Sci U S A. 2016;113(16):4470-5 - PMID: 27044097 - PMCID: PMC4843449 - DOI: 10.1073/pnas.1525349113

Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Proc Natl Acad Sci U S A. 2016;113(16):4476-81 - PMID: 27044098 - PMCID: PMC4843473 - DOI: 10.1073/pnas.1525360113

Blakeley JO, Ye X, Duda DG, Halpin CF, Bergner AL, Muzikansky A, Merker VL, Gerstner ER, Fayad LM, Ahlawat S, Jacobs MA, Jain RK, Zalewski C, Dombi E, Widemann BC, Plotkin SR

Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas.
J Clin Oncol. 2016;34(14):1669-75 - PMID: 26976425 - PMCID: PMC4872317 - DOI: 10.1200/JCO.2015.64.3817

Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam T, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop I, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D

PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity.
Clin Cancer Res. 2016;22(12):2993-3004 - PMID: 26861455 - PMCID: PMC4911258 - DOI: 10.1158/1078-0432.CCR-15-1839

Fukumura D, Incio J, Shankaraiah R, Jain RK

Obesity and cancer: an angiogenic and inflammatory link.
Microcirculation. 2016;23(3):191-206 - PMID: 26808917 - PMCID: PMC4818678 - DOI: 10.1111/micc.12270

Park KR, Monsky WL, Lee CG, Song CH, Kim DH, Jain RK, Fukumura D

Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability.
Radiat Res. 2016;185(2):182-189 - PMID: 26771172 - PMCID: PMC4761451 - DOI: 10.1667/RR14190.1

Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.
Sci Transl Med. 2016;8(320):320ra4 - PMID: 26738797 - PMCID: PMC4794335 - DOI: 10.1126/scitranslmed.aad0293

Lee EQ, Kaley TJ, Duda DG, Schiff D, Lassman AB, Wong ET, Mikkelsen T, Purow BW, Muzikansky A, Ancukiewicz M, Huse JT, Ramkissoon S, Drappatz J, Norden AD, Beroukhim R, Weiss SE, Alexander BM, McCluskey CS, Gerard M, Smith KH, Jain RK, Batchelor TT, Ligon KL, Wen PY

A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients.
Clin Cancer Res. 2015;21(16):3610-8 - PMID: 25910950 - PMCID: PMC4790106 - DOI: 10.1158/1078-0432.CCR-14-3220

Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, Duda DG

CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Hepatology. 2015;61(5):1591-602 - PMID: 25529917 - PMCID: PMC4406806 - DOI: 10.1002/hep.27665

Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
PLoS One. 2015;10(12):e0141392 - PMID: 26641266 - PMCID: PMC4671732 - DOI: 10.1371/journal.pone.0141392

Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, Winer EP, Krop IE, Jain RK

Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
Proc Natl Acad Sci U S A. 2015;112(46):14325-14330 - PMID: 26578779 - PMCID: PMC4655544 - DOI: 10.1073/pnas.1518808112

Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L

Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model.
Proc Natl Acad Sci U S A. 2015;112(47):14676-81 - PMID: 26554010 - PMCID: PMC4664377 - DOI: 10.1073/pnas.1512570112

Samuel R, Duda DG, Fukumura D, Jain RK

Vascular diseases await translation of blood vessels engineered from stem cells.
Sci Transl Med. 2015;7(309):309rv6 - PMID: 26468328 - PMCID: PMC4799660 - DOI: 10.1126/scitranslmed.aaa1805

Stylianopoulos T, Jain RK

Design considerations for nanotherapeutics in oncology.
Nanomedicine. 2015;11(8):1893-907 - PMID: 26282377 - PMCID: PMC4628869 - DOI: 10.1016/j.nano.2015.07.015

Jain RK, Fukumura D, Duda DG

From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey.
Cancer J. 2015;21(4):235-236 - PMID: 26222072 - PMCID: PMC4791947 - DOI: 10.1097/PPO.0000000000000136

Batista A, Riedemann L, Vardam T, Jain RK

Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment.
Cancer J. 2015;21(4):307-13 - PMID: 26222083 - DOI: 10.1097/PPO.0000000000000125

Reiberger T, Chen Y, Ramjiawan RR, Hato T, Fan C, Samuel R, Roberge S, Huang P, Lauwers GY, Zhu AX, Bardeesy N, Jain RK, Duda DG

An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Nat Protoc. 2015;10(8):1264-1274 - PMID: 26203823 - PMCID: PMC4800979 - DOI: 10.1038/nprot.2015.080

Lemon CM, Karnas E, Han X, Bruns OT, Kempa TJ, Fukumura D, Bawendi MG, Jain RK, Duda DG, Nocera DG

Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.
J Am Chem Soc. 2015;137(31):9832-42 - PMID: 26149349 - PMCID: PMC4750386 - DOI: 10.1021/jacs.5b04765

Zou HY, Friboulet L, Kodack DP, Engstrom LD, Li Q, West M, Tang RW, Wang H, Tsaparikos K, Wang J, Timofeevski S, Katayama R, Dinh DM, Lam H, Lam JL, Yamazaki S, Hu W, Patel B, Bezwada D, Frias RL, Lifshits E, Mahmood S, Gainor JF, Affolter T, Lappin PB, Gukasyan H, Lee N, Deng S, Jain RK, Johnson TW, Shaw AT, Fantin VR, Smeal T

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Cancer Cell. 2015;28(1):70-81 - PMID: 26144315 - PMCID: PMC4504786 - DOI: 10.1016/j.ccell.2015.05.010

Duda DG, Heist RS, Sahani DV, Stylianopoulos T, Engelman JA, Jain RK

Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.
Proc Natl Acad Sci U S A. 2015;112(27):E3454 - PMID: 26080434 - PMCID: PMC4500270 - DOI: 10.1073/pnas.1507225112

Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP

Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.
J Natl Cancer Inst. 2015;107(9):ePub - PMID: 26063793 - PMCID: PMC4651102 - DOI: 10.1093/jnci/djv155

Jain RK, Fukumura D, Duda DG

Lessons From 30 Years of Teaching About the Microenvironment of Tumors.
Cancer J. 2015;21(3):137 - PMID: 26049690 - PMCID: PMC4792516 - DOI: 10.1097/PPO.0000000000000119

Gerstner ER, Ye X, Duda DG, Levine MA, Mikkelsen T, Kaley TJ, Olson JJ, Nabors BL, Ahluwalia MS, Wen PY, Jain RK, Batchelor TT, Grossman S

A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma.
Neuro Oncol. 2015;17(10):1386-92 - PMID: 26008604 - PMCID: PMC4578584 - DOI: 10.1093/neuonc/nov085

Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK

Lessons From Anti-Vascular Endothelial Growth Factor and Anti-Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma.
J Clin Oncol. 2015;33(10):1197-213 - PMID: 25713439 - PMCID: PMC4517055 - DOI: 10.1200/JCO.2014.55.9575

Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.
J Natl Cancer Inst. 2015;107(4):ePub - PMID: 25710962 - PMCID: PMC4402365 - DOI: 10.1093/jnci/djv017

Kodack DP, Askoxylakis V, Ferraro GB, Fukumura D, Jain RK

Emerging Strategies for Treating Brain Metastases from Breast Cancer.
Cancer Cell. 2015;27(2):163-175 - PMID: 25670078 - PMCID: PMC4325273 - DOI: 10.1016/j.ccell.2015.01.001

Stylianopoulos T, Economides EA, Baish JW, Fukumura D, Jain RK

Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors.
Ann Biomed Eng. 2015;43(9):2291-300 - PMID: 25670323 - PMCID: PMC4519365 - DOI: 10.1007/s10439-015-1276-9

Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery.
Proc Natl Acad Sci U S A. 2015;112(6):1827-32 - PMID: 25624495 - PMCID: PMC4330784 - DOI: 10.1073/pnas.1424563112

Han HS, Niemeyer E, Huang Y, Kamoun WS, Martin JD, Bhaumik J, Chen Y, Roberge S, Cui J, Martin MR, Fukumura D, Jain RK, Bawendi MG, Duda DG

Quantum dot/antibody conjugates for in vivo cytometric imaging in mice.
Proc Natl Acad Sci U S A. 2015;112(5):1350-5 - PMID: 25605916 - PMCID: PMC4321304 - DOI: 10.1073/pnas.1421632111

Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.
Proc Natl Acad Sci U S A. 2015;112(5):1547-52 - PMID: 25605928 - PMCID: PMC4321320 - DOI: 10.1073/pnas.1424024112

Naxerova K, Jain RK

Using tumour phylogenetics to identify the roots of metastasis in humans.
Nat Rev Clin Oncol. 2015;12(5):258-72 - PMID: 25601447 - DOI: 10.1038/nrclinonc.2014.238

Jain RK, Netti PA

Letter to the editor regarding recent article by Wu et Al. [journal of theoretical biology, 355, 194-207 (2014)].
J Theor Biol. 2014;363:453 - PMID: 25219622 - DOI: 10.1016/j.jtbi.2014.08.052

Babykutty S, Heishi T, Tsukada K, Huang Y, Kozin S, Conner D, Lin Q, Kucherlapati R, Jain RK, Fukumura D

Restoring perivascular nitric oxide gradients normalizes breast cancer vasculature.
Nitric Oxide. 2014;42C:115 - PMID: 25519573

Jain RK

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia.
Cancer Cell. 2014;26(5):605-622 - PMID: 25517747 - PMCID: PMC4269830 - DOI: 10.1016/j.ccell.2014.10.006

Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R

Correlative intravital imaging of cGMP signals and vasodilation in mice.
Front Physiol. 2014;5:394 - PMID: 25352809 - PMCID: PMC4196583 - DOI: 10.3389/fphys.2014.00394

Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG

Magneto-fluorescent core-shell supernanoparticles.
Nat Commun. 2014;5:5093 - PMID: 25298155 - PMCID: PMC4264679 - DOI: 10.1038/ncomms6093

Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.
Nat Cell Biol. 2014;16(10):931-941 - PMID: 25218639 - PMCID: PMC4564017 - DOI: 10.1038/ncb3036

Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen B, Loeffler JS, Wen PY, Sorensen AG, Jain RK

Increased perfusion due to vascular normalization improves oxygenation and survival in glioblastoma patients treated with cediranib with or without chemoradiation.
Neuro Oncol. 2014;16 Suppl 3:iii12 - PMID: 25165209 - PMCID: PMC4144509

Emblem KE, Farrar CT, Gerstner ER, Batchelor TT, Borra RJ, Rosen BR, Sorensen AG, Jain RK

Vessel calibre-a potential MRI biomarker of tumour response in clinical trials.
Nat Rev Clin Oncol. 2014;11(10):566-584 - PMID: 25113840 - PMCID: PMC4445139 - DOI: 10.1038/nrclinonc.2014.126

Duda DG, Ancukiewicz M, Isakoff SJ, Krop IE, Jain RK

Seeds and soil: unraveling the role of local tumor stroma in distant metastasis.
J Natl Cancer Inst. 2014;106(8):ePub - PMID: 25082335 - DOI: 10.1093/jnci/dju187

Jain RK, Fukumura D, Duda DG

Modes of neovascularization in tumors and clinical translation of antiangiogenic therapy.
In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (Editor: LM McManus & RN Mitchell). Elsevier Press, Oxford. 2014;:(in press)

Chung E, Yeon C, Jain RK, Fukumura D

Uncovering tumor biology by intravital microscopy.
In: Comprehensive Biomedical Physics, Volume: IV 'Optical molecular imaging' (Editor: Kiessling Alves & Anders Brahme). Elsevier Press. 2014;:(in press)

Jain RK, Duda DG

Molecular Pathophysiology of Tumors.
In: Principles and Practice of Radiation Oncology, 6th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2014;Chapter 4:(in press)

Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure.
Cancer Cell. 2014;26(1):14-15 - PMID: 25026209 - PMCID: PMC4381566 - DOI: 10.1016/j.ccr.2014.06.003

Jain RK, Martin JD, Stylianopoulos T

The role of mechanical forces in tumor growth and therapy.
Annu Rev Biomed Eng. 2014;16:321-46 - PMID: 25014786 - PMCID: PMC4109025 - DOI: 10.1146/annurev-bioeng-071813-105259

Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG

A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma.
Int J Radiat Oncol Biol Phys. 2014;89(4):830-8 - PMID: 24867540 - PMCID: PMC4791180 - DOI: 10.1016/j.ijrobp.2014.03.034

Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK

Hypermutable DNA chronicles the evolution of human colon cancer.
Proc Natl Acad Sci U S A. 2014;111(18):E1889-98 - PMID: 24753616 - PMCID: PMC4020055 - DOI: 10.1073/pnas.1400179111

Jain RK

An indirect way to tame cancer
Sci Am. 2014;310(2):46-53 - PMID: 24640331 - DOI: 10.1038/scientificamerican0214-46

Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK

Benefits of Vascular Normalization Are Dose and Time Dependent--Letter.
Cancer Res. 2013;73(23):7144-6 - PMID: 24265277 - PMCID: PMC3876035 - DOI: 10.1158/0008-5472.CAN-13-1989

Huang Y, Goel S, Duda DG, Fukumura D, Jain RK

Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
Cancer Res. 2013;73(10):2943-8 - PMID: 23440426 - PMCID: PMC3655127 - DOI: 10.1158/0008-5472.CAN-12-4354

Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, Lu-Emerson C, Iafrate AJ, Ivy SP, Rosen BR, Loeffler JS, Wen PY, Sorensen AG, Jain RK

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Proc Natl Acad Sci U S A. 2013;110(47):19059-64 - PMID: 24190997 - PMCID: PMC3839699 - DOI: 10.1073/pnas.1318022110

Stylianopoulos T, Jain RK

Combining two strategies to improve perfusion and drug delivery in solid tumors.
Proc Natl Acad Sci U S A. 2013;110(46):18632-7 - PMID: 24167277 - PMCID: PMC3832007 - DOI: 10.1073/pnas.1318415110

Chauhan VP, Jain RK

Strategies for advancing cancer nanomedicine.
Nat Mater. 2013;12(11):958-62 - PMID: 24150413 - PMCID: PMC4120281 - DOI: 10.1038/nmat3792

Zhu AX, Finn RS, Mulcahy M, Gurtler J, Sun W, Schwartz JD, Dalal RP, Joshi A, Hozak RR, Xu Y, Ancukiewicz M, Jain RK, Nugent F, Duda DG, Stuart K

A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2 in Patients with Advanced Hepatocellular Cancer.
Clin Cancer Res. 2013;19(23):6614-23 - PMID: 24088738 - PMCID: PMC4795808 - DOI: 10.1158/1078-0432.CCR-13-1442

Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516

Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJ, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG

Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Nat Med. 2013;19(9):1178-83 - PMID: 23955713 - PMCID: PMC3769525 - DOI: 10.1038/nm.3289

Batchelor TT, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, Mason W, Mikkelsen T, Phuphanich S, Ashby LS, Degroot J, Gattamaneni R, Cher L, Rosenthal M, Payer F, Jürgensmeier JM, Jain RK, Sorensen AG, Xu J, Liu Q, van den Bent M

Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma.
J Clin Oncol. 2013;31(26):3212-3218 - PMID: 23940216 - PMCID: PMC4021043 - DOI: 10.1200/JCO.2012.47.2464

Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164

Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK

Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Proc Natl Acad Sci U S A. 2013;110(31):12774-9 - PMID: 23861493 - PMCID: PMC3732948 - DOI: 10.1073/pnas.1310675110

Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, Dietrich J, Stemmer-Rachamimov AO, Batchelor TT, Jain RK

Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
Neuro Oncol. 2013;15(8):1079-87 - PMID: 23828240 - PMCID: PMC3714160 - DOI: 10.1093/neuonc/not082

Sahani DV, Jiang T, Hayano K, Duda DG, Catalano OA, Ancukiewicz M, Jain RK, Zhu AX

Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy.
J Hematol Oncol. 2013;6(1):51 - PMID: 23842041 - PMCID: PMC3722053 - DOI: 10.1186/1756-8722-6-51

Jain RK, Munn LL, Fukumura D

Measuring Interstitial pH and pO2 in Mouse Tumors.
Cold Spring Harb Protoc. 2013;2013(7):675-7 - PMID: 23818669 - DOI: 10.1101/pdb.prot075713

Jain RK, Munn LL, Fukumura D

Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.
Cold Spring Harb Protoc. 2013;2013(7):678-80 - PMID: 23818670 - DOI: 10.1101/pdb.prot075721

Thunemann M, Wen L, Hillenbrand M, Vachaviolos IA, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R

Transgenic Mice for cGMP Imaging.
Circ Res. 2013;113(4):365-71 - PMID: 23801067 - PMCID: PMC3896241 - DOI: 10.1161/CIRCRESAHA.113.301063

Jain RK, Munn LL, Fukumura D

Measuring leukocyte-endothelial interactions in mice.
Cold Spring Harb Protoc. 2013;2013(6):561-3 - PMID: 23734020 - DOI: 10.1101/pdb.prot075085

Jain RK

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers.
J Clin Oncol. 2013;31(17):2205-18 - PMID: 23669226 - PMCID: PMC3731977 - DOI: 10.1200/JCO.2012.46.3653

Duda DG, Munn LL, Jain RK

Can We Identify Predictive Biomarkers for Antiangiogenic Therapy of Cancer Using Mathematical Modeling?
J Natl Cancer Inst. 2013;105(11):762-5 - PMID: 23670727 - PMCID: PMC3672078 - DOI: 10.1093/jnci/djt114

Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK

Co-evolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse.
Cancer Res. 2013;73(13):3833-3841 - PMID: 23633490 - PMCID: PMC3702668 - DOI: 10.1158/0008-5472.CAN-12-4521

Jain RK, Munn LL, Fukumura D

Measuring vascular permeability in mice.
Cold Spring Harb Protoc. 2013;2013(5):444-6 - PMID: 23637370 - DOI: 10.1101/pdb.prot074344

Jain RK, Munn LL, Fukumura D

Measuring angiogenesis and hemodynamics in mice.
Cold Spring Harb Protoc. 2013;2013(4):354-8 - PMID: 23547161 - DOI: 10.1101/pdb.prot073916

Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK

Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Cell. 2013;152(5):1065-76 - PMID: 23452854 - PMCID: PMC3587980 - DOI: 10.1016/j.cell.2013.01.036

Prabhakar U, Blakey DC, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST, Gabizon A, Grodzinski P

Challenges and key considerations of the enhanced permeability and retention effect (EPR) for nanomedicine drug delivery in oncology.
Cancer Res. 2013;73(8):2412-2417 - PMID: 23423979 - PMCID: PMC3916009 - DOI: 10.1158/0008-5472.CAN-12-4561

Zhu AX, Ancukiewicz M, Supko JG, Sahani DV, Blaszkowsky LS, Meyerhardt JA, Abrams TA, Jackson McCleary N, Bhargava P, Muzikansky A, Sheehan S, Regan E, Vasudev E, Knowles M, Fuchs CS, Ryan DP, Jain RK, Duda DG

Efficacy, safety, pharmacokinetics and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: A phase II study.
Clin Cancer Res. 2013;19(6):1557-66 - PMID: 23362324 - PMCID: PMC3609423 - DOI: 10.1158/1078-0432.CCR-12-3041

Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG

Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
Nat Mater. 2013;12(5):445-51 - PMID: 23377294 - PMCID: PMC3677691 - DOI: 10.1038/nmat3539

Jain RK, Munn LL, Fukumura D

Lung window preparation in mice.
Cold Spring Harb Protoc. 2013;2013(1):ePub - PMID: 23282642 - DOI: 10.1101/pdb.prot072678

Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG, Nocera DG

A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
Chem Sci. 2012;3(10):2980-2985 - PMID: 26413260 - PMCID: PMC4582792 - DOI: 10.1039/C2SC20212C

Somers RC, Lanning RM, Snee PT, Greytak AB, Jain RK, Bawendi MG and Nocera DG

A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
Chemical Science. 2012;:ePub

Jain RK

Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2012;64(Suppl):353-365 - PMID: 24511174 - PMCID: PMC3914635 - DOI: 10.1016/j.addr.2012.09.011

Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK

Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.
Intravital. 2012;1(1):ePub - PMID: 24353926 - PMCID: PMC3864876 - DOI: 10.4161/intv.21557

Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK

Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Annu Rev Chem Biomol Eng. 2012;2:281-98 - PMID: 22432620 - DOI: 10.1146/annurev-chembioeng-061010-114300

Jain RK, Munn LL, Fukumura D

Pancreatic tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209145 - DOI: 10.1101/pdb.prot072363

Jain RK, Munn LL, Fukumura D

Liver tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209146 - DOI: 10.1101/pdb.prot072371

Jain RK, Munn LL, Fukumura D

Lymphangiography of the mouse tail.
Cold Spring Harb Protoc. 2012;2012(11):1177-8 - PMID: 23118364 - DOI: 10.1101/pdb.prot072108

Jain RK, Munn LL, Fukumura D

Lymphangiography of the mouse ear.
Cold Spring Harb Protoc. 2012;2012(11):1179-80 - PMID: 23118365 - DOI: 10.1101/pdb.prot072116

Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK

Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Proc Natl Acad Sci U S A. 2012;109(45):E3119-27 - PMID: 23071298 - PMCID: PMC3494882 - DOI: 10.1073/pnas.1216078109

Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Proc Natl Acad Sci U S A. 2012;109(43):17561-6 - PMID: 23045683 - PMCID: PMC3491458 - DOI: 10.1073/pnas.1215397109

Jain RK, Munn LL, Fukumura D

Mammary fat pad chamber preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1113-4 - PMID: 23028075 - DOI: 10.1101/pdb.prot071506

Jain RK, Munn LL, Fukumura D

Mammary fat pad tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1115-6 - PMID: 23028076 - DOI: 10.1101/pdb.prot071514

Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L

TGF-? blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2012;109(41):16618-23 - PMID: 22996328 - PMCID: PMC3478596 - DOI: 10.1073/pnas.1117610109

Jain RK

Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2012;:ePub - PMID: 22983334

Jain RK, Munn LL, Fukumura D

Corneal pocket assay in rabbits.
Cold Spring Harb Protoc. 2012;2012(9):1017-8 - PMID: 22949714 - DOI: 10.1101/pdb.prot070052

Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Proc Natl Acad Sci U S A. 2012;109(38):15101-8 - PMID: 22932871 - PMCID: PMC3458380 - DOI: 10.1073/pnas.1213353109

Kozin SV, Duda DG, Munn LL, Jain RK

Neovascularization After Irradiation: What is the Source of Newly Formed Vessels in Recurring Tumors?
J Natl Cancer Inst. 2012;104(12):899-905 - PMID: 22572994 - PMCID: PMC3379722 - DOI: 10.1093/jnci/djs239

Goel S, Wong AH, Jain RK

Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Cold Spring Harb Perspect Med. 2012;2(3):a006486 - PMID: 22393532 - PMCID: PMC3282493 - DOI: 10.1101/cshperspect.a006486

Jain RK, Carmeliet P

SnapShot: Tumor angiogenesis.
Cell. 2012;149(6):1408-1408.e1 - PMID: 22682256 - DOI: 10.1016/j.cell.2012.05.025

Meyerhardt JA, Ancukiewicz M, Abrams TA, Schrag D, Enzinger PC, Chan JA, Kulke MH, Wolpin BM, Goldstein M, Blaszkowsky L, Zhu AX, Elliott M, Regan E, Jain RK, Duda DG

Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
PLoS One. 2012;7(6):e38231 - PMID: 22701615 - PMCID: PMC3373492 - DOI: 10.1371/journal.pone.0038231

Jain RK, Munn LL, Fukumura D

Rabbit ear chambers.
Cold Spring Harb Protoc. 2012;2012(7):813-14 - PMID: 22753607 - DOI: 10.1101/pdb.prot070045

Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK

Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.
Neoplasia. 2012;14(2):84-94 - PMID: 22431917 - PMCID: PMC3306254 - DOI: 10.1593/neo.111600

Saylor PJ, Kozak KR, Smith MR, Ancukiewicz MA, Efstathiou JA, Zietman AL, Jain RK, Duda DG

Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.
Oncologist. 2012;17(2):212-9 - PMID: 22302227 - PMCID: PMC3286170 - DOI: 10.1634/theoncologist.2011-0321

Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK

Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
PLoS One. 2012;7(2):e26331 - PMID: 22347360 - PMCID: PMC3274514 - DOI: 10.1371/journal.pone.0026331

Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK

An isolated tumor perfusion model in mice.
Nat Protoc. 2012;7(4):749-55 - PMID: 22441293 - PMCID: PMC3375334 - DOI: 10.1038/nprot.2012.030

Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG

Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Nat Protoc. 2012;7(4):756-62 - PMID: 22441294 - PMCID: PMC3380105 - DOI: 10.1038/nprot.2012.031

Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D

A transient parabiosis skin transplantation model in mice.
Nat Protoc. 2012;7(4):763-70 - PMID: 22441295 - PMCID: PMC3375333 - DOI: 10.1038/nprot.2012.032

Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D

Multistage nanoparticles for improved delivery into tumor tissue.
Methods Enzymol. 2012;508:109-30 - PMID: 22449923 - PMCID: PMC3774840 - DOI: 10.1016/B978-0-12-391860-4.00006-9

Vakoc BJ, Fukumura D, Jain RK, Bouma BE

Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.
Nat Rev Cancer. 2012;12(5):363-8 - PMID: 22475930 - PMCID: PMC3560400 - DOI: 10.1038/nrc3235

Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Nat Nanotechnol. 2012;7(6):383-8 - PMID: 22484912 - PMCID: PMC3370066 - DOI: 10.1038/nnano.2012.45

Goel S, Fukumura D, Jain RK

Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology.
Proc Natl Acad Sci U S A. 2012;109(20):E1214 - PMID: 22550180 - PMCID: PMC3356659 - DOI: 10.1073/pnas.1203794109

Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL

Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
Blood. 2011;118(17):4740-9 - PMID: 21835951 - PMCID: PMC3208287 - DOI: 10.1182/blood-2011-02-338426

Jain A, Munn LL

Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.
Lab Chip. 2011;11(17):2941-7 - PMID: 21773633 - PMCID: PMC3743538 - DOI: 10.1039/c1lc20401g

Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D

Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Proc Natl Acad Sci U S A. 2011;108(6):2426-31 - PMID: 21245339 - PMCID: PMC3038705 - DOI: 10.1073/pnas.1018382108

Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK

Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Angew Chem Int Ed Engl. 2011;50(48):11417-20 - PMID: 22113800 - PMCID: PMC3260125 - DOI: 10.1002/anie.201104449

Dawson MR, Chae SS, Jain RK, Duda DG

Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
Am J Cancer Res. 2011;1(2):144-54 - PMID: 21822499 - PMCID: PMC3150110

Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK

Normalization of the vasculature for treatment of cancer and other diseases.
Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010

Kozin SV, Duda DG, Munn LL, Jain RK

Is vasculogenesis crucial for the regrowth of irradiated tumours?
Nat Rev Cancer. 2011;11(7):532 - PMID: 21701514 - PMCID: PMC4790119 - DOI: 10.1038/nrc2007-c1

Zhu AX, Duda DG, Sahani DV, Jain RK

HCC and angiogenesis: possible targets and future directions.
Nat Rev Clin Oncol. 2011;8(5):292-301 - PMID: 21386818 - PMCID: PMC3266719 - DOI: 10.1038/nrclinonc.2011.30

Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proc Natl Acad Sci U S A. 2011;108(7):2909-14 - PMID: 21282607 - PMCID: PMC3041115 - DOI: 10.1073/pnas.1018892108

Jain RK, Munn LL, Fukumura D, Melder RJ

In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553

Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG

Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
PLoS One. 2011;6(3):e17228 - PMID: 21390238 - PMCID: PMC3048404 - DOI: 10.1371/journal.pone.0017228

Zhao W, Schafer S, Choi J, Yamanaka YJ, Lombardi ML, Bose S, Carlson AL, Phillips JA, Teo W, Droujinine IA, Cui CH, Jain RK, Lammerding J, Love JC, Lin CP, Sarkar D, Karnik R, Karp JM

Cell-surface sensors for real-time probing of cellular environments.
Nat Nanotechnol. 2011;6(8):524-31 - PMID: 21765401 - PMCID: PMC3163485 - DOI: 10.1038/nnano.2011.101

Carmeliet P, Jain RK

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.
Nat Rev Drug Discov. 2011;10(6):417-27 - PMID: 21629292 - DOI: 10.1038/nrd3455

Carmeliet P, Jain RK

Molecular mechanisms and clinical applications of angiogenesis.
Nature. 2011;473(7347):298-307 - PMID: 21593862 - PMCID: PMC4049445 - DOI: 10.1038/nature10144

Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG

Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma.
Cancer Res. 2011;71(11):3745-52 - PMID: 21507932 - PMCID: PMC3107375 - DOI: 10.1158/0008-5472.CAN-10-2991

Emblem KE, Bjornerud A, Mouridsen K, Borra RJ, Batchelor TT, Jain RK, Sorensen AG

T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients.
J Cereb Blood Flow Metab. 2011;31(10):2054-64 - PMID: 21505476 - PMCID: PMC3208147 - DOI: 10.1038/jcbfm.2011.39

Faber AC, Corcoran RB, Ebi H, Sequist LV, Waltman BA, Chung E, Incio J, Digumarthy SR, Pollack SF, Song Y, Muzikansky A, Lifshits E, Roberge S, Coffman EJ, Benes CH, Gómez HL, Baselga J, Arteaga CL, Rivera MN, Dias-Santagata D, Jain RK, Engelman JA

BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Cancer Discov. 2011;1(4):352-65 - PMID: 22145099 - PMCID: PMC3229203 - DOI: 10.1158/2159-8290.CD-11-0106

di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK

Glioblastoma recurrence after cediranib therapy in patients: lack of rebound revascularization as mode of escape.
Cancer Res. 2011;71(1):19-28 - PMID: 21199795 - PMCID: PMC3074948 - DOI: 10.1158/0008-5472.CAN-10-2602

Huang Y, Snuderl M, Jain RK

Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Cancer Cell. 2011;19(1):1-2 - PMID: 21251607 - PMCID: PMC3037265 - DOI: 10.1016/j.ccr.2011.01.005

Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK

Dehydro-alpha-lapachone, a plant product with antivascular activity.
Proc Natl Acad Sci U S A. 2011;108(28):11596-601 - PMID: 21709229 - PMCID: PMC3136298 - DOI: 10.1073/pnas.1104225108

Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT

Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
J Neurooncol. 2011;103(2):325-32 - PMID: 20821342 - PMCID: PMC4090923 - DOI: 10.1007/s11060-010-0390-7

Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK

Scaling rules for diffusive drug delivery in tumor and normal tissues.
Proc Natl Acad Sci U S A. 2011;108(5):1799-803 - PMID: 21224417 - PMCID: PMC3033252 - DOI: 10.1073/pnas.1018154108

Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L

TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
Clin Cancer Res. 2011;17(6):1415-24 - PMID: 21278244 - PMCID: PMC3060297 - DOI: 10.1158/1078-0432.CCR-10-2429

Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 2011;108(9):3725-30 - PMID: 21321210 - PMCID: PMC3048115 - DOI: 10.1073/pnas.1100446108

Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK

CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636

Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L

PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Clin Cancer Res. 2011;17(11):3638-48 - PMID: 21459800 - PMCID: PMC3107920 - DOI: 10.1158/1078-0432.CCR-10-2456

Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK

The biology of brain metastases-translation to new therapies.
Nat Rev Clin Oncol. 2011;8(6):344-56 - PMID: 21487419 - PMCID: PMC3259742 - DOI: 10.1038/nrclinonc.2011.58

Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y

Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer Res. 2011;71(13):4527-38 - PMID: 21571860 - DOI: 10.1158/0008-5472.CAN-10-4376

Huang P, Westmoreland SV, Jain RK, Fukumura D

Spontaneous nonthymic tumors in SCID mice.
Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755

Horowitz NS, Penson RT, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Cohen KS, Berlin S, Krasner CN, Moses MA, Jain RK

Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Clin Ovarian Cancer Other Gynecol Malig. 2011;4(1):26-33 - PMID: 21833345 - PMCID: PMC3151740 - DOI: 10.1016/j.cloc.2011.04.003

Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP

Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108

Jain RK, Munn LL, Fukumura D

Intravital microscopy of normal and diseased tissues in the mouse.
In: Live Cell Imaging: A Laboratory Manual, 2nd Edition, (R. D. Goldman, J. R. Swedlow and D. L. Specter, Eds.), CSH Press, Cold Spring Harbor, NY. 2010;Chapter 26:475-521

Liao S, Padera TP, Jain RK

Notch leads lymphatics and links them to blood vessels.
Arterioscler Thromb Vasc Biol. 2010;30(9):1682-3 - PMID: 20720193 - PMCID: PMC2945915 - DOI: 10.1161/ATVBAHA.110.210633

Jain RK, Stylianopoulos T

Delivering nanomedicine to solid tumors.
Nat Rev Clin Oncol. 2010;7(11):653-64 - PMID: 20838415 - PMCID: PMC3065247 - DOI: 10.1038/nrclinonc.2010.139

Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E

Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
Cancer Res. 2010;70(9):3483-93 - PMID: 20406973 - PMCID: PMC4785015 - DOI: 10.1158/0008-5472.CAN-09-3107

Gerstner ER, Chen PJ, Wen PY, Jain RK, Batchelor TT, Sorensen G

Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.
Neuro Oncol. 2010;12(5):466-72 - PMID: 20406897 - PMCID: PMC2940624 - DOI: 10.1093/neuonc/nop051

Finn AV, Jain RK

Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization?
JACC Cardiovasc Imaging. 2010;3(1):41-4 - PMID: 20129529 - PMCID: PMC2842010 - DOI: 10.1016/j.jcmg.2009.11.001

Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH

In vivo wide-area cellular imaging by side-view endomicroscopy.
Nat Methods. 2010;7(4):303-5 - PMID: 20228814 - PMCID: PMC2849759 - DOI: 10.1038/nmeth.1440

Fukumura D, Duda DG, Munn LL, Jain RK

Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x

Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK

Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Biophys J. 2010;99(5):1342-9 - PMID: 20816045 - PMCID: PMC2931749 - DOI: 10.1016/j.bpj.2010.06.016

Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK

Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Biophys J. 2010;99(10):3119-28 - PMID: 21081058 - PMCID: PMC2980743 - DOI: 10.1016/j.bpj.2010.08.065

Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK

Malignant cells facilitate lung metastasis by bringing their own soil.
Proc Natl Acad Sci U S A. 2010;107(50):21677-82 - PMID: 21098274 - PMCID: PMC3003109 - DOI: 10.1073/pnas.1016234107

Willett CG, Duda DG, Ancukiewicz M, Shah M, Czito BG, Bentley R, Poleski M, Fujita H, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Chung DC, Clark JW, Jain RK

A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.
Oncologist. 2010;15(8):845-51 - PMID: 20667969 - PMCID: PMC3078712 - DOI: 10.1634/theoncologist.2010-0030

Duda DG, Jain RK

Premetastatic lung niche: is vascular endothelial growth factor receptor 1 activation required?
Cancer Res. 2010;70(14):5670-3 - PMID: 20587530 - PMCID: PMC2919170 - DOI: 10.1158/0008-5472.CAN-10-0119

Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH

Lymphotoxin-alpha contributes to lymphangiogenesis.
Blood. 2010;116(12):2173-82 - PMID: 20566898 - PMCID: PMC2951858 - DOI: 10.1182/blood-2009-12-256065

Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK

Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.
Oncologist. 2010;15(6):577-83 - PMID: 20484123 - PMCID: PMC3061828 - DOI: 10.1634/theoncologist.2010-0029

Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG

In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.
Neuro Oncol. 2010;12(4):341-50 - PMID: 20308312 - PMCID: PMC2940602 - DOI: 10.1093/neuonc/nop032

Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK

Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
J Clin Oncol. 2010;28(17):2817-23 - PMID: 20458050 - PMCID: PMC2903316 - DOI: 10.1200/JCO.2009.26.3988

Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG

Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.
Cancer Res. 2010;70(14):5679-85 - PMID: 20631066 - PMCID: PMC2918387 - DOI: 10.1158/0008-5472.CAN-09-4446

Brown E, Munn LL, Fukumura D, Jain RK

In vivo imaging of tumors.
Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452

Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Nat Methods. 2010;7(8):655-60 - PMID: 20581828 - PMCID: PMC2921873 - DOI: 10.1038/nmeth.1475

Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D

Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073

Choi B, Bouma B, Fukumura D, Jain RK

Optical methods in vascular biology and medicine.
J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696

Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG

Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
J Am Chem Soc. 2010;132(2):472-83 - PMID: 20025223 - PMCID: PMC2871316 - DOI: 10.1021/ja908137d

Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG

InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
J Am Chem Soc. 2010;132(2):470-1 - PMID: 20025222 - PMCID: PMC2862004 - DOI: 10.1021/ja908250r

Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG

A nanoparticle size series for in vivo fluorescence imaging.
Angew Chem Int Ed Engl. 2010;49(46):8649-52 - PMID: 20886481 - PMCID: PMC3035057 - DOI: 10.1002/anie.201003142

Jain RK, Tam J, Au P, Fukumura D

Angiogenesis in Development, Disease and Regeneration.
In: Santin M, editor. Strategies in Regenerative Medicine: Integrating Biology with Materials Design. Springer, New York. 2009;Chapter 6:ePub

Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT

The potential utility of anti-VEGF agents to normalize tumor vasculature and alleviate edema in brain and spinal cord tumor patients.
Nat Clin Pract Oncol. 2009;6:229-36

Jain A, Munn LL

Determinants of leukocyte margination in rectangular microchannels.
PLoS One. 2009;4(9):e7104 - PMID: 19768109 - PMCID: PMC2740820 - DOI: 10.1371/journal.pone.0007104

Cheng G, Tse J, Jain RK, Munn LL

Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.
PLoS One. 2009;4(2):e4632 - PMID: 19247489 - PMCID: PMC2645686 - DOI: 10.1371/journal.pone.0004632

Perentes JY, Duda DG, Jain RK

Visualizing anti-tumor immune responses in vivo.
Dis Model Mech. 2009;2(3-4):107-10 - PMID: 19259379 - PMCID: PMC2650205 - DOI: 10.1242/dmm.001842

Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D

Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Cancer Res. 2009;69(7):2801-8 - PMID: 19318557 - PMCID: PMC2670480 - DOI: 10.1158/0008-5472.CAN-08-4051

Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
J Clin Oncol. 2009;27(18):3020-6 - PMID: 19470921 - PMCID: PMC2702234 - DOI: 10.1200/JCO.2008.21.1771

Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG

Biomarkers of response and resistance to antiangiogenic therapy.
Nat Rev Clin Oncol. 2009;6(6):327-38 - PMID: 19483739 - PMCID: PMC3057433 - DOI: 10.1038/nrclinonc.2009.63

Jain RK

A new target for tumor therapy.
N Engl J Med. 2009;360(25):2669-71 - PMID: 19535806 - PMCID: PMC4792114 - DOI: 10.1056/NEJMcibr0902054

Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK

Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Biophys J. 2009;97(1):330-6 - PMID: 19580771 - PMCID: PMC2711376 - DOI: 10.1016/j.bpj.2009.03.064

Zhu AX, Duda DG, Sahani DV, Jain RK

Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Cancer J. 2009;15(4):263-8 - PMID: 19672141 - PMCID: PMC4792519 - DOI: 10.1097/PPO.0b013e3181af5e35

Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK

Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo.
Am J Pathol. 2009;175(1):294-302 - PMID: 19477947 - PMCID: PMC2708815 - DOI: 10.2353/ajpath.2009.080887

Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
J Clin Oncol. 2009;27(18):3027-35 - PMID: 19470923 - PMCID: PMC2702235 - DOI: 10.1200/JCO.2008.20.9908

Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT

VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.
Nat Rev Clin Oncol. 2009;6(4):229-36 - PMID: 19333229 - PMCID: PMC4793889 - DOI: 10.1038/nrclinonc.2009.14

Tam J, Fukumura D, Jain RK

A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Cell Metab. 2009;9(1):52-63 - PMID: 19117546 - PMCID: PMC2643084 - DOI: 10.1016/j.cmet.2008.11.005

Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971

Dawson MR, Duda DG, Fukumura D, Jain RK

VEGFR1-activity-independent metastasis formation.
Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254

Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK

VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
PLoS One. 2009;4(9):e6525 - PMID: 19763275 - PMCID: PMC2744279 - DOI: 10.1371/journal.pone.0006525

Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Cancer Res. 2009;69(20):7905-10 - PMID: 19826039 - PMCID: PMC2859041 - DOI: 10.1158/0008-5472.CAN-09-2099

Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK

Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
PLoS One. 2009;4(12):e8316 - PMID: 20016816 - PMCID: PMC2789383 - DOI: 10.1371/journal.pone.0008316

Jain RK, Duda DG, Sorensen AG

Emerging paradigms and potential biomarkers of response and resistance in anatiangiogenic therapy of cancer
ASCO 2009 Educational Book. 2009;:716-21

Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, Ligon KL, Aldape K, Jain RK, Stiles CD, Egorin MJ, Prados MD

Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).
Neuro Oncol. 2009;11(6):853-60 - PMID: 19293394 - PMCID: PMC2802405 - DOI: 10.1215/15228517-2009-010

Gerstner ER, Sorensen AG, Jain RK, Batchelor TT

Anti-vascular endothelial growth factor therapy for malignant glioma.
Curr Neurol Neurosci Rep. 2009;9(3):254-62 - PMID: 19348715 - PMCID: PMC4790123 - DOI: 10.1007/s11910-009-0037-2

di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.
PLoS One. 2009;4(4):e5123 - PMID: 19352490 - PMCID: PMC2662415 - DOI: 10.1371/journal.pone.0005123

Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK

Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
J Cell Physiol. 2009;219(2):430-7 - PMID: 19170073 - PMCID: PMC2665001 - DOI: 10.1002/jcp.21686

Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D, Jain RK

Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.
PLoS One. 2009;4(3):e4974 - PMID: 19333381 - PMCID: PMC2659427 - DOI: 10.1371/journal.pone.0004974

Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK

Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
J Clin Oncol. 2009;27(15):2542-52 - PMID: 19332720 - PMCID: PMC2739611 - DOI: 10.1200/JCO.2008.19.9356

Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E

Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
N Engl J Med. 2009;361(4):358-67 - PMID: 19587327 - PMCID: PMC4816642 - DOI: 10.1056/NEJMoa0902579

Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA

Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.
Opt Lett. 2009;34(13):2066-8 - PMID: 19572001 - PMCID: PMC2872111 - DOI: 10.1364/ol.34.002066

Sorensen AG, Batchelor TT, Zhang WT, Chen PJ, Yeo P, Wang M, Jennings D, Wen PY, Lahdenranta J, Ancukiewicz M, di Tomaso E, Duda DG, Jain RK

A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.
Cancer Res. 2009;69(13):5296-300 - PMID: 19549889 - PMCID: PMC2824172 - DOI: 10.1158/0008-5472.CAN-09-0814

Chi AS, Sorensen AG, Jain RK, Batchelor TT

Angiogenesis as a therapeutic target in malignant gliomas.
Oncologist. 2009;14(6):621-36 - PMID: 19487335 - PMCID: PMC4790121 - DOI: 10.1634/theoncologist.2008-0272

Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295

Mok W, Stylianopoulos T, Boucher Y, Jain RK

Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Clin Cancer Res. 2009;15(7):2352-60 - PMID: 19318482 - PMCID: PMC2872130 - DOI: 10.1158/1078-0432.CCR-08-2082

Willett CG, Duda DG, Xu L, diTomaso E, Boucher Y, Czito B, Ancukiewicz M, Clark J, Carroll M, Lauwers G, Jain RK

Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).
J Clin Oncol. 2008;26(15_suppl):4096 - PMID: 27949464

Jain RK, Duda DG, Batchelor TT, Sorensen AG, Willett CG

Normalization of tumor vasculature and microenvironment.
In: Angiogenesis: An Integrative Approach from Science to Medicine (Editors: W. D. Figg and J. Folkman), Springer. 2008;:173-282

Jain RK, Duda DG

Vascular and interstitial biology of tumors
In: Clinical Oncology. 4th Edition, (Editors: Abeloff M, Armitage J, Niederhuber J, Kastan M, McKenna WG), Elsevier, Philadelphia. 2008;:105-24

Jain RK, Kozak K

Molecular Pathophysiology of Tumors.
In: Principles and Practice of Radiation Oncology, 5th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2008;Chapter 4:126-141

Jain RK, Booth MF, Padera TP, Munn LL, Fukumura D, Brown E

Applications of nonlinear intravital microscopy in tumor biology.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 29:735-756

Brown E, Majewska A, Jain RK

Photobleaching and recovery with nonlinear microscopy.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 26:673-688

Jain RK

Judah Folkman
Journal of Clinical Investigation. 2008;118:823

Gerstner ER, Sorensen AG, Jain RK, Batchelor TT

Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Curr Opin Neurol. 2008;21(6):728-35 - PMID: 18989120 - DOI: 10.1097/WCO.0b013e328318402a

Fukumura D, Jain RK

Imaging angiogenesis and the microenvironment.
APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x

Sorensen AG, Batchelor TT, Wen PY, Zhang WT, Jain RK

Response criteria for glioma.
Nat Clin Pract Oncol. 2008;5(11):634-44 - PMID: 18711427 - PMCID: PMC4795821 - DOI: 10.1038/ncponc1204

Padera TP, Jain RK

VEGFR3: a new target for antiangiogenesis therapy?
Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014

Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182

Nagano S, Perentes JY, Jain RK, Boucher Y

Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193

Jain RK

Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Nat Rev Cancer. 2008;8(4):309-16 - PMID: 18337733 - DOI: 10.1038/nrc2346

Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DG

A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):388-97 - PMID: 18323810 - PMCID: PMC2676340 - DOI: 10.1038/nprot.2007.537

Jones RC, Capen D, Petersen B, Jain RK, Duda DG

A protocol for a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):378-87 - PMID: 18323809 - PMCID: PMC2676330 - DOI: 10.1038/nprot.2007.536

Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D

Perivascular nitric oxide gradients normalize tumor vasculature.
Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730

Jain RK

Taming vessels to treat cancer.
Sci Am. 2008;298(1):56-63 - PMID: 18225696 - DOI: 10.1038/scientificamerican0108-56

Huang P, Duda DG, Jain RK, Fukumura D

Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079

Jain RK, Lahdenranta J, Fukumura D

Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
PLoS Med. 2008;5(1):e24 - PMID: 18232729 - PMCID: PMC2214795 - DOI: 10.1371/journal.pmed.0050024

Au P, Tam J, Fukumura D, Jain RK

Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Blood. 2008;111(9):4551-8 - PMID: 18256324 - PMCID: PMC2343592 - DOI: 10.1182/blood-2007-10-118273

Jain RK, Fukumura D, Munn LL, Brown E

Tumor Angiogenesis and Blood Flow.
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:199-201

Jain RK, Fukumura D, Munn LL, Brown E

Optical Microscopy in Small Animal Research
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:183-187

Jain RK, Batchelor TT, Duda DG, Willett CG

Normalization of tumor vasculature and microenvironment.
In: Antiangiogenic Agents in Cancer Therapy. (Editors: Beverly Teicher and Lee Ellis), Humana Press. 2007;:261-76

Jain RK, Duda DG

Normalization of tumor vasculature and microenvironment by antiangiogenic therapy.
In: Angiogenesis: Mechanisms and Cancer Therapy (Editors: Dieter Marm and Norbert E. Fusenig), Springer-Verlag, Berlin. 2007;:577-92

Jain RK, Duda DG

Angiogenesis in Solid Tumors
In: Antiangiogenic Cancer Therapy (Editors: James L. Abbruzzese, Darren W. Davis and Roy S. Herbst), CRC Press, Boca Raton. 2007;:43-90

Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Data do not support benefits of anti-VEGFR3 therapy
Cancer Research. 2007;67:5055

Willett CG, Duda DG, Jain RK

Surrogate biomarkers for anti-angiogenic therapy for advanced colorectal cancer.
Current Colorectal Cancer Reports. 2007;3:94-98

Jain RK, Munn LL

Vascular normalization as rationale for combining chemotherapy with antiangiogenic agents
PPO Updates. 2007;21:1-7

Duda DG, Cohen KS, Au P, Scadden DT, Willett CG, Jain RK

Detection of circulating endothelial cells: CD146- based magnetic separation enrichment or flow cytometric assay?
J Clin Oncol. 2007;25:e3-e5

Fukumura D, Jain RK

Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
J Cell Biochem. 2007;101(4):937-49 - PMID: 17171643 - DOI: 10.1002/jcb.21187

Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Cancer Cell. 2007;11(1):83-95 - PMID: 17222792 - PMCID: PMC2748664 - DOI: 10.1016/j.ccr.2006.11.021

Tyrrell JA, di Tomaso E, Fuja D, Tong R, Kozak K, Jain RK, Roysam B

Robust 3-D modeling of vasculature imagery using superellipsoids.
IEEE Trans Med Imaging. 2007;26(2):223-37 - PMID: 17304736 - DOI: 10.1109/TMI.2006.889722

Duda DG, Cohen KS, Scadden DT, Jain RK

A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.
Nat Protoc. 2007;2(4):805-10 - PMID: 17446880 - PMCID: PMC2686125 - DOI: 10.1038/nprot.2007.111

Bockhorn M, Jain RK, Munn LL

Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Lancet Oncol. 2007;8(5):444-8 - PMID: 17466902 - PMCID: PMC2712886 - DOI: 10.1016/S1470-2045(07)70140-7

Fukumura D, Jain RK

Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
Microvasc Res. 2007;74(2-3):72-84 - PMID: 17560615 - PMCID: PMC2100036 - DOI: 10.1016/j.mvr.2007.05.003

Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT

Angiogenesis in brain tumours.
Nat Rev Neurosci. 2007;8(8):610-22 - PMID: 17643088 - DOI: 10.1038/nrn2175

Jain RK, Finn AV, Kolodgie FD, Gold HK, Virmani R

Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization.
Nat Clin Pract Cardiovasc Med. 2007;4(9):491-502 - PMID: 17712362 - DOI: 10.1038/ncpcardio0979

Au P, Tam J, Fukumura D, Jain RK

Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11

Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK

Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643

Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT

Antiangiogenic agents for the treatment of glioblastoma.
Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895

Mok W, Boucher Y, Jain RK

Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107

Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK

Targeted therapy in rectal cancer.
Oncology (Williston Park). 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim - PMID: 17910311 - PMCID: PMC2686129

Sun C, Jain RK, Munn LL

Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.
Ann Biomed Eng. 2007;35(12):2121-9 - PMID: 17846892 - PMCID: PMC2752713 - DOI: 10.1007/s10439-007-9377-8

Xu L, Jain RK

Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma.
Mol Cancer Res. 2007;5(9):873-80 - PMID: 17704140 - DOI: 10.1158/1541-7786.MCR-06-0141

Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.
Nat Clin Pract Oncol. 2007;4(5):316-21 - PMID: 17464339 - PMCID: PMC2686127 - DOI: 10.1038/ncponc0813

Jain RK, Tong RT, Munn LL

Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
Cancer Res. 2007;67(6):2729-35 - PMID: 17363594 - PMCID: PMC3022341 - DOI: 10.1158/0008-5472.CAN-06-4102

Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB

Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma.
J Soc Integr Oncol. 2007;5(1):11-7 - PMID: 17309809 - DOI: 10.2310/7200.2006.033

Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.
Nat Biotechnol. 2007;25(3):317-8 - PMID: 17322871 - DOI: 10.1038/nbt1287

Duda DG, Batchelor TT, Willett CG, Jain RK

VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.
Trends Mol Med. 2007;13(6):223-30 - PMID: 17462954 - PMCID: PMC2686126 - DOI: 10.1016/j.molmed.2007.04.001

Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Anti-VEGFR-3 therapy and lymph node metastasis [corrected].
Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935

Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y

Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Cancer Res. 2007;67(11):5076-82 - PMID: 17545583 - DOI: 10.1158/0008-5472.CAN-06-3664

Duda DG, Jain RK, Willett CG

Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.
J Clin Oncol. 2007;25(26):4033-42 - PMID: 17827451 - PMCID: PMC2686120 - DOI: 10.1200/JCO.2007.11.3985

Jain RK, Xu L

alphaPlGF: a new kid on the antiangiogenesis block.
Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023

Jain RK

Seminal findings and an allergy to black flies.
In: Reflections from the Frontiers, Explorations for the Future: Gordon Research Conferences, 1931-2006 (Editors: Arthur A. Daemmrich, Nancy Ryan Gray and Leah Shaper), Gordon Research Conferences and Chemical Heritage Foundation, Philadelphia. 2006;:70-71

Jain RK, Duda DG, Clark JW, Loeffler JS

Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Nat Clin Pract Oncol. 2006;3(1):24-40 - PMID: 16407877 - DOI: 10.1038/ncponc0403

McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK

Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Cancer Res. 2006;66(5):2509-13 - PMID: 16510565 - DOI: 10.1158/0008-5472.CAN-05-2242

Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK

Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655

Reddy ST, Berk DA, Jain RK, Swartz MA

A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
J Appl Physiol. 2006;101(4):1162-9 - PMID: 16763103 - DOI: 10.1152/japplphysiol.00389.2006

Fukumura D, Kashiwagi S, Jain RK

The role of nitric oxide in tumour progression.
Nat Rev Cancer. 2006;6(7):521-34 - PMID: 16794635 - DOI: 10.1038/nrc1910

Cochran DM, Fukumura D, Ancukiewicz M, Carmeliet P, Jain RK

Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Ann Biomed Eng. 2006;34(8):1247-58 - PMID: 16832606 - DOI: 10.1007/s10439-006-9134-4

Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH

Platelet-derived growth factor receptor-beta in Gorham's disease.
Nat Clin Pract Oncol. 2006;3(12):693-7 - PMID: 17139320 - PMCID: PMC2693369 - DOI: 10.1038/ncponc0660

Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Proc Natl Acad Sci U S A. 2006;103(4):855-60 - PMID: 16418262 - PMCID: PMC1348013 - DOI: 10.1073/pnas.0510412103

Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK

Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
J Clin Oncol. 2006;24(9):1449-53 - PMID: 16549839 - PMCID: PMC2718681 - DOI: 10.1200/JCO.2005.04.2861

Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D

Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Cancer Res. 2006;66(8):3971-7 - PMID: 16618713 - DOI: 10.1158/0008-5472.CAN-04-3085

Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK

Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392

Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK

Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Semin Oncol. 2006;33(5 Suppl 10):S35-40 - PMID: 17145523 - PMCID: PMC2686124 - DOI: 10.1053/j.seminoncol.2006.08.007

Brown EB, Munn LL, Fukumura D, Jain RK

A Practical Guide to in vivo Imaging of Tumors.
In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 92:695-700

Brown E, Majewska A, Jain RK

FRAP and Multiphoton FRAP.
In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 56:429-438

Jain RK

Antiangiogenic therapy for cancer: current and emerging concepts.
Oncology (Williston Park). 2005;19(4 Suppl 3):7-16 - PMID: 15934498

di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL

Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Cancer Res. 2005;65(13):5740-9 - PMID: 15994949 - DOI: 10.1158/0008-5472.CAN-04-4552

Jain RK, Au P, Tam J, Duda DG, Fukumura D

Engineering vascularized tissue.
Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821

Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Héligon C, Terclavers S, Ciesiolka M, Kälin R, Man WY, Senn I, Wyns S, Lupu F, Brändli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P

A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nat Med. 2005;11(9):998-1004 - PMID: 16116431 - DOI: 10.1038/nm1285

Hagendoorn J, Padera TP, Fukumura D, Jain RK

Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003

Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B

A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.
Microvasc Res. 2005;70(3):165-78 - PMID: 16239015 - DOI: 10.1016/j.mvr.2005.08.005

Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
J Clin Oncol. 2005;23(31):8136-9 - PMID: 16258121 - DOI: 10.1200/JCO.2005.02.5635

Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D

NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
J Clin Invest. 2005;115(7):1816-27 - PMID: 15951843 - PMCID: PMC1143589 - DOI: 10.1172/JCI24015

Huang P, McKee TD, Jain RK, Fukumura D

Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171

Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN

Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
J Clin Oncol. 2005;23(9):1951-61 - PMID: 15774788 - DOI: 10.1200/JCO.2005.08.119

Jain RK

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Science. 2005;307(5706):58-62 - PMID: 15637262 - DOI: 10.1126/science.1104819

Duda DG, Jain RK

Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
J Clin Invest. 2005;115(3):596-8 - PMID: 15765145 - PMCID: PMC1052004 - DOI: 10.1172/JCI24511

Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y

Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682

Xu L, Tong R, Cochran DM, Jain RK

Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Cancer Res. 2005;65(13):5711-9 - PMID: 15994946 - DOI: 10.1158/0008-5472.CAN-04-4313

Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P

Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003

Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Nat Med. 2005;11(6):678-82 - PMID: 15880117 - PMCID: PMC2686110 - DOI: 10.1038/nm1247

Jain RK

Vascular and Interstitial Biology of Tumors.
In: Clinical Oncology, 3rd Edition (Editors: M. Abeleff, J. Armitage, J. Niederhuber, M. Kastan and G. McKenna), Elsevier, Philadelphia, PA. 2004;Chapter 9:153-172

Jain RK, Brown EB, Munn LL, Fukumura D

Intravital microscopy of normal and diseased tissues in the mouse.
In: Live Cell Imaging: A Laboratory Manual (Editors: R. D. Goldman and D. L. Spector). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 2004;Chapter 24:435-466

Jain RK

Correspondence: Recognition of tumor blood vessel normalization as a new antiangiogenic concept.
Nature Medicine. 2004;10:329-330

Chan YT, Zimmer JP, Stroh M, Steckel JS, Jain RK, Bawendi MG

Incorporation of luminescent nanocrystals into monodisperse core-shell silica microspheres.
Advanced Materials. 2004;16:23-24

Willett CG, Duda DG, Fischman A, Jain RK

Correspondence: PET concerns in bevacizumab treatment
Nature Medicine. 2004;10:561

Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK

Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Nat Med. 2004;10(2):203-7 - PMID: 14716306 - DOI: 10.1038/nm981

Gohongi T, Todoroki T, Fukumura D, Jain RK

Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Oncol Rep. 2004;11(4):803-7 - PMID: 15010876

Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK

Tissue engineering: creation of long-lasting blood vessels.
Nature. 2004;428(6979):138-9 - PMID: 15014486 - DOI: 10.1038/428138a

Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Nature. 2004;428(6980):328-32 - PMID: 15029197 - DOI: 10.1038/nature02329

Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LL

Differential gene expression in metastasizing cells shed from kidney tumors.
Cancer Res. 2004;64(7):2469-73 - PMID: 15059900 - DOI: 10.1158/0008-5472.can-03-0256

Brown EB, Boucher Y, Nasser S, Jain RK

Measurement of macromolecular diffusion coefficients in human tumors.
Microvasc Res. 2004;67(3):231-6 - PMID: 15121448 - DOI: 10.1016/j.mvr.2004.02.001

Duda DG, Fukumura D, Jain RK

Role of eNOS in neovascularization: NO for endothelial progenitor cells.
Trends Mol Med. 2004;10(4):143-5 - PMID: 15162796 - DOI: 10.1016/j.molmed.2004.02.001

Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK

Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752

Jain RK, Stroh M

Zooming in and out with quantum dots.
Nat Biotechnol. 2004;22(8):959-60 - PMID: 15286644 - DOI: 10.1038/nbt0804-959

Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Cancer Cell. 2004;6(6):553-63 - PMID: 15607960 - DOI: 10.1016/j.ccr.2004.10.011

Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Nat Med. 2004;10(2):145-7 - PMID: 14745444 - PMCID: PMC2693485 - DOI: 10.1038/nm988

Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK

Differential transplantability of tumor-associated stromal cells.
Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268

Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Cancer Res. 2004;64(11):3731-6 - PMID: 15172975 - DOI: 10.1158/0008-5472.CAN-04-0074

Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK

Pathology: cancer cells compress intratumour vessels.
Nature. 2004;427(6976):695 - PMID: 14973470 - DOI: 10.1038/427695a

Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK

Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.
Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24

Jain RK

Molecular Pathophysiology of Tumors
In: Principles and Practice of Radiation Oncology, 4th Edition (Editors: C. A. Parez, L. W. Brady, E. C. Halperin, and R. Schmidt-Ullrich), Lippincott, Williams & Wilkins, New York. 2003;Chapter 4:163-179

Netti PA, Jain RK

Interstitial Transport in Solid Tumors
In: Cancer Modeling and Simulation (Editor: L Preziosi), Chapman & Hall, Boca Raton, FL. 2003;Chapter 3:51-74

Netti PA, Travascio F, Jain RK

Coupled Macromolecular Transport and Gel Mechanics: Poroviscoelastic Approach.
AIChE Journal. 2003;49:1580-1596

Jain RK

Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy.
Cold Spring Harb Symp Quant Biol. 2003;67:239-48 - PMID: 12858546 - DOI: 10.1101/sqb.2002.67.239

Mollica F, Jain RK, Netti PA

A model for temporal heterogeneities of tumor blood flow.
Microvasc Res. 2003;65(1):56-60 - PMID: 12535873 - DOI: 10.1016/s0026-2862(02)00012-2

Dolmans DE, Fukumura D, Jain RK

Photodynamic therapy for cancer.
Nat Rev Cancer. 2003;3(5):380-7 - PMID: 12724736 - DOI: 10.1038/nrc1071

Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879

Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK

A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Blood. 2003;102(7):2555-61 - PMID: 12775571 - DOI: 10.1182/blood-2003-02-0365

Jain RK

Molecular regulation of vessel maturation.
Nat Med. 2003;9(6):685-93 - PMID: 12778167 - DOI: 10.1038/nm0603-685

Jain RK, Duda DG

Role of bone marrow-derived cells in tumor angiogenesis and treatment.
Cancer Cell. 2003;3(6):515-6 - PMID: 12842078 - DOI: 10.1016/s1535-6108(03)00138-7

Padera TP, Stoll BR, So PT, Jain RK

Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Mol Imaging. 2003;1(1):9-15 - PMID: 12920856 - DOI: 10.1162/15353500200200004

Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B

Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.
Microvasc Res. 2003;66(2):113-25 - PMID: 12935769 - DOI: 10.1016/s0026-2862(03)00039-6

Jain RK, Booth MF

What brings pericytes to tumor vessels?
J Clin Invest. 2003;112(8):1134-6 - PMID: 14561696 - PMCID: PMC213497 - DOI: 10.1172/JCI20087

Roose T, Netti PA, Munn LL, Boucher Y, Jain RK

Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.
Microvasc Res. 2003;66(3):204-12 - PMID: 14609526 - DOI: 10.1016/s0026-2862(03)00057-8

Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y

Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Clin Cancer Res. 2003;9(15):5508-13 - PMID: 14654530

Padera TP, Boucher Y, Jain RK

Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026

Jain RK, Padera TP

Development. Lymphatics make the break.
Science. 2003;299(5604):209-10 - PMID: 12522236 - DOI: 10.1126/science.1081345

Forbes NS, Munn LL, Fukumura D, Jain RK

Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Cancer Res. 2003;63(17):5188-93 - PMID: 14500342

Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD

Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer Res. 2003;63(4):747-51 - PMID: 12591719

Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK

Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.
Circ Res. 2003;93(9):e88-97 - PMID: 14525808 - PMCID: PMC2755542 - DOI: 10.1161/01.RES.0000099243.20096.FA

Davies Cde L, Berk DA, Pluen A, Jain RK

Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.
Br J Cancer. 2002;86(10):1639-44 - PMID: 12085216 - PMCID: PMC2746604 - DOI: 10.1038/sj.bjc.6600270

Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM

Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
Am J Pathol. 2002;160(3):985-1000 - PMID: 11891196 - PMCID: PMC1867175 - DOI: 10.1016/S0002-9440(10)64920-6

Jain RK, Fenton BT

Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
J Natl Cancer Inst. 2002;94(6):417-21 - PMID: 11904313 - DOI: 10.1093/jnci/94.6.417

Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK

Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Neoplasia. 2002;4(1):3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209

Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK

Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Cancer Res. 2002;62(7):2151-6 - PMID: 11929837

Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK

Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Clin Cancer Res. 2002;8(4):1008-13 - PMID: 11948107

Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK

Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
Clin Cancer Res. 2002;8(4):1284-91 - PMID: 11948144

Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK

Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
Br J Cancer. 2002;86(6):947-53 - PMID: 11953828 - PMCID: PMC2364140 - DOI: 10.1038/sj.bjc.6600158

Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK

Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420

Jain RK, Munn LL, Fukumura D

Dissecting tumour pathophysiology using intravital microscopy.
Nat Rev Cancer. 2002;2(4):266-76 - PMID: 12001988 - DOI: 10.1038/nrc778

Jain RK, Padera TP

Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.
J Natl Cancer Inst. 2002;94(11):785-7 - PMID: 12048260 - DOI: 10.1093/jnci/94.11.785

Dolmans DE, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D

Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.
Cancer Res. 2002;62(15):4289-94 - PMID: 12154031

Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK

Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Biophys J. 2002;83(3):1650-60 - PMID: 12202388 - PMCID: PMC1302261 - DOI: 10.1016/S0006-3495(02)73933-7

Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LL

Red blood cells augment leukocyte rolling in a virtual blood vessel.
Biophys J. 2002;83(4):1834-41 - PMID: 12324405 - PMCID: PMC1302276 - DOI: 10.1016/S0006-3495(02)73948-9

Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL

Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Cancer Res. 2002;62(23):6831-6 - PMID: 12460895

Jain RK

Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Semin Oncol. 2002;29(6 Suppl 16):3-9 - PMID: 12516032 - DOI: 10.1053/sonc.2002.37265

Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RK

Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.
Neoplasia. 2002;4(5):449-63 - PMID: 12192604 - PMCID: PMC1661679 - DOI: 10.1038/sj.neo.7900260

Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK

Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Nature. 2002;416(6878):279-80 - PMID: 11907566 - DOI: 10.1038/416279b

Chung HW, Chung HJ

Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683-3688, 2000.
Cancer Res. 2001;61(22):8347-50 - PMID: 11719469

Jain RK, Munn LL, Fukumura D

Transparent Window Models and Intravital Microscopy: Imaging Gene Expression
Physiological Function and Drug Delivery in Tumors, In: Tumor Models in Cancer Research, B. Teicher, Ed., Humana Press, Inc., Totowa, NJ. 2001;Chapter 34:647-671

Jain RK

In Memoriam: Pietro M. Gullino (1919-2001)
Cancer Research. 2001;61:8930-8931

Baish JW, Jain RK

Correspondence Regarding Fractals and Cancer.
Cancer Research. 2001;61:8347-8351

Jain RK, Carmeliet PF

Vessels of death or life.
Sci Am. 2001;285(6):38-45 - PMID: 11759584 - DOI: 10.1038/scientificamerican1201-38

Jain RK, Forbes NS

Can engineered bacteria help control cancer?
Proc Natl Acad Sci U S A. 2001;98(26):14748-50 - PMID: 11752416 - PMCID: PMC64926 - DOI: 10.1073/pnas.261606598

Jain RK

Transport of molecules, particles, and cells in solid tumors.
Annu Rev Biomed Eng. 2001;1:241-63 - PMID: 11701489 - DOI: 10.1146/annurev.bioeng.1.1.241

Jain RK

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.
Nat Med. 2001;7(9):987-9 - PMID: 11533692 - DOI: 10.1038/nm0901-987

Jain RK

Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
J Control Release. 2001;74(1-3):7-25 - PMID: 11489479 - DOI: 10.1016/s0168-3659(01)00306-6

Jain RK

Clearing the smoke on nicotine and angiogenesis.
Nat Med. 2001;7(7):775-7 - PMID: 11433337 - DOI: 10.1038/89889

Jain RK

Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2001;46(1-3):149-68 - PMID: 11259838 - DOI: 10.1016/s0169-409x(00)00131-9

Yuan J, Melder RJ, Jain RK, Munn LL

Lateral view flow system for studies of cell adhesion and deformation under flow conditions.
Biotechniques. 2001;30(2):388-94 - PMID: 11233608 - PMCID: PMC2752719 - DOI: 10.2144/01302rr02

Dull RO, Yuan J, Chang YS, Tarbell J, Jain RK, Munn LL

Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.
Microvasc Res. 2001;61(2):203-10 - PMID: 11254400 - DOI: 10.1006/mvre.2000.2298

Melder RJ, Kristensen CA, Munn LL, Jain RK

Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery.
Biorheology. 2001;38(2-3):151-9 - PMID: 11381172

Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher Y

Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvasc Res. 2001;62(1):26-42 - PMID: 11421658 - DOI: 10.1006/mvre.2001.2311

Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nat Med. 2001;7(7):864-8 - PMID: 11433354 - DOI: 10.1038/89997

Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D

Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Lab Invest. 2001;81(10):1439-51 - PMID: 11598156 - DOI: 10.1038/labinvest.3780357

Patan S, Munn LL, Tanda S, Roberge S, Jain RK, Jones RC

Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.
Circ Res. 2001;89(8):723-31 - PMID: 11597996 - DOI: 10.1161/hh2001.097870

Patan S, Tanda S, Roberge S, Jones RC, Jain RK, Munn LL

Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation.
Circ Res. 2001;89(8):732-9 - PMID: 11597997 - PMCID: PMC2752899 - DOI: 10.1161/hh2001.097872

Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer Res. 2001;61(1):39-44 - PMID: 11196192

Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proc Natl Acad Sci U S A. 2001;98(8):4628-33 - PMID: 11274375 - PMCID: PMC31885 - DOI: 10.1073/pnas.081626898

Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK

Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105

Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045

Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA

A potential murine model for flap-related investigations.
Plast Reconstr Surg. 2001;107(6):1504-8 - PMID: 11335827 - DOI: 10.1097/00006534-200105000-00032

Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK

LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer Res. 2001;61(22):8079-84 - PMID: 11719431

Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.
Proc Natl Acad Sci U S A. 2001;98(5):2604-9 - PMID: 11226286 - PMCID: PMC30185 - DOI: 10.1073/pnas.041359198

Jain RK

Delivery of Biologic Molecules and Cells to Tumors
In: Biologic Therapy of Cancer: Principles and Practice, S. Rosenberg, Ed., Lippincott, Williams and Watkins, Philadelphia. 2000;:865-874

Carmeliet P, Jain RK

Angiogenesis in cancer and other diseases.
Nature. 2000;407(6801):249-57 - PMID: 11001068 - DOI: 10.1038/35025220

Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK

Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.
Cancer Res. 2000;60(16):4324-7 - PMID: 10969769

Baish JW, Jain RK

Fractals and cancer.
Cancer Res. 2000;60(14):3683-8 - PMID: 10919633

Helmlinger G, Endo M, Ferrara N, Hlatky L, Jain RK

Formation of endothelial cell networks.
Nature. 2000;405(6783):139-41 - PMID: 10821260 - DOI: 10.1038/35012132

Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK

Role of extracellular matrix assembly in interstitial transport in solid tumors.
Cancer Res. 2000;60(9):2497-503 - PMID: 10811131

Dellian M, Yuan F, Trubetskoy VS, Torchilin VP, Jain RK

Vascular permeability in a human tumour xenograft: molecular charge dependence.
Br J Cancer. 2000;82(9):1513-8 - PMID: 10789717 - PMCID: PMC2363402 - DOI: 10.1054/bjoc.1999.1171

Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, Jain RK, McDonald DM

Openings between defective endothelial cells explain tumor vessel leakiness.
Am J Pathol. 2000;156(4):1363-80 - PMID: 10751361 - PMCID: PMC1876882 - DOI: 10.1016/S0002-9440(10)65006-7

Ramanujan S, Koenig GC, Padera TP, Stoll BR, Jain RK

Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Cancer Res. 2000;60(5):1442-8 - PMID: 10728711

Jain RK, Munn LL

Leaky vessels? Call Ang1!
Nat Med. 2000;6(2):131-2 - PMID: 10655092 - DOI: 10.1038/72212

Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JM

Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Microvasc Res. 2000;59(2):265-77 - PMID: 10684732 - DOI: 10.1006/mvre.1999.2225

Melder RJ, Yuan J, Munn LL, Jain RK

Erythrocytes enhance lymphocyte rolling and arrest in vivo.
Microvasc Res. 2000;59(2):316-22 - PMID: 10684738 - DOI: 10.1006/mvre.1999.2223

Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL

Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.
Proc Natl Acad Sci U S A. 2000;97(26):14608-13 - PMID: 11121063 - PMCID: PMC18966 - DOI: 10.1073/pnas.97.26.14608

McDonald DM, Munn L, Jain RK

Vasculogenic mimicry: how convincing, how novel, and how significant?
Am J Pathol. 2000;156(2):383-8 - PMID: 10666365 - PMCID: PMC1850027 - DOI: 10.1016/S0002-9440(10)64740-2

Somasundaran P, Simpson S, Jain RK, Ivanov I, Raghuraman V

Investigation of Thin Aqueous Films on Silica Using a Modified Interferometric Technique.
J Colloid Interface Sci. 2000;225(1):243-246 - PMID: 10767167 - DOI: 10.1006/jcis.2000.6735

Hartford AC, Gohongi T, Fukumura D, Jain RK

Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
Cancer Res. 2000;60(8):2128-31 - PMID: 10786673

Stohrer M, Boucher Y, Stangassinger M, Jain RK

Oncotic pressure in solid tumors is elevated.
Cancer Res. 2000;60(15):4251-5 - PMID: 10945638

Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK

Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer Res. 2000;60(16):4556-60 - PMID: 10969807

Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer Res. 2000;60(19):5565-70 - PMID: 11034104

Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK

Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer Res. 2000;60(22):6248-52 - PMID: 11103778

Kaur A, Hale CL, Ramanujan S, Jain RK, Johnson RP

Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.
J Virol. 2000;74(18):8413-24 - PMID: 10954541 - PMCID: PMC116352 - DOI: 10.1128/jvi.74.18.8413-8424.2000

Somasundaran P, Simpson S, Ivanov I, Jain RK, Sarkar D

Thinning and Rupture of Aqueous Surfactant Films on Silica
Langmuir. 1999;15:7658-7661

Kristensen CA, Hamberg LM, Hunter GJ, Roberge S, Kierstead D, Wolf GL, Jain RK

Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy.
Neoplasia. 1999;1(6):518-25 - PMID: 10935499 - PMCID: PMC1508121 - DOI: 10.1038/sj.neo.7900063

Heijn M, Roberge S, Jain RK

Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.
Cancer Res. 1999;59(17):4458-63 - PMID: 10485498

Endo M, Jain RK, Witwer B, Brown D

Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.
Microvasc Res. 1999;58(2):89-98 - PMID: 10458924 - DOI: 10.1006/mvre.1999.2158

Jain RK

Understanding barriers to drug delivery: high resolution in vivo imaging is key.
Clin Cancer Res. 1999;5(7):1605-6 - PMID: 10430057

Moulton KS, Melder RJ, Dharnidharka VR, Hardin-Young J, Jain RK, Briscoe DM

Angiogenesis in the huPBL-SCID model of human transplant rejection.
Transplantation. 1999;67(12):1626-31 - PMID: 10401773 - DOI: 10.1097/00007890-199906270-00020

Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK

Return of lymphatic function after flap transfer for acute lymphedema.
Ann Surg. 1999;229(3):421-7 - PMID: 10077056 - PMCID: PMC1191709 - DOI: 10.1097/00000658-199903000-00017

Kristensen CA, Askenasy N, Jain RK, Koretsky AP

Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.
Br J Cancer. 1999;79(2):278-85 - PMID: 9888469 - PMCID: PMC2362210 - DOI: 10.1038/sj.bjc.6690045

Lichtenbeld HC, Ferarra N, Jain RK, Munn LL

Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.
Microvasc Res. 1999;57(3):357-62 - PMID: 10329263 - DOI: 10.1006/mvre.1998.2140

Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA

Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.
Microcirculation. 1999;5(2-3):153-71 - PMID: 9789256

Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK

Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Proc Natl Acad Sci U S A. 1999;96(6):3137-42 - PMID: 10077650 - PMCID: PMC15908 - DOI: 10.1073/pnas.96.6.3137

Swartz MA, Kristensen CA, Melder RJ, Roberge S, Calautti E, Fukumura D, Jain RK

Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.
Br J Cancer. 1999;81(5):756-9 - PMID: 10555742 - PMCID: PMC2374305 - DOI: 10.1038/sj.bjc.6690760

Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK

Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
J Biomech. 1999;32(12):1297-307 - PMID: 10569708 - DOI: 10.1016/s0021-9290(99)00125-6

Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK

Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.
Cancer Res. 1999;59(15):3776-82 - PMID: 10446995

Monsky WL, Fukumura D, Gohongi T, Ancukiewcz M, Weich HA, Torchilin VP, Yuan F, Jain RK

Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Cancer Res. 1999;59(16):4129-35 - PMID: 10463618

Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK

Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nat Med. 1999;5(10):1203-8 - PMID: 10502827 - DOI: 10.1038/13524

Pluen A, Netti PA, Jain RK, Berk DA

Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.
Biophys J. 1999;77(1):542-52 - PMID: 10388779 - PMCID: PMC1300351 - DOI: 10.1016/S0006-3495(99)76911-0

Berlin K, Jain RK, Richert C

Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins.
Biotechnol Bioeng. 1998;61(2):107-18 - PMID: 10099504 - DOI: 10.1002/(sici)1097-0290(199821)61:2<107::aid-bit5>3.0.co;2-q

Jain RK

Delivery of Monoclonal Antibodies to the Tumor Cell
In: Monoclonal Antibody-Based Therapy of Cancer, M.L. Grossbard, Ed., Marcel Dekker, Inc., New York. 1998;:23-52

Jain RK, Munn LL, Fukumura D, Melder RJ

In Vitro and In Vivo Quantification of Adhesion Between Leukocytes and Vascular Endothelium.
In: Methods in Molecular Medicine - Methods in Tissue Engineering, J.R. Morgan and M.L. Yarmush, Eds., Humana Press, Totowa. 1998;:553-575

Jain RK

Microcirculation and Transport Phenomena in Tumours
In: Connective Tissue Biology: Integration and Reductionism. Eds. R.K. Reed and K. Rubin, Portland Press Ltd, London. 1998;71:269-293

Sckell A, Safabakhsh N, Dellian M, Jain RK

Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice.
Cancer Res. 1998;58(24):5866-9 - PMID: 9865747

Jain RK

Delivery of molecular and cellular medicine to solid tumors.
J Control Release. 1998;53(1-3):49-67 - PMID: 9741913 - DOI: 10.1016/s0168-3659(97)00237-x

Baish JW, Jain RK

Cancer, angiogenesis and fractals.
Nat Med. 1998;4(9):984 - PMID: 9734370 - DOI: 10.1038/1952

Jain RK, Safabakhsh N, Sckell A, Chen Y, Jiang P, Benjamin L, Yuan F, Keshet E

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor.
Proc Natl Acad Sci U S A. 1998;95(18):10820-5 - PMID: 9724788 - PMCID: PMC27979 - DOI: 10.1073/pnas.95.18.10820

Jain RK

The next frontier of molecular medicine: delivery of therapeutics.
Nat Med. 1998;4(6):655-7 - PMID: 9623964 - DOI: 10.1038/nm0698-655

Jain RK

Integrative pathophysiology of solid tumors: role in detection and treatment.
Cancer J Sci Am. 1998;4 Suppl 1:S48-57 - PMID: 9619271

Rosenzweig M, DeMaria MA, Harper DM, Friedrich S, Jain RK, Johnson RP

Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques.
Proc Natl Acad Sci U S A. 1998;95(11):6388-93 - PMID: 9600975 - PMCID: PMC27734 - DOI: 10.1073/pnas.95.11.6388

Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R

Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.
Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01

Hunter GJ, Hamberg LM, Choi N, Jain RK, McCloud T, Fischman AJ

Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism.
Clin Cancer Res. 1998;4(4):949-55 - PMID: 9563889

Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Proc Natl Acad Sci U S A. 1998;95(8):4607-12 - PMID: 9539785 - PMCID: PMC22537 - DOI: 10.1073/pnas.95.8.4607

Zhu H, Jain RK, Baxter LT

Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
J Nucl Med. 1998;39(1):65-76 - PMID: 9443740

Fukumura D, Jain RK

Role of nitric oxide in angiogenesis and microcirculation in tumors.
Cancer Metastasis Rev. 1998;17(1):77-89 - PMID: 9544424 - DOI: 10.1023/a:1005908805527

Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK

Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.
J Invest Dermatol. 1998;111(1):1-6 - PMID: 9665379 - DOI: 10.1046/j.1523-1747.1998.00262.x

Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E, Keshet E

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature. 1998;394(6692):485-90 - PMID: 9697772 - DOI: 10.1038/28867

Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B

Tumor induction of VEGF promoter activity in stromal cells.
Cell. 1998;94(6):715-25 - PMID: 9753319 - DOI: 10.1016/s0092-8674(00)81731-6

Boucher Y, Brekken C, Netti PA, Baxter LT, Jain RK

Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
Br J Cancer. 1998;78(11):1442-8 - PMID: 9836476 - PMCID: PMC2063228 - DOI: 10.1038/bjc.1998.705

Jain RK

Tumor Microcirculation: Role in Drug and Nutrient Delivery
In: Advances in Blood Substitutes, Eds, R.M. Winslow, K. D. Vandegriff, and M. Intaglietta, Birkhuser, Boston. 1997;:46-70

Jain RK

Delivery of Molecular Medicine to Solid Tumors
In: Microcirculation Annual 1997, M. Tsuchiya, M. Asano and N. Sato, Eds, Nihon-Igakukan, Tokyo. 1997;13:1-5

Jain RK

Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection and Treatment
In: Tumor Angiogenesis, R. Bicknell, C. Lewis and N. Ferrara, Eds, Oxford University Press, Oxford. 1997;:45-59

Jain RK

Tumor Microcirculation: Role in Delivery of Molecular and Cellular Medicine
In: The Biology of Tumors, Proceedings of the Ninth Annual Pezcoller Symposium on the Biology of Tumors, Rovereto, Italy. 1997;:319-345

Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK

Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors
AIChE Journal. 1997;43:818-834

Kristensen CA, Roberge S, Jain RK

Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.
Clin Cancer Res. 1997;3(3):319-24 - PMID: 10026014

Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK

Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Microcirculation. 1997;4(4):395-402 - PMID: 9431507 - DOI: 10.3109/10739689709146803

Jain RK, Schlenger K, Höckel M, Yuan F

Quantitative angiogenesis assays: progress and problems.
Nat Med. 1997;3(11):1203-8 - PMID: 9359693 - DOI: 10.1038/nm1197-1203

Griffon-Etienne G, Boucher Y, Jain RK, Suit HD

Effects of needle insertion in tumors on interstitial fluid pressure.
Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037

Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CG, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, Suit HD

Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.
J Surg Oncol. 1997;66(1):30-8 - PMID: 9290690 - DOI: 10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o

Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK

Solid stress inhibits the growth of multicellular tumor spheroids.
Nat Biotechnol. 1997;15(8):778-83 - PMID: 9255794 - DOI: 10.1038/nbt0897-778

Leunig M, Yuan F, Gerweck LE, Jain RK

Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice.
Int J Microcirc Clin Exp. 1997;17(1):1-9 - PMID: 9176719 - DOI: 10.1159/000179199

Baish JW, Netti PA, Jain RK

Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Microvasc Res. 1997;53(2):128-41 - PMID: 9143544 - DOI: 10.1006/mvre.1996.2005

Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK

Geometric resistance and microvascular network architecture of human colorectal carcinoma.
Microcirculation. 1997;4(1):25-33 - PMID: 9110281 - DOI: 10.3109/10739689709148315

Jain RK

The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Microcirculation. 1997;4(1):1-23 - PMID: 9110280 - DOI: 10.3109/10739689709148314

Briscoe DM, Ganz P, Alexander SI, Melder RJ, Jain RK, Cotran RS, Lichtman AH

The problem of chronic rejection: influence of leukocyte-endothelial interactions.
Kidney Int Suppl. 1997;58:S22-7 - PMID: 9067938

Berk DA, Yuan F, Leunig M, Jain RK

Direct in vivo measurement of targeted binding in a human tumor xenograft.
Proc Natl Acad Sci U S A. 1997;94(5):1785-90 - PMID: 9050856 - PMCID: PMC19994 - DOI: 10.1073/pnas.94.5.1785

Helmlinger G, Yuan F, Dellian M, Jain RK

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nat Med. 1997;3(2):177-82 - PMID: 9018236 - DOI: 10.1038/nm0297-177

Boucher Y, Salehi H, Witwer B, Harsh GR, Jain RK

Interstitial fluid pressure in intracranial tumours in patients and in rodents.
Br J Cancer. 1997;75(6):829-36 - PMID: 9062403 - PMCID: PMC2063404 - DOI: 10.1038/bjc.1997.148

Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
Science. 1997;276(5317):1423-5 - PMID: 9162011 - DOI: 10.1126/science.276.5317.1423

Fukumura D, Yuan F, Monsky WL, Chen Y, Jain RK

Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
Am J Pathol. 1997;151(3):679-88 - PMID: 9284816 - PMCID: PMC1857859

Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJ

Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.
Am J Pathol. 1997;150(6):2099-112 - PMID: 9176401 - PMCID: PMC1858325

Jain RK

Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 1997;26(2-3):71-90 - PMID: 10837535 - DOI: 10.1016/s0169-409x(97)00027-6

Melder RJ, Koenig GC, Munn LL, Jain RK

Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.
Nat Immun. 1997;15(2-3):154-63 - PMID: 9162265

Fukumura D, Yuan F, Endo M, Jain RK

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.
Am J Pathol. 1997;150(2):713-25 - PMID: 9033284 - PMCID: PMC1858293

Zhu H, Baxter LT, Jain RK

Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.
J Nucl Med. 1997;38(5):731-41 - PMID: 9170438

Jain RK

Solid Tumor Barriers to Anticancer Drugs.
Cope. 1996;12:22-23

Saltzman WM, Jain RK

Drug Delivery: Barriers to Drug Transport and the Design of Novel Therapeutic Agents.
Molecular Medicine Today. 1996;1:4

Kristjansen PE, Brown TJ, Shipley LA, Jain RK

Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
Clin Cancer Res. 1996;2(2):359-67 - PMID: 9816179

Lichtenbeld HC, Yuan F, Michel CC, Jain RK

Perfusion of single tumor microvessels: application to vascular permeability measurement.
Microcirculation. 1996;3(4):349-57 - PMID: 9086446 - DOI: 10.3109/10739689609148307

Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK

Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Microvasc Res. 1996;51(3):327-46 - PMID: 8992232 - DOI: 10.1006/mvre.1996.0031

Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Proc Natl Acad Sci U S A. 1996;93(25):14765-70 - PMID: 8962129 - PMCID: PMC26210 - DOI: 10.1073/pnas.93.25.14765

Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS

Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Biophys J. 1996;71(5):2656-68 - PMID: 8913603 - PMCID: PMC1233752 - DOI: 10.1016/S0006-3495(96)79457-2

Dellian M, Helmlinger G, Yuan F, Jain RK

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
Br J Cancer. 1996;74(8):1206-15 - PMID: 8883406 - PMCID: PMC2075944 - DOI: 10.1038/bjc.1996.518

Jain RK

1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Ann Biomed Eng. 1996;24(4):457-73 - PMID: 8841721 - DOI: 10.1007/BF02648108

Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.
Acta Orthop Scand. 1996;67(4):383-8 - PMID: 8792744 - DOI: 10.3109/17453679609002336

Zhu H, Melder RJ, Baxter LT, Jain RK

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Cancer Res. 1996;56(16):3771-81 - PMID: 8706023

Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.
Am J Pathol. 1996;149(1):59-71 - PMID: 8686763 - PMCID: PMC1865247

Nozue M, Lee I, Manning JM, Manning LR, Jain RK

Oxygenation in tumors by modified hemoglobins.
J Surg Oncol. 1996;62(2):109-14 - PMID: 8649036 - DOI: 10.1002/(SICI)1096-9098(199606)62:2<109::AID-JSO6>3.0.CO;2-C

Jain RK

Delivery of molecular medicine to solid tumors.
Science. 1996;271(5252):1079-80 - PMID: 8599082 - DOI: 10.1126/science.271.5252.1079

Leunig M, Yuan F, Gerweck LE, Berk DA, Jain RK

Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.
Res Exp Med (Berl). 1996;195(5):275-88 - PMID: 8578003 - DOI: 10.1007/BF02576798

Nozue M, Lee I, Hartford A, Tanda S, Suit H, Jain R

pO(2) measurement in murine tumors by Eppendorf 'Histograph'.
Int J Oncol. 1996;9(5):955-62 - PMID: 21541601 - DOI: 10.3892/ijo.9.5.955

Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK

Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer Res. 1996;56(5):964-68 - PMID: 8640786

Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ

Leukocyte-endothelial adhesion and angiogenesis in tumors.
Cancer Metastasis Rev. 1996;15(2):195-204 - PMID: 8842491 - DOI: 10.1007/BF00437472

Kristensen CA, Nozue M, Boucher Y, Jain RK

Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
Br J Cancer. 1996;74(4):533-6 - PMID: 8761366 - PMCID: PMC2074665 - DOI: 10.1038/bjc.1996.397

Boucher Y, Leunig M, Jain RK

Tumor angiogenesis and interstitial hypertension.
Cancer Res. 1996;56(18):4264-6 - PMID: 8797602

Munn LL, Melder RJ, Jain RK

Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.
Biophys J. 1996;71(1):466-78 - PMID: 8804629 - PMCID: PMC1233497 - DOI: 10.1016/S0006-3495(96)79248-2

Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK

During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.
Nat Med. 1996;2(9):992-7 - PMID: 8782456 - DOI: 10.1038/nm0996-992

Patan S, Munn LL, Jain RK

Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.
Microvasc Res. 1996;51(2):260-72 - PMID: 8778579 - DOI: 10.1006/mvre.1996.0025

Skalak R, Zargaryan S, Jain RK, Netti PA, Hoger A

Compatibility and the genesis of residual stress by volumetric growth.
J Math Biol. 1996;34(8):889-914 - PMID: 8858855 - DOI: 10.1007/BF01834825

Johnson EM, Berk DA, Jain RK, Deen WM

Hindered diffusion in agarose gels: test of effective medium model.
Biophys J. 1996;70(2):1017-23 - PMID: 8789119 - PMCID: PMC1225002 - DOI: 10.1016/S0006-3495(96)79645-5

Berk DA, Swartz MA, Leu AJ, Jain RK

Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching.
Am J Physiol. 1996;270(1 Pt 2):H330-7 - PMID: 8769769 - DOI: 10.1152/ajpheart.1996.270.1.H330

Swartz MA, Berk DA, Jain RK

Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory.
Am J Physiol. 1996;270(1 Pt 2):H324-9 - PMID: 8769768 - DOI: 10.1152/ajpheart.1996.270.1.H324

Baxter LT, Jain RK

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.
Br J Cancer. 1996;73(4):447-56 - PMID: 8595158 - PMCID: PMC2074453 - DOI: 10.1038/bjc.1996.80

Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK

Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Microvasc Res. 1996;52(1):27-46 - PMID: 8812751 - DOI: 10.1006/mvre.1996.0041

Jain RK, Janda KD, Saltzman WM

Drug discovery and delivery.
Mol Med Today. 1995;1(1):4 - PMID: 9415129 - DOI: 10.1016/1357-4310(95)80005-0

Melder RJ, Salehi HA, Jain RK

Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.
Microvasc Res. 1995;50(1):35-44 - PMID: 7476578 - DOI: 10.1006/mvre.1995.1036

Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Cancer Res. 1995;55(17):3752-6 - PMID: 7641188

Boucher Y, Lee I, Jain RK

Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Microvasc Res. 1995;50(2):175-82 - PMID: 8538498 - DOI: 10.1006/mvre.1995.1051

Zlotecki RA, Baxter LT, Boucher Y, Jain RK

Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Microvasc Res. 1995;50(3):429-43 - PMID: 8583955 - DOI: 10.1006/mvre.1995.1069

Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK

Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer Res. 1995;55(22):5451-8 - PMID: 7585615

Gazit Y, Berk DA, Leunig M, Baxter LT, Jain RK

Scale-invariant behavior and vascular network formation in normal and tumor tissue.
Phys Rev Lett. 1995;75(12):2428-2431 - PMID: 10059301 - DOI: 10.1103/PhysRevLett.75.2428

Munn LL, Koenig GC, Jain RK, Melder RJ

Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.
Biotechniques. 1995;19(4):622-6, 628-31 - PMID: 8777057

Yamada S, Mayadas TN, Yuan F, Wagner DD, Hynes RO, Melder RJ, Jain RK

Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin.
Blood. 1995;86(9):3487-92 - PMID: 7579454

Baxter LT, Zhu H, Mackensen DG, Butler WF, Jain RK

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.
Cancer Res. 1995;55(20):4611-22 - PMID: 7553638

Yamada S, Melder RJ, Leunig M, Ohkubo C, Jain RK

Leukocyte rolling increases with age.
Blood. 1995;86(12):4707-8 - PMID: 8541569

Melder RJ, Munn LL, Yamada S, Ohkubo C, Jain RK

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.
Biophys J. 1995;69(5):2131-8 - PMID: 8580357 - PMCID: PMC1236447 - DOI: 10.1016/S0006-3495(95)80087-1

Fukumura D, Salehi HA, Witwer B, Tuma RF, Melder RJ, Jain RK

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.
Cancer Res. 1995;55(21):4824-9 - PMID: 7585514

Johnson EM, Berk DA, Jain RK, Deen WM

Diffusion and partitioning of proteins in charged agarose gels.
Biophys J. 1995;68(4):1561-8 - PMID: 7787041 - PMCID: PMC1282050 - DOI: 10.1016/S0006-3495(95)80328-0

Jain RK

Tumor Microcirculation: Role in Cancer Diagnosis and Treatment
In: Progress in Microcirculation Research, H. Niimi, et al, Eds., Pergamon Press, Tarrytown. 1994;:29-36

Jain RK

Transport Phenomena in Tumors
Advances in Chemical Engineering. 1994;20:129-200

Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.
Br J Cancer. 1994;69(1):101-3 - PMID: 8286189 - PMCID: PMC1968758 - DOI: 10.1038/bjc.1994.15

Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK

Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684 - DOI: 10.1093/jnci/86.4.293

Baxter LT, Zhu H, Mackensen DG, Jain RK

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Cancer Res. 1994;54(6):1517-28 - PMID: 8137258

Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313 - DOI: 10.1073/pnas.91.6.2081

Jain RK

Barriers to drug delivery in solid tumors.
Sci Am. 1994;271(1):58-65 - PMID: 8066425 - DOI: 10.1038/scientificamerican0794-58

Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Cancer Res. 1994;54(13):3352-6 - PMID: 8012948

Hamberg LM, Kristjansen PE, Hunter GJ, Wolf GL, Jain RK

Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.
Cancer Res. 1994;54(23):6032-6 - PMID: 7954440

Leu AJ, Berk DA, Yuan F, Jain RK

Flow velocity in the superficial lymphatic network of the mouse tail.
Am J Physiol. 1994;267(4 Pt 2):H1507-13 - PMID: 7943396 - DOI: 10.1152/ajpheart.1994.267.4.H1507

Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK

A method for labeling cells for positron emission tomography (PET) studies.
J Immunol Methods. 1994;175(1):79-87 - PMID: 7930641 - DOI: 10.1016/0022-1759(94)90333-6

Melder RJ, Jain RK

Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.
J Immunol Methods. 1994;175(1):69-77 - PMID: 7930640 - DOI: 10.1016/0022-1759(94)90332-8

Martin GR, Jain RK

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.
Cancer Res. 1994;54(21):5670-4 - PMID: 7923215

Kristjansen PE, Roberge S, Lee I, Jain RK

Tissue-isolated human tumor xenografts in athymic nude mice.
Microvasc Res. 1994;48(3):389-402 - PMID: 7731400 - DOI: 10.1006/mvre.1994.1063

Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.
Lab Invest. 1994;71(2):300-7 - PMID: 7521447

Melder RJ, Jain RK

Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells.
Cell Biophys. 1994;20(2-3):161-76 - PMID: 1285298 - DOI: 10.1007/BF02823656

Lee I, Boucher Y, Demhartner TJ, Jain RK

Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.
Br J Cancer. 1994;69(3):492-6 - PMID: 8123479 - PMCID: PMC1968875 - DOI: 10.1038/bjc.1994.89

Lee I, Demhartner TJ, Boucher Y, Jain RK, Intaglietta M

Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.
Microvasc Res. 1994;48(1):1-12 - PMID: 7990716 - DOI: 10.1006/mvre.1994.1034

Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.
Cancer Res. 1994;54(17):4564-8 - PMID: 8062241

Munn LL, Melder RJ, Jain RK

Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.
Biophys J. 1994;67(2):889-95 - PMID: 7948702 - PMCID: PMC1225432 - DOI: 10.1016/S0006-3495(94)80550-8

Melder RJ, Jain RK

Delivery of Effector Cells to Tumors
In: '93 Recent Advances in Cancer Research, J.G. Park, Ed., Seoul National University, Seoul. 1993;:202-217

Jain RK

Physiological Resistance to the Treatment of Solid Tumors
In: Drug Resistance in Oncology, B. Teicher, Ed., M. Dekker, New York. 1993;Chapter 4:87-105

Jain RK, Baxter LT

Extravasation and Interstitial Transport in Tumors
In: Biological Barriers to Protein Delivery, K.L. Audus and T.J. Raub, Eds., Plenum Press, New York. 1993;Chapter 15:441-465

Eskey CJ, Koretsky AP, Domach MM, Jain RK

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Proc Natl Acad Sci U S A. 1993;90(7):2646-50 - PMID: 8464871 - PMCID: PMC46152 - DOI: 10.1073/pnas.90.7.2646

Yuan F, Leunig M, Berk DA, Jain RK

Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Microvasc Res. 1993;45(3):269-89 - PMID: 8321142 - DOI: 10.1006/mvre.1993.1024

Berk DA, Yuan F, Leunig M, Jain RK

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Biophys J. 1993;65(6):2428-36 - PMID: 8312481 - PMCID: PMC1225983 - DOI: 10.1016/S0006-3495(93)81326-2

Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK

Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.
Cancer Res. 1993;53(24):5867-71 - PMID: 8261395

Martin GR, Jain RK

Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.
Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048

Zlotecki RA, Boucher Y, Lee I, Baxter LT, Jain RK

Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.
Cancer Res. 1993;53(11):2466-8 - PMID: 8495405

Kristjansen PE, Boucher Y, Jain RK

Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.
Cancer Res. 1993;53(20):4764-6 - PMID: 8402656

Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, Messmer K

Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.
Cancer Res. 1992;52(2):487-90 - PMID: 1728421

Kaufman EN, Jain RK

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Cancer Res. 1992;52(15):4157-67 - PMID: 1638531

Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, Jain RK

Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.
Cancer Res. 1992;52(7):1993-5 - PMID: 1551128

Eskey CJ, Koretsky AP, Domach MM, Jain RK

2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.
Cancer Res. 1992;52(21):6010-9 - PMID: 1394226

Baxter LT, Yuan F, Jain RK

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Cancer Res. 1992;52(20):5838-44 - PMID: 1394212

Kaufman EN, Jain RK

In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching.
J Immunol Methods. 1992;155(1):1-17 - PMID: 1383343 - DOI: 10.1016/0022-1759(92)90265-u

Lee I, Boucher Y, Jain RK

Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Cancer Res. 1992;52(11):3237-40 - PMID: 1534273

Boucher Y, Jain RK

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.
Cancer Res. 1992;52(18):5110-4 - PMID: 1516068

Less JR, Posner MC, Boucher Y, Borochovitz D, Wolmark N, Jain RK

Interstitial hypertension in human breast and colorectal tumors.
Cancer Res. 1992;52(22):6371-4 - PMID: 1423283

Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, Jain RK

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
Cancer Res. 1992;52(23):6553-60 - PMID: 1384965

Ward KA, Jain RK

Blood Flow Response to Hyperglycemia.
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub

Sevick EM, Jain RK

Viscous Resistance to Blood Flow in the Tumor Microcirculation: Clinical Implications.
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub

Baxter LT, Jain RK

Vascular and Interstitial Transport in Tumors
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub

Jain RK

Parameters Governing Tumor Blood Flow
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub

Ward KA, DiPette DJ, Held TN, Jain RK

Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1991;51(13):3612-6 - PMID: 2054796

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Microvasc Res. 1991;41(2):252-72 - PMID: 2051960 - DOI: 10.1016/0026-2862(91)90026-8

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Microvasc Res. 1991;41(1):5-23 - PMID: 2051954 - DOI: 10.1016/0026-2862(91)90003-t

Sasaki A, Melder RJ, Whiteside TL, Herberman RB, Jain RK

Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.
J Natl Cancer Inst. 1991;83(6):433-7 - PMID: 1999850 - DOI: 10.1093/jnci/83.6.433

Sevick EM, Jain RK

Measurement of capillary filtration coefficient in a solid tumor.
Cancer Res. 1991;51(4):1352-5 - PMID: 1997172

Jain RK

Therapeutic implications of tumor physiology.
Curr Opin Oncol. 1991;3(6):1105-8 - PMID: 1843113 - DOI: 10.1097/00001622-199112000-00020

Jain RK

Haemodynamic and transport barriers to the treatment of solid tumours.
Int J Radiat Biol. 1991;60(1-2):85-100 - PMID: 1678003 - DOI: 10.1080/09553009114551621

Kaufman EN, Jain RK

Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime.
Biophys J. 1991;60(3):596-610 - PMID: 1932550 - PMCID: PMC1260103 - DOI: 10.1016/S0006-3495(91)82089-6

Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK

Interstitial hypertension in superficial metastatic melanomas in humans.
Cancer Res. 1991;51(24):6691-4 - PMID: 1742743

Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK

Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.
Cancer Res. 1991;51(24):6695-8 - PMID: 1742744

Yuan F, Baxter LT, Jain RK

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Cancer Res. 1991;51(12):3119-30 - PMID: 2039991

Sevick EM, Jain RK

Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Cancer Res. 1991;51(10):2727-30 - PMID: 2021951

Less JR, Skalak TC, Sevick EM, Jain RK

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Cancer Res. 1991;51(1):265-73 - PMID: 1988088

Ohkubo C, Bigos D, Jain RK

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Cancer Res. 1991;51(5):1561-3 - PMID: 1997196

Herberman RB, Basse P, Jain RK, Melder RJ, Goldfarb RH, Ernstoff MS, Kirkwood JM, Whiteside TL

Approaches to immunotherapy with defined populations of IL-2 cultured NK cells, immune T Cells or tumor infiltrating lymphocytes.
In: Biology and Clinical Applications of IL-2, R.C. Rees, Ed., Oxford University Press, London. 1990;Chapter 12:111-119

Jain RK

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Cancer Res. 1990;50(3 Suppl):814s-819s - PMID: 2404582

Clauss MA, Jain RK

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer Res. 1990;50(12):3487-92 - PMID: 2340499

Jain RK

Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Cancer Metastasis Rev. 1990;9(3):253-66 - PMID: 2292138 - DOI: 10.1007/BF00046364

Kaufman EN, Jain RK

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Biophys J. 1990;58(4):873-85 - PMID: 2248992 - PMCID: PMC1281033 - DOI: 10.1016/S0006-3495(90)82432-2

Jain RK

Tumor physiology and antibody delivery.
Front Radiat Ther Oncol. 1990;24:32-46; discussion 64-8 - PMID: 2187763

Boucher Y, Baxter LT, Jain RK

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer Res. 1990;50(15):4478-84 - PMID: 2369726

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Microvasc Res. 1990;40(2):246-63 - PMID: 2250603 - DOI: 10.1016/0026-2862(90)90023-k

Jain RK, Stock RJ, Chary SR, Rueter M

Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Microvasc Res. 1990;39(1):77-93 - PMID: 2314308 - DOI: 10.1016/0026-2862(90)90060-5

Chary SR, Jain RK

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.
Proc Natl Acad Sci U S A. 1989;86(14):5385-9 - PMID: 2748592 - PMCID: PMC297627 - DOI: 10.1073/pnas.86.14.5385

Sevick EM, Jain RK

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Cancer Res. 1989;49(13):3506-12 - PMID: 2731172

Jain RK

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
J Natl Cancer Inst. 1989;81(8):570-6 - PMID: 2649688 - DOI: 10.1093/jnci/81.8.570

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Microvasc Res. 1989;37(1):77-104 - PMID: 2646512 - DOI: 10.1016/0026-2862(89)90074-5

Sevick EM, Jain RK

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.
Cancer Res. 1989;49(13):3513-9 - PMID: 2731173

Sasaki A, Jain RK, Maghazachi AA, Goldfarb RH, Herberman RB

Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Cancer Res. 1989;49(14):3742-6 - PMID: 2500233

Maldarelli C, Jain RK

Stability of thin films: characterization and applications in industrial and biological systems.
Thin Liquid Films, I.B. Ivanov, Ed., M. Dekker, New York. 1988;:497-568

Jain RK

Transvascular and interstitial transport in tumors
Vascular Endothelium in Health and Disease, S. Chien (Ed.), Elsevier, Amsterdam . 1988;:215-220

Jain RK

Transport of molecules across tumor vasculature.
Cancer Metastasis Rev. 1988;6(4):559-93 - PMID: 3327633 - DOI: 10.1007/BF00047468

Ward KA, Jain RK

Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia.
Int J Hyperthermia. 1988;4(3):223-50 - PMID: 3290346 - DOI: 10.3109/02656738809051100

Jain RK

Determinants of tumor blood flow: a review.
Cancer Res. 1988;48(10):2641-58 - PMID: 3282647

DiPette DJ, Ward KA, Jain RK, Kerr NE, Schwarzenberger K

Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1988;48(6):1476-80 - PMID: 3345521

Jain RK, Baxter LT

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Cancer Res. 1988;48(24 Pt 1):7022-32 - PMID: 3191477

Baxter LT, Jain RK

Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.
Microvasc Res. 1988;36(1):108-15 - PMID: 3185299 - DOI: 10.1016/0026-2862(88)90043-x

Sevick EM, Jain RK

Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.
Cancer Res. 1988;48(5):1201-7 - PMID: 3342400

Jain RK

Tumor blood flow response to hyperthermia and pharmacological agents.
Radiation Research, E.M. Fieldman et al (eds.), Taylor and Francis, London. 1987;Volume 2:813-818

Jain RK

Interstitial transport in tumors.
Advances in Microcirculation. 1987;13:266-284

Chary SC, Jain RK

Analysis of diffusive and convective recovery after photobleaching-uniform flow field.
Chemical Engineering Commun. 1987;55:235-249

Ward-Hartley KA, Jain RK

Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.
Cancer Res. 1987;47(2):371-7 - PMID: 3791228

Traykov TT, Jain RK

Effect of glucose and galactose on red blood cell membrane deformability.
Int J Microcirc Clin Exp. 1987;6(1):35-44 - PMID: 3583577

Baxter LT, Jain RK, Svensjö E

Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Microvasc Res. 1987;34(3):336-48 - PMID: 2448593 - DOI: 10.1016/0026-2862(87)90066-5

Jain RK, Ward-Hartley KA

Dynamics of cancer cell interactions with microvasculature and interstitium.
Biorheology. 1987;24(2):117-25 - PMID: 3651585 - DOI: 10.3233/bir-1987-24205

Jain RK

Transport of molecules in the tumor interstitium: a review.
Cancer Res. 1987;47(12):3039-51 - PMID: 3555767

DiPette D, Ward-Hartley K, Jain RK

Effect of hyperglycemia on systemic hemodynamics and blood flow rate in normal and neoplastic tissues in rats
Cancer Res. 1986;46:6299-6304

Traykov TT, Jain RK

Effect of transmembrane potential on the deformability of RBC's suspended in carbohydrate-saline solutions.
J Colloid and Interface Science. 1986;114:273-276

Traykov TT, Jain RK

Effect of glucose, galactose, and transmembrane potential on shear elastic modulus of erythrocyte membrane.
AIChE Symposium Series. 1986;82:190-194

Gerlowski LE, Jain RK

Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Int J Microcirc Clin Exp. 1986;4(4):363-72 - PMID: 4086191

Jain RK, Gerlowski LE

Extravascular transport in normal and tumor tissues.
Crit Rev Oncol Hematol. 1986;5(2):115-70 - PMID: 3521923 - DOI: 10.1016/s1040-8428(86)80023-3

DiPette DJ, Ward-Hartley KA, Jain RK

Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1986;46(12 Pt 1):6299-304 - PMID: 3779648

Gerlowski LE, Jain RK

Microvascular permeability of normal and neoplastic tissues.
Microvasc Res. 1986;31(3):288-305 - PMID: 2423854 - DOI: 10.1016/0026-2862(86)90018-x

Jain RK

Analysis of heat transfer and temperature distributions in tissues during local and whole body hyperthermia
Heat Transfer in Medicine and Biology, A. Shitzer and R. Eberhart, Eds., Plenum Press, New York, Volume 2. 1985;Chapter 16:3-54

Ivanov B, Dimitrov DS, Somasundaran P, Jain RK

Thinning of films with deformable surfaces: diffusion-controlled surfactant transfer
Chemical Engineering Science. 1985;40:137-150

Dimitrov DS, Zhelev DV, Jain RK

Stability of membrane systems modeled as multilayered viscoelastic films.
J Theor Biol. 1985;113(2):353-77 - PMID: 3999781 - DOI: 10.1016/s0022-5193(85)80232-0

Jain RK

Transport of macromolecules in tumor microcirculation.
Biotechnol Prog. 1985;1(2):81-94 - PMID: 20568145 - DOI: 10.1002/btpr.5420010205

Jain RK

Mass and heat transfer in tumors: applications in detection and treatment
Advances in Transport Processes. 1984;3:205-339

Jain RK, Ward-Hartley KA

Tumor blood flow: characterization, modifications and role in hyperthermia
IEEE Transactions in Sonics and Ultrasonics; Special Issue on Hyperthermia. 1984;31:504-526

Dimitrov DS, Jain RK

Stability of thin viscoelastic films between permeable membranes
J Colloid and Interface Science. 1984;101:489-499

Dimitrov DS, Li J, Angelova M, Jain RK

Surface effects in preparation of cell-size liposomes.
FEBS Letters. 1984;176:398-400

Dudar TE, Jain RK

Differential response of normal and tumor microcirculation to hyperthermia.
Cancer Res. 1984;44(2):605-12 - PMID: 6692365

Peloso R, Tuma DT, Jain RK

Dielectric properties of solid tumors during normothermia and hyperthermia.
IEEE Trans Biomed Eng. 1984;31(11):725-8 - PMID: 6500596 - DOI: 10.1109/TBME.1984.325399

Dimitrov DS, Jain RK

Membrane stability.
Biochim Biophys Acta. 1984;779(4):437-68 - PMID: 6391549 - DOI: 10.1016/0304-4157(84)90020-0

Nugent LJ, Jain RK

Extravascular diffusion in normal and neoplastic tissues.
Cancer Res. 1984;44(1):238-44 - PMID: 6197161

Nugent LJ, Jain RK

Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed.
Am J Physiol. 1984;246(1 Pt 2):H129-37 - PMID: 6198927 - DOI: 10.1152/ajpheart.1984.246.1.H129

Jain RK, Shah SA, Finney PL

Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.
J Natl Cancer Inst. 1984;73(2):429-36 - PMID: 6589435 - DOI: 10.1093/jnci/73.2.429

Nugent LJ, Jain RK

Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.
Microvasc Res. 1984;28(2):270-4 - PMID: 6209533 - DOI: 10.1016/0026-2862(84)90022-0

Nugent LJ, Jain RK

Two-compartment model for plasma pharmacokinetics in individual blood vessels.
J Pharmacokinet Biopharm. 1984;12(4):451-61 - PMID: 6084709 - DOI: 10.1007/BF01062668

Jain RK

Bioheat transfer: mathematical models of thermal systems.
Hyperthermia in Cancer Therapy, F.K. Storm, Ed., G.K. Hall and Co., Boston. 1983;Chapter 2:9-46

Dudar TE, Jain RK

Mathematical models for microcirculatory changes during hyperthermia in normal and neoplastic tissues
AIChE Symposium Series 227. 1983;79:153-162

Nugent LJ, Jain RK

Interstitial diffusion of macromolecules in normal and tumor capillary beds
AIChE Symposium Series 227. 1983;79:1-10

Jain RK, Maldarelli C

Stability of thin viscoelastic films with applications to biological membrane deformation.
Annals of New York Academy of Sciences. 1983;404:89-102

Volpe BT, Jain RK

Temperature distributions and thermal response in humans. II. Simulation of whole-body, regional and localized hyperthermia in cancer patients
AIChE Symposium Series 227. 1983;79:116-123

Shah SA, Jain RK, Finney PL

Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma.
Adv Exp Med Biol. 1983;157:23-42 - PMID: 7158522 - DOI: 10.1007/978-1-4684-4388-2_4

Dudar TE, Jain RK

Microcirculatory flow changes during tissue growth.
Microvasc Res. 1983;25(1):1-21 - PMID: 6188025 - DOI: 10.1016/0026-2862(83)90040-7

Shah SA, Jain RK, Finney PL

Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.
Cancer Lett. 1983;19(3):317-23 - PMID: 6883314 - DOI: 10.1016/0304-3835(83)90101-5

Gerlowski LE, Jain RK

Physiologically based pharmacokinetic modeling: principles and applications.
J Pharm Sci. 1983;72(10):1103-27 - PMID: 6358460 - DOI: 10.1002/jps.2600721003

Shah SA, Jain RK, Finney PL

Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rats bearing W256 carcinosarcoma
Hyperthermia, H.I. Bicher and D.F. Bruley, eds., Plenum Publishing Corporation, New York. 1982;:23-42

Maldarelli C, Jain RK

The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film II. Extension of the theory to the study of the onset of small-scale cell membrane motions.
J. Colloid and Interface Science. 1982;90:263-276

Maldarelli C, Jain RK

The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. I. General formulation and a derivation of the dispersion equation.
J. Colloid and Interface Science. 1982;90:233-262

Grossmann IE, Drabbant RD, Jain RK

Incorporating toxicology in the synthesis of industrial chemical complexes
Chemical Engineering Commun. 1982;17:151-170

Townsend JG, Jain RK, Cashmore AR

In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.
J Pharm Sci. 1982;71(10):1102-5 - PMID: 7143204 - DOI: 10.1002/jps.2600711005

Gullino PM, Jain RK, Grantham FH

Temperature gradients and local perfusion in a mammary carcinoma.
J Natl Cancer Inst. 1982;68(3):519-33 - PMID: 6950181

Volpe BT, Jain RK

Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.
Med Phys. 1982;9(4):506-13 - PMID: 7110081 - DOI: 10.1118/1.595115

Nugent LJ, Jain RK

Monitoring transport in the rabbit ear chamber.
Microvasc Res. 1982;24(2):204-9 - PMID: 7176939 - DOI: 10.1016/0026-2862(82)90057-7

Jain RK, Gerlowski L, Weissbrod J, Wang J, Pierson RN, Jr

Kinetics of uptake, distribution and excretion of zinc in rats.
Annals of Biomedical Engineering. 1981;9:347-361

Zawicki DF, Jain RK, Schmid-Schoenbein GW, Chien S

Dynamics of neovascularization in normal tissue.
Microvasc Res. 1981;21(1):27-47 - PMID: 7010086 - DOI: 10.1016/0026-2862(81)90003-0

Jain RK, Weissbrod JM, Wei J

Mass transport in tumors: characterization and applications to chemotherapy.
Adv Cancer Res. 1981;33:251-310 - PMID: 7006335 - DOI: 10.1016/s0065-230x(08)60672-7

Jain RK

Heat transfer in tumors: characterization and applications to thermography and hyperthermia.
Advances in Biomedical Engineering, edited by D.O. Cooney, Marcel Dekker, Inc., New York, Part I. 1980;Chapter 2:59-91

Jain RK, Ivanov IB

Thinning and rupture of ring-shaped films
J Chemical Society, Faraday Transactions II. 1980;76:250-266

Sien HP, Jain RK

Intratumour temperature distributions during hyperthermia
J Thermal Biology. 1980;5:127-130

Jain RK, Gullino PM

Analysis of transient temperature distribution in a perfused medium Due to a spherical heat source with application to heat transfer in tumors: homogeneous and infinite medium
Chemical Engineering Commun. 1980;4:95-118

Maldarelli C, Jain RK, Ivanov IB, Ruckenstein E

Stability of symmetric and unsymmetric, thin liquid films to short and long wavelength perturbations
J Colloid and Interface Science. 1980;78:118-143

Jain RK

Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.
Ann N Y Acad Sci. 1980;335:48-66 - PMID: 6931539 - DOI: 10.1111/j.1749-6632.1980.tb50736.x

Weissbrod JM, Jain RK

Preliminary model for streptozocin metabolism in mice.
J Pharm Sci. 1980;69(6):691-4 - PMID: 6451687 - DOI: 10.1002/jps.2600690621

Chryanthopoulos GS, Jain RK

Thermal interactions between normal and neoplastic tissues in the rat, rabbit, swine, and dog during hyperthermia.
Med Phys. 1980;7(5):529-39 - PMID: 7421764 - DOI: 10.1118/1.594668

Ivanov IB, Jain RK, Somasundaran P, Traykov TT

The role of surfactants on the coalescences of emulsion droplets
Solution Chemistry of Surfactants, edited by K.A. Mittal, Plenum Press, New York. 1979;2:817-840

Jain RK, Ivanov IB, Maldarelli C, Ruckenstein E

Instability and rupture of thin liquid films
Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:140-167

Ivanov IB, Jain RK

Formation and thinning of thin liquid films
Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:120-139

Jain RK

Transient temperature distributions in an infinite perfused medium due to a time-dependent, spherical heat source
Trans. ASME J. Biomechanical Engineering. 1979;101:82-86

Tzeghai G, Jain RK

A semi-empirical model for cell kill kinetics during hyperthermia.
J Thermal Biology. 1979;4:257-258

Sien HP, Jain RK

Temperature distributions in normal and neoplastic tissues during hyperthermia: a lumped parameter model
J Thermal Biology. 1979;4:157-164

Jain RK, Wei J, Gullino PM

Pharmacokinetics of methotrexate in solid tumors.
J Pharmacokinet Biopharm. 1979;7(2):181-94 - PMID: 20218013 - DOI: 10.1007/BF01059737

Jain RK, Grantham FH, Gullino PM

Blood flow and heat transfer in Walker 256 mammary carcinoma.
J Natl Cancer Inst. 1979;62(4):927-33 - PMID: 285296

Jain RK, Maldarelli C, Ruckenstein E

Onset of microvilli in normal and neoplastic cells.
AIChE Symposium Series, Biorheology. 1978;74:120-124

Jain RK

Effect of inhomogeneities and finite boundaries on temperature distribution in a perfused medium with application to tumors
Trans. ASME J. Biomechanical Engineering. 1978;100:235-241

Weissbrod JM, Jain RK, Sirotnak FM

Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.
J Pharmacokinet Biopharm. 1978;6(6):487-503 - PMID: 731413 - DOI: 10.1007/BF01062105

Pierson RN, Price DC, Wang J, Jain RK

Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man.
Am J Physiol. 1978;235(3):F254-64 - PMID: 696835 - DOI: 10.1152/ajprenal.1978.235.3.F254

Jain RK, Wei J

Dynamics of drug transport in solid tumors: distributed parameter model
J Bioengineering. 1977;1:313-329

Jain RK, Denn MM

Short term regulation of BOD upsets in an estuary
Trans. ASME J. Dynamic Systems, Measurement and Control. 1976;98, Series G:30-31

Jain RK, Ruckenstein E

Stability of stagnant viscous films on a solid surface
J Colloid and Interface Science. 1976;54:108-116

Ruckenstein E, Jain RK

Spontaneous rupture of thin liquid films
J Chemical Society, Faraday Transactions II. 1974;70:132-147
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