Jain Lab

Krishnan S, Lee S, Amoozgar Z, Subudhi S, Srinivasan Kumar A, Posada JM, Lindeman N, Lei P, Duquette M, Steinbuch S, Charabati M, Huang P, Andersson P, Datta M, Munn LL, Fukumura D, Jain RK

Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma.
Proc Natl Acad Sci U S A. 2025;122(38):e2414941122 - PMID: 40953263 - PMCID: PMC12478157 - DOI: 10.1073/pnas.2414941122

Hadjigeorgiou AG, Munn LL, Stylianopoulos T, Jain RK

Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors.
bioRxiv. 2025;:ePub - PMID: 40894718 - PMCID: PMC12393523 - DOI: 10.1101/2025.08.20.671229

Munn LL, Jain RK

Challenges and opportunities for the next generation of computational tumor models.
PLoS Biol. 2025;23(7):e3003269 - PMID: 40700394 - PMCID: PMC12286354 - DOI: 10.1371/journal.pbio.3003269

Hale AT, Kalailingam P, Kundishora AJ, Reeves BC, Brastianos PK, Shih HA, Jain RK, Ning M, Stapleton CJ, Patel AB, Smith ER, Chapman PH, Rabinov JD, Kleinstiver BP, Musolino PL, Kahle KT

An opportune time for targeted brain arteriovenous malformation therapy.
J Neurosurg. 2025;:1-4 - PMID: 40644723 - PMCID: PMC12477702 - DOI: 10.3171/2025.4.JNS25260

Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LH, Singh A, Fu J, Waterton SK, Cheng YC, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA

Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.
Immunity. 2025;58(7):1688-1705.e9 - PMID: 40592342 - PMCID: PMC12233199 - DOI: 10.1016/j.immuni.2025.06.005

Voutouri C, Munn LL, Stylianopoulos T, Jain RK

Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions.
PLoS Comput Biol. 2025;21(6):e1013163 - PMID: 40504865 - PMCID: PMC12201673 - DOI: 10.1371/journal.pcbi.1013163

Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK

Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
Clin Cancer Res. 2025;31(16):3571-3580 - PMID: 40495423 - PMCID: PMC12351280 - DOI: 10.1158/1078-0432.CCR-24-4159

Hadjigeorgiou AG, Harkos C, Mishra AK, Morad G, Johnson SB, Ajami NJ, Wargo JA, Munn LL, Stylianopoulos T, Jain RK

Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy.
Cancer Res. 2025;85(16):3139-3155 - PMID: 40439571 - PMCID: PMC12355177 - DOI: 10.1158/0008-5472.CAN-24-2232

Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR, Neurofibromatosis Clinical Trials Consortium

Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104.
J Neurooncol. 2025;173(3):751-757 - PMID: 40434540 - DOI: 10.1007/s11060-025-05020-1

Talele NP, Kumra H, Gomes-Santos IL, Ho WW, Andersson P, Siwicki M, Huang P, Duda DG, Pittet MJ, Fukumura D, Jain RK

IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity.
J Immunother Cancer. 2025;13(5):ePub - PMID: 40413022 - PMCID: PMC12104899 - DOI: 10.1136/jitc-2024-011404

Harkos C, Hadjigeorgiou AG, Voutouri C, Kumar AS, Stylianopoulos T, Jain RK

Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer.
Nat Rev Cancer. 2025;25(5):324-340 - PMID: 39972158 - DOI: 10.1038/s41568-025-00796-w

Ren J, Amoozgar Z, Uccello TP, Lei PJ, Zhao Y, Ho WW, Huang P, Kardian A, Mack SC, Duda DG, Xu L, Jain RK

Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma.
Proc Natl Acad Sci U S A. 2025;122(4):e2319474122 - PMID: 39841145 - PMCID: PMC11789170 - DOI: 10.1073/pnas.2319474122

Nia HT, Munn LL, Jain RK

Probing the physical hallmarks of cancer.
Nat Methods. 2025;22(9):1800-1818 - PMID: 39815103 - DOI: 10.1038/s41592-024-02564-4
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