Padera Lab

Fanning JE, Tsai LL, Amore MA, Crescenzi R, De Paepe KN, Donohoe KJ, Maki JH, Padera TP, Pieper CC, Reynolds HM, Suami H, Singhal D

Bringing to Light the Invisible Lymphatic Anatomy of the Upper Extremity: Report From the 2024 Harvard Radcliffe Institute Accelerator Workshop.
Ann Surg. 2025;:ePub - PMID: 40767571 - DOI: 10.1097/SLA.0000000000006893

Lei PJ, Padera TP

Closing in on pacemaker cells.
Elife. 2025;14:ePub - PMID: 40693539 - PMCID: PMC12283070 - DOI: 10.7554/eLife.108102

Mahfoud S, Padera TP

S1PR1, an endothelial-immune influencer.
J Exp Med. 2025;222(9):ePub - PMID: 40663043 - DOI: 10.1084/jem.20251056

Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP

A multiresolution approach with method-informed statistical analysis for quantifying lymphatic pumping dynamics.
Npj Imaging. 2025;3(1):2 - PMID: 40604254 - PMCID: PMC12091688 - DOI: 10.1038/s44303-024-00061-z

Roh K, Li H, Freeman RN, Zazzeron L, Lee A, Zhou C, Shen S, Xia P, Guerra JRB, Sheffield C, Padera TP, Zhou Y, Kim S, Aguirre A, Houstis N, Roh JD, Ichinose F, Malhotra R, Rosenzweig A, Rhee J

Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart.
Aging Cell. 2025;24(6):e70043 - PMID: 40083143 - PMCID: PMC12151892 - DOI: 10.1111/acel.70043

Westcott GP, Emont MP, Gulko A, Zhou Z, Kim C, Varma G, Tsai LL, O'Donnell E, Loureiro ZY, Liang W, Jacobs C, Tsai LT, Padera TP, Singhal D, Rosen ED

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population.
bioRxiv. 2025;:ePub - PMID: 40027673 - PMCID: PMC11870541 - DOI: 10.1101/2025.02.18.638907

Menzel L, Zschummel M, O'Melia MJ, Zhou H, Lei PJ, Liu L, Sen DR, Munn LL, Padera TP

Lymph nodes link sex-biased immune aging to compromised antigen recognition.
bioRxiv. 2025;:ePub - PMID: 39990447 - PMCID: PMC11844512 - DOI: 10.1101/2025.02.11.637693

Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Razavi MS, Zhou H, Menzel L, Huang L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Kurpios NA, Ubellacker JM, Padera TP

Aging-induced changes in lymphatic muscle cell transcriptomes are associated with reduced pumping of peripheral collecting lymphatic vessels in mice.
Dev Cell. 2024;60(7):1118-1133.e5 - PMID: 39731913 - PMCID: PMC11981864 - DOI: 10.1016/j.devcel.2024.12.010

Lei PJ, Fraser C, Jones D, Ubellacker JM, Padera TP

Lymphatic system regulation of anti-cancer immunity and metastasis.
Front Immunol. 2024;15:1449291 - PMID: 39211044 - PMCID: PMC11357954 - DOI: 10.3389/fimmu.2024.1449291

Li H, Zhang J, Padera TP, Baish JW, Munn LL

Fluid dynamics and leukocyte transit in the lymphatic system.
PNAS Nexus. 2024;3(6):pgae195 - PMID: 38827815 - PMCID: PMC11141778 - DOI: 10.1093/pnasnexus/pgae195

Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP

A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics.
bioRxiv. 2024;:ePub - PMID: 38712181 - PMCID: PMC11071510 - DOI: 10.1101/2024.04.24.590950

Razavi MS, Munn LL, Padera TP

Mechanics of Lymphatic Pumping and Lymphatic Function.
Cold Spring Harb Perspect Med. 2024;15(3):ePub - PMID: 38692743 - PMCID: PMC11875091 - DOI: 10.1101/cshperspect.a041171

Gruionu G, Baish J, McMahon S, Blauvelt D, Gruionu LG, Lenco MO, Vakoc BJ, Padera TP, Munn LL

Experimental and theoretical model of microvascular network remodeling and blood flow redistribution following minimally invasive microvessel laser ablation.
Sci Rep. 2024;14(1):8767 - PMID: 38627467 - PMCID: PMC11021487 - DOI: 10.1038/s41598-024-59296-w

Gruionu G, Baish J, McMahon S, Blauvelt D, Gruionu LG, Lenco MO, Vakoc BJ, Padera TP, Munn LL

Experimental and Theoretical Model of Single Vessel Minimally Invasive Micro-Laser Ablation: Inducing Microvascular Network Remodeling and Blood Flow Redistribution Without Compromising Host Tissue Function.
Res Sq. 2023;:ePub - PMID: 38196660 - PMCID: PMC10775362 - DOI: 10.21203/rs.3.rs-3754775/v1

Chen Z, Ghavimi SAA, Wu M, McNamara J, Barreiro O, Maridas D, Kratchmarov R, Siegel A, Djeddi S, Gutierrez-Arcelus M, Brennan PJ, Padera TP, von Andrian U, Mehrara B, Greene AK, Kahn CR, Orgill DP, Sinha I, Rosen V, Agarwal S

PPARγ; agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells.
JCI Insight. 2023;8(24):ePub - PMID: 38131378 - PMCID: PMC10807713 - DOI: 10.1172/jci.insight.165324

Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Arroyo-Ataz G, Razavi MS, Zhou H, Menzel L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Ubellacker JM, Jones D, Padera TP

Lymphatic muscle cells are unique cells that undergo aging induced changes.
bioRxiv. 2023;:ePub - PMID: 38014141 - PMCID: PMC10680808 - DOI: 10.1101/2023.11.18.567621

Nikmaneshi MR, Baish JW, Zhou H, Padera TP, Munn LL

Transport Barriers Influence the Activation of Anti-Tumor Immunity: A Systems Biology Analysis.
Adv Sci (Weinh). 2023;10(36):e2304076 - PMID: 37949675 - PMCID: PMC10754116 - DOI: 10.1002/advs.202304076

Zhou H, Baish JW, O'Melia MJ, Darragh LB, Specht E, Czapla J, Lei PJ, Menzel L, Rajotte JJ, Nikmaneshi MR, Razavi MS, Heiden MGV, Ubellacker JM, Munn LL, Boland GM, Cohen S, Karam SD, Padera TP

Cancer immunotherapy responses persist after lymph node resection.
bioRxiv. 2023;:ePub - PMID: 37781599 - PMCID: PMC10541098 - DOI: 10.1101/2023.09.19.558262

Lei PJ, Pereira ER, Andersson P, Amoozgar Z, Van Wijnbergen JW, O'Melia MJ, Zhou H, Chatterjee S, Ho WW, Posada JM, Kumar AS, Morita S, Menzel L, Chung C, Ergin I, Jones D, Huang P, Beyaz S, Padera TP

Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes.
J Exp Med. 2023;220(9):ePub - PMID: 37341991 - PMCID: PMC10286805 - DOI: 10.1084/jem.20221847

Singhal D, BörnerK, Chaikof EL, Detmar M, Hollmén M, Iliff JJ, Itkin M, Makinen T, Oliver G, Padera TP, Quardokus EM, Radtke AJ, Suami H, Weber GM, Rovira II, Muratoglu SC, Galis ZS

Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium.
Front Physiol. 2023;14:1099403 - PMID: 36814475 - PMCID: PMC9939837 - DOI: 10.3389/fphys.2023.1099403

Li Z, Huang S, He Y, van Wijnbergen JW, Zhang Y, Cottrell RD, Smith SG, Hammond PT, Chen DZ, Padera TP, Belcher AM

A new label-free optical imaging method for the lymphatic system enhanced by deep learning.
bioRxiv. 2023;:ePub - PMID: 36711668 - PMCID: PMC9882203 - DOI: 10.1101/2023.01.13.523938

Li H, Wei H, Padera TP, Baish JW, Munn LL

Computational simulations of the effects of gravity on lymphatic transport.
PNAS Nexus. 2022;1(5):pgac237 - PMID: 36712369 - PMCID: PMC9802413 - DOI: 10.1093/pnasnexus/pgac237

Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK

Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.
Clin Cancer Res. 2022;28(14):3076-3090 - PMID: 35584239 - PMCID: PMC9355624 - DOI: 10.1158/1078-0432.CCR-22-0486

van den Bent L, Frenkel NC, Poghosyan S, Molenaar IQ, Padera TP, Kranenburg O, Borel Rinkes IHM, Hagendoorn J

Liver lymphatic drainage patterns follow segmental anatomy.
Br J Surg. 2022;109(6):559-560 - PMID: 35576376 - PMCID: PMC10364678 - DOI: 10.1093/bjs/znac076

Jones D, Wang Z, Chen I, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, Van Wijnbergen JW, Pereira E, Vakoc B, Huang P, Nia H, Padera T

Solid stress impairs lymphocyte infiltration into lymph node metastases.
FASEB J. 2022;36 Suppl 1:ePub - PMID: 35557097 - DOI: 10.1096/fasebj.2022.36.S1.R4616

Baish JW, Padera TP, Munn LL

The effects of gravity and compression on interstitial fluid transport in the lower limb.
Sci Rep. 2022;12(1):4890 - PMID: 35318426 - PMCID: PMC8941011 - DOI: 10.1038/s41598-022-09028-9

Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ

A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.
Sci Immunol. 2021;6(66):eabf1152 - PMID: 34860581 - PMCID: PMC8763571 - DOI: 10.1126/sciimmunol.abf1152

Keahey P, Si P, Razavi M, Yu S, Lippok N, Villiger M, Padera TP, de la Zerda A, Bouma B

Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.
Nano Lett. 2021;21(20):8595-8601 - PMID: 34644094 - PMCID: PMC8555503 - DOI: 10.1021/acs.nanolett.1c02291

Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP

Solid stress impairs lymphocyte infiltration into lymph-node metastases.
Nat Biomed Eng. 2021;5(12):1426-1436 - PMID: 34282290 - PMCID: PMC8678215 - DOI: 10.1038/s41551-021-00766-1

Nathanson SD, Detmar M, Padera TP, Yates LR, Welch DR, Beadnell TC, Scheid AD, Wrenn ED, Cheung K

Mechanisms of breast cancer metastasis.
Clin Exp Metastasis. 2021;39(1):117-137 - PMID: 33950409 - PMCID: PMC8568733 - DOI: 10.1007/s10585-021-10090-2

Zhou H, Lei PJ, Padera TP

Progression of Metastasis through Lymphatic System.
Cells. 2021;10(3):ePub - PMID: 33808959 - PMCID: PMC7999434 - DOI: 10.3390/cells10030627

Meijer EF, Bouta EM, Mendonca C, Skolny MN, Salama LW, Taghian AG, Padera TP

A retrospective analysis of commonly prescribed medications and the risk of developing breast cancer related lymphedema.
Clin Res Trials. 2020;6(1):ePub - PMID: 32864167 - PMCID: PMC7455025 - DOI: 10.15761/crt.1000293

Tamburini BAJ, Padera TP, Lund AW

Editorial: Regulation of Immune Function by the Lymphatic Vasculature.
Front Immunol. 2019;10:2597 - PMID: 31781105 - PMCID: PMC6856668 - DOI: 10.3389/fimmu.2019.02597

Ruscic KJ, Padera TP

Silence of the Lymphs: Some anaesthetic regimens inhibit lymphatic pumping.
J Physiol. 2019;597(11):2827-2828 - PMID: 31032908 - PMCID: PMC6995671 - DOI: 10.1113/JP277914

Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Nat Biomed Eng. 2019;3(3):230-245 - PMID: 30948807 - PMCID: PMC6452896 - DOI: 10.1038/s41551-018-0334-7

Johnson AR, Granoff MD, Lee BT, Padera TP, Bouta EM, Singhal D

The Impact of Taxane-based Chemotherapy on the Lymphatic System.
Ann Plast Surg. 2019;82(4S Suppl 3):S173-S178 - PMID: 30855384 - DOI: 10.1097/SAP.0000000000001884

Nathanson SD, Krag D, Kuerer HM, Newman LA, Brown M, Kerjaschki D, Pereira ER, Padera TP

Breast cancer metastasis through the lympho-vascular system.
Clin Exp Metastasis. 2018;35(5-6):443-454 - PMID: 29796854 - DOI: 10.1007/s10585-018-9902-1

Bourquard A, Pablo-Trinidad A, Butterworth I, Sánchez-Ferro Á, Cerrato C, Humala K, Fabra Urdiola M, Del Rio C, Valles B, Tucker-Schwartz JM, Lee ES, Vakoc BJ, Padera TP, Ledesma-Carbayo MJ, Chen YB, Hochberg EP, Gray ML, Castro-González C

Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation.
Sci Rep. 2018;8(1):5301 - PMID: 29593221 - PMCID: PMC5871877 - DOI: 10.1038/s41598-018-23591-0

Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
Science. 2018;359(6382):1403-1407 - PMID: 29567713 - PMCID: PMC6002772 - DOI: 10.1126/science.aal3622

Jones D, Pereira ER, Padera TP

Growth and Immune Evasion of Lymph Node Metastasis.
Front Oncol. 2018;8:36 - PMID: 29527513 - PMCID: PMC5829610 - DOI: 10.3389/fonc.2018.00036

Bouta EM, Blatter C, Ruggieri TA, Meijer EF, Munn LL, Vakoc BJ, Padera TP

Lymphatic function measurements influenced by contrast agent volume and body position.
JCI Insight. 2018;3(2):ePub - PMID: 29367467 - PMCID: PMC5821192 - DOI: 10.1172/jci.insight.96591

Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction.
Sci Transl Med. 2018;10(424):ePub - PMID: 29343625 - PMCID: PMC5953194 - DOI: 10.1126/scitranslmed.aam7964

Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE

Depolarization signatures map gold nanorods within biological tissue.
Nat Photonics. 2017;11:583-588 - PMID: 29201136 - PMCID: PMC5703429 - DOI: 10.1038/nphoton.2017.128

Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D

Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Proc Natl Acad Sci U S A. 2017;114(39):10455-10460 - PMID: 28900008 - PMCID: PMC5625928 - DOI: 10.1073/pnas.1710754114

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
J Clin Invest. 2017;127(8):3039-3051 - PMID: 28691930 - PMCID: PMC5531423 - DOI: 10.1172/JCI93182

Meijer EFJ, Jeong HS, Pereira ER, Ruggieri TA, Blatter C, Vakoc BJ, Padera TP

Murine chronic lymph node window for longitudinal intravital lymph node imaging.
Nat Protoc. 2017;12(8):1513-1520 - PMID: 28683064 - PMCID: PMC5592697 - DOI: 10.1038/nprot.2017.045

Meijer EF, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP

Lymph node effective vascular permeability and chemotherapy uptake.
Microcirculation. 2017;24(6):ePub - PMID: 28510992 - PMCID: PMC5706450 - DOI: 10.1111/micc.12381

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK

Solid stress and elastic energy as measures of tumour mechanopathology.
Nat Biomed Eng. 2016;1:ePub - PMID: 28966873 - PMCID: PMC5621647 - DOI: 10.1038/s41551-016-0004

Baish JW, Kunert C, Padera TP, Munn LL

Synchronization and Random Triggering of Lymphatic Vessel Contractions.
PLoS Comput Biol. 2016;12(12):e1005231 - PMID: 27935958 - PMCID: PMC5147819 - DOI: 10.1371/journal.pcbi.1005231

Meijer EF, Baish JW, Padera TP, Fukumura D

Measuring Vascular Permeability In Vivo.
Methods Mol Biol. 2016;1458:71-85 - PMID: 27581015 - PMCID: PMC5435480 - DOI: 10.1007/978-1-4939-3801-8_6

Blatter C, Meijer EF, Nam AS, Jones D, Bouma BE, Padera TP, Vakoc BJ

In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography.
Sci Rep. 2016;6:29035 - PMID: 27377852 - PMCID: PMC4932526 - DOI: 10.1038/srep29035

Padera TP, Meijer EF, Munn LL

The Lymphatic System in Disease Processes and Cancer Progression.
Annu Rev Biomed Eng. 2016;18:125-58 - PMID: 26863922 - PMCID: PMC4946986 - DOI: 10.1146/annurev-bioeng-112315-031200

Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP

Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.
J Natl Cancer Inst. 2015;107(9):ePub - PMID: 26063793 - PMCID: PMC4651102 - DOI: 10.1093/jnci/djv155

Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP

Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.
FASEB J. 2015;29(9):3668-77 - PMID: 25977256 - PMCID: PMC4550378 - DOI: 10.1096/fj.14-268920

Cho JK, Hyun SH, Choi N, Kim MJ, Padera TP, Choi JY, Jeong HS

Significance of lymph node metastasis in cancer dissemination of head and neck cancer.
Transl Oncol. 2015;8(2):119-25 - PMID: 25926078 - PMCID: PMC4415144 - DOI: 10.1016/j.tranon.2015.03.001

Padera TP

Editorial.
Semin Cell Dev Biol. 2015;38:53-4 - PMID: 25868083 - DOI: 10.1016/j.semcdb.2015.03.007

Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI

Local Failure in Parameningeal Rhabdomyosarcoma Correlates With Poor Response to Induction Chemotherapy.
Int J Radiat Oncol Biol Phys. 2015;92(2):358-67 - PMID: 25864172 - PMCID: PMC5479480 - DOI: 10.1016/j.ijrobp.2015.01.049

Pereira ER, Jones D, Jung K, Padera TP

The lymph node microenvironment and its role in the progression of metastatic cancer.
Semin Cell Dev Biol. 2015;38:98-105 - PMID: 25620792 - PMCID: PMC4397158 - DOI: 10.1016/j.semcdb.2015.01.008

Kuo AH, Ancukiewicz M, Kozak KR, Yock TI, Padera TP

Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation.
Radiat Oncol. 2015;10(1):5 - PMID: 25573181 - PMCID: PMC4293110 - DOI: 10.1186/s13014-014-0324-1

Liao S, Jones D, Cheng G, Padera TP

Method for the quantitative measurement of collecting lymphatic vessel contraction in mice.
J Biol Methods. 2014;1(2):ePub - PMID: 25512945 - PMCID: PMC4264607 - DOI: 10.14440/jbm.2014.26

Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure.
Cancer Cell. 2014;26(1):14-15 - PMID: 25026209 - PMCID: PMC4381566 - DOI: 10.1016/j.ccr.2014.06.003

Munn LL, Padera TP

Imaging the Lymphatic System.
Microvasc Res. 2014;96C:55-63 - PMID: 24956510 - PMCID: PMC4268344 - DOI: 10.1016/j.mvr.2014.06.006

Liao S, Padera TP

Lymphatic Function and Immune Regulation in Health and Disease.
Lymphat Res Biol. 2013;11(3):136-43 - PMID: 24024577 - PMCID: PMC3780287 - DOI: 10.1089/lrb.2013.0012

Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164

Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK

Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.
Intravital. 2012;1(1):ePub - PMID: 24353926 - PMCID: PMC3864876 - DOI: 10.4161/intv.21557

Kesler CT, Liao S, Munn LL, Padera TP

Lymphatic vessels in health and disease.
Wiley Interdiscip Rev Syst Biol Med. 2012;5(1):111-24 - PMID: 23209022 - PMCID: PMC3527689 - DOI: 10.1002/wsbm.1201

Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP

Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108

Liao S, Padera TP, Jain RK

Notch leads lymphatics and links them to blood vessels.
Arterioscler Thromb Vasc Biol. 2010;30(9):1682-3 - PMID: 20720193 - PMCID: PMC2945915 - DOI: 10.1161/ATVBAHA.110.210633

Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH

Lymphotoxin-alpha contributes to lymphangiogenesis.
Blood. 2010;116(12):2173-82 - PMID: 20566898 - PMCID: PMC2951858 - DOI: 10.1182/blood-2009-12-256065

Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D

Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Cancer Res. 2009;69(7):2801-8 - PMID: 19318557 - PMCID: PMC2670480 - DOI: 10.1158/0008-5472.CAN-08-4051

Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK

Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Biophys J. 2009;97(1):330-6 - PMID: 19580771 - PMCID: PMC2711376 - DOI: 10.1016/j.bpj.2009.03.064

Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971

Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK

Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
J Cell Physiol. 2009;219(2):430-7 - PMID: 19170073 - PMCID: PMC2665001 - DOI: 10.1002/jcp.21686

Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E

Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
N Engl J Med. 2009;361(4):358-67 - PMID: 19587327 - PMCID: PMC4816642 - DOI: 10.1056/NEJMoa0902579

Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295

Jain RK, Booth MF, Padera TP, Munn LL, Fukumura D, Brown E

Applications of nonlinear intravital microscopy in tumor biology.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 29:735-756

Padera TP, Jain RK

VEGFR3: a new target for antiangiogenesis therapy?
Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014

Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182

Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Data do not support benefits of anti-VEGFR3 therapy
Cancer Research. 2007;67:5055

Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK

Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643

Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Anti-VEGFR-3 therapy and lymph node metastasis [corrected].
Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935

Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK

Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655

Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH

Platelet-derived growth factor receptor-beta in Gorham's disease.
Nat Clin Pract Oncol. 2006;3(12):693-7 - PMID: 17139320 - PMCID: PMC2693369 - DOI: 10.1038/ncponc0660

Hoon DS, Kitago M, Kim J, Mori T, Piris A, Szyfelbein K, Mihm MC, Nathanson SD, Padera TP, Chambers AF, Vantyghem SA, MacDonald IC, Shivers SC, Alsarraj M, Reintgen DS, Passlick B, Sienel W, Pantel K

Molecular mechanisms of metastasis.
Cancer Metastasis Rev. 2006;25(2):203-20 - PMID: 16770533 - DOI: 10.1007/s10555-006-8500-x

Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK

Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392

Hagendoorn J, Padera TP, Fukumura D, Jain RK

Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003

Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK

Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752

Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK

Pathology: cancer cells compress intratumour vessels.
Nature. 2004;427(6976):695 - PMID: 14973470 - DOI: 10.1038/427695a

Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK

Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.
Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24

Padera TP, Stoll BR, So PT, Jain RK

Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Mol Imaging. 2003;1(1):9-15 - PMID: 12920856 - DOI: 10.1162/15353500200200004

Padera TP, Boucher Y, Jain RK

Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026

Jain RK, Padera TP

Development. Lymphatics make the break.
Science. 2003;299(5604):209-10 - PMID: 12522236 - DOI: 10.1126/science.1081345

Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK

Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420

Jain RK, Padera TP

Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.
J Natl Cancer Inst. 2002;94(11):785-7 - PMID: 12048260 - DOI: 10.1093/jnci/94.11.785

Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK

Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105

Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK

LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer Res. 2001;61(22):8079-84 - PMID: 11719431

Ramanujan S, Koenig GC, Padera TP, Stoll BR, Jain RK

Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Cancer Res. 2000;60(5):1442-8 - PMID: 10728711

Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK

Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer Res. 2000;60(16):4556-60 - PMID: 10969807
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