Sort by:
Jain RK
Integrative pathophysiology of solid tumors: role in detection and treatment.
Cancer J Sci Am. 1998;4 Suppl 1:S48-57 - PMID: 9619271
Rosenzweig M, DeMaria MA, Harper DM, Friedrich S, Jain RK, Johnson RP
Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques.
Proc Natl Acad Sci U S A. 1998;95(11):6388-93 - PMID: 9600975 - PMCID: PMC27734 - DOI: 10.1073/pnas.95.11.6388
Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R
Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.
Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01
Hunter GJ, Hamberg LM, Choi N, Jain RK, McCloud T, Fischman AJ
Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism.
Clin Cancer Res. 1998;4(4):949-55 - PMID: 9563889
Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Proc Natl Acad Sci U S A. 1998;95(8):4607-12 - PMID: 9539785 - PMCID: PMC22537 - DOI: 10.1073/pnas.95.8.4607
Zhu H, Jain RK, Baxter LT
Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
J Nucl Med. 1998;39(1):65-76 - PMID: 9443740
Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK
Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Microcirculation. 1997;4(4):395-402 - PMID: 9431507 - DOI: 10.3109/10739689709146803
Jain RK, Schlenger K, Höckel M, Yuan F
Quantitative angiogenesis assays: progress and problems.
Nat Med. 1997;3(11):1203-8 - PMID: 9359693 - DOI: 10.1038/nm1197-1203
Griffon-Etienne G, Boucher Y, Jain RK, Suit HD
Effects of needle insertion in tumors on interstitial fluid pressure.
Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037
Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CG, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, Suit HD
Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.
J Surg Oncol. 1997;66(1):30-8 - PMID: 9290690 - DOI: 10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o
Kaufman EN, Jain RK
Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Biophys J. 1990;58(4):873-85 - PMID: 2248992 - PMCID: PMC1281033 - DOI: 10.1016/S0006-3495(90)82432-2
Jain RK
Transport of molecules across tumor vasculature.
Cancer Metastasis Rev. 1988;6(4):559-93 - PMID: 3327633 - DOI: 10.1007/BF00047468
Ward KA, Jain RK
Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia.
Int J Hyperthermia. 1988;4(3):223-50 - PMID: 3290346 - DOI: 10.3109/02656738809051100
Jain RK
Determinants of tumor blood flow: a review.
Cancer Res. 1988;48(10):2641-58 - PMID: 3282647
Chary SR, Jain RK
Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.
Proc Natl Acad Sci U S A. 1989;86(14):5385-9 - PMID: 2748592 - PMCID: PMC297627 - DOI: 10.1073/pnas.86.14.5385
Sevick EM, Jain RK
Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Cancer Res. 1989;49(13):3506-12 - PMID: 2731172
Jain RK
Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
J Natl Cancer Inst. 1989;81(8):570-6 - PMID: 2649688 - DOI: 10.1093/jnci/81.8.570
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Microvasc Res. 1989;37(1):77-104 - PMID: 2646512 - DOI: 10.1016/0026-2862(89)90074-5
Baxter LT, Jain RK, Svensjö E
Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Microvasc Res. 1987;34(3):336-48 - PMID: 2448593 - DOI: 10.1016/0026-2862(87)90066-5
Jain RK
Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Cancer Res. 1990;50(3 Suppl):814s-819s - PMID: 2404582
Clauss MA, Jain RK
Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer Res. 1990;50(12):3487-92 - PMID: 2340499
Jain RK
Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Cancer Metastasis Rev. 1990;9(3):253-66 - PMID: 2292138 - DOI: 10.1007/BF00046364
Jain RK, Gerlowski LE
Extravascular transport in normal and tumor tissues.
Crit Rev Oncol Hematol. 1986;5(2):115-70 - PMID: 3521923 - DOI: 10.1016/s1040-8428(86)80023-3
Jain RK
Tumor physiology and antibody delivery.
Front Radiat Ther Oncol. 1990;24:32-46; discussion 64-8 - PMID: 2187763
Ward KA, DiPette DJ, Held TN, Jain RK
Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1991;51(13):3612-6 - PMID: 2054796
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Microvasc Res. 1991;41(2):252-72 - PMID: 2051960 - DOI: 10.1016/0026-2862(91)90026-8
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Microvasc Res. 1991;41(1):5-23 - PMID: 2051954 - DOI: 10.1016/0026-2862(91)90003-t
Sasaki A, Melder RJ, Whiteside TL, Herberman RB, Jain RK
Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.
J Natl Cancer Inst. 1991;83(6):433-7 - PMID: 1999850 - DOI: 10.1093/jnci/83.6.433
Sevick EM, Jain RK
Measurement of capillary filtration coefficient in a solid tumor.
Cancer Res. 1991;51(4):1352-5 - PMID: 1997172
Jain RK
Therapeutic implications of tumor physiology.
Curr Opin Oncol. 1991;3(6):1105-8 - PMID: 1843113 - DOI: 10.1097/00001622-199112000-00020
Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, Messmer K
Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.
Cancer Res. 1992;52(2):487-90 - PMID: 1728421
Jain RK
Haemodynamic and transport barriers to the treatment of solid tumours.
Int J Radiat Biol. 1991;60(1-2):85-100 - PMID: 1678003 - DOI: 10.1080/09553009114551621
Kaufman EN, Jain RK
Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Cancer Res. 1992;52(15):4157-67 - PMID: 1638531
Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, Jain RK
Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.
Cancer Res. 1992;52(7):1993-5 - PMID: 1551128
Kristjansen PE, Roberge S, Lee I, Jain RK
Tissue-isolated human tumor xenografts in athymic nude mice.
Microvasc Res. 1994;48(3):389-402 - PMID: 7731400 - DOI: 10.1006/mvre.1994.1063
Martin GR, Jain RK
Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.
Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048
Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK
Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684 - DOI: 10.1093/jnci/86.4.293
Baxter LT, Zhu H, Mackensen DG, Jain RK
Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Cancer Res. 1994;54(6):1517-28 - PMID: 8137258
Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK
Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313 - DOI: 10.1073/pnas.91.6.2081
Jain RK
Barriers to drug delivery in solid tumors.
Sci Am. 1994;271(1):58-65 - PMID: 8066425 - DOI: 10.1038/scientificamerican0794-58
Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Cancer Res. 1994;54(13):3352-6 - PMID: 8012948
Hamberg LM, Kristjansen PE, Hunter GJ, Wolf GL, Jain RK
Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.
Cancer Res. 1994;54(23):6032-6 - PMID: 7954440
Leu AJ, Berk DA, Yuan F, Jain RK
Flow velocity in the superficial lymphatic network of the mouse tail.
Am J Physiol. 1994;267(4 Pt 2):H1507-13 - PMID: 7943396 - DOI: 10.1152/ajpheart.1994.267.4.H1507
Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK
A method for labeling cells for positron emission tomography (PET) studies.
J Immunol Methods. 1994;175(1):79-87 - PMID: 7930641 - DOI: 10.1016/0022-1759(94)90333-6
Melder RJ, Jain RK
Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.
J Immunol Methods. 1994;175(1):69-77 - PMID: 7930640 - DOI: 10.1016/0022-1759(94)90332-8
Martin GR, Jain RK
Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.
Cancer Res. 1994;54(21):5670-4 - PMID: 7923215
Eskey CJ, Koretsky AP, Domach MM, Jain RK
2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.
Cancer Res. 1992;52(21):6010-9 - PMID: 1394226
Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK
Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.
Lab Invest. 1994;71(2):300-7 - PMID: 7521447
Melder RJ, Salehi HA, Jain RK
Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.
Microvasc Res. 1995;50(1):35-44 - PMID: 7476578 - DOI: 10.1006/mvre.1995.1036
Townsend JG, Jain RK, Cashmore AR
In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.
J Pharm Sci. 1982;71(10):1102-5 - PMID: 7143204 - DOI: 10.1002/jps.2600711005
606