Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - DOI: 10.1038/s41588-022-01134-8
A nonrandomized phase I and biomarker trial of regorafenib in advanced myeloid malignancies.
A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.
Clin Cancer Res. 2022;:ePub - PMID: 35833850 - DOI: 10.1158/1078-0432.CCR-22-1169
The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy.
Cancer Cell. 2022;40(7):701-702 - PMID: 35714604 - DOI: 10.1016/j.ccell.2022.05.016
Refining genetic and molecular classifications to facilitate breakthrough treatments in intrahepatic cholangiocarcinoma: are we there yet?
Gut. 2022;:ePub - PMID: 35772925 - DOI: 10.1136/gutjnl-2022-327782
Impact of renin-angiotensin system inhibitors on outcomes in patients with metastatic renal cell carcinoma treated with immune-checkpoint inhibitors
Clin Genitourin Cancer. 2022;20(4):301-306 - PMID: 35614012 - DOI: 10.1016/j.clgc.2022.04.012
Liver lymphatic drainage patterns follow segmental anatomy.
Br J Surg. 2022;109(6):559-560 - PMID: 35576376 - DOI: 10.1093/bjs/znac076
Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.
Clin Cancer Res. 2022;28(14):3076-3090 - PMID: 35584239 - DOI: 10.1158/1078-0432.CCR-22-0486
Solid stress impairs lymphocyte infiltration into lymph node metastases.
FASEB J. 2022;36 Suppl 1:ePub - PMID: 35557097 - DOI: 10.1096/fasebj.2022.36.S1.R4616
VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Novel patient-derived xenograft and cell line models for therapeutic screening in NF2-associated schwannoma.
J Pathol. 2022;257(5):620-634 - PMID: 35394061 - DOI: 10.1002/path.5908
Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.
The effects of gravity and compression on interstitial fluid transport in the lower limb.
Increased CD8+ T-Cell Infiltration and Efficacy for Multikinase Inhibitors after PD-1 Blockade in Hepatocellular Carcinoma.
J Natl Cancer Inst. 2022;:ePub - PMID: 35288743 - DOI: 10.1093/jnci/djac051
Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy
Journal of Controlled Release. 2022;345:190-199 - PMID: 35271911 - PMCID: PMC9168447 - DOI: 10.1016/j.jconrel.2022.03.008
Towards principled design of cancer nanomedicine to accelerate clinical translation.
Mater Today Bio. 2022;13:100208 - PMID: 35198957 - PMCID: PMC8841842 - DOI: 10.1016/j.mtbio.2022.100208
Leveraging Blood-Based Diagnostics to Predict Tumor Biology and Extend the Application and Personalization of Radiotherapy in Liver Cancers.
Predictive Modeling of Survival and Toxicity in Patients With Hepatocellular Carcinoma After Radiotherapy.
JCO Clin Cancer Inform. 2022;6:e2100169 - PMID: 35192402 - PMCID: PMC8863122 - DOI: 10.1200/CCI.21.00169
Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy.
Glycocalyx mechanotransduction mechanisms are involved in renal cancer metastasis.
Matrix Biol Plus. 2022;13:100100 - PMID: 35106474 - PMCID: PMC8789524 - DOI: 10.1016/j.mbplus.2021.100100
Renin–angiotensin–aldosterone system inhibitors and survival in patients with hypertension treated with immune checkpoint inhibitors
European Journal of Cancer. 2022;163:108-118 - PMID: 35065368 - DOI: 10.1016/j.ejca.2021.12.024
Strategies to minimize heterogeneity and optimize
clinical trials in Acute Respiratory Distress Syndrome
(ARDS): Insights from mathematical modelling
EBioMedicine. 2022;75:103809 - PMID: 35033853 - PMCID: PMC8757652 - DOI: 10.1016/j.ebiom.2021.103809
Kendrick Mass Defect Variation to Decipher Isotopic Labeling in Brain Metastases Studied by Mass Spectrometry Imaging.
Anal Chem. 2021;93(49):16314-16319 - PMID: 34860501 - DOI: 10.1021/acs.analchem.1c03916
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.
Sci Immunol. 2021;6(66):eabf1152 - PMID: 34860581 - PMCID: PMC8763571 - DOI: 10.1126/sciimmunol.abf1152
Changes in Blood Biomarkers of Angiogenesis and Immune Modulation after Radiation Therapy and Their Association with Outcomes in Thoracic Malignancies.
Cancers (Basel). 2021;13(22):ePub - PMID: 34830880 - PMCID: PMC8616228 - DOI: 10.3390/cancers13225725
Publisher Correction: A metastasis map of human cancer cell lines.
Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
Proc Natl Acad Sci U S A. 2021;118(45):ePub - PMID: 34725151 - PMCID: PMC8609309 - DOI: 10.1073/pnas.2105323118
Machine Learning for Future Subtyping of the Tumor Microenvironment of Gastro-Esophageal Adenocarcinomas.
Cancers (Basel). 2021;13(19):ePub - PMID: 34638408 - PMCID: PMC8507866 - DOI: 10.3390/cancers13194919
Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.
Nano Lett. 2021;21(20):8595-8601 - PMID: 34644094 - PMCID: PMC8555503 - DOI: 10.1021/acs.nanolett.1c02291
Solid stress impairs lymphocyte infiltration into lymph-node metastases.
Nat Biomed Eng. 2021;5(12):1426-1436 - PMID: 34282290 - PMCID: PMC8678215 - DOI: 10.1038/s41551-021-00766-1
Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models.
Sci Transl Med. 2021;13(602):ePub - PMID: 34261799 - PMCID: PMC8409338 - DOI: 10.1126/scitranslmed.abd4816
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients
NPJ Precis Oncol. 2021;5(1):62 - PMID: 34188163 - PMCID: PMC8242049 - DOI: 10.1038/s41698-021-00197-w
Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19.
Angiotensin Blockade Modulates the Activity of PD1/L1 Inhibitors in Metastatic Urothelial Carcinoma.
Clin Genitourin Cancer. 2021;19(6):540-546 - PMID: 34011489 - PMCID: PMC8526625 - DOI: 10.1016/j.clgc.2021.04.002
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Mechanisms of breast cancer metastasis.
Clin Exp Metastasis. 2021;39(1):117-137 - PMID: 33950409 - PMCID: PMC8568733 - DOI: 10.1007/s10585-021-10090-2
Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib.
Oncotarget. 2021;12(8):756-766 - PMID: 33889299 - PMCID: PMC8057275 - DOI: 10.18632/oncotarget.27924
Radiotherapy to Enhance Chimeric Antigen Receptor T-Cell Therapeutic Efficacy in Solid Tumors: A Narrative Review.
JAMA Oncol. 2021;7(7):1051-1059 - PMID: 33885725 - PMCID: PMC8668197 - DOI: 10.1001/jamaoncol.2021.0168
Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade.
Cancer Immunol Res. 2021;9(7):765-778 - PMID: 33839688 - PMCID: PMC8295193 - DOI: 10.1158/2326-6066.CIR-20-0499
Fatty acid synthesis is required for breast cancer brain metastasis
Nature Cancer. 2021;:ePub
Progression of Metastasis through Lymphatic System.
Toward Personalized Radiation Therapy of Liver Metastasis: Importance of Serial Blood Biomarkers.
JCO Clin Cancer Inform. 2021;5:315-325 - PMID: 33764817 - PMCID: PMC8462658 - DOI: 10.1200/CCI.20.00118
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Nature. 2021;592(7854):450-456 - PMID: 33762733 - PMCID: PMC8046670 - DOI: 10.1038/s41586-021-03362-0
Vascular normalization to improve treatment of COVID-19: Lessons from treatment of cancer.
Clin Cancer Res. 2021;27(10):2706-2711 - PMID: 33648989 - PMCID: PMC8127351 - DOI: 10.1158/1078-0432.CCR-20-4750
Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.
Implications of a granulocyte-high glioblastoma microenvironment in immune suppression and therapy resistance†.
Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma.
In silico dynamics of COVID-19 phenotypes for optimizing clinical management.
Proc Natl Acad Sci U S A. 2021;118(3):ePub - PMID: 33402434 - PMCID: PMC7826337 - DOI: 10.1073/pnas.2021642118
Randomized phase II and biomarker study of pembrolizumab plus bevacizumab versus pembrolizumab alone for recurrent glioblastoma patients.
Clin Cancer Res. 2021;27(4):1048-1057 - PMID: 33199490 - PMCID: PMC8284901 - DOI: 10.1158/1078-0432.CCR-20-2500
The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review.
JAMA Oncol. 2021;7(1):113-123 - PMID: 33090190 - PMCID: PMC8265820 - DOI: 10.1001/jamaoncol.2020.3381
Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients.
Neurooncol Adv. 2020;2(1):vdaa157 - PMID: 33392506 - PMCID: PMC7764510 - DOI: 10.1093/noajnl/vdaa157
A metastasis map of human cancer cell lines.
Nature. 2020;588(7837):331-336 - PMID: 33299191 - PMCID: PMC8439149 - DOI: 10.1038/s41586-020-2969-2
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
J Immunother Cancer. 2020;8(2):ePub - PMID: 33234602 - PMCID: PMC7689089 - DOI: 10.1136/jitc-2020-001435
Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Nat Biomed Eng. 2020;4(12):1222 - PMID: 33235308 - PMCID: PMC8328147 - DOI: 10.1038/s41551-020-00664-y
Physical traits of cancer.
NAD<sup>+</sup>-mediated rescue of prenatal forebrain angiogenesis restores postnatal behavior.
Impact of Integrating Insulin-Like Growth Factor 1 Levels into Model for End-Stage Liver Disease Score for Survival Prediction in Hepatocellular Carcinoma Patients.
In silico dynamics of COVID-19 phenotypes for optimizing clinical management
A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade
Natl Acad Sci U S A. 2020;117(38):23684-23694 - PMID: 32907939 - PMCID: PMC7519254 - DOI: 10.1073/pnas.2002806117
Normalizing the tumor microenvironment for radiosensitization. In “Molecular Targeted Radiosensitizers: Opportunities and Challenges"
Cancer Drug Discovery and Development. 2020;Chapter 12:301-338
Phase 1 and Biomarker Study of the Wnt Pathway Modulator DKN-01 in Combination with Gemcitabine/Cisplatin in Advanced Biliary Tract Cancer.
Clin Cancer Res. 2020;26(23):6158-6167 - PMID: 32878766 - DOI: 10.1158/1078-0432.CCR-20-1310
Oncolytic Virus With Attributes of Vesicular Stomatitis Virus and Measles Virus in Hepatobiliary and Pancreatic Cancers.
Mol Ther Oncolytics. 2020;18:546-555 - PMID: 32839735 - PMCID: PMC7437509 - DOI: 10.1016/j.omto.2020.08.007
Going Beyond VEGF Pathway Inhibition for Antiangiogenic Cancer Therapy: Is Inhibition of the PP2A/B55α Complex the Answer?
Circ Res. 2020;127(6):724-726 - PMID: 32853096 - PMCID: PMC7462096 - DOI: 10.1161/CIRCRESAHA.120.317720
A retrospective analysis of commonly prescribed medications and the risk of developing breast cancer related lymphedema.
In vivo compression and imaging in mouse brain to measure the effects of solid stress.
Nat Protoc. 2020;15(8):2321-2340 - PMID: 32681151 - DOI: 10.1038/s41596-020-0328-2
Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines.
Cancer Res. 2020;80(20):4314-4323 - PMID: 32641416 - PMCID: PMC7572582 - DOI: 10.1158/0008-5472.CAN-20-0291
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Cancer Discov. 2020;10(9):1352-1373 - PMID: 32571778 - PMCID: PMC7483776 - DOI: 10.1158/2159-8290.CD-19-1228
Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Nat Biomed Eng. 2020;4(8):801-813 - PMID: 32572196 - PMCID: PMC8310386 - DOI: 10.1038/s41551-020-0569-y
A mechanobiological mathematical model of liver metabolism.
Biotechnol Bioeng. 2020;117(9):2861-2874 - PMID: 32501531 - DOI: 10.1002/bit.27451
Potential Circulating Biomarkers of Recurrence after Hepatic Resection or Liver Transplantation in Hepatocellular Carcinoma Patients.
Cancers (Basel). 2020;12(5):ePub - PMID: 32443546 - PMCID: PMC7281651 - DOI: 10.3390/cancers12051275
Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma.
Combination therapy with mTOR kinase inhibitor and dasatinib as a novel therapeutic strategy for vestibular schwannoma.
A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth.
Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy.
Nat Biotechnol. 2020;38(4):420-425 - PMID: 32042168 - PMCID: PMC7456461 - DOI: 10.1038/s41587-019-0404-8
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges.
Nat Rev Clin Oncol. 2020;17(4):251-266 - PMID: 32034288 - PMCID: PMC8272676 - DOI: 10.1038/s41571-019-0308-z
Overcoming sorafenib treatment-resistance in hepatocellular carcinoma: A future perspective at a time of rapidly changing treatment paradigms.
EBioMedicine. 2020;52:102644 - PMID: 32014823 - PMCID: PMC6997488 - DOI: 10.1016/j.ebiom.2020.102644
Combining microenvironment normalization strategies to improve cancer immunotherapy.
Proc Natl Acad Sci U S A. 2020;117(7):3728-3737 - PMID: 32015113 - PMCID: PMC7035612 - DOI: 10.1073/pnas.1919764117
A framework for advancing our understanding of cancer-associated fibroblasts.
Nat Rev Cancer. 2020;20(3):174-186 - PMID: 31980749 - PMCID: PMC7046529 - DOI: 10.1038/s41568-019-0238-1
CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas.
Proc Natl Acad Sci U S A. 2020;117(2):1129-1138 - PMID: 31879345 - PMCID: PMC6969504 - DOI: 10.1073/pnas.1910856117
Vessel co-option in glioblastoma: emerging insights and opportunities.
Angiogenesis. 2020;23(1):9-16 - PMID: 31679081 - PMCID: PMC7012982 - DOI: 10.1007/s10456-019-09691-z
The blood-brain barrier and blood-tumour barrier in brain tumours and metastases.
Nat Rev Cancer. 2020;20(1):26-41 - PMID: 31601988 - PMCID: PMC8246629 - DOI: 10.1038/s41568-019-0205-x
Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma.
Clin Cancer Res. 2020;26(1):206-212 - PMID: 31558474 - PMCID: PMC7139851 - DOI: 10.1158/1078-0432.CCR-19-1739
A phase II study of cabozantinib alone or in combination with trastuzumab in breast cancer patients with brain metastases.
Breast Cancer Res Treat. 2020;179(1):113-123 - PMID: 31541381 - DOI: 10.1007/s10549-019-05445-z
Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC.
Increasing the penetration depth of temporal focusing multiphoton microscopy for neurobiological applications.
J Phys D Appl Phys. 2019;52(26):264001 - PMID: 33191950 - PMCID: PMC7655118 - DOI: 10.1088/1361-6463/ab16b4
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes <i>p53</i>-deficient cancers to mTOR inhibition.
Sci Transl Med. 2019;11(523):ePub - PMID: 31852795 - PMCID: PMC7024563 - DOI: 10.1126/scitranslmed.aaw1565
Editorial: Regulation of Immune Function by the Lymphatic Vasculature.
A Novel Approach to Quantifying Lymphatic Contractility during Indocyanine Green Lymphangiography.
Plast Reconstr Surg. 2019;144(5):1197-1201 - PMID: 31688768 - DOI: 10.1097/PRS.0000000000006176
Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma.
J Clin Oncol. 2019;37(35):3446-3454 - PMID: 31626572 - PMCID: PMC7098833 - DOI: 10.1200/JCO.19.01367
Mechanosensing tensile solid stresses.
Proc Natl Acad Sci U S A. 2019;116(44):21960-21962 - PMID: 31619566 - PMCID: PMC6825278 - DOI: 10.1073/pnas.1916115116
Effect of Aflibercept Plus Modified FOLFOX6 Induction Chemotherapy Before Standard Chemoradiotherapy and Surgery in Patients With High-Risk Rectal Adenocarcinoma: The GEMCAD 1402 Randomized Clinical Trial.
JAMA Oncol. 2019;5(11):1566-1573 - PMID: 31465088 - PMCID: PMC6865228 - DOI: 10.1001/jamaoncol.2019.2294
Phase II trial of ponatinib in patients with bevacizumab-refractory glioblastoma.
cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice.
J Cereb Blood Flow Metab. 2019;39(12):2379-2391 - PMID: 31423931 - PMCID: PMC6893979 - DOI: 10.1177/0271678X19870583
Vascular regulation of antitumor immunity.
Inter-patient variations of radiation-induced normal-tissue changes in Gd-EOB-DTPA-enhanced hepatic MRI scans during fractionated proton therapy.
Clin Transl Radiat Oncol. 2019;18:113-119 - PMID: 31341986 - PMCID: PMC6630151 - DOI: 10.1016/j.ctro.2019.04.013
The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations.
Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol.
Endosc Ultrasound. 2019;8(4):235-240 - PMID: 31249159 - PMCID: PMC6714481 - DOI: 10.4103/eus.eus_16_19
The cancer cell glycocalyx proteoglycan glypican-1 mediates interstitial flow mechanotransduction to enhance cell migration and metastasis.
Biorheology. 2019;56(2-3):151-161 - PMID: 31256115 - DOI: 10.3233/BIR-180203
Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.
JAMA Oncol. 2019;5(7):1020-1027 - PMID: 31145418 - PMCID: PMC6547247 - DOI: 10.1001/jamaoncol.2019.0892
Reprogramming the Tumor Microenvironment to Improve Immunotherapy: Emerging Strategies and Combination Therapies.
Am Soc Clin Oncol Educ Book. 2019;39:165-174 - PMID: 31099649 - PMCID: PMC6596289 - DOI: 10.1200/EDBK_237987
Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System?
Cancer Res. 2019;79(9):2104-2106 - PMID: 31043429 - PMCID: PMC6601607 - DOI: 10.1158/0008-5472.CAN-19-0749
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Proc Natl Acad Sci U S A. 2019;116(22):10674-10680 - PMID: 31040208 - PMCID: PMC6561160 - DOI: 10.1073/pnas.1819889116
Silence of the Lymphs: Some anaesthetic regimens inhibit lymphatic pumping.
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Nat Biomed Eng. 2019;3(3):230-245 - PMID: 30948807 - PMCID: PMC6452896 - DOI: 10.1038/s41551-018-0334-7
FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial.
The Impact of Taxane-based Chemotherapy on the Lymphatic System.
Ann Plast Surg. 2019;82(4S Suppl 3):S173-S178 - PMID: 30855384 - DOI: 10.1097/SAP.0000000000001884
Retraction Note: A homing system targets therapeutic T cells to brain cancer.
Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.
Annu Rev Physiol. 2019;81:505-534 - PMID: 30742782 - PMCID: PMC6571025 - DOI: 10.1146/annurev-physiol-020518-114700
Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies.
Proc Natl Acad Sci U S A. 2019;116(7):2662-2671 - PMID: 30700544 - PMCID: PMC6377457 - DOI: 10.1073/pnas.1818322116
Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer.
Proc Natl Acad Sci U S A. 2019;116(10):4558-4566 - PMID: 30700545 - PMCID: PMC6410779 - DOI: 10.1073/pnas.1815515116
Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.
Nat Cell Biol. 2019;21(2):190-202 - PMID: 30598531 - PMCID: PMC6525097 - DOI: 10.1038/s41556-018-0256-3
A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.
Nat Protoc. 2019;14(2):541-555 - PMID: 30617350 - PMCID: PMC6571021 - DOI: 10.1038/s41596-018-0105-7
Mapping physical tumor microenvironment and drug delivery.
Clin Cancer Res. 2019;25(7):2024-2026 - PMID: 30630829 - PMCID: PMC6445672 - DOI: 10.1158/1078-0432.CCR-18-3724
Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2019;116(6):2210-2219 - PMID: 30659155 - PMCID: PMC6369817 - DOI: 10.1073/pnas.1818357116
Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer.
Inducible Nitric Oxide Synthase and CD11b<sup>+</sup>Gr1<sup>+</sup> Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels.
Lymphat Res Biol. 2019;17(3):294-300 - PMID: 30358484 - PMCID: PMC6589499 - DOI: 10.1089/lrb.2018.0013
A Phase II and Biomarker Study of Sorafenib Combined with FOLFOX in Patients with Advanced Hepatocellular Carcinoma (HCC).
Clin Cancer Res. 2019;25(1):80-89 - PMID: 30190369 - PMCID: PMC6320284 - DOI: 10.1158/1078-0432.CCR-18-0847
Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study.
Transl Cancer Res. 2018;7(Suppl 1):S16-S20 - PMID: 30175050 - PMCID: PMC6117158 - DOI: 10.21037/tcr.2017.12.17
Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy.
Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities.
Nat Rev Cancer. 2018;18(11):720 - PMID: 30337715 - PMCID: PMC6357229 - DOI: 10.1038/s41568-018-0072-x
A homing system targets therapeutic T cells to brain cancer.
Nature. 2018;561(7723):331-337 - PMID: 30185905 - PMCID: PMC6402337 - DOI: 10.1038/s41586-018-0499-y
Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Proc Natl Acad Sci U S A. 2018;115(37):E8717-E8726 - PMID: 30150398 - PMCID: PMC6140479 - DOI: 10.1073/pnas.1807105115
Phase I and biomarker study of plerixafor and bevacizumab in recurrent high-grade glioma.
Clin Cancer Res. 2018;24(19):4643-4649 - PMID: 29941486 - DOI: 10.1158/1078-0432.CCR-18-1025
Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer.
Int J Radiat Oncol Biol Phys. 2018;101(5):1222-1225 - PMID: 29859792 - PMCID: PMC6050125 - DOI: 10.1016/j.ijrobp.2018.04.026
Breast cancer metastasis through the lympho-vascular system.
Clin Exp Metastasis. 2018;35(5-6):443-454 - PMID: 29796854 - DOI: 10.1007/s10585-018-9902-1
Consensus guidelines for the use and interpretation of angiogenesis assays.
Angiogenesis. 2018;21(3):425-532 - PMID: 29766399 - PMCID: PMC6237663 - DOI: 10.1007/s10456-018-9613-x
Understanding the tumor immune microenvironment (TIME) for effective therapy.
A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Cancer Cell. 2018;33(5):874-889.e7 - PMID: 29681511 - PMCID: PMC6211172 - DOI: 10.1016/j.ccell.2018.03.020
Quantifying solid stress and elastic energy from excised or in situ tumors.
Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green.
Proc Natl Acad Sci U S A. 2018;115(17):4465-4470 - PMID: 29626132 - PMCID: PMC5924901 - DOI: 10.1073/pnas.1718917115
Renin-angiotensin system inhibitors to mitigate cancer treatment-related adverse events.
Clin Cancer Res. 2018;24(16):3803-3812 - PMID: 29610292 - PMCID: PMC6095804 - DOI: 10.1158/1078-0432.CCR-18-0236
A Physical View of Cancer.
Trends Cancer. 2018;4(4):257 - PMID: 29606305 - PMCID: PMC6296379 - DOI: 10.1016/j.trecan.2018.03.001
Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.
Trends Cancer. 2018;4(4):258-259 - PMID: 29606306 - PMCID: PMC6161778 - DOI: 10.1016/j.trecan.2018.02.010
Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.
Trends Cancer. 2018;4(4):292-319 - PMID: 29606314 - PMCID: PMC5930008 - DOI: 10.1016/j.trecan.2018.02.005
Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation.
Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.
Science. 2018;359(6382):1403-1407 - PMID: 29567713 - PMCID: PMC6002772 - DOI: 10.1126/science.aal3622
Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2.
Sci Transl Med. 2018;10(432):ePub - PMID: 29540614 - PMCID: PMC5936748 - DOI: 10.1126/scitranslmed.aag0945
The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion<i>via</i>IGF-1 and PAI-1.
Oncotarget. 2018;9(12):10375-10387 - PMID: 29535813 - PMCID: PMC5828213 - DOI: 10.18632/oncotarget.23735
Growth and Immune Evasion of Lymph Node Metastasis.
Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Nat Rev Clin Oncol. 2018;15(5):325-340 - PMID: 29508855 - PMCID: PMC5921900 - DOI: 10.1038/nrclinonc.2018.29
Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.
J Immunol. 2018;200(8):3000-3007 - PMID: 29500245 - PMCID: PMC5893394 - DOI: 10.4049/jimmunol.1700407
Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development.
Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.
Proc Natl Acad Sci U S A. 2018;115(9):E2077-E2084 - PMID: 29440379 - PMCID: PMC5834719 - DOI: 10.1073/pnas.1719966115
Lymphatic function measurements influenced by contrast agent volume and body position.
SLPI: a new target for stopping metastasis.
Aging (Albany NY). 2018;10(1):13-14 - PMID: 29356683 - PMCID: PMC5811255 - DOI: 10.18632/aging.101372
Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction.
Sci Transl Med. 2018;10(424):ePub - PMID: 29343625 - PMCID: PMC5953194 - DOI: 10.1126/scitranslmed.aam7964
Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma.
Cancer. 2018;124(7):1438-1448 - PMID: 29266174 - DOI: 10.1002/cncr.31172
Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior.
MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma.
J Neurooncol. 2018;136(1):63-71 - PMID: 29081036 - PMCID: PMC5922763 - DOI: 10.1007/s11060-017-2646-y
Can smart nanomedicine deliver effective targeted cytotoxic treatments to hepatocellular carcinomas while reducing the liver damage?
Anti-VEGF treatment improves neurological function in tumors of the nervous system.
Exp Neurol. 2018;299(Pt B):326-333 - PMID: 28911884 - DOI: 10.1016/j.expneurol.2017.09.008
Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography.
J Biophotonics. 2018;11(8):e201700017 - PMID: 28700145 - PMCID: PMC5766440 - DOI: 10.1002/jbio.201700017
Vascular beds maintain pancreatic tumor explants for ex vivo drug screening.
J Tissue Eng Regen Med. 2018;12(1):e318-e322 - PMID: 28568605 - PMCID: PMC5711628 - DOI: 10.1002/term.2481
Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers.
Oncotarget. 2017;8(65):108292-108302 - PMID: 29312532 - PMCID: PMC5752445 - DOI: 10.18632/oncotarget.22660
Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival.
Depolarization signatures map gold nanorods within biological tissue.
Oncolytic virus delivery: from nano-pharmacodynamics to enhanced oncolytic effect.
Use of inhibitors of the renin-angiotensin system is associated with longer survival in patients with hepatocellular carcinoma.
United European Gastroenterol J. 2017;5(7):987-996 - PMID: 29163965 - PMCID: PMC5676550 - DOI: 10.1177/2050640617695698
Wide-field three-photon excitation in biological samples.
Next-generation in vivo optical imaging with short-wave infrared quantum dots.
MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.
Oncotarget. 2017;8(43):73938-73946 - PMID: 29088758 - PMCID: PMC5650313 - DOI: 10.18632/oncotarget.17881
Engineering and physical sciences in oncology: challenges and opportunities.
Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy.
Sci Transl Med. 2017;9(410):ePub - PMID: 28978752 - PMCID: PMC5928511 - DOI: 10.1126/scitranslmed.aan5616
A cerebellar window for intravital imaging of normal and disease states in mice.
Nat Protoc. 2017;12(11):2251-2262 - PMID: 28981123 - PMCID: PMC5918134 - DOI: 10.1038/nprot.2017.101
Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Proc Natl Acad Sci U S A. 2017;114(39):10455-10460 - PMID: 28900008 - PMCID: PMC5625928 - DOI: 10.1073/pnas.1710754114
YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.
Dev Cell. 2017;42(5):462-478.e7 - PMID: 28867486 - DOI: 10.1016/j.devcel.2017.08.002
Gut microbiota is critical for the induction of chemotherapy-induced pain.
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.
Origins of lymphatic and distant metastases in human colorectal cancer.
Murine chronic lymph node window for longitudinal intravital lymph node imaging.
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
Cancer Discov. 2017;7(10):1116-1135 - PMID: 28667006 - PMCID: PMC5628134 - DOI: 10.1158/2159-8290.CD-17-0368
Emerging Strategies for Delivering Antiangiogenic Therapies to Primary and Metastatic Brain Tumors.
Adv Drug Deliv Rev. 2017;119:159-174 - PMID: 28648712 - DOI: 10.1016/j.addr.2017.06.011
Antibody-based therapies for the treatment of brain metastases from HER2-positive breast cancer: time to rethink the importance of the BBB?
Breast Cancer Res Treat. 2017;165(2):467-468 - PMID: 28643019 - DOI: 10.1007/s10549-017-4351-0
Effect of angiotensin system inhibitors on survival in newly diagnosed glioma patients and recurrent glioblastoma patients receiving chemotherapy and/or bevacizumab.
J Neurooncol. 2017;134(2):325-330 - PMID: 28631191 - DOI: 10.1007/s11060-017-2528-3
Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma.
Clin Cancer Res. 2017;23(19):5959-5969 - PMID: 28600474 - PMCID: PMC5856249 - DOI: 10.1158/1078-0432.CCR-17-0256
MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.
Oncotarget. 2017;:ePub - PMID: 28575858
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.
Sci Transl Med. 2017;9(391):ePub - PMID: 28539475 - PMCID: PMC5917603 - DOI: 10.1126/scitranslmed.aal4682
The brain microenvironment mediates resistance in luminal breast cancer to
PI3K inhibition through HER3 activation
Science Translational Medicine. 2017;9(391):eaal4682
CD4(+) T Cell Activation and Vascular Normalization: Two Sides of the Same Coin?
Immunity. 2017;46(5):773-775 - PMID: 28514684 - DOI: 10.1016/j.immuni.2017.04.015
Lymph node effective vascular permeability and chemotherapy uptake.
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway?
Onco Targets Ther. 2017;10:1403-1412 - PMID: 28424556 - PMCID: PMC5344425 - DOI: 10.2147/OTT.S111681
Genomic and proteomic characterization of ARID1A chromatin remodeller in ampullary tumors.
Am J Cancer Res. 2017;7(3):484-502 - PMID: 28401006 - PMCID: PMC5385638
Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
Angiogenesis. 2017;20(2):185-204 - PMID: 28361267 - PMCID: PMC5439974 - DOI: 10.1007/s10456-017-9552-y
Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors.
Rationally combining anti-VEGF therapy with radiation in NF2 schwannoma.
J Rare Dis Res Treat. 2017;1(2):51-55 - PMID: 28191549 - PMCID: PMC5300073
A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma.
Role of vascular normalization in benefit from metronomic chemotherapy.
Proc Natl Acad Sci U S A. 2017;114(8):1994-1999 - PMID: 28174262 - PMCID: PMC5338413 - DOI: 10.1073/pnas.1700340114
Stress granule-associated protein G3BP2 regulates breast tumor initiation.
Proc Natl Acad Sci U S A. 2017;114(5):1033-1038 - PMID: 28096337 - PMCID: PMC5293063 - DOI: 10.1073/pnas.1525387114
New Directions in Anti-Angiogenic Therapy for Glioblastoma.
Neurotherapeutics. 2017;14(2):321-332 - PMID: 28083806 - PMCID: PMC5398985 - DOI: 10.1007/s13311-016-0510-y
Cancer and inflammation.
Wiley Interdiscip Rev Syst Biol Med. 2017;9(2):ePub - PMID: 27943646 - PMCID: PMC5561333 - DOI: 10.1002/wsbm.1370
Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma.
J Neurooncol. 2017;131(3):603-610 - PMID: 27853960 - PMCID: PMC7672995 - DOI: 10.1007/s11060-016-2332-5
Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients.
Oncologist. 2017;22(1):25-32 - PMID: 27789775 - PMCID: PMC5313267 - DOI: 10.1634/theoncologist.2016-0229
Feasibility, phase I, and phase II studies of tandutinib, an oral platelet-derived growth factor receptor-? tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer.
Clin Lung Cancer. 2017;18(2):189-197.e3 - PMID: 27637408 - PMCID: PMC5424707 - DOI: 10.1016/j.cllc.2016.07.008
Hypoxia-induced DNA hypermethylation: another reason to normalize tumor vessels
Translational Cancer Research. 2016;5:7
The forces of cancer
In: The Scientist. 2016;30(4):ePub
Solid stress and elastic energy as measures of tumour mechanopathology.
Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai.
Ecancermedicalscience. 2016;10:689 - PMID: 27994645 - PMCID: PMC5130328 - DOI: 10.3332/ecancer.2016.689
Synchronization and Random Triggering of Lymphatic Vessel Contractions.
PLoS Comput Biol. 2016;12(12):e1005231 - PMID: 27935958 - PMCID: PMC5147819 - DOI: 10.1371/journal.pcbi.1005231
Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds.
Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27908927 - PMCID: PMC5131752 - DOI: 10.1101/cshperspect.a031195
Self-assembly of vascularized tissue to support tumor explants in vitro.
Integr Biol (Camb). 2016;8(12):1301-1311 - PMID: 27787529 - PMCID: PMC5155578 - DOI: 10.1039/c6ib00108d
Improving treatment of liver metastases by targeting nonangiogenic mechanisms.
Nat Med. 2016;22(11):1209-1210 - PMID: 27824818 - DOI: 10.1038/nm.4228
Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma.
Transl Oncol. 2016;9(5):431-437 - PMID: 27751347 - PMCID: PMC5067928 - DOI: 10.1016/j.tranon.2016.07.004
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
Sci Transl Med. 2016;8(360):360ra135 - PMID: 27733559 - PMCID: PMC5457741 - DOI: 10.1126/scitranslmed.aaf5219
Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting.
Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27663981 - PMCID: PMC5131751 - DOI: 10.1101/cshperspect.a027094
Measuring Vascular Permeability In Vivo.
Methods Mol Biol. 2016;1458:71-85 - PMID: 27581015 - PMCID: PMC5435480 - DOI: 10.1007/978-1-4939-3801-8_6
Heparan Sulfate Proteoglycans Mediate Renal Carcinoma Metastasis.
Closing the gap between astrocytes and brain metastasis progression.
Role of stromal cell-derived factor 1? pathway in bone metastatic prostate cancer.
J Biomed Res. 2016;30(3):181-185 - PMID: 27533927 - PMCID: PMC4885164 - DOI: 10.7555/JBR.30.20150114
Immune modulation by hypofractionated stereotactic radiation therapy: Therapeutic implications.
Radiother Oncol. 2016;120(2):185-94 - PMID: 27495145 - DOI: 10.1016/j.radonc.2016.07.013
Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma.
EBioMedicine. 2016;8:195-202 - PMID: 27428430 - PMCID: PMC4919562 - DOI: 10.1016/j.ebiom.2016.04.034
In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography.
Identification of Glypican-3 as a potential metastasis suppressor gene in gastric cancer.
Oncotarget. 2016;7(28):44406-44416 - PMID: 27259271 - PMCID: PMC5190106 - DOI: 10.18632/oncotarget.9763
Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy.
Cancer Discov. 2016;6(8):852-69 - PMID: 27246539 - PMCID: PMC4972679 - DOI: 10.1158/2159-8290.CD-15-1177
Implantable tissue isolation chambers for analyzing tumor dynamics in vivo.
Arginine dependence of tumor cells: targeting a chink in cancer's armor.
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.
Proc Natl Acad Sci U S A. 2016;113(16):4470-5 - PMID: 27044097 - PMCID: PMC4843449 - DOI: 10.1073/pnas.1525349113
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.
Proc Natl Acad Sci U S A. 2016;113(16):4476-81 - PMID: 27044098 - PMCID: PMC4843473 - DOI: 10.1073/pnas.1525360113
A protein and mRNA expression-based classification of gastric cancer.
Mod Pathol. 2016;29(7):772-84 - PMID: 27032689 - DOI: 10.1038/modpathol.2016.55
Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2-Associated Vestibular Schwannomas.
J Clin Oncol. 2016;34(14):1669-75 - PMID: 26976425 - PMCID: PMC4872317 - DOI: 10.1200/JCO.2015.64.3817
Exploration of Imaging Biomarkers for Predicting Survival of Patients With Advanced Non-Small Cell Lung Cancer Treated With Antiangiogenic Chemotherapy.
AJR Am J Roentgenol. 2016;206(5):987-93 - PMID: 26934729 - DOI: 10.2214/AJR.15.15528
The Lymphatic System in Disease Processes and Cancer Progression.
Annu Rev Biomed Eng. 2016;18:125-58 - PMID: 26863922 - PMCID: PMC4946986 - DOI: 10.1146/annurev-bioeng-112315-031200
Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma.
PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity.
Clin Cancer Res. 2016;22(12):2993-3004 - PMID: 26861455 - PMCID: PMC4911258 - DOI: 10.1158/1078-0432.CCR-15-1839
Obesity and cancer: an angiogenic and inflammatory link.
Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability.
A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.
Sci Transl Med. 2016;8(320):320ra4 - PMID: 26738797 - PMCID: PMC4794335 - DOI: 10.1126/scitranslmed.aad0293
Reply to Davis: Nitric oxide regulates lymphatic contractions.
Proc Natl Acad Sci U S A. 2016;113(2):E106 - PMID: 26719425 - PMCID: PMC4720299 - DOI: 10.1073/pnas.1522233113
Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity.
Proc Natl Acad Sci U S A. 2016;113(1):122-7 - PMID: 26699463 - PMCID: PMC4711836 - DOI: 10.1073/pnas.1522401112
Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment.
J Natl Cancer Inst. 2016;108(2):ePub - PMID: 26547932 - PMCID: PMC4862418 - DOI: 10.1093/jnci/djv313
Mathematical Model of Oxygen Transport in Tuberculosis Granulomas.
Ann Biomed Eng. 2016;44(4):863-872 - PMID: 26253038 - PMCID: PMC4795989 - DOI: 10.1007/s10439-015-1415-3
A Multicenter, Phase II, Randomized, Noncomparative Clinical Trial of Radiation and Temozolomide with or without Vandetanib in Newly Diagnosed Glioblastoma Patients.
Clin Cancer Res. 2015;21(16):3610-8 - PMID: 25910950 - PMCID: PMC4790106 - DOI: 10.1158/1078-0432.CCR-14-3220
CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice.
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
PLoS One. 2015;10(12):e0141392 - PMID: 26641266 - PMCID: PMC4671732 - DOI: 10.1371/journal.pone.0141392
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
Proc Natl Acad Sci U S A. 2015;112(46):14325-14330 - PMID: 26578779 - PMCID: PMC4655544 - DOI: 10.1073/pnas.1518808112
Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model.
Proc Natl Acad Sci U S A. 2015;112(47):14676-81 - PMID: 26554010 - PMCID: PMC4664377 - DOI: 10.1073/pnas.1512570112
Vascular diseases await translation of blood vessels engineered from stem cells.
Sci Transl Med. 2015;7(309):309rv6 - PMID: 26468328 - PMCID: PMC4799660 - DOI: 10.1126/scitranslmed.aaa1805
Targeting immunosuppression after standard sorafenib treatment to facilitate immune checkpoint blockade in hepatocellular carcinoma - an auto-commentary on clinical potential and future development.
Oncoimmunology. 2015;4(10):e1029703 - PMID: 26451297 - PMCID: PMC4589048 - DOI: 10.1080/2162402X.2015.1029703
Familial Gastric Cancers.
Oncologist. 2015;20(12):1365-1377 - PMID: 26424758 - PMCID: PMC4679084 - DOI: 10.1634/theoncologist.2015-0205
Design considerations for nanotherapeutics in oncology.
Nanomedicine. 2015;11(8):1893-907 - PMID: 26282377 - PMCID: PMC4628869 - DOI: 10.1016/j.nano.2015.07.015
Mechanobiological oscillators control lymph flow.
Proc Natl Acad Sci U S A. 2015;112(35):10938-43 - PMID: 26283382 - PMCID: PMC4568261 - DOI: 10.1073/pnas.1508330112
From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey.
Cancer J. 2015;21(4):235-236 - PMID: 26222072 - PMCID: PMC4791947 - DOI: 10.1097/PPO.0000000000000136
Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment.
Cancer J. 2015;21(4):307-13 - PMID: 26222083 - DOI: 10.1097/PPO.0000000000000125
An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis.
Chemotherapy and antiangiogenics in biliary tract cancer.
Lancet Oncol. 2015;16(8):882-3 - PMID: 26179202 - DOI: 10.1016/S1470-2045(15)00093-5
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.
J Am Chem Soc. 2015;137(31):9832-42 - PMID: 26149349 - PMCID: PMC4750386 - DOI: 10.1021/jacs.5b04765
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.
Cancer Cell. 2015;28(1):70-81 - PMID: 26144315 - PMCID: PMC4504786 - DOI: 10.1016/j.ccell.2015.05.010
Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.
Proc Natl Acad Sci U S A. 2015;112(27):E3454 - PMID: 26080434 - PMCID: PMC4500270 - DOI: 10.1073/pnas.1507225112
Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases.
J Natl Cancer Inst. 2015;107(9):ePub - PMID: 26063793 - PMCID: PMC4651102 - DOI: 10.1093/jnci/djv155
Lessons From 30 Years of Teaching About the Microenvironment of Tumors.
A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma.
Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.
Significance of lymph node metastasis in cancer dissemination of head and neck cancer.
Transl Oncol. 2015;8(2):119-25 - PMID: 25926078 - PMCID: PMC4415144 - DOI: 10.1016/j.tranon.2015.03.001
Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis.
Editorial.
Semin Cell Dev Biol. 2015;38:53-4 - PMID: 25868083 - DOI: 10.1016/j.semcdb.2015.03.007
Local Failure in Parameningeal Rhabdomyosarcoma Correlates With Poor Response to Induction Chemotherapy.
Int J Radiat Oncol Biol Phys. 2015;92(2):358-67 - PMID: 25864172 - PMCID: PMC5479480 - DOI: 10.1016/j.ijrobp.2015.01.049
Texture Analysis of Non-Contrast-Enhanced Computed Tomography for Assessing Angiogenesis and Survival of Soft Tissue Sarcoma.
J Comput Assist Tomogr. 2015;39(4):607-612 - PMID: 25793653 - PMCID: PMC4504795 - DOI: 10.1097/RCT.0000000000000239
Lessons From Anti-Vascular Endothelial Growth Factor and Anti-Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma.
J Clin Oncol. 2015;33(10):1197-213 - PMID: 25713439 - PMCID: PMC4517055 - DOI: 10.1200/JCO.2014.55.9575
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.
J Natl Cancer Inst. 2015;107(4):ePub - PMID: 25710962 - PMCID: PMC4402365 - DOI: 10.1093/jnci/djv017
Emerging Strategies for Treating Brain Metastases from Breast Cancer.
Cancer Cell. 2015;27(2):163-175 - PMID: 25670078 - PMCID: PMC4325273 - DOI: 10.1016/j.ccell.2015.01.001
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors.
Ann Biomed Eng. 2015;43(9):2291-300 - PMID: 25670323 - PMCID: PMC4519365 - DOI: 10.1007/s10439-015-1276-9
Mechanobiology of lymphatic contractions.
Semin Cell Dev Biol. 2015;38:67-74 - PMID: 25636584 - DOI: 10.1016/j.semcdb.2015.01.010
Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery.
Proc Natl Acad Sci U S A. 2015;112(6):1827-32 - PMID: 25624495 - PMCID: PMC4330784 - DOI: 10.1073/pnas.1424563112
The lymph node microenvironment and its role in the progression of metastatic cancer.
Semin Cell Dev Biol. 2015;38:98-105 - PMID: 25620792 - PMCID: PMC4397158 - DOI: 10.1016/j.semcdb.2015.01.008
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice.
Proc Natl Acad Sci U S A. 2015;112(5):1350-5 - PMID: 25605916 - PMCID: PMC4321304 - DOI: 10.1073/pnas.1421632111
Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.
Proc Natl Acad Sci U S A. 2015;112(5):1547-52 - PMID: 25605928 - PMCID: PMC4321320 - DOI: 10.1073/pnas.1424024112
Using tumour phylogenetics to identify the roots of metastasis in humans.
Nat Rev Clin Oncol. 2015;12(5):258-72 - PMID: 25601447 - DOI: 10.1038/nrclinonc.2014.238
Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation.
CT Perfusion as an Imaging Biomarker in Monitoring Response to Neoadjuvant Bevacizumab and Radiation in Soft-Tissue Sarcomas: Comparison With Tumor Morphology, Circulating and Tumor Biomarkers, and Gene Expression.
AJR Am J Roentgenol. 2015;204(1):W11-8 - PMID: 25539263 - PMCID: PMC4479405 - DOI: 10.2214/AJR.13.12412
Translation of anticancer efficacy from nonclinical models to the clinic.
CPT Pharmacometrics Syst Pharmacol. 2014;3:e128 - PMID: 25098530 - PMCID: PMC4150926 - DOI: 10.1038/psp.2014.28
Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons.
Int J Radiat Oncol Biol Phys. 2014;89(1):161-6 - PMID: 24725699 - PMCID: PMC4298825 - DOI: 10.1016/j.ijrobp.2014.01.057
Restoring perivascular nitric oxide gradients normalizes breast cancer vasculature.
Nitric Oxide. 2014;42C:115 - PMID: 25519573
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia.
Cancer Cell. 2014;26(5):605-622 - PMID: 25517747 - PMCID: PMC4269830 - DOI: 10.1016/j.ccell.2014.10.006
Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study.
Method for the quantitative measurement of collecting lymphatic vessel contraction in mice.
Microfluidic model of angiogenic sprouting.
Methods Mol Biol. 2014;1214:243-54 - PMID: 25468609 - DOI: 10.1007/978-1-4939-1462-3_15
Correlative intravital imaging of cGMP signals and vasodilation in mice.
Magneto-fluorescent core-shell supernanoparticles.
Determinates of tumor response to radiation: Tumor cells, tumor stroma and permanent local control.
Radiother Oncol. 2014;113(1):146-9 - PMID: 25284063 - PMCID: PMC4280081 - DOI: 10.1016/j.radonc.2014.09.006
Letter to the editor regarding recent article by Wu et Al. [journal of theoretical biology, 355, 194-207 (2014)].
J Theor Biol. 2014;363:453 - PMID: 25219622 - DOI: 10.1016/j.jtbi.2014.08.052
Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.
Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: Potential mechanism.
Med Hypotheses. 2014;83(4):477-81 - PMID: 25175713 - DOI: 10.1016/j.mehy.2014.08.004
Increased perfusion due to vascular normalization improves oxygenation and survival in glioblastoma patients treated with cediranib with or without chemoradiation.
Neuro Oncol. 2014;16 Suppl 3:iii12 - PMID: 25165209 - PMCID: PMC4144509
Vessel calibre-a potential MRI biomarker of tumour response in clinical trials.
Nat Rev Clin Oncol. 2014;11(10):566-584 - PMID: 25113840 - PMCID: PMC4445139 - DOI: 10.1038/nrclinonc.2014.126
Seeds and soil: unraveling the role of local tumor stroma in distant metastasis.
J Natl Cancer Inst. 2014;106(8):ePub - PMID: 25082335 - DOI: 10.1093/jnci/dju187
Modes of neovascularization in tumors and clinical translation of antiangiogenic therapy.
In: Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (Editor: LM McManus & RN Mitchell). Elsevier Press, Oxford. 2014;:(in press)
Uncovering tumor biology by intravital microscopy.
In: Comprehensive Biomedical Physics, Volume: IV 'Optical molecular imaging' (Editor: Kiessling Alves & Anders Brahme). Elsevier Press. 2014;:(in press)
Molecular Pathophysiology of Tumors.
In: Principles and Practice of Radiation Oncology, 6th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2014;Chapter 4:(in press)
Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Proc Natl Acad Sci U S A. 2014;111(30):E3091-100 - PMID: 25024225 - PMCID: PMC4121834 - DOI: 10.1073/pnas.1411679111
Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure.
The role of mechanical forces in tumor growth and therapy.
Annu Rev Biomed Eng. 2014;16:321-46 - PMID: 25014786 - PMCID: PMC4109025 - DOI: 10.1146/annurev-bioeng-071813-105259
Blocking the formation of radiation-induced breast cancer stem cells.
Imaging the Lymphatic System.
Immune checkpoint blockade in hepatocellular carcinoma: Current progress and future directions.
A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma.
Int J Radiat Oncol Biol Phys. 2014;89(4):830-8 - PMID: 24867540 - PMCID: PMC4791180 - DOI: 10.1016/j.ijrobp.2014.03.034
Hypermutable DNA chronicles the evolution of human colon cancer.
Proc Natl Acad Sci U S A. 2014;111(18):E1889-98 - PMID: 24753616 - PMCID: PMC4020055 - DOI: 10.1073/pnas.1400179111
Characterization of Functional Transient Receptor Potential Melastatin 8 Channels in Human Pancreatic Ductal Adenocarcinoma Cells.
Pancreas. 2014;43(5):795-800 - PMID: 24658318 - DOI: 10.1097/MPA.0000000000000106
Pioglitazone decreases portosystemic shunting by modulating inflammation and angiogenesis in cirrhotic and non-cirrhotic portal hypertensive rats.
J Hepatol. 2014;60(6):1135-42 - PMID: 24530596 - DOI: 10.1016/j.jhep.2014.01.025
An indirect way to tame cancer
Sci Am. 2014;310(2):46-53 - PMID: 24640331 - DOI: 10.1038/scientificamerican0214-46
Low Incidence of Pseudoprogression by Imaging in Newly Diagnosed Glioblastoma Patients Treated With Cediranib in Combination With Chemoradiation.
Oncologist. 2014;19(1):75-81 - PMID: 24309981 - PMCID: PMC3903059 - DOI: 10.1634/theoncologist.2013-0101
Differential effects of sorafenib on liver versus tumor fibrosis mediated by SDF1a/CXCR4 axis and Gr-1+ myeloid cell infiltration in mice.
Novel molecular pathways in Gorham disease: Implications for treatment.
Pediatr Blood Cancer. 2014;61(3):401-6 - PMID: 24214028 - PMCID: PMC4123459 - DOI: 10.1002/pbc.24832
Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells.
Angiogenesis. 2014;17(2):419-27 - PMID: 24201897 - PMCID: PMC3981926 - DOI: 10.1007/s10456-013-9400-7
mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL inhibition by Suppressing MCL-1.
Cancer Discov. 2014;4(1):42-52 - PMID: 24163374 - PMCID: PMC3973435 - DOI: 10.1158/2159-8290.CD-13-0315
Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.
Discoveries: an innovative platform for publishing cutting-edge research discoveries in medicine, biology and chemistry.
Molecular Biomarkers of Response to Antiangiogenic Therapy for Cancer.
Dynamics of tissue topology during cancer invasion and metastasis.
Phys Biol. 2013;10(6):065003 - PMID: 24304856 - PMCID: PMC4324506 - DOI: 10.1088/1478-3975/10/6/065003
Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.
Nat Genet. 2013;45(12):1474-8 - PMID: 24185513 - DOI: 10.1038/ng.2806
Benefits of Vascular Normalization Are Dose and Time Dependent--Letter.
Cancer Res. 2013;73(23):7144-6 - PMID: 24265277 - PMCID: PMC3876035 - DOI: 10.1158/0008-5472.CAN-13-1989
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Proc Natl Acad Sci U S A. 2013;110(47):19059-64 - PMID: 24190997 - PMCID: PMC3839699 - DOI: 10.1073/pnas.1318022110
Combining two strategies to improve perfusion and drug delivery in solid tumors.
Proc Natl Acad Sci U S A. 2013;110(46):18632-7 - PMID: 24167277 - PMCID: PMC3832007 - DOI: 10.1073/pnas.1318415110
Strategies for advancing cancer nanomedicine.
A Phase II and Biomarker Study of Ramucirumab, a Human Monoclonal Antibody Targeting the VEGF Receptor-2 in Patients with Advanced Hepatocellular Cancer.
Clin Cancer Res. 2013;19(23):6614-23 - PMID: 24088738 - PMCID: PMC4795808 - DOI: 10.1158/1078-0432.CCR-13-1442
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion.
Integr Biol (Camb). 2013;5(11):1334-43 - PMID: 24077103 - PMCID: PMC4249644 - DOI: 10.1039/c3ib40057c
Lymphatic Function and Immune Regulation in Health and Disease.
Lymphat Res Biol. 2013;11(3):136-43 - PMID: 24024577 - PMCID: PMC3780287 - DOI: 10.1089/lrb.2013.0012
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma.
J Clin Oncol. 2013;31(26):3212-3218 - PMID: 23940216 - PMCID: PMC4021043 - DOI: 10.1200/JCO.2012.47.2464
Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
J Natl Cancer Inst. 2013;105(16):1188-1201 - PMID: 23899555 - PMCID: PMC3748004 - DOI: 10.1093/jnci/djt164
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.
Proc Natl Acad Sci U S A. 2013;110(31):12774-9 - PMID: 23861493 - PMCID: PMC3732948 - DOI: 10.1073/pnas.1310675110
Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma.
Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy.
Measuring Interstitial pH and pO2 in Mouse Tumors.
Cold Spring Harb Protoc. 2013;2013(7):675-7 - PMID: 23818669 - DOI: 10.1101/pdb.prot075713
Measuring interstitial diffusion, convection, and binding parameters in mouse tumors.
Cold Spring Harb Protoc. 2013;2013(7):678-80 - PMID: 23818670 - DOI: 10.1101/pdb.prot075721
Transgenic Mice for cGMP Imaging.
Circ Res. 2013;113(4):365-71 - PMID: 23801067 - PMCID: PMC3896241 - DOI: 10.1161/CIRCRESAHA.113.301063
Measuring leukocyte-endothelial interactions in mice.
Cold Spring Harb Protoc. 2013;2013(6):561-3 - PMID: 23734020 - DOI: 10.1101/pdb.prot075085
Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers.
J Clin Oncol. 2013;31(17):2205-18 - PMID: 23669226 - PMCID: PMC3731977 - DOI: 10.1200/JCO.2012.46.3653
Can We Identify Predictive Biomarkers for Antiangiogenic Therapy of Cancer Using Mathematical Modeling?
J Natl Cancer Inst. 2013;105(11):762-5 - PMID: 23670727 - PMCID: PMC3672078 - DOI: 10.1093/jnci/djt114
Co-evolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse.
Cancer Res. 2013;73(13):3833-3841 - PMID: 23633490 - PMCID: PMC3702668 - DOI: 10.1158/0008-5472.CAN-12-4521
Measuring vascular permeability in mice.
Cold Spring Harb Protoc. 2013;2013(5):444-6 - PMID: 23637370 - DOI: 10.1101/pdb.prot074344
Measuring angiogenesis and hemodynamics in mice.
Cold Spring Harb Protoc. 2013;2013(4):354-8 - PMID: 23547161 - DOI: 10.1101/pdb.prot073916
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
Vascular normalization as an emerging strategy to enhance cancer immunotherapy.
Cancer Res. 2013;73(10):2943-8 - PMID: 23440426 - PMCID: PMC3655127 - DOI: 10.1158/0008-5472.CAN-12-4354
Challenges and key considerations of the enhanced permeability and retention effect (EPR) for nanomedicine drug delivery in oncology.
Cancer Res. 2013;73(8):2412-2417 - PMID: 23423979 - PMCID: PMC3916009 - DOI: 10.1158/0008-5472.CAN-12-4561
Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking.
Efficacy, safety, pharmacokinetics and biomarkers of cediranib monotherapy in advanced hepatocellular carcinoma: A phase II study.
Clin Cancer Res. 2013;19(6):1557-66 - PMID: 23362324 - PMCID: PMC3609423 - DOI: 10.1158/1078-0432.CCR-12-3041
Lung window preparation in mice.
Cold Spring Harb Protoc. 2013;2013(1):ePub - PMID: 23282642 - DOI: 10.1101/pdb.prot072678
Spatial Charge Configuration Regulates Nanoparticle Transport and Binding Behavior In Vivo.
Angew Chem Int Ed Engl. 2013;52(5):1414-9 - PMID: 23255143 - PMCID: PMC3755124 - DOI: 10.1002/anie.201208331
Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model.
Ann Biomed Eng. 2013;41(1):68-77 - PMID: 22855118 - PMCID: PMC3886728 - DOI: 10.1007/s10439-012-0630-4
A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
A Nanocrystal-based Ratiometric pH Sensor for Natural pH Ranges.
Chemical Science. 2012;:ePub
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2012;64(Suppl):353-365 - PMID: 24511174 - PMCID: PMC3914635 - DOI: 10.1016/j.addr.2012.09.011
Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment.
Lymphatic vessels in health and disease.
Wiley Interdiscip Rev Syst Biol Med. 2012;5(1):111-24 - PMID: 23209022 - PMCID: PMC3527689 - DOI: 10.1002/wsbm.1201
Pancreatic tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209145 - DOI: 10.1101/pdb.prot072363
Liver tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(12):ePub - PMID: 23209146 - DOI: 10.1101/pdb.prot072371
Lymphangiography of the mouse tail.
Cold Spring Harb Protoc. 2012;2012(11):1177-8 - PMID: 23118364 - DOI: 10.1101/pdb.prot072108
Lymphangiography of the mouse ear.
Cold Spring Harb Protoc. 2012;2012(11):1179-80 - PMID: 23118365 - DOI: 10.1101/pdb.prot072116
RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis.
Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases.
Proc Natl Acad Sci U S A. 2012;109(45):E3119-27 - PMID: 23071298 - PMCID: PMC3494882 - DOI: 10.1073/pnas.1216078109
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.
Proc Natl Acad Sci U S A. 2012;109(43):17561-6 - PMID: 23045683 - PMCID: PMC3491458 - DOI: 10.1073/pnas.1215397109
Mammary fat pad chamber preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1113-4 - PMID: 23028075 - DOI: 10.1101/pdb.prot071506
Mammary fat pad tumor preparation in mice.
Cold Spring Harb Protoc. 2012;2012(10):1115-6 - PMID: 23028076 - DOI: 10.1101/pdb.prot071514
TGF-? blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2012;109(41):16618-23 - PMID: 22996328 - PMCID: PMC3478596 - DOI: 10.1073/pnas.1117610109
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2012;:ePub - PMID: 22983334
Going beyond systemic fluoropyrimidines with radiation therapy for rectal cancer: what should be the priority?
Oncology (Williston Park). 2012;26(8):741-3 - PMID: 22957407 - PMCID: PMC3682651
Corneal pocket assay in rabbits.
Cold Spring Harb Protoc. 2012;2012(9):1017-8 - PMID: 22949714 - DOI: 10.1101/pdb.prot070052
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Proc Natl Acad Sci U S A. 2012;109(38):15101-8 - PMID: 22932871 - PMCID: PMC3458380 - DOI: 10.1073/pnas.1213353109
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.
Cancer Res. 2012;72(2):402-7 - PMID: 22127927 - PMCID: PMC3261301 - DOI: 10.1158/0008-5472.CAN-11-2464
Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Cold Spring Harb Perspect Med. 2012;2(3):a006486 - PMID: 22393532 - PMCID: PMC3282493 - DOI: 10.1101/cshperspect.a006486
Quantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis.
Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis.
SnapShot: Tumor angiogenesis.
Cell. 2012;149(6):1408-1408.e1 - PMID: 22682256 - DOI: 10.1016/j.cell.2012.05.025
Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
An Exploratory Study of Inflammatory Cytokines as Prognostic Biomarkers in Patients With Ductal Pancreatic Adenocarcinoma.
Pancreas. 2012;41(7):1001-7 - PMID: 22722257 - DOI: 10.1097/MPA.0b013e3182546e13
Rabbit ear chambers.
Cold Spring Harb Protoc. 2012;2012(7):813-14 - PMID: 22753607 - DOI: 10.1101/pdb.prot070045
Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.
Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Annu Rev Chem Biomol Eng. 2012;2:281-98 - PMID: 22432620 - DOI: 10.1146/annurev-chembioeng-061010-114300
Mechanical compression drives cancer cells toward invasive phenotype.
Proc Natl Acad Sci U S A. 2012;109(3):911-6 - PMID: 22203958 - PMCID: PMC3271885 - DOI: 10.1073/pnas.1118910109
Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.
Oncologist. 2012;17(2):212-9 - PMID: 22302227 - PMCID: PMC3286170 - DOI: 10.1634/theoncologist.2011-0321
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
An isolated tumor perfusion model in mice.
Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
A transient parabiosis skin transplantation model in mice.
Multistage nanoparticles for improved delivery into tumor tissue.
Methods Enzymol. 2012;508:109-30 - PMID: 22449923 - PMCID: PMC3774840 - DOI: 10.1016/B978-0-12-391860-4.00006-9
Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology.
Proc Natl Acad Sci U S A. 2012;109(20):E1214 - PMID: 22550180 - PMCID: PMC3356659 - DOI: 10.1073/pnas.1203794109
Neovascularization After Irradiation: What is the Source of Newly Formed Vessels in Recurring Tumors?
J Natl Cancer Inst. 2012;104(12):899-905 - PMID: 22572994 - PMCID: PMC3379722 - DOI: 10.1093/jnci/djs239
Targeting Tumor Angiogenesis: Biomarkers of Angiogenesis and Antiangiogenic Therapy in Cancer
Angiogenesis Foundation CME e-publication. 2011;:ePub
Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas.
Int J Radiat Oncol Biol Phys. 2011;81(4):1081-90 - PMID: 20932656 - PMCID: PMC3021107 - DOI: 10.1016/j.ijrobp.2010.07.024
Lessons from the adjuvant bevacizumab trial on colon cancer: what next?
J Clin Oncol. 2011;29(1):1-4 - PMID: 21115866 - DOI: 10.1200/JCO.2010.32.2701
Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model.
T(1)- and T(2)(*)-dominant extravasation correction in DSC-MRI: part II-predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients.
J Cereb Blood Flow Metab. 2011;31(10):2054-64 - PMID: 21505476 - PMCID: PMC3208147 - DOI: 10.1038/jcbfm.2011.39
Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma.
Cancer Res. 2011;71(11):3745-52 - PMID: 21507932 - PMCID: PMC3107375 - DOI: 10.1158/0008-5472.CAN-10-2991
Molecular mechanisms and clinical applications of angiogenesis.
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases.
Nat Rev Drug Discov. 2011;10(6):417-27 - PMID: 21629292 - DOI: 10.1038/nrd3455
Cell-surface sensors for real-time probing of cellular environments.
Nat Nanotechnol. 2011;6(8):524-31 - PMID: 21765401 - PMCID: PMC3163485 - DOI: 10.1038/nnano.2011.101
Fluid forces control endothelial sprouting.
Proc Natl Acad Sci U S A. 2011;108(37):15342-7 - PMID: 21876168 - PMCID: PMC3174629 - DOI: 10.1073/pnas.1105316108
BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Cancer Discov. 2011;1(4):352-65 - PMID: 22145099 - PMCID: PMC3229203 - DOI: 10.1158/2159-8290.CD-11-0106
Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.
Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Glioblastoma recurrence after cediranib therapy in patients: lack of rebound revascularization as mode of escape.
Cancer Res. 2011;71(1):19-28 - PMID: 21199795 - PMCID: PMC3074948 - DOI: 10.1158/0008-5472.CAN-10-2602
In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553
Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
J Neurooncol. 2011;103(2):325-32 - PMID: 20821342 - PMCID: PMC4090923 - DOI: 10.1007/s11060-010-0390-7
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.
Anesthesiology. 2011;114(3):603-13 - PMID: 21270629 - PMCID: PMC3044772 - DOI: 10.1097/ALN.0b013e31820a4d5b
Dehydro-alpha-lapachone, a plant product with antivascular activity.
Proc Natl Acad Sci U S A. 2011;108(28):11596-601 - PMID: 21709229 - PMCID: PMC3136298 - DOI: 10.1073/pnas.1104225108
Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
Clin Cancer Res. 2011;17(4):918-27 - PMID: 20843836 - PMCID: PMC3023846 - DOI: 10.1158/1078-0432.CCR-10-0515
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc Natl Acad Sci U S A. 2011;108(1):302-7 - PMID: 21173223 - PMCID: PMC3017172 - DOI: 10.1073/pnas.1016917108
Scaling rules for diffusive drug delivery in tumor and normal tissues.
Proc Natl Acad Sci U S A. 2011;108(5):1799-803 - PMID: 21224417 - PMCID: PMC3033252 - DOI: 10.1073/pnas.1018154108
Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Proc Natl Acad Sci U S A. 2011;108(6):2426-31 - PMID: 21245339 - PMCID: PMC3038705 - DOI: 10.1073/pnas.1018382108
TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
Clin Cancer Res. 2011;17(6):1415-24 - PMID: 21278244 - PMCID: PMC3060297 - DOI: 10.1158/1078-0432.CCR-10-2429
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proc Natl Acad Sci U S A. 2011;108(7):2909-14 - PMID: 21282607 - PMCID: PMC3041115 - DOI: 10.1073/pnas.1018892108
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 2011;108(9):3725-30 - PMID: 21321210 - PMCID: PMC3048115 - DOI: 10.1073/pnas.1100446108
CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636
HCC and angiogenesis: possible targets and future directions.
Nat Rev Clin Oncol. 2011;8(5):292-301 - PMID: 21386818 - PMCID: PMC3266719 - DOI: 10.1038/nrclinonc.2011.30
PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Clin Cancer Res. 2011;17(11):3638-48 - PMID: 21459800 - PMCID: PMC3107920 - DOI: 10.1158/1078-0432.CCR-10-2456
The biology of brain metastases-translation to new therapies.
Nat Rev Clin Oncol. 2011;8(6):344-56 - PMID: 21487419 - PMCID: PMC3259742 - DOI: 10.1038/nrclinonc.2011.58
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer Res. 2011;71(13):4527-38 - PMID: 21571860 - DOI: 10.1158/0008-5472.CAN-10-4376
Is vasculogenesis crucial for the regrowth of irradiated tumours?
Normalization of the vasculature for treatment of cancer and other diseases.
Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010
Spontaneous nonthymic tumors in SCID mice.
Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755
Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
Am J Cancer Res. 2011;1(2):144-54 - PMID: 21822499 - PMCID: PMC3150110
Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Clin Ovarian Cancer Other Gynecol Malig. 2011;4(1):26-33 - PMID: 21833345 - PMCID: PMC3151740 - DOI: 10.1016/j.cloc.2011.04.003
Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108
Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Angew Chem Int Ed Engl. 2011;50(48):11417-20 - PMID: 22113800 - PMCID: PMC3260125 - DOI: 10.1002/anie.201104449
Intravital microscopy of normal and diseased tissues in the mouse.
In: Live Cell Imaging: A Laboratory Manual, 2nd Edition, (R. D. Goldman, J. R. Swedlow and D. L. Specter, Eds.), CSH Press, Cold Spring Harbor, NY. 2010;Chapter 26:475-521
Epigenetic markers in rectal cancer.
Clin Cancer Res. 2010;16(10):2699-701 - PMID: 20460492 - DOI: 10.1158/1078-0432.CCR-10-0559
Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers?
J Clin Oncol. 2010;28(2):183-5 - PMID: 19949009 - DOI: 10.1200/JCO.2009.24.8021
p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model.
Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer.
Oncologist. 2010;15(6):577-83 - PMID: 20484123 - PMCID: PMC3061828 - DOI: 10.1634/theoncologist.2010-0029
Lymphotoxin-alpha contributes to lymphangiogenesis.
Blood. 2010;116(12):2173-82 - PMID: 20566898 - PMCID: PMC2951858 - DOI: 10.1182/blood-2009-12-256065
Premetastatic lung niche: is vascular endothelial growth factor receptor 1 activation required?
Cancer Res. 2010;70(14):5670-3 - PMID: 20587530 - PMCID: PMC2919170 - DOI: 10.1158/0008-5472.CAN-10-0119
A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer.
Oncologist. 2010;15(8):845-51 - PMID: 20667969 - PMCID: PMC3078712 - DOI: 10.1634/theoncologist.2010-0030
Notch leads lymphatics and links them to blood vessels.
Arterioscler Thromb Vasc Biol. 2010;30(9):1682-3 - PMID: 20720193 - PMCID: PMC2945915 - DOI: 10.1161/ATVBAHA.110.210633
Delivering nanomedicine to solid tumors.
Nat Rev Clin Oncol. 2010;7(11):653-64 - PMID: 20838415 - PMCID: PMC3065247 - DOI: 10.1038/nrclinonc.2010.139
Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.
Cancer Res. 2010;70(14):5679-85 - PMID: 20631066 - PMCID: PMC2918387 - DOI: 10.1158/0008-5472.CAN-09-4446
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
J Clin Oncol. 2010;28(17):2817-23 - PMID: 20458050 - PMCID: PMC2903316 - DOI: 10.1200/JCO.2009.26.3988
Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
Cancer Res. 2010;70(9):3483-93 - PMID: 20406973 - PMCID: PMC4785015 - DOI: 10.1158/0008-5472.CAN-09-3107
Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.
Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization?
JACC Cardiovasc Imaging. 2010;3(1):41-4 - PMID: 20129529 - PMCID: PMC2842010 - DOI: 10.1016/j.jcmg.2009.11.001
InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
Optical methods in vascular biology and medicine.
J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696
In vivo wide-area cellular imaging by side-view endomicroscopy.
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x
Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073
Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
In vivo imaging of tumors.
Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452
Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
A nanoparticle size series for in vivo fluorescence imaging.
Angew Chem Int Ed Engl. 2010;49(46):8649-52 - PMID: 20886481 - PMCID: PMC3035057 - DOI: 10.1002/anie.201003142
Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Biophys J. 2010;99(10):3119-28 - PMID: 21081058 - PMCID: PMC2980743 - DOI: 10.1016/j.bpj.2010.08.065
Malignant cells facilitate lung metastasis by bringing their own soil.
Proc Natl Acad Sci U S A. 2010;107(50):21677-82 - PMID: 21098274 - PMCID: PMC3003109 - DOI: 10.1073/pnas.1016234107
Angiogenesis in Development, Disease and Regeneration.
In: Santin M, editor. Strategies in Regenerative Medicine: Integrating Biology with Materials Design. Springer, New York. 2009;Chapter 6:ePub
The potential utility of anti-VEGF agents to normalize tumor vasculature and alleviate edema in brain and spinal cord tumor patients.
Nat Clin Pract Oncol. 2009;6:229-36
Emerging paradigms and potential biomarkers of response and resistance in anatiangiogenic therapy of cancer
ASCO 2009 Educational Book. 2009;:716-21
Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice.
Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.
Visualizing anti-tumor immune responses in vivo.
Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).
Neuro Oncol. 2009;11(6):853-60 - PMID: 19293394 - PMCID: PMC2802405 - DOI: 10.1215/15228517-2009-010
Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis.
Cancer Res. 2009;69(7):2801-8 - PMID: 19318557 - PMCID: PMC2670480 - DOI: 10.1158/0008-5472.CAN-08-4051
Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.
J Clin Oncol. 2009;27(15):2542-52 - PMID: 19332720 - PMCID: PMC2739611 - DOI: 10.1200/JCO.2008.19.9356
Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells.
Anti-vascular endothelial growth factor therapy for malignant glioma.
Curr Neurol Neurosci Rep. 2009;9(3):254-62 - PMID: 19348715 - PMCID: PMC4790123 - DOI: 10.1007/s11910-009-0037-2
PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
J Clin Oncol. 2009;27(18):3020-6 - PMID: 19470921 - PMCID: PMC2702234 - DOI: 10.1200/JCO.2008.21.1771
Biomarkers of response and resistance to antiangiogenic therapy.
Nat Rev Clin Oncol. 2009;6(6):327-38 - PMID: 19483739 - PMCID: PMC3057433 - DOI: 10.1038/nrclinonc.2009.63
A new target for tumor therapy.
N Engl J Med. 2009;360(25):2669-71 - PMID: 19535806 - PMCID: PMC4792114 - DOI: 10.1056/NEJMcibr0902054
Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.
Int J Radiat Oncol Biol Phys. 2009;74(5):1580-91 - PMID: 19540073 - DOI: 10.1016/j.ijrobp.2009.03.047
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients.
Cancer Res. 2009;69(13):5296-300 - PMID: 19549889 - PMCID: PMC2824172 - DOI: 10.1158/0008-5472.CAN-09-0814
Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast.
Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
Determinants of leukocyte margination in rectangular microchannels.
Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Angiogenesis as a therapeutic target in malignant gliomas.
Oncologist. 2009;14(6):621-36 - PMID: 19487335 - PMCID: PMC4790121 - DOI: 10.1634/theoncologist.2008-0272
Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo.
Am J Pathol. 2009;175(1):294-302 - PMID: 19477947 - PMCID: PMC2708815 - DOI: 10.2353/ajpath.2009.080887
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
J Clin Oncol. 2009;27(18):3027-35 - PMID: 19470923 - PMCID: PMC2702235 - DOI: 10.1200/JCO.2008.20.9908
VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).
J Cell Mol Med. 2009;13(9B):3720-9 - PMID: 19426150 - PMCID: PMC2832073 - DOI: 10.1111/j.1582-4934.2009.00785.x
VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.
Nat Rev Clin Oncol. 2009;6(4):229-36 - PMID: 19333229 - PMCID: PMC4793889 - DOI: 10.1038/nrclinonc.2009.14
Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Clin Cancer Res. 2009;15(7):2352-60 - PMID: 19318482 - PMCID: PMC2872130 - DOI: 10.1158/1078-0432.CCR-08-2082
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
VEGFR1-activity-independent metastasis formation.
Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254
VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Cancer Res. 2009;69(20):7905-10 - PMID: 19826039 - PMCID: PMC2859041 - DOI: 10.1158/0008-5472.CAN-09-2099
Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).
J Clin Oncol. 2008;26(15_suppl):4096 - PMID: 27949464
Normalization of tumor vasculature and microenvironment.
In: Angiogenesis: An Integrative Approach from Science to Medicine (Editors: W. D. Figg and J. Folkman), Springer. 2008;:173-282
Vascular and interstitial biology of tumors
In: Clinical Oncology. 4th Edition, (Editors: Abeloff M, Armitage J, Niederhuber J, Kastan M, McKenna WG), Elsevier, Philadelphia. 2008;:105-24
Molecular Pathophysiology of Tumors.
In: Principles and Practice of Radiation Oncology, 5th Edition (Editors: E. C. Halperin, C. A. Parez, L. W. Brady), Lippincott, Williams & Wilkins, New York. 2008;Chapter 4:126-141
Applications of nonlinear intravital microscopy in tumor biology.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 29:735-756
Photobleaching and recovery with nonlinear microscopy.
In: Handbook of Biomedical Nonlinear Optical Microscopy (Editors: B. R. Masters and P. T. C. So). Oxford University Press, New York. 2008;Chapter 26:673-688
Judah Folkman
Journal of Clinical Investigation. 2008;118:823
Inter- and intramouse heterogeneity of radiation response for a growing paired organ.
Radiat Res. 2008;170(2):264-7 - PMID: 18666813 - DOI: 10.1667/RR1262.1
Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.
Lattice Boltzmann simulation of blood flow in digitized vessel networks.
Comput Math Appl. 2008;55(7):1594-1600 - PMID: 19343080 - PMCID: PMC2390865 - DOI: 10.1016/j.camwa.2007.08.019
Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Curr Opin Neurol. 2008;21(6):728-35 - PMID: 18989120 - DOI: 10.1097/WCO.0b013e328318402a
Imaging angiogenesis and the microenvironment.
APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x
Response criteria for glioma.
Nat Clin Pract Oncol. 2008;5(11):634-44 - PMID: 18711427 - PMCID: PMC4795821 - DOI: 10.1038/ncponc1204
VEGFR3: a new target for antiangiogenesis therapy?
Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182
Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079
Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193
Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Nat Rev Cancer. 2008;8(4):309-16 - PMID: 18337733 - DOI: 10.1038/nrc2346
A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.
A protocol for a lung neovascularization model in rodents.
Perivascular nitric oxide gradients normalize tumor vasculature.
Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730
Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Taming vessels to treat cancer.
Sci Am. 2008;298(1):56-63 - PMID: 18225696 - DOI: 10.1038/scientificamerican0108-56
Blood cell interactions and segregation in flow.
Ann Biomed Eng. 2008;36(4):534-44 - PMID: 18188702 - PMCID: PMC2752714 - DOI: 10.1007/s10439-007-9429-0
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.
Tumor Angiogenesis and Blood Flow.
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:199-201
Optical Microscopy in Small Animal Research
In: Imaging of Vertebrates (Editors: Tavitian B, Leroy-Willig A & Ntziachristos V). Wiley, London. 2007;:183-187
Normalization of tumor vasculature and microenvironment.
In: Antiangiogenic Agents in Cancer Therapy. (Editors: Beverly Teicher and Lee Ellis), Humana Press. 2007;:261-76
Normalization of tumor vasculature and microenvironment by antiangiogenic therapy.
In: Angiogenesis: Mechanisms and Cancer Therapy (Editors: Dieter Marm and Norbert E. Fusenig), Springer-Verlag, Berlin. 2007;:577-92
Angiogenesis in Solid Tumors
In: Antiangiogenic Cancer Therapy (Editors: James L. Abbruzzese, Darren W. Davis and Roy S. Herbst), CRC Press, Boca Raton. 2007;:43-90
Data do not support benefits of anti-VEGFR3 therapy
Cancer Research. 2007;67:5055
Surrogate biomarkers for anti-angiogenic therapy for advanced colorectal cancer.
Current Colorectal Cancer Reports. 2007;3:94-98
Vascular normalization as rationale for combining chemotherapy with antiangiogenic agents
PPO Updates. 2007;21:1-7
Detection of circulating endothelial cells: CD146- based magnetic separation enrichment or flow cytometric assay?
J Clin Oncol. 2007;25:e3-e5
Endothelial cell-based therapy for hematopoiesis
Blood. 2007;109(6):2272-3
Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
J Cell Biochem. 2007;101(4):937-49 - PMID: 17171643 - DOI: 10.1002/jcb.21187
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Robust 3-D modeling of vasculature imagery using superellipsoids.
IEEE Trans Med Imaging. 2007;26(2):223-37 - PMID: 17304736 - DOI: 10.1109/TMI.2006.889722
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
Cancer Res. 2007;67(6):2729-35 - PMID: 17363594 - PMCID: PMC3022341 - DOI: 10.1158/0008-5472.CAN-06-4102
A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.
Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Lancet Oncol. 2007;8(5):444-8 - PMID: 17466902 - PMCID: PMC2712886 - DOI: 10.1016/S1470-2045(07)70140-7
Influence of tumor cell and stroma sensitivity on tumor response to radiation.
Cancer Res. 2007;67(9):4016-21 - PMID: 17483312 - DOI: 10.1158/0008-5472.CAN-06-4498
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
Microvasc Res. 2007;74(2-3):72-84 - PMID: 17560615 - PMCID: PMC2100036 - DOI: 10.1016/j.mvr.2007.05.003
American Association for Cancer Research 98th Annual Meeting. Angiogenesis and anti-angiogenesis in cancer.
IDrugs. 2007;10(6):366-9 - PMID: 17641996
Angiogenesis in brain tumours.
Nat Rev Neurosci. 2007;8(8):610-22 - PMID: 17643088 - DOI: 10.1038/nrn2175
Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization.
Nat Clin Pract Cardiovasc Med. 2007;4(9):491-502 - PMID: 17712362 - DOI: 10.1038/ncpcardio0979
Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11
Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Antiangiogenic agents for the treatment of glioblastoma.
Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107
alphaPlGF: a new kid on the antiangiogenesis block.
Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023
Targeted therapy in rectal cancer.
Oncology (Williston Park). 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim - PMID: 17910311 - PMCID: PMC2686129
Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.
Ann Biomed Eng. 2007;35(12):2121-9 - PMID: 17846892 - PMCID: PMC2752713 - DOI: 10.1007/s10439-007-9377-8
Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.
J Clin Oncol. 2007;25(26):4033-42 - PMID: 17827451 - PMCID: PMC2686120 - DOI: 10.1200/JCO.2007.11.3985
Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma.
Mol Cancer Res. 2007;5(9):873-80 - PMID: 17704140 - DOI: 10.1158/1541-7786.MCR-06-0141
Modeling the flow of dense suspensions of deformable particles in three dimensions.
Phys Rev E Stat Nonlin Soft Matter Phys. 2007;75(6 Pt 2):066707 - PMID: 17677389 - PMCID: PMC2752716 - DOI: 10.1103/PhysRevE.75.066707
Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Cancer Res. 2007;67(11):5076-82 - PMID: 17545583 - DOI: 10.1158/0008-5472.CAN-06-3664
Anti-VEGFR-3 therapy and lymph node metastasis [corrected].
Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935
Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.
Nat Clin Pract Oncol. 2007;4(5):316-21 - PMID: 17464339 - PMCID: PMC2686127 - DOI: 10.1038/ncponc0813
VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.
Trends Mol Med. 2007;13(6):223-30 - PMID: 17462954 - PMCID: PMC2686126 - DOI: 10.1016/j.molmed.2007.04.001
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.
Nat Biotechnol. 2007;25(3):317-8 - PMID: 17322871 - DOI: 10.1038/nbt1287
Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma.
J Soc Integr Oncol. 2007;5(1):11-7 - PMID: 17309809 - DOI: 10.2310/7200.2006.033
Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region.
Cancer Gene Ther. 2006;13(3):242-52 - PMID: 16179928 - DOI: 10.1038/sj.cgt.7700902
PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension.
Cell Tissue Res. 2006;326(3):759-69 - PMID: 16794827 - DOI: 10.1007/s00441-006-0177-5
Seminal findings and an allergy to black flies.
In: Reflections from the Frontiers, Explorations for the Future: Gordon Research Conferences, 1931-2006 (Editors: Arthur A. Daemmrich, Nancy Ryan Gray and Leah Shaper), Gordon Research Conferences and Chemical Heritage Foundation, Philadelphia. 2006;:70-71
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Nat Clin Pract Oncol. 2006;3(1):24-40 - PMID: 16407877 - DOI: 10.1038/ncponc0403
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Proc Natl Acad Sci U S A. 2006;103(4):855-60 - PMID: 16418262 - PMCID: PMC1348013 - DOI: 10.1073/pnas.0510412103
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Cancer Res. 2006;66(5):2509-13 - PMID: 16510565 - DOI: 10.1158/0008-5472.CAN-05-2242
Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
J Clin Oncol. 2006;24(9):1449-53 - PMID: 16549839 - PMCID: PMC2718681 - DOI: 10.1200/JCO.2005.04.2861
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655
Antiangiogenesis and drug delivery to tumors: bench to bedside and back.
Cancer Res. 2006;66(8):3967-70 - PMID: 16618712 - DOI: 10.1158/0008-5472.CAN-05-4536
Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Cancer Res. 2006;66(8):3971-7 - PMID: 16618713 - DOI: 10.1158/0008-5472.CAN-04-3085
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
J Appl Physiol. 2006;101(4):1162-9 - PMID: 16763103 - DOI: 10.1152/japplphysiol.00389.2006
Molecular mechanisms of metastasis.
Cancer Metastasis Rev. 2006;25(2):203-20 - PMID: 16770533 - DOI: 10.1007/s10555-006-8500-x
The role of nitric oxide in tumour progression.
Nat Rev Cancer. 2006;6(7):521-34 - PMID: 16794635 - DOI: 10.1038/nrc1910
Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Ann Biomed Eng. 2006;34(8):1247-58 - PMID: 16832606 - DOI: 10.1007/s10439-006-9134-4
Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392
Platelet-derived growth factor receptor-beta in Gorham's disease.
Nat Clin Pract Oncol. 2006;3(12):693-7 - PMID: 17139320 - PMCID: PMC2693369 - DOI: 10.1038/ncponc0660
Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Semin Oncol. 2006;33(5 Suppl 10):S35-40 - PMID: 17145523 - PMCID: PMC2686124 - DOI: 10.1053/j.seminoncol.2006.08.007
A Practical Guide to in vivo Imaging of Tumors.
In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 92:695-700
FRAP and Multiphoton FRAP.
In: Imaging in Neuroscience and Development: A Laboratory Manual (Editors: R. Yuste and A. Konnerth), Cold Spring Harbor Press, Cold Spring Harbor, New York. 2005;Chapter 56:429-438
Particulate nature of blood determines macroscopic rheology: a 2-D lattice Boltzmann analysis.
Biophys J. 2005;88(3):1635-45 - PMID: 15613630 - PMCID: PMC1305220 - DOI: 10.1529/biophysj.104.051151
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.
Science. 2005;307(5706):58-62 - PMID: 15637262 - DOI: 10.1126/science.1104819
Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device.
An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol.
Cancer Biol Ther. 2005;4(1):48-9 - PMID: 15711122 - DOI: 10.4161/cbt.4.1.1572
Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
J Clin Oncol. 2005;23(9):1951-61 - PMID: 15774788 - DOI: 10.1200/JCO.2005.08.119
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Antiangiogenic therapy for cancer: current and emerging concepts.
Oncology (Williston Park). 2005;19(4 Suppl 3):7-16 - PMID: 15934498
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Cancer Res. 2005;65(13):5711-9 - PMID: 15994946 - DOI: 10.1158/0008-5472.CAN-04-4313
Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Cancer Res. 2005;65(13):5740-9 - PMID: 15994949 - DOI: 10.1158/0008-5472.CAN-04-4552
Engineering vascularized tissue.
Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nat Med. 2005;11(9):998-1004 - PMID: 16116431 - DOI: 10.1038/nm1285
Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003
A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.
Microvasc Res. 2005;70(3):165-78 - PMID: 16239015 - DOI: 10.1016/j.mvr.2005.08.005
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
J Clin Oncol. 2005;23(31):8136-9 - PMID: 16258121 - DOI: 10.1200/JCO.2005.02.5635
Vascular and Interstitial Biology of Tumors.
In: Clinical Oncology, 3rd Edition (Editors: M. Abeleff, J. Armitage, J. Niederhuber, M. Kastan and G. McKenna), Elsevier, Philadelphia, PA. 2004;Chapter 9:153-172
Intravital microscopy of normal and diseased tissues in the mouse.
In: Live Cell Imaging: A Laboratory Manual (Editors: R. D. Goldman and D. L. Spector). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 2004;Chapter 24:435-466
Correspondence: Recognition of tumor blood vessel normalization as a new antiangiogenic concept.
Nature Medicine. 2004;10:329-330
Incorporation of luminescent nanocrystals into monodisperse core-shell silica microspheres.
Advanced Materials. 2004;16:23-24
Correspondence: PET concerns in bevacizumab treatment
Nature Medicine. 2004;10:561
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Nat Med. 2004;10(2):203-7 - PMID: 14716306 - DOI: 10.1038/nm981
Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells.
Clin Cancer Res. 2004;10(2):701-7 - PMID: 14760093 - DOI: 10.1158/1078-0432.ccr-0953-03
Pathology: cancer cells compress intratumour vessels.
Nature. 2004;427(6976):695 - PMID: 14973470 - DOI: 10.1038/427695a
Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site.
Oncol Rep. 2004;11(4):803-7 - PMID: 15010876
Tissue engineering: creation of long-lasting blood vessels.
Nature. 2004;428(6979):138-9 - PMID: 15014486 - DOI: 10.1038/428138a
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.
Nature. 2004;428(6980):328-32 - PMID: 15029197 - DOI: 10.1038/nature02329
Differential gene expression in metastasizing cells shed from kidney tumors.
Cancer Res. 2004;64(7):2469-73 - PMID: 15059900 - DOI: 10.1158/0008-5472.can-03-0256
The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
Pancreas. 2004;28(3):311-6 - PMID: 15084978 - DOI: 10.1097/00006676-200404000-00019
Measurement of macromolecular diffusion coefficients in human tumors.
Microvasc Res. 2004;67(3):231-6 - PMID: 15121448 - DOI: 10.1016/j.mvr.2004.02.001
Role of eNOS in neovascularization: NO for endothelial progenitor cells.
Trends Mol Med. 2004;10(4):143-5 - PMID: 15162796 - DOI: 10.1016/j.molmed.2004.02.001
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Cancer Res. 2004;64(11):3731-6 - PMID: 15172975 - DOI: 10.1158/0008-5472.CAN-04-0074
Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function.
Cancer Res. 2004;64(13):4400-4 - PMID: 15231646 - DOI: 10.1158/0008-5472.CAN-04-0752
Zooming in and out with quantum dots.
Nat Biotechnol. 2004;22(8):959-60 - PMID: 15286644 - DOI: 10.1038/nbt0804-959
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.
Cancer Cell. 2004;6(6):553-63 - PMID: 15607960 - DOI: 10.1016/j.ccr.2004.10.011
Differential transplantability of tumor-associated stromal cells.
Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268
Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.
Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Specific keynote: molecular determinants of angiogenesis in ovarian cancer.
Gynecol Oncol. 2003;88(1 Pt 2):S29-36; discussion S37-42 - PMID: 12586082 - DOI: 10.1006/gyno.2002.6680
Mechanisms of leukotriene B4--triggered monocyte adhesion.
Arterioscler Thromb Vasc Biol. 2003;23(10):1761-7 - PMID: 12947016 - DOI: 10.1161/01.ATV.0000092941.77774.3C
Molecular Pathophysiology of Tumors
In: Principles and Practice of Radiation Oncology, 4th Edition (Editors: C. A. Parez, L. W. Brady, E. C. Halperin, and R. Schmidt-Ullrich), Lippincott, Williams & Wilkins, New York. 2003;Chapter 4:163-179
Interstitial Transport in Solid Tumors
In: Cancer Modeling and Simulation (Editor: L Preziosi), Chapman & Hall, Boca Raton, FL. 2003;Chapter 3:51-74
Coupled Macromolecular Transport and Gel Mechanics: Poroviscoelastic Approach.
AIChE Journal. 2003;49:1580-1596
Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy.
Cold Spring Harb Symp Quant Biol. 2003;67:239-48 - PMID: 12858546 - DOI: 10.1101/sqb.2002.67.239
Specific Keynote: Molecular determinants of angiogenesis in ovarian cancer
Gynecologic Oncology. 2003;88:S290S36
A model for temporal heterogeneities of tumor blood flow.
Microvasc Res. 2003;65(1):56-60 - PMID: 12535873 - DOI: 10.1016/s0026-2862(02)00012-2
Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts.
Cancer Res. 2003;63(4):747-51 - PMID: 12591719
Photodynamic therapy for cancer.
Nat Rev Cancer. 2003;3(5):380-7 - PMID: 12724736 - DOI: 10.1038/nrc1071
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.
Blood. 2003;102(7):2555-61 - PMID: 12775571 - DOI: 10.1182/blood-2003-02-0365
Molecular regulation of vessel maturation.
Nat Med. 2003;9(6):685-93 - PMID: 12778167 - DOI: 10.1038/nm0603-685
Role of bone marrow-derived cells in tumor angiogenesis and treatment.
Cancer Cell. 2003;3(6):515-6 - PMID: 12842078 - DOI: 10.1016/s1535-6108(03)00138-7
Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions.
Mol Imaging. 2003;1(1):9-15 - PMID: 12920856 - DOI: 10.1162/153535002753395662
Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.
Microvasc Res. 2003;66(2):113-25 - PMID: 12935769 - DOI: 10.1016/s0026-2862(03)00039-6
Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors.
Cancer Res. 2003;63(17):5188-93 - PMID: 14500342
Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.
Angiogenesis. 2003;6(1):15-24 - PMID: 14517400 - DOI: 10.1023/a:1025803600840
Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts.
Clin Cancer Res. 2003;9(11):4221-6 - PMID: 14519649
Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.
Circ Res. 2003;93(9):e88-97 - PMID: 14525808 - PMCID: PMC2755542 - DOI: 10.1161/01.RES.0000099243.20096.FA
Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
Oncogene. 2003;22(44):6857-64 - PMID: 14534532 - DOI: 10.1038/sj.onc.1206751
What brings pericytes to tumor vessels?
Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.
Microvasc Res. 2003;66(3):204-12 - PMID: 14609526 - DOI: 10.1016/s0026-2862(03)00057-8
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Clin Cancer Res. 2003;9(15):5508-13 - PMID: 14654530
Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026
Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis.
Biophys J. 2003;85(1):208-22 - PMID: 12829477 - PMCID: PMC1303078 - DOI: 10.1016/S0006-3495(03)74467-1
Aberrant vascular architecture in tumors and its importance in drug-based therapies.
Drug Discov Today. 2003;8(9):396-403 - PMID: 12706657 - DOI: 10.1016/s1359-6446(03)02686-2
Development. Lymphatics make the break.
Science. 2003;299(5604):209-10 - PMID: 12522236 - DOI: 10.1126/science.1081345
Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.
Expression of metastasis-related genes in human epithelial ovarian tumors.
Int J Oncol. 2002;20(1):5-13 - PMID: 11743636
Gene therapy for pancreatic cancer based on genetic characterization of the disease.
J Hepatobiliary Pancreat Surg. 2002;9(1):32-8 - PMID: 12021895 - DOI: 10.1007/s005340200002
Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.
Genes Chromosomes Cancer. 2002;34(2):234-42 - PMID: 11979557 - DOI: 10.1002/gcc.10060
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.
J Biol Chem. 2002;277(13):11368-74 - PMID: 11741977 - DOI: 10.1074/jbc.M108347200
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
Am J Pathol. 2002;160(3):985-1000 - PMID: 11891196 - PMCID: PMC1867175 - DOI: 10.1016/S0002-9440(10)64920-6
Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
J Natl Cancer Inst. 2002;94(6):417-21 - PMID: 11904313 - DOI: 10.1093/jnci/94.6.417
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Nature. 2002;416(6878):279-80 - PMID: 11907566 - DOI: 10.1038/416279b
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Cancer Res. 2002;62(7):2151-6 - PMID: 11929837
Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Clin Cancer Res. 2002;8(4):1008-13 - PMID: 11948107
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
Clin Cancer Res. 2002;8(4):1284-91 - PMID: 11948144
Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420
Dissecting tumour pathophysiology using intravital microscopy.
Nat Rev Cancer. 2002;2(4):266-76 - PMID: 12001988 - DOI: 10.1038/nrc778
Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.
J Natl Cancer Inst. 2002;94(11):785-7 - PMID: 12048260 - DOI: 10.1093/jnci/94.11.785
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett. 2002;524(1-3):163-71 - PMID: 12135761 - DOI: 10.1016/s0014-5793(02)03049-1
Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor.
Pancreas. 2002;25(2):111-21 - PMID: 12142732 - DOI: 10.1097/00006676-200208000-00001
Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.
Cancer Res. 2002;62(15):4289-94 - PMID: 12154031
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Biophys J. 2002;83(3):1650-60 - PMID: 12202388 - PMCID: PMC1302261 - DOI: 10.1016/S0006-3495(02)73933-7
Red blood cells augment leukocyte rolling in a virtual blood vessel.
Biophys J. 2002;83(4):1834-41 - PMID: 12324405 - PMCID: PMC1302276 - DOI: 10.1016/S0006-3495(02)73948-9
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.
Cancer Res. 2002;62(23):6831-6 - PMID: 12460895
Tumor angiogenesis and accessibility: role of vascular endothelial growth factor.
Semin Oncol. 2002;29(6 Suppl 16):3-9 - PMID: 12516032 - DOI: 10.1053/sonc.2002.37265
Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.
Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683-3688, 2000.
Cancer Res. 2001;61(22):8347-50 - PMID: 11719469
Transparent Window Models and Intravital Microscopy: Imaging Gene Expression
Physiological Function and Drug Delivery in Tumors, In: Tumor Models in Cancer Research, B. Teicher, Ed., Humana Press, Inc., Totowa, NJ. 2001;Chapter 34:647-671
In Memoriam: Pietro M. Gullino (1919-2001)
Cancer Research. 2001;61:8930-8931
Correspondence Regarding Fractals and Cancer.
Cancer Research. 2001;61:8347-8351
Vessels of death or life.
Sci Am. 2001;285(6):38-45 - PMID: 11759584 - DOI: 10.1038/scientificamerican1201-38
Can engineered bacteria help control cancer?
Proc Natl Acad Sci U S A. 2001;98(26):14748-50 - PMID: 11752416 - PMCID: PMC64926 - DOI: 10.1073/pnas.261606598
Transport of molecules, particles, and cells in solid tumors.
Annu Rev Biomed Eng. 2001;1:241-63 - PMID: 11701489 - DOI: 10.1146/annurev.bioeng.1.1.241
Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.
Nat Med. 2001;7(9):987-9 - PMID: 11533692 - DOI: 10.1038/nm0901-987
Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
J Control Release. 2001;74(1-3):7-25 - PMID: 11489479 - DOI: 10.1016/s0168-3659(01)00306-6
Clearing the smoke on nicotine and angiogenesis.
Nat Med. 2001;7(7):775-7 - PMID: 11433337 - DOI: 10.1038/89889
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2001;46(1-3):149-68 - PMID: 11259838 - DOI: 10.1016/s0169-409x(00)00131-9
In vivo evaluation of the early events associated with liver metastasis of circulating cancer cells
Lateral view flow system for studies of cell adhesion and deformation under flow conditions.
Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.
Microvasc Res. 2001;61(2):203-10 - PMID: 11254400 - DOI: 10.1006/mvre.2000.2298
Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery.
Biorheology. 2001;38(2-3):151-9 - PMID: 11381172
Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy.
Circ Res. 2001;89(8):723-31 - PMID: 11597996 - DOI: 10.1161/hh2001.097870
Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation.
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer Res. 2001;61(1):39-44 - PMID: 11196192
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proc Natl Acad Sci U S A. 2001;98(8):4628-33 - PMID: 11274375 - PMCID: PMC31885 - DOI: 10.1073/pnas.081626898
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvasc Res. 2001;62(1):26-42 - PMID: 11421658 - DOI: 10.1006/mvre.2001.2311
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nat Med. 2001;7(7):864-8 - PMID: 11433354 - DOI: 10.1038/89997
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045
Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Lab Invest. 2001;81(10):1439-51 - PMID: 11598156 - DOI: 10.1038/labinvest.3780357
LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer Res. 2001;61(22):8079-84 - PMID: 11719431
A potential murine model for flap-related investigations.
Plast Reconstr Surg. 2001;107(6):1504-8 - PMID: 11335827 - DOI: 10.1097/00006534-200105000-00032
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.
Proc Natl Acad Sci U S A. 2001;98(5):2604-9 - PMID: 11226286 - PMCID: PMC30185 - DOI: 10.1073/pnas.041359198
Delivery of Biologic Molecules and Cells to Tumors
In: Biologic Therapy of Cancer: Principles and Practice, S. Rosenberg, Ed., Lippincott, Williams and Watkins, Philadelphia. 2000;:865-874
Angiogenesis in cancer and other diseases.
Nature. 2000;407(6801):249-57 - PMID: 11001068 - DOI: 10.1038/35025220
Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.
Cancer Res. 2000;60(16):4324-7 - PMID: 10969769
Fractals and cancer.
Cancer Res. 2000;60(14):3683-8 - PMID: 10919633
Formation of endothelial cell networks.
Nature. 2000;405(6783):139-41 - PMID: 10821260 - DOI: 10.1038/35012132
Role of extracellular matrix assembly in interstitial transport in solid tumors.
Cancer Res. 2000;60(9):2497-503 - PMID: 10811131
Vascular permeability in a human tumour xenograft: molecular charge dependence.
Openings between defective endothelial cells explain tumor vessel leakiness.
Am J Pathol. 2000;156(4):1363-80 - PMID: 10751361 - PMCID: PMC1876882 - DOI: 10.1016/S0002-9440(10)65006-7
Interferon-mediated antiangiogenic therapy
Journal of National Cancer Institute. 2000;1092:4-12
Critical determinants of neoplastic angiogenesis
The Cancer Journal. 2000;6 Suppl 3:S225-36 - PMID: 10874492
Interleukin 8: an autocrine growth factor for human ovarian cancer.
Oncol Res. 2000;12(2):97-106 - PMID: 11132928 - DOI: 10.3727/096504001108747567
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
Int J Oncol. 2000;16(3):445-54 - PMID: 10675474 - DOI: 10.3892/ijo.16.3.445
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells.
Cancer Res. 2000;60(16):4610-6 - PMID: 10969814
Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors.
Cancer Res. 2000;60(5):1442-8 - PMID: 10728711
The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice.
Pancreas. 2000;20(3):227-33 - PMID: 10766447 - DOI: 10.1097/00006676-200004000-00002
Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12.
Cancer Res. 2000;60(4):1111-6 - PMID: 10706132
Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.
Hum Gene Ther. 2000;11(2):223-35 - PMID: 10680837 - DOI: 10.1089/10430340050015978
Leaky vessels? Call Ang1!
Nat Med. 2000;6(2):131-2 - PMID: 10655092 - DOI: 10.1038/72212
Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties.
Microvasc Res. 2000;59(2):265-77 - PMID: 10684732 - DOI: 10.1006/mvre.1999.2225
Erythrocytes enhance lymphocyte rolling and arrest in vivo.
Microvasc Res. 2000;59(2):316-22 - PMID: 10684738 - DOI: 10.1006/mvre.1999.2223
Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.
Proc Natl Acad Sci U S A. 2000;97(26):14608-13 - PMID: 11121063 - PMCID: PMC18966 - DOI: 10.1073/pnas.97.26.14608
Vasculogenic mimicry: how convincing, how novel, and how significant?
Am J Pathol. 2000;156(2):383-8 - PMID: 10666365 - PMCID: PMC1850027 - DOI: 10.1016/S0002-9440(10)64740-2
Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction.
Cancer Res. 2000;60(8):2128-31 - PMID: 10786673
Oncotic pressure in solid tumors is elevated.
Cancer Res. 2000;60(15):4251-5 - PMID: 10945638
Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy.
Cancer Res. 2000;60(16):4556-60 - PMID: 10969807
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer Res. 2000;60(19):5565-70 - PMID: 11034104
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--&gt; hypoxia response element--&gt; VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer Res. 2000;60(22):6248-52 - PMID: 11103778
Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.
J Virol. 2000;74(18):8413-24 - PMID: 10954541 - PMCID: PMC116352 - DOI: 10.1128/jvi.74.18.8413-8424.2000
Investigation of Thin Aqueous Films on Silica Using a Modified Interferometric Technique.
J Colloid Interface Sci. 2000;225(1):243-246 - PMID: 10767167 - DOI: 10.1006/jcis.2000.6735
Thinning and Rupture of Aqueous Surfactant Films on Silica
Langmuir. 1999;15:7658-7661
Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy.
Cellular membrane permeability of anthracyclines does not correlate with their delivery in a tissue-isolated tumor.
Cancer Res. 1999;59(17):4458-63 - PMID: 10485498
Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas.
Microvasc Res. 1999;58(2):89-98 - PMID: 10458924 - DOI: 10.1006/mvre.1999.2158
Understanding barriers to drug delivery: high resolution in vivo imaging is key.
Clin Cancer Res. 1999;5(7):1605-6 - PMID: 10430057
Angiogenesis in the huPBL-SCID model of human transplant rejection.
Transplantation. 1999;67(12):1626-31 - PMID: 10401773 - DOI: 10.1097/00007890-199906270-00020
Return of lymphatic function after flap transfer for acute lymphedema.
Ann Surg. 1999;229(3):421-7 - PMID: 10077056 - PMCID: PMC1191709 - DOI: 10.1097/00000658-199903000-00017
Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: 31P and 1H magnetic resonance spectroscopic studies.
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
Cancer Res. 1999;59(22):5822-9 - PMID: 10582705
Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.
Microvasc Res. 1999;57(3):357-62 - PMID: 10329263 - DOI: 10.1006/mvre.1998.2140
Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium.
Microcirculation. 1999;5(2-3):153-71 - PMID: 9789256
Omeprazole attenuates neutrophil-endothelial cell adhesive interaction induced by extracts of Helicobacter pylori.
J Gastroenterol Hepatol. 1999;14(1):27-31 - PMID: 10029274 - DOI: 10.1046/j.1440-1746.1999.01809.x
Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Proc Natl Acad Sci U S A. 1999;96(6):3137-42 - PMID: 10077650 - PMCID: PMC15908 - DOI: 10.1073/pnas.96.6.3137
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.
Cancer Res. 1999;59(15):3776-82 - PMID: 10446995
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor.
Cancer Res. 1999;59(16):4129-35 - PMID: 10463618
Suppression of ING1 expression in sporadic breast cancer.
Oncogene. 1999;18(37):5187-93 - PMID: 10498868 - DOI: 10.1038/sj.onc.1202905
Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nat Med. 1999;5(10):1203-8 - PMID: 10502827 - DOI: 10.1038/13524
Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
Nat Genet. 1999;23(3):373 - PMID: 10545957 - DOI: 10.1038/15566
Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity.
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
J Biomech. 1999;32(12):1297-307 - PMID: 10569708 - DOI: 10.1016/s0021-9290(99)00125-6
Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.
Biophys J. 1999;77(1):542-52 - PMID: 10388779 - PMCID: PMC1300351 - DOI: 10.1016/S0006-3495(99)76911-0
Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins.
Biotechnol Bioeng. 1998;61(2):107-18 - PMID: 10099504 - DOI: 10.1002/(sici)1097-0290(199821)61:2<107::aid-bit5>3.0.co;2-q
Delivery of Monoclonal Antibodies to the Tumor Cell
In: Monoclonal Antibody-Based Therapy of Cancer, M.L. Grossbard, Ed., Marcel Dekker, Inc., New York. 1998;:23-52
In Vitro and In Vivo Quantification of Adhesion Between Leukocytes and Vascular Endothelium.
In: Methods in Molecular Medicine - Methods in Tissue Engineering, J.R. Morgan and M.L. Yarmush, Eds., Humana Press, Totowa. 1998;:553-575
Microcirculation and Transport Phenomena in Tumours
In: Connective Tissue Biology: Integration and Reductionism. Eds. R.K. Reed and K. Rubin, Portland Press Ltd, London. 1998;71:269-293
Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice.
Cancer Res. 1998;58(24):5866-9 - PMID: 9865747
Delivery of molecular and cellular medicine to solid tumors.
J Control Release. 1998;53(1-3):49-67 - PMID: 9741913 - DOI: 10.1016/s0168-3659(97)00237-x
Cancer, angiogenesis and fractals.
Nat Med. 1998;4(9):984 - PMID: 9734370 - DOI: 10.1038/1952
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor.
Proc Natl Acad Sci U S A. 1998;95(18):10820-5 - PMID: 9724788 - PMCID: PMC27979 - DOI: 10.1073/pnas.95.18.10820
The next frontier of molecular medicine: delivery of therapeutics.
Nat Med. 1998;4(6):655-7 - PMID: 9623964 - DOI: 10.1038/nm0698-655
Integrative pathophysiology of solid tumors: role in detection and treatment.
Cancer J Sci Am. 1998;4 Suppl 1:S48-57 - PMID: 9619271
Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques.
Proc Natl Acad Sci U S A. 1998;95(11):6388-93 - PMID: 9600975 - PMCID: PMC27734 - DOI: 10.1073/pnas.95.11.6388
Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.
Biotechniques. 1998;24(4):642-6, 648-51 - PMID: 9564539 - DOI: 10.2144/98244rr01
Dynamic T1-weighted magnetic resonance imaging and positron emission tomography in patients with lung cancer: correlating vascular physiology with glucose metabolism.
Clin Cancer Res. 1998;4(4):949-55 - PMID: 9563889
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Proc Natl Acad Sci U S A. 1998;95(8):4607-12 - PMID: 9539785 - PMCID: PMC22537 - DOI: 10.1073/pnas.95.8.4607
Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
J Nucl Med. 1998;39(1):65-76 - PMID: 9443740
Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase.
Hum Gene Ther. 1998;9(18):2699-708 - PMID: 9874268 - DOI: 10.1089/hum.1998.9.18-2699
Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene.
Hum Gene Ther. 1998;9(6):845-54 - PMID: 9581907 - DOI: 10.1089/hum.1998.9.6-845
Use of the comet assay for assessment of drug resistance and its modulation in vivo.
The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.
Nature. 1998;391(6664):295-8 - PMID: 9440695 - DOI: 10.1038/34675
Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence.
Exp Gerontol. 1998;33(1-2):81-94 - PMID: 9467719 - DOI: 10.1016/s0531-5565(97)00086-7
Role of nitric oxide in angiogenesis and microcirculation in tumors.
Cancer Metastasis Rev. 1998;17(1):77-89 - PMID: 9544424 - DOI: 10.1023/a:1005908805527
Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.
J Invest Dermatol. 1998;111(1):1-6 - PMID: 9665379 - DOI: 10.1046/j.1523-1747.1998.00262.x
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature. 1998;394(6692):485-90 - PMID: 9697772 - DOI: 10.1038/28867
Tumor induction of VEGF promoter activity in stromal cells.
Cell. 1998;94(6):715-25 - PMID: 9753319 - DOI: 10.1016/s0092-8674(00)81731-6
Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
Tumor Microcirculation: Role in Drug and Nutrient Delivery
In: Advances in Blood Substitutes, Eds, R.M. Winslow, K. D. Vandegriff, and M. Intaglietta, Birkhuser, Boston. 1997;:46-70
Delivery of Molecular Medicine to Solid Tumors
In: Microcirculation Annual 1997, M. Tsuchiya, M. Asano and N. Sato, Eds, Nihon-Igakukan, Tokyo. 1997;13:1-5
Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection and Treatment
In: Tumor Angiogenesis, R. Bicknell, C. Lewis and N. Ferrara, Eds, Oxford University Press, Oxford. 1997;:45-59
Tumor Microcirculation: Role in Delivery of Molecular and Cellular Medicine
In: The Biology of Tumors, Proceedings of the Ninth Annual Pezcoller Symposium on the Biology of Tumors, Rovereto, Italy. 1997;:319-345
Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors
AIChE Journal. 1997;43:818-834
Effect of tumor necrosis factor alpha on vascular resistance, nitric oxide production, and glucose and oxygen consumption in perfused tissue-isolated human melanoma xenografts.
Clin Cancer Res. 1997;3(3):319-24 - PMID: 10026014
Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Microcirculation. 1997;4(4):395-402 - PMID: 9431507 - DOI: 10.3109/10739689709146803
Quantitative angiogenesis assays: progress and problems.
Nat Med. 1997;3(11):1203-8 - PMID: 9359693 - DOI: 10.1038/nm1197-1203
Effects of needle insertion in tumors on interstitial fluid pressure.
Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037
Interlaboratory variation in oxygen tension measurement by Eppendorf &quot;Histograph&quot; and comparison with hypoxic marker.
J Surg Oncol. 1997;66(1):30-8 - PMID: 9290690 - DOI: 10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o
Solid stress inhibits the growth of multicellular tumor spheroids.
Nat Biotechnol. 1997;15(8):778-83 - PMID: 9255794 - DOI: 10.1038/nbt0897-778
Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice.
Int J Microcirc Clin Exp. 1997;17(1):1-9 - PMID: 9176719 - DOI: 10.1159/000179199
Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Microvasc Res. 1997;53(2):128-41 - PMID: 9143544 - DOI: 10.1006/mvre.1996.2005
Geometric resistance and microvascular network architecture of human colorectal carcinoma.
Microcirculation. 1997;4(1):25-33 - PMID: 9110281 - DOI: 10.3109/10739689709148315
The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Microcirculation. 1997;4(1):1-23 - PMID: 9110280 - DOI: 10.3109/10739689709148314
The problem of chronic rejection: influence of leukocyte-endothelial interactions.
Kidney Int Suppl. 1997;58:S22-7 - PMID: 9067938
Direct in vivo measurement of targeted binding in a human tumor xenograft.
Proc Natl Acad Sci U S A. 1997;94(5):1785-90 - PMID: 9050856 - PMCID: PMC19994 - DOI: 10.1073/pnas.94.5.1785
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nat Med. 1997;3(2):177-82 - PMID: 9018236 - DOI: 10.1038/nm0297-177
Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma.
Cancer Biother Radiopharm. 1997;12(3):167-75 - PMID: 10851463 - DOI: 10.1089/cbr.1997.12.167
Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.
Clin Cancer Res. 1997;3(12 Pt 1):2283-94 - PMID: 9815626
Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene. 1997;15(7):771-9 - PMID: 9266963 - DOI: 10.1038/sj.onc.1201239
Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.
Nat Immun. 1997;15(2-3):154-63 - PMID: 9162265
Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.
Am J Pathol. 1997;150(6):2099-112 - PMID: 9176401 - PMCID: PMC1858325
Omeprazole attenuates oxygen-derived free radical production from human neutrophils.
Free Radic Biol Med. 1997;21(5):727-31 - PMID: 8891677 - DOI: 10.1016/0891-5849(96)00180-3
Interstitial fluid pressure in intracranial tumours in patients and in rodents.
Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1).
Cytogenet Cell Genet. 1997;76(3-4):176-8 - PMID: 9186514 - DOI: 10.1159/000134539
Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.
Am J Pathol. 1997;150(2):713-25 - PMID: 9033284 - PMCID: PMC1858293
Amelioration of chronic inflammation by ingestion of elemental diet in a rat model of granulomatous enteritis.
Dig Dis Sci. 1997;42(2):408-19 - PMID: 9052527 - DOI: 10.1023/a:1018890624384
A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.
Cancer Res. 1997;57(7):1255-8 - PMID: 9102209
Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor.
Active oxidants mediate IFN-alpha-induced microvascular alterations in rat mesentery.
J Immunol. 1997;158(10):4893-900 - PMID: 9144506
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
Science. 1997;276(5317):1423-5 - PMID: 9162011 - DOI: 10.1126/science.276.5317.1423
Integrated map of the Schizosaccharomyces pombe genome.
Chromosoma. 1997;106(4):254-65 - PMID: 9254727 - DOI: 10.1007/s004120050246
Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
Am J Pathol. 1997;151(3):679-88 - PMID: 9284816 - PMCID: PMC1857859
Effect of lipopolysaccharides on erythrocyte flow velocity in rat liver.
J Gastroenterol. 1997;32(6):783-90 - PMID: 9430017 - DOI: 10.1007/BF02936955
Specific monoclonal antibody raised against the p33ING1 tumor suppressor.
Hybridoma. 1997;16(6):537-40 - PMID: 9455706 - DOI: 10.1089/hyb.1997.16.537
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 1997;26(2-3):71-90 - PMID: 10837535 - DOI: 10.1016/s0169-409x(97)00027-6
Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.
J Nucl Med. 1997;38(5):731-41 - PMID: 9170438
A model for the kinetics of homotypic cellular aggregation under static conditions.
Biophys J. 1997;72(1):51-64 - PMID: 8994592 - PMCID: PMC1184296 - DOI: 10.1016/S0006-3495(97)78646-6
Solid Tumor Barriers to Anticancer Drugs.
Cope. 1996;12:22-23
Drug Delivery: Barriers to Drug Transport and the Design of Novel Therapeutic Agents.
Molecular Medicine Today. 1996;1:4
Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer.
Clin Cancer Res. 1996;2(2):359-67 - PMID: 9816179
Perfusion of single tumor microvessels: application to vascular permeability measurement.
Microcirculation. 1996;3(4):349-57 - PMID: 9086446 - DOI: 10.3109/10739689609148307
Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Microvasc Res. 1996;51(3):327-46 - PMID: 8992232 - DOI: 10.1006/mvre.1996.0031
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Proc Natl Acad Sci U S A. 1996;93(25):14765-70 - PMID: 8962129 - PMCID: PMC26210 - DOI: 10.1073/pnas.93.25.14765
Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Biophys J. 1996;71(5):2656-68 - PMID: 8913603 - PMCID: PMC1233752 - DOI: 10.1016/S0006-3495(96)79457-2
Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Ann Biomed Eng. 1996;24(4):457-73 - PMID: 8841721 - DOI: 10.1007/BF02648108
Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.
Acta Orthop Scand. 1996;67(4):383-8 - PMID: 8792744 - DOI: 10.3109/17453679609002336
Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Cancer Res. 1996;56(16):3771-81 - PMID: 8706023
Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.
Am J Pathol. 1996;149(1):59-71 - PMID: 8686763 - PMCID: PMC1865247
Oxygenation in tumors by modified hemoglobins.
J Surg Oncol. 1996;62(2):109-14 - PMID: 8649036 - DOI: 10.1002/(SICI)1096-9098(199606)62:2<109::AID-JSO6>3.0.CO;2-C
Delivery of molecular medicine to solid tumors.
Science. 1996;271(5252):1079-80 - PMID: 8599082 - DOI: 10.1126/science.271.5252.1079
Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.
Res Exp Med (Berl). 1996;195(5):275-88 - PMID: 8578003 - DOI: 10.1007/BF02576798
pO(2) measurement in murine tumors by Eppendorf 'Histograph'.
Int J Oncol. 1996;9(5):955-62 - PMID: 21541601 - DOI: 10.3892/ijo.9.5.955
Compatibility and the genesis of residual stress by volumetric growth.
J Math Biol. 1996;34(8):889-914 - PMID: 8858855 - DOI: 10.1007/BF01834825
Hindered diffusion in agarose gels: test of effective medium model.
Biophys J. 1996;70(2):1017-23 - PMID: 8789119 - PMCID: PMC1225002 - DOI: 10.1016/S0006-3495(96)79645-5
Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching.
Am J Physiol. 1996;270(1 Pt 2):H330-7 - PMID: 8769769 - DOI: 10.1152/ajpheart.1996.270.1.H330
Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory.
Am J Physiol. 1996;270(1 Pt 2):H324-9 - PMID: 8769768 - DOI: 10.1152/ajpheart.1996.270.1.H324
Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.
The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft.
Radiat Res. 1996;145(3):337-42 - PMID: 8927702
Spontaneous metastasis, proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenografts.
Radiother Oncol. 1996;41(1):73-81 - PMID: 8961371 - DOI: 10.1016/s0167-8140(96)91803-4
Spontaneous osteosarcoma in a severe combined immunodeficient (SCID/Sed) mouse.
Contemp Top Lab Anim Sci. 1996;35(6):75-7 - PMID: 16450991
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.
Microvasc Res. 1996;51(2):260-72 - PMID: 8778579 - DOI: 10.1006/mvre.1996.0025
During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.
Nat Med. 1996;2(9):992-7 - PMID: 8782456 - DOI: 10.1038/nm0996-992
Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.
Biophys J. 1996;71(1):466-78 - PMID: 8804629 - PMCID: PMC1233497 - DOI: 10.1016/S0006-3495(96)79248-2
Gastric microcirculatory disturbance and behaviour of leucocytes after thermal injury: intravital observation of arteriovenous shunting channels in the gastric submucosal layer.
J Gastroenterol Hepatol. 1996;10(4):365-70 - PMID: 8527699 - DOI: 10.1111/j.1440-1746.1995.tb01585.x
Bile acid-induced depolarization of mitochondrial membrane potential preceding cell injury in cultured gastric mucosal cells.
J Gastroenterol Hepatol. 1996;10(6):621-6 - PMID: 8580403 - DOI: 10.1111/j.1440-1746.1995.tb01360.x
Enhanced levels of chemiluminescence and platelet activating factor in urease-positive gastric ulcers.
Free Radic Biol Med. 1996;20(3):449-54 - PMID: 8720917 - DOI: 10.1016/0891-5849(96)02048-5
Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer Res. 1996;56(5):964-68 - PMID: 8640786
Role of endothelin-1 in repeated electrical stimulation-induced microcirculatory disturbance and mucosal damage in rat stomach.
J Gastroenterol Hepatol. 1996;11(3):279-85 - PMID: 8742927 - DOI: 10.1111/j.1440-1746.1996.tb00076.x
Leukocyte-endothelial adhesion and angiogenesis in tumors.
Cancer Metastasis Rev. 1996;15(2):195-204 - PMID: 8842491 - DOI: 10.1007/BF00437472
Role in nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicity in vitro and ex vivo.
Hepatology. 1996;24(1):141-9 - PMID: 8707254 - DOI: 10.1053/jhep.1996.v24.pm0008707254
Kupffer cell-mediated cytotoxicity against hepatoma cells occurs through production of nitric oxide and adhesion via ICAM-1/CD18.
Int Immunol. 1996;8(7):1165-72 - PMID: 8757962 - DOI: 10.1093/intimm/8.7.1165
Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Microvasc Res. 1996;52(1):27-46 - PMID: 8812751 - DOI: 10.1006/mvre.1996.0041
Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
Roles of ET-1 in endotoxin-induced microcirculatory disturbance in rat small intestine.
Am J Physiol. 1996;271(3 Pt 1):G461-9 - PMID: 8843771 - DOI: 10.1152/ajpgi.1996.271.3.G461
Tumor angiogenesis and interstitial hypertension.
Cancer Res. 1996;56(18):4264-6 - PMID: 8797602
Rat Kupffer cell-derived nitric oxide suppresses proliferation and induces apoptosis of syngeneic hepatoma cells.
Gastroenterology. 1996;111(4):1058-70 - PMID: 8831602 - DOI: 10.1016/s0016-5085(96)70075-6
Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles for tumor necrosis factor alpha.
Hepatology. 1996;24(5):1185-92 - PMID: 8903396 - DOI: 10.1002/hep.510240534
Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation.
Nat Genet. 1996;14(4):415-20 - PMID: 8944021 - DOI: 10.1038/ng1296-415
IL-1 is an important mediator for microcirculatory changes in endotoxin-induced intestinal mucosal damage.
Dig Dis Sci. 1996;41(12):2482-92 - PMID: 9011462 - DOI: 10.1007/BF02100147
Drug discovery and delivery.
Mol Med Today. 1995;1(1):4 - PMID: 9415129 - DOI: 10.1016/1357-4310(95)80005-0
Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.
Microvasc Res. 1995;50(1):35-44 - PMID: 7476578 - DOI: 10.1006/mvre.1995.1036
Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin.
Blood. 1995;86(9):3487-92 - PMID: 7579454
Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.
Cancer Res. 1995;55(20):4611-22 - PMID: 7553638
Leukocyte rolling increases with age.
Blood. 1995;86(12):4707-8 - PMID: 8541569
Quantitative comparison of xenotransplantation of a human soft tissue sarcoma into the subcutaneous tissue of normal, postincision, and postincision plus indomethacin-treated nude mice.
J Surg Oncol. 1995;58(4):257-62 - PMID: 7723370 - DOI: 10.1002/jso.2930580412
The effect of combining recombinant human tumor necrosis factor-alpha with local radiation on tumor control probability of a human glioblastoma multiforme xenograft in nude mice.
Int J Radiat Oncol Biol Phys. 1995;32(1):93-8 - PMID: 7721643 - DOI: 10.1016/0360-3016(94)00492-4
The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice.
Int J Radiat Oncol Biol Phys. 1995;32(1):105-11 - PMID: 7721606 - DOI: 10.1016/0360-3016(95)00511-V
Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice.
J Neurosurg. 1995;83(2):308-15 - PMID: 7616277 - DOI: 10.3171/jns.1995.83.2.0308
Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.
Biophys J. 1995;69(5):2131-8 - PMID: 8580357 - PMCID: PMC1236447 - DOI: 10.1016/S0006-3495(95)80087-1
Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.
Biotechniques. 1995;19(4):622-6, 628-31 - PMID: 8777057
Spatial heterogeneity of mucosal blood flow during ischemia-reperfusion injury of rat stomach investigated by laser Doppler perfusion imaging.
J Gastroenterol. 1995;30(3):279-86 - PMID: 7647892 - DOI: 10.1007/BF02347500
Increased activity of p53 in senescing fibroblasts.
Proc Natl Acad Sci U S A. 1995;92(18):8348-52 - PMID: 7667293 - PMCID: PMC41154 - DOI: 10.1073/pnas.92.18.8348
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Cancer Res. 1995;55(17):3752-6 - PMID: 7641188
Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Microvasc Res. 1995;50(2):175-82 - PMID: 8538498 - DOI: 10.1006/mvre.1995.1051
Intravital demonstration of sequential migration process of lymphocyte subpopulations in rat Peyer's patches.
Gastroenterology. 1995;109(4):1113-23 - PMID: 7557076 - DOI: 10.1016/0016-5085(95)90569-3
Oxidative stress in gastric mucosal injury: role of platelet-activating factor-activated granulocytes.
J Gastroenterol. 1995;30(5):565-71 - PMID: 8574326 - DOI: 10.1007/BF02367780
Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.
Cancer Res. 1995;55(21):4824-9 - PMID: 7585514
Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Microvasc Res. 1995;50(3):429-43 - PMID: 8583955 - DOI: 10.1006/mvre.1995.1069
Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer Res. 1995;55(22):5451-8 - PMID: 7585615
Rat Kupffer cell-derived nitric oxide modulates induction of lymphokine-activated killer cell.
Gastroenterology. 1995;109(6):1958-68 - PMID: 7498662 - DOI: 10.1016/0016-5085(95)90764-5
Scale-invariant behavior and vascular network formation in normal and tumor tissue.
Phys Rev Lett. 1995;75(12):2428-2431 - PMID: 10059301 - DOI: 10.1103/PhysRevLett.75.2428
Diffusion and partitioning of proteins in charged agarose gels.
Biophys J. 1995;68(4):1561-8 - PMID: 7787041 - PMCID: PMC1282050 - DOI: 10.1016/S0006-3495(95)80328-0
Tumor Microcirculation: Role in Cancer Diagnosis and Treatment
In: Progress in Microcirculation Research, H. Niimi, et al, Eds., Pergamon Press, Tarrytown. 1994;:29-36
Transport Phenomena in Tumors
Advances in Chemical Engineering. 1994;20:129-200
Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.
Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684 - DOI: 10.1093/jnci/86.4.293
Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Cancer Res. 1994;54(6):1517-28 - PMID: 8137258
Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313 - DOI: 10.1073/pnas.91.6.2081
Barriers to drug delivery in solid tumors.
Sci Am. 1994;271(1):58-65 - PMID: 8066425 - DOI: 10.1038/scientificamerican0794-58
Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Cancer Res. 1994;54(13):3352-6 - PMID: 8012948
Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.
Cancer Res. 1994;54(23):6032-6 - PMID: 7954440
Flow velocity in the superficial lymphatic network of the mouse tail.
Am J Physiol. 1994;267(4 Pt 2):H1507-13 - PMID: 7943396 - DOI: 10.1152/ajpheart.1994.267.4.H1507
A method for labeling cells for positron emission tomography (PET) studies.
J Immunol Methods. 1994;175(1):79-87 - PMID: 7930641 - DOI: 10.1016/0022-1759(94)90333-6
Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.
J Immunol Methods. 1994;175(1):69-77 - PMID: 7930640 - DOI: 10.1016/0022-1759(94)90332-8
Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.
Cancer Res. 1994;54(21):5670-4 - PMID: 7923215
Tissue-isolated human tumor xenografts in athymic nude mice.
Microvasc Res. 1994;48(3):389-402 - PMID: 7731400 - DOI: 10.1006/mvre.1994.1063
Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.
Lab Invest. 1994;71(2):300-7 - PMID: 7521447
Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells.
Cell Biophys. 1994;20(2-3):161-76 - PMID: 1285298 - DOI: 10.1007/BF02823656
Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.
Biophys J. 1994;67(2):889-95 - PMID: 7948702 - PMCID: PMC1225432 - DOI: 10.1016/S0006-3495(94)80550-8
Attenuating effect of antithrombin III on the fibrinolytic activation and microvascular derangement in rat gastric mucosa.
Thromb Haemost. 1994;71(1):119-23 - PMID: 8165629
Evidence of direct interaction between Kupffer cells and colon cancer cells: an ultrastructural study of the co-culture.
Liver. 1994;14(1):37-44 - PMID: 8177028 - DOI: 10.1111/j.1600-0676.1994.tb00005.x
Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.
Verotoxin induces hemorrhagic lesions in rat small intestine. Temporal alteration of vasoactive substances.
Dig Dis Sci. 1994;39(6):1230-8 - PMID: 8200255 - DOI: 10.1007/BF02093788
Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.
Microvasc Res. 1994;48(1):1-12 - PMID: 7990716 - DOI: 10.1006/mvre.1994.1034
Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.
Cancer Res. 1994;54(17):4564-8 - PMID: 8062241
Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants.
Analysis of lymphocyte activation and proliferation by video microscopy and digital imaging.
Cytometry. 1993;14(7):772-82 - PMID: 8243206 - DOI: 10.1002/cyto.990140710
Delivery of Effector Cells to Tumors
In: '93 Recent Advances in Cancer Research, J.G. Park, Ed., Seoul National University, Seoul. 1993;:202-217
Physiological Resistance to the Treatment of Solid Tumors
In: Drug Resistance in Oncology, B. Teicher, Ed., M. Dekker, New York. 1993;Chapter 4:87-105
Extravasation and Interstitial Transport in Tumors
In: Biological Barriers to Protein Delivery, K.L. Audus and T.J. Raub, Eds., Plenum Press, New York. 1993;Chapter 15:441-465
Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Proc Natl Acad Sci U S A. 1993;90(7):2646-50 - PMID: 8464871 - PMCID: PMC46152 - DOI: 10.1073/pnas.90.7.2646
Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Microvasc Res. 1993;45(3):269-89 - PMID: 8321142 - DOI: 10.1006/mvre.1993.1024
Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Biophys J. 1993;65(6):2428-36 - PMID: 8312481 - PMCID: PMC1225983 - DOI: 10.1016/S0006-3495(93)81326-2
Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.
Cancer Res. 1993;53(24):5867-71 - PMID: 8261395
Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.
Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048
Analysis of lymphocyte aggregation using digital image analysis.
J Immunol Methods. 1993;166(1):11-25 - PMID: 8228280 - DOI: 10.1016/0022-1759(93)90324-z
[Genome mapping of Schizosaccharomyces pombe].
Tanpakushitsu Kakusan Koso. 1993;38(3):677-84 - PMID: 8488304
A 13 kb resolution cosmid map of the 14 Mb fission yeast genome by nonrandom sequence-tagged site mapping.
Cell. 1993;73(1):121-32 - PMID: 8462095 - DOI: 10.1016/0092-8674(93)90165-m
Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid.
Am J Physiol. 1993;264(5 Pt 1):G828-34 - PMID: 8498509 - DOI: 10.1152/ajpgi.1993.264.5.G828
Oxyradical generation from leukocytes during endotoxin-induced microcirculatory disturbance in rat mesentery--attenuating effect of cetraxate.
Toxicol Appl Pharmacol. 1993;120(1):37-44 - PMID: 8511781 - DOI: 10.1006/taap.1993.1084
Fluorographic study on the oxidative stress in the process of gastric mucosal injury: attenuating effect of vitamin E.
J Gastroenterol Hepatol. 1993;8(3):254-8 - PMID: 8518396 - DOI: 10.1111/j.1440-1746.1993.tb01196.x
Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst.
Cancer Res. 1993;53(11):2676-82 - PMID: 8388320
Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.
Cancer Res. 1993;53(11):2466-8 - PMID: 8495405
Nitric oxide mediates vasoactive effects of endothelin-3 on rat mesenteric microvascular beds in vivo.
Angiology. 1993;44(6):483-90 - PMID: 8503515 - DOI: 10.1177/000331979304400609
Microinfusions of excitatory amino acid antagonists into the trigeminal sensory complex antagonize the jaw opening reflex in freely moving rats.
Brain Res. 1993;614(1-2):155-63 - PMID: 8102311 - DOI: 10.1016/0006-8993(93)91029-r
Nitric oxide mediates lipopolysaccharide-induced alteration of mitochondrial function in cultured hepatocytes and isolated perfused liver.
Hepatology. 1993;18(2):380-8 - PMID: 8340067
Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.
Cancer Res. 1993;53(20):4764-6 - PMID: 8402656
Mechanisms of endothelin-induced macromolecular leakage in microvascular beds of rat mesentery.
Eur J Pharmacol. 1993;250(1):85-94 - PMID: 8119327 - DOI: 10.1016/0014-2999(93)90624-q
Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.
Cancer Res. 1992;52(2):487-90 - PMID: 1728421
Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Cancer Res. 1992;52(15):4157-67 - PMID: 1638531
Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.
Cancer Res. 1992;52(7):1993-5 - PMID: 1551128
2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.
Cancer Res. 1992;52(21):6010-9 - PMID: 1394226
Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Cancer Res. 1992;52(20):5838-44 - PMID: 1394212
In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching.
J Immunol Methods. 1992;155(1):1-17 - PMID: 1383343 - DOI: 10.1016/0022-1759(92)90265-u
Tissue-type plasminogen activator of colonic mucosa in ulcerative colitis. Evidence of endothelium-derived fibrinolytic activation.
Dig Dis Sci. 1992;37(2):307-11 - PMID: 1735352 - DOI: 10.1007/BF01308189
Visualization of oxidative processes at the cellular level during neutrophil-mediated cytotoxicity against a human hepatoma cell line, HCC-M.
Int J Cancer. 1992;51(1):124-9 - PMID: 1314229 - DOI: 10.1002/ijc.2910510122
Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Cancer Res. 1992;52(11):3237-40 - PMID: 1534273
Role of platelet activating factor on the fibrinolytic activation in the pathogenesis of gastric mucosal damage induced by endothelin-1.
Oxiradical-dependent photoemission induced by a phacoemulsification probe.
Invest Ophthalmol Vis Sci. 1992;33(10):2904-7 - PMID: 1326494
Quantitative analysis of mesenteric microcirculatory disturbances induced by autonomic nervous irritation.
Keio J Med. 1992;41(3):128-33 - PMID: 1434306 - DOI: 10.2302/kjm.41.128
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.
Cancer Res. 1992;52(18):5110-4 - PMID: 1516068
Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury.
Am J Physiol. 1992;263(5 Pt 1):G719-25 - PMID: 1443147 - DOI: 10.1152/ajpgi.1992.263.5.G719
Interstitial hypertension in human breast and colorectal tumors.
Cancer Res. 1992;52(22):6371-4 - PMID: 1423283
Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
Cancer Res. 1992;52(23):6553-60 - PMID: 1384965
Blood Flow Response to Hyperglycemia.
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Viscous Resistance to Blood Flow in the Tumor Microcirculation: Clinical Implications.
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Vascular and Interstitial Transport in Tumors
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Parameters Governing Tumor Blood Flow
In: Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, P. Vaupel and R.K. Jain, Eds., Fischer Publications, Stuttgart. 1991;:ePub
Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1991;51(13):3612-6 - PMID: 2054796
Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Microvasc Res. 1991;41(2):252-72 - PMID: 2051960 - DOI: 10.1016/0026-2862(91)90026-8
Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Microvasc Res. 1991;41(1):5-23 - PMID: 2051954 - DOI: 10.1016/0026-2862(91)90003-t
Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.
J Natl Cancer Inst. 1991;83(6):433-7 - PMID: 1999850 - DOI: 10.1093/jnci/83.6.433
Measurement of capillary filtration coefficient in a solid tumor.
Cancer Res. 1991;51(4):1352-5 - PMID: 1997172
Therapeutic implications of tumor physiology.
Curr Opin Oncol. 1991;3(6):1105-8 - PMID: 1843113 - DOI: 10.1097/00001622-199112000-00020
Haemodynamic and transport barriers to the treatment of solid tumours.
Int J Radiat Biol. 1991;60(1-2):85-100 - PMID: 1678003 - DOI: 10.1080/09553009114551621
Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime.
Biophys J. 1991;60(3):596-610 - PMID: 1932550 - PMCID: PMC1260103 - DOI: 10.1016/S0006-3495(91)82089-6
[Xenograft of human nasopharyngeal mucosa in nude mice].
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1991;24(4):219-20, 255 - PMID: 2486076
[Adult nasopharyngeal mucosa xenograft and dinitrosopiperazine carcinogenesis in nude mice].
Zhonghua Yi Xue Za Zhi. 1991;71(8):441-3, 32 - PMID: 1660764
Ischemic bowel necrosis induced by endothelin-1: an experimental model in rats.
Digestion. 1991;48(3):163-72 - PMID: 1916037 - DOI: 10.1159/000200689
Kupffer cell-mediated oxidative stress on colon cancer cell line visualized by digital imaging fluorescence microscopy.
Cancer Lett. 1991;59(3):201-9 - PMID: 1913616 - DOI: 10.1016/0304-3835(91)90142-5
Interstitial hypertension in superficial metastatic melanomas in humans.
Cancer Res. 1991;51(24):6691-4 - PMID: 1742743
Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.
Cancer Res. 1991;51(24):6695-8 - PMID: 1742744
Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Cancer Res. 1991;51(12):3119-30 - PMID: 2039991
Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Cancer Res. 1991;51(10):2727-30 - PMID: 2021951
Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Cancer Res. 1991;51(5):1561-3 - PMID: 1997196
Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Cancer Res. 1991;51(1):265-73 - PMID: 1988088
Approaches to immunotherapy with defined populations of IL-2 cultured NK cells, immune T Cells or tumor infiltrating lymphocytes.
In: Biology and Clinical Applications of IL-2, R.C. Rees, Ed., Oxford University Press, London. 1990;Chapter 12:111-119
Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Cancer Res. 1990;50(3 Suppl):814s-819s - PMID: 2404582
Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer Res. 1990;50(12):3487-92 - PMID: 2340499
Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Cancer Metastasis Rev. 1990;9(3):253-66 - PMID: 2292138 - DOI: 10.1007/BF00046364
Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Biophys J. 1990;58(4):873-85 - PMID: 2248992 - PMCID: PMC1281033 - DOI: 10.1016/S0006-3495(90)82432-2
Tumor physiology and antibody delivery.
Front Radiat Ther Oncol. 1990;24:32-46; discussion 64-8 - PMID: 2187763
Effects of monoclonal antibody anti-EGF receptor on human nasopharyngeal carcinoma cell and other tumor cells.
Sci China B. 1990;33(11):1334-40 - PMID: 2095159
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer Res. 1990;50(15):4478-84 - PMID: 2369726
Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Microvasc Res. 1990;39(1):77-93 - PMID: 2314308 - DOI: 10.1016/0026-2862(90)90060-5
Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Microvasc Res. 1990;40(2):246-63 - PMID: 2250603 - DOI: 10.1016/0026-2862(90)90023-k
Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.
Proc Natl Acad Sci U S A. 1989;86(14):5385-9 - PMID: 2748592 - PMCID: PMC297627 - DOI: 10.1073/pnas.86.14.5385
Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Cancer Res. 1989;49(13):3506-12 - PMID: 2731172
Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
J Natl Cancer Inst. 1989;81(8):570-6 - PMID: 2649688 - DOI: 10.1093/jnci/81.8.570
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Microvasc Res. 1989;37(1):77-104 - PMID: 2646512 - DOI: 10.1016/0026-2862(89)90074-5
Growth inhibition of human nasopharyngeal carcinoma in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies.
Int J Cell Cloning. 1989;7(4):242-56 - PMID: 2768842 - DOI: 10.1002/stem.5530070406
Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.
Cancer Res. 1989;49(13):3513-9 - PMID: 2731173
Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Cancer Res. 1989;49(14):3742-6 - PMID: 2500233
Variability of human rRNA genes: inheritance and nonrandom chromosomal distribution of structural variants of nontranscribed spacer sequences.
Hum Genet. 1988;81(1):31-7 - PMID: 3198124 - DOI: 10.1007/BF00283725
Stability of thin films: characterization and applications in industrial and biological systems.
Thin Liquid Films, I.B. Ivanov, Ed., M. Dekker, New York. 1988;:497-568
Transvascular and interstitial transport in tumors
Vascular Endothelium in Health and Disease, S. Chien (Ed.), Elsevier, Amsterdam . 1988;:215-220
Transport of molecules across tumor vasculature.
Cancer Metastasis Rev. 1988;6(4):559-93 - PMID: 3327633 - DOI: 10.1007/BF00047468
Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia.
Int J Hyperthermia. 1988;4(3):223-50 - PMID: 3290346 - DOI: 10.3109/02656738809051100
Determinants of tumor blood flow: a review.
Cancer Res. 1988;48(10):2641-58 - PMID: 3282647
Wikstroemia indica promotes development of nasopharyngeal carcinoma in rats initiated by dinitrosopiperazine.
J Cancer Res Clin Oncol. 1988;114(4):429-31 - PMID: 3410882 - DOI: 10.1007/BF02128191
Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1988;48(6):1476-80 - PMID: 3345521
Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.
Cancer Res. 1988;48(5):1201-7 - PMID: 3342400
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Cancer Res. 1988;48(24 Pt 1):7022-32 - PMID: 3191477
Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.
Microvasc Res. 1988;36(1):108-15 - PMID: 3185299 - DOI: 10.1016/0026-2862(88)90043-x
Tumor blood flow response to hyperthermia and pharmacological agents.
Radiation Research, E.M. Fieldman et al (eds.), Taylor and Francis, London. 1987;Volume 2:813-818
Interstitial transport in tumors.
Advances in Microcirculation. 1987;13:266-284
Analysis of diffusive and convective recovery after photobleaching-uniform flow field.
Chemical Engineering Commun. 1987;55:235-249
Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.
Cancer Res. 1987;47(2):371-7 - PMID: 3791228
Effect of glucose and galactose on red blood cell membrane deformability.
Int J Microcirc Clin Exp. 1987;6(1):35-44 - PMID: 3583577
Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Microvasc Res. 1987;34(3):336-48 - PMID: 2448593 - DOI: 10.1016/0026-2862(87)90066-5
Dynamics of cancer cell interactions with microvasculature and interstitium.
Biorheology. 1987;24(2):117-25 - PMID: 3651585 - DOI: 10.3233/bir-1987-24205
Transport of molecules in the tumor interstitium: a review.
Cancer Res. 1987;47(12):3039-51 - PMID: 3555767
Effect of hyperglycemia on systemic hemodynamics and blood flow rate in normal and neoplastic tissues in rats
Cancer Res. 1986;46:6299-6304
Effect of transmembrane potential on the deformability of RBC's suspended in carbohydrate-saline solutions.
J Colloid and Interface Science. 1986;114:273-276
Effect of glucose, galactose, and transmembrane potential on shear elastic modulus of erythrocyte membrane.
AIChE Symposium Series. 1986;82:190-194
Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Int J Microcirc Clin Exp. 1986;4(4):363-72 - PMID: 4086191
Extravascular transport in normal and tumor tissues.
Crit Rev Oncol Hematol. 1986;5(2):115-70 - PMID: 3521923 - DOI: 10.1016/s1040-8428(86)80023-3
Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1986;46(12 Pt 1):6299-304 - PMID: 3779648
Microvascular permeability of normal and neoplastic tissues.
Microvasc Res. 1986;31(3):288-305 - PMID: 2423854 - DOI: 10.1016/0026-2862(86)90018-x
Analysis of heat transfer and temperature distributions in tissues during local and whole body hyperthermia
Heat Transfer in Medicine and Biology, A. Shitzer and R. Eberhart, Eds., Plenum Press, New York, Volume 2. 1985;Chapter 16:3-54
Thinning of films with deformable surfaces: diffusion-controlled surfactant transfer
Chemical Engineering Science. 1985;40:137-150
Stability of membrane systems modeled as multilayered viscoelastic films.
J Theor Biol. 1985;113(2):353-77 - PMID: 3999781 - DOI: 10.1016/s0022-5193(85)80232-0
Ultrastructural comparative study on lymphatic capillaries of the subendocardium, myocardium, and subepicardium of the heart left ventricle.
Microvasc Res. 1985;29(3):305-19 - PMID: 3999989 - DOI: 10.1016/0026-2862(85)90021-4
Transient ultrastructural variations of pulmonary lymphatic capillaries during the respiratory cycle of the rat lung.
Anat Rec. 1985;213(4):551-9 - PMID: 4083535 - DOI: 10.1002/ar.1092130411
Transport of macromolecules in tumor microcirculation.
Biotechnol Prog. 1985;1(2):81-94 - PMID: 20568145 - DOI: 10.1002/btpr.5420010205
Mass and heat transfer in tumors: applications in detection and treatment
Advances in Transport Processes. 1984;3:205-339
Tumor blood flow: characterization, modifications and role in hyperthermia
IEEE Transactions in Sonics and Ultrasonics; Special Issue on Hyperthermia. 1984;31:504-526
Stability of thin viscoelastic films between permeable membranes
J Colloid and Interface Science. 1984;101:489-499
Surface effects in preparation of cell-size liposomes.
FEBS Letters. 1984;176:398-400
Differential response of normal and tumor microcirculation to hyperthermia.
Cancer Res. 1984;44(2):605-12 - PMID: 6692365
Dielectric properties of solid tumors during normothermia and hyperthermia.
IEEE Trans Biomed Eng. 1984;31(11):725-8 - PMID: 6500596 - DOI: 10.1109/TBME.1984.325399
Membrane stability.
Biochim Biophys Acta. 1984;779(4):437-68 - PMID: 6391549 - DOI: 10.1016/0304-4157(84)90020-0
Extravascular diffusion in normal and neoplastic tissues.
Cancer Res. 1984;44(1):238-44 - PMID: 6197161
Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed.
Am J Physiol. 1984;246(1 Pt 2):H129-37 - PMID: 6198927 - DOI: 10.1152/ajpheart.1984.246.1.H129
Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.
J Natl Cancer Inst. 1984;73(2):429-36 - PMID: 6589435 - DOI: 10.1093/jnci/73.2.429
Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.
Microvasc Res. 1984;28(2):270-4 - PMID: 6209533 - DOI: 10.1016/0026-2862(84)90022-0
Two-compartment model for plasma pharmacokinetics in individual blood vessels.
J Pharmacokinet Biopharm. 1984;12(4):451-61 - PMID: 6084709 - DOI: 10.1007/BF01062668
Bioheat transfer: mathematical models of thermal systems.
Hyperthermia in Cancer Therapy, F.K. Storm, Ed., G.K. Hall and Co., Boston. 1983;Chapter 2:9-46
Mathematical models for microcirculatory changes during hyperthermia in normal and neoplastic tissues
AIChE Symposium Series 227. 1983;79:153-162
Interstitial diffusion of macromolecules in normal and tumor capillary beds
AIChE Symposium Series 227. 1983;79:1-10
Stability of thin viscoelastic films with applications to biological membrane deformation.
Annals of New York Academy of Sciences. 1983;404:89-102
Temperature distributions and thermal response in humans. II. Simulation of whole-body, regional and localized hyperthermia in cancer patients
AIChE Symposium Series 227. 1983;79:116-123
Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma.
Adv Exp Med Biol. 1983;157:23-42 - PMID: 7158522 - DOI: 10.1007/978-1-4684-4388-2_4
Microcirculatory flow changes during tissue growth.
Microvasc Res. 1983;25(1):1-21 - PMID: 6188025 - DOI: 10.1016/0026-2862(83)90040-7
Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.
Cancer Lett. 1983;19(3):317-23 - PMID: 6883314 - DOI: 10.1016/0304-3835(83)90101-5
Physiologically based pharmacokinetic modeling: principles and applications.
J Pharm Sci. 1983;72(10):1103-27 - PMID: 6358460 - DOI: 10.1002/jps.2600721003
Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rats bearing W256 carcinosarcoma
Hyperthermia, H.I. Bicher and D.F. Bruley, eds., Plenum Publishing Corporation, New York. 1982;:23-42
The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film II. Extension of the theory to the study of the onset of small-scale cell membrane motions.
J. Colloid and Interface Science. 1982;90:263-276
The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. I. General formulation and a derivation of the dispersion equation.
J. Colloid and Interface Science. 1982;90:233-262
Incorporating toxicology in the synthesis of industrial chemical complexes
Chemical Engineering Commun. 1982;17:151-170
In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.
J Pharm Sci. 1982;71(10):1102-5 - PMID: 7143204 - DOI: 10.1002/jps.2600711005
Temperature gradients and local perfusion in a mammary carcinoma.
J Natl Cancer Inst. 1982;68(3):519-33 - PMID: 6950181
Temperature distributions and thermal response in humans. I. Simulations of various modes of whole-body hyperthermia in normal subjects.
Med Phys. 1982;9(4):506-13 - PMID: 7110081 - DOI: 10.1118/1.595115
Monitoring transport in the rabbit ear chamber.
Microvasc Res. 1982;24(2):204-9 - PMID: 7176939 - DOI: 10.1016/0026-2862(82)90057-7
Kinetics of uptake, distribution and excretion of zinc in rats.
Annals of Biomedical Engineering. 1981;9:347-361
Dynamics of neovascularization in normal tissue.
Microvasc Res. 1981;21(1):27-47 - PMID: 7010086 - DOI: 10.1016/0026-2862(81)90003-0
Mass transport in tumors: characterization and applications to chemotherapy.
Adv Cancer Res. 1981;33:251-310 - PMID: 7006335 - DOI: 10.1016/s0065-230x(08)60672-7
Heat transfer in tumors: characterization and applications to thermography and hyperthermia.
Advances in Biomedical Engineering, edited by D.O. Cooney, Marcel Dekker, Inc., New York, Part I. 1980;Chapter 2:59-91
Thinning and rupture of ring-shaped films
J Chemical Society, Faraday Transactions II. 1980;76:250-266
Intratumour temperature distributions during hyperthermia
J Thermal Biology. 1980;5:127-130
Analysis of transient temperature distribution in a perfused medium Due to a spherical heat source with application to heat transfer in tumors: homogeneous and infinite medium
Chemical Engineering Commun. 1980;4:95-118
Stability of symmetric and unsymmetric, thin liquid films to short and long wavelength perturbations
J Colloid and Interface Science. 1980;78:118-143
Temperature distributions in normal and neoplastic tissues during normothermia and hyperthermia.
Ann N Y Acad Sci. 1980;335:48-66 - PMID: 6931539 - DOI: 10.1111/j.1749-6632.1980.tb50736.x
Preliminary model for streptozocin metabolism in mice.
J Pharm Sci. 1980;69(6):691-4 - PMID: 6451687 - DOI: 10.1002/jps.2600690621
Thermal interactions between normal and neoplastic tissues in the rat, rabbit, swine, and dog during hyperthermia.
Med Phys. 1980;7(5):529-39 - PMID: 7421764 - DOI: 10.1118/1.594668
The role of surfactants on the coalescences of emulsion droplets
Solution Chemistry of Surfactants, edited by K.A. Mittal, Plenum Press, New York. 1979;2:817-840
Instability and rupture of thin liquid films
Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:140-167
Formation and thinning of thin liquid films
Dynamics and Instability of Fluid Interfaces, edited by T.S. Sorensen, Springer-Verlag, New York. 1979;:120-139
Transient temperature distributions in an infinite perfused medium due to a time-dependent, spherical heat source
Trans. ASME J. Biomechanical Engineering. 1979;101:82-86
A semi-empirical model for cell kill kinetics during hyperthermia.
J Thermal Biology. 1979;4:257-258
Temperature distributions in normal and neoplastic tissues during hyperthermia: a lumped parameter model
J Thermal Biology. 1979;4:157-164
Pharmacokinetics of methotrexate in solid tumors.
J Pharmacokinet Biopharm. 1979;7(2):181-94 - PMID: 20218013 - DOI: 10.1007/BF01059737
Blood flow and heat transfer in Walker 256 mammary carcinoma.
J Natl Cancer Inst. 1979;62(4):927-33 - PMID: 285296
Onset of microvilli in normal and neoplastic cells.
AIChE Symposium Series, Biorheology. 1978;74:120-124
Effect of inhomogeneities and finite boundaries on temperature distribution in a perfused medium with application to tumors
Trans. ASME J. Biomechanical Engineering. 1978;100:235-241
Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.
J Pharmacokinet Biopharm. 1978;6(6):487-503 - PMID: 731413 - DOI: 10.1007/BF01062105
Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man.
Am J Physiol. 1978;235(3):F254-64 - PMID: 696835 - DOI: 10.1152/ajprenal.1978.235.3.F254
Dynamics of drug transport in solid tumors: distributed parameter model
J Bioengineering. 1977;1:313-329
Short term regulation of BOD upsets in an estuary
Trans. ASME J. Dynamic Systems, Measurement and Control. 1976;98, Series G:30-31
Stability of stagnant viscous films on a solid surface
J Colloid and Interface Science. 1976;54:108-116
Spontaneous rupture of thin liquid films
J Chemical Society, Faraday Transactions II. 1974;70:132-147
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