Steele Labs :: Publications

Jain RK, Shah SA, Finney PL

Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.

J Natl Cancer Inst. 1984;73(2):429-36 - PMID: 6589435 - DOI: 10.1093/jnci/73.2.429

Jain RK, Weissbrod JM, Wei J

Mass transport in tumors: characterization and applications to chemotherapy.

Adv Cancer Res. 1981;33:251-310 - PMID: 7006335 - DOI: 10.1016/s0065-230x(08)60672-7

Johnson EM, Berk DA, Jain RK, Deen WM

Diffusion and partitioning of proteins in charged agarose gels.

Biophys J. 1995;68(4):1561-8 - PMID: 7787041 - PMCID: PMC1282050 - DOI: 10.1016/S0006-3495(95)80328-0

Neelamegham S, Munn LL, Zygourakis K

A model for the kinetics of homotypic cellular aggregation under static conditions.

Biophys J. 1997;72(1):51-64 - PMID: 8994592 - PMCID: PMC1184296 - DOI: 10.1016/S0006-3495(97)78646-6

Zhu H, Baxter LT, Jain RK

Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies.

J Nucl Med. 1997;38(5):731-41 - PMID: 9170438

Gazit Y, Berk DA, Leunig M, Baxter LT, Jain RK

Scale-invariant behavior and vascular network formation in normal and tumor tissue.

Phys Rev Lett. 1995;75(12):2428-2431 - PMID: 10059301 - DOI: 10.1103/PhysRevLett.75.2428

Pluen A, Netti PA, Jain RK, Berk DA

Diffusion of macromolecules in agarose gels: comparison of linear and globular configurations.

Biophys J. 1999;77(1):542-52 - PMID: 10388779 - PMCID: PMC1300351 - DOI: 10.1016/S0006-3495(99)76911-0

Somasundaran P, Simpson S, Jain RK, Ivanov I, Raghuraman V

Investigation of Thin Aqueous Films on Silica Using a Modified Interferometric Technique.

J Colloid Interface Sci. 2000;225(1):243-246 - PMID: 10767167 - DOI: 10.1006/jcis.2000.6735

Jain RK

Delivery of molecular and cellular medicine to solid tumors.

Adv Drug Deliv Rev. 1997;26(2-3):71-90 - PMID: 10837535 - DOI: 10.1016/s0169-409x(97)00027-6

Kaur A, Hale CL, Ramanujan S, Jain RK, Johnson RP

Differential dynamics of CD4(+) and CD8(+) T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection.

J Virol. 2000;74(18):8413-24 - PMID: 10954541 - PMCID: PMC116352 - DOI: 10.1128/jvi.74.18.8413-8424.2000

Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK

Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.

Proc Natl Acad Sci U S A. 2001;98(5):2604-9 - PMID: 11226286 - PMCID: PMC30185 - DOI: 10.1073/pnas.041359198

Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA

A potential murine model for flap-related investigations.

Plast Reconstr Surg. 2001;107(6):1504-8 - PMID: 11335827 - DOI: 10.1097/00006534-200105000-00032

Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK

LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.

Cancer Res. 2001;61(22):8079-84 - PMID: 11719431

Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RK

Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model.

Neoplasia. 2002;4(5):449-63 - PMID: 12192604 - PMCID: PMC1661679 - DOI: 10.1038/sj.neo.7900260

Jain RK, Padera TP

Development. Lymphatics make the break.

Science. 2003;299(5604):209-10 - PMID: 12522236 - DOI: 10.1126/science.1081345

Munn LL

Aberrant vascular architecture in tumors and its importance in drug-based therapies.

Drug Discov Today. 2003;8(9):396-403 - PMID: 12706657 - DOI: 10.1016/s1359-6446(03)02686-2

Sun C, Migliorini C, Munn LL

Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis.

Biophys J. 2003;85(1):208-22 - PMID: 12829477 - PMCID: PMC1303078 - DOI: 10.1016/S0006-3495(03)74467-1

Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.

Nat Med. 2004;10(2):145-7 - PMID: 14745444 - PMCID: PMC2693485 - DOI: 10.1038/nm988

Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK

Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics.

Circ Res. 2004;95(2):204-9 - PMID: 15192027 - DOI: 10.1161/01.RES.0000135549.72828.24

Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK

Differential transplantability of tumor-associated stromal cells.

Cancer Res. 2004;64(17):5920-4 - PMID: 15342367 - DOI: 10.1158/0008-5472.CAN-04-1268

Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB

Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma.

J Soc Integr Oncol. 2007;5(1):11-7 - PMID: 17309809 - DOI: 10.2310/7200.2006.033

Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.

Nat Biotechnol. 2007;25(3):317-8 - PMID: 17322871 - DOI: 10.1038/nbt1287

Duda DG, Batchelor TT, Willett CG, Jain RK

VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects.

Trends Mol Med. 2007;13(6):223-30 - PMID: 17462954 - PMCID: PMC2686126 - DOI: 10.1016/j.molmed.2007.04.001

Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK

Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.

Nat Clin Pract Oncol. 2007;4(5):316-21 - PMID: 17464339 - PMCID: PMC2686127 - DOI: 10.1038/ncponc0813

Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK

Anti-VEGFR-3 therapy and lymph node metastasis [corrected].

Cancer Res. 2007;67(10):5055; author reply 5056 - PMID: 17510438 - DOI: 10.1158/0008-5472.CAN-06-2935

Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y

Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.

Cancer Res. 2007;67(11):5076-82 - PMID: 17545583 - DOI: 10.1158/0008-5472.CAN-06-3664

Dupin MM, Halliday I, Care CM, Alboul L, Munn LL

Modeling the flow of dense suspensions of deformable particles in three dimensions.

Phys Rev E Stat Nonlin Soft Matter Phys. 2007;75(6 Pt 2):066707 - PMID: 17677389 - PMCID: PMC2752716 - DOI: 10.1103/PhysRevE.75.066707

Xu L, Jain RK

Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma.

Mol Cancer Res. 2007;5(9):873-80 - PMID: 17704140 - DOI: 10.1158/1541-7786.MCR-06-0141

Duda DG, Jain RK, Willett CG

Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers.

J Clin Oncol. 2007;25(26):4033-42 - PMID: 17827451 - PMCID: PMC2686120 - DOI: 10.1200/JCO.2007.11.3985

Sun C, Jain RK, Munn LL

Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion.

Ann Biomed Eng. 2007;35(12):2121-9 - PMID: 17846892 - PMCID: PMC2752713 - DOI: 10.1007/s10439-007-9377-8

Martin GR, Jain RK

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.

Cancer Res. 1994;54(21):5670-4 - PMID: 7923215

Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK

Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.

Cancer Res. 1993;53(24):5867-71 - PMID: 8261395

Martin GR, Jain RK

Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.

Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048

Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK

Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.

J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684 - DOI: 10.1093/jnci/86.4.293

Baxter LT, Zhu H, Mackensen DG, Jain RK

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

Cancer Res. 1994;54(6):1517-28 - PMID: 8137258

Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.

Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313 - DOI: 10.1073/pnas.91.6.2081

Jain RK

Barriers to drug delivery in solid tumors.

Sci Am. 1994;271(1):58-65 - PMID: 8066425 - DOI: 10.1038/scientificamerican0794-58

Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

Cancer Res. 1994;54(13):3352-6 - PMID: 8012948

Hamberg LM, Kristjansen PE, Hunter GJ, Wolf GL, Jain RK

Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.

Cancer Res. 1994;54(23):6032-6 - PMID: 7954440

Leu AJ, Berk DA, Yuan F, Jain RK

Flow velocity in the superficial lymphatic network of the mouse tail.

Am J Physiol. 1994;267(4 Pt 2):H1507-13 - PMID: 7943396 - DOI: 10.1152/ajpheart.1994.267.4.H1507

Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK

A method for labeling cells for positron emission tomography (PET) studies.

J Immunol Methods. 1994;175(1):79-87 - PMID: 7930641 - DOI: 10.1016/0022-1759(94)90333-6

Melder RJ, Jain RK

Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.

J Immunol Methods. 1994;175(1):69-77 - PMID: 7930640 - DOI: 10.1016/0022-1759(94)90332-8

Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.

Br J Cancer. 1994;69(1):101-3 - PMID: 8286189 - PMCID: PMC1968758 - DOI: 10.1038/bjc.1994.15

Kristjansen PE, Roberge S, Lee I, Jain RK

Tissue-isolated human tumor xenografts in athymic nude mice.

Microvasc Res. 1994;48(3):389-402 - PMID: 7731400 - DOI: 10.1006/mvre.1994.1063

Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.

Lab Invest. 1994;71(2):300-7 - PMID: 7521447

Melder RJ, Salehi HA, Jain RK

Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice.

Microvasc Res. 1995;50(1):35-44 - PMID: 7476578 - DOI: 10.1006/mvre.1995.1036

Townsend JG, Jain RK, Cashmore AR

In vivo pharmacokinetics of triazinate in L-1210 and W-256 cells.

J Pharm Sci. 1982;71(10):1102-5 - PMID: 7143204 - DOI: 10.1002/jps.2600711005

Dudar TE, Jain RK

Differential response of normal and tumor microcirculation to hyperthermia.

Cancer Res. 1984;44(2):605-12 - PMID: 6692365

Peloso R, Tuma DT, Jain RK

Dielectric properties of solid tumors during normothermia and hyperthermia.

IEEE Trans Biomed Eng. 1984;31(11):725-8 - PMID: 6500596 - DOI: 10.1109/TBME.1984.325399

Dimitrov DS, Jain RK

Membrane stability.

Biochim Biophys Acta. 1984;779(4):437-68 - PMID: 6391549 - DOI: 10.1016/0304-4157(84)90020-0