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Gerlowski LE, Jain RK
Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.
Int J Microcirc Clin Exp. 1986;4(4):363-72 - PMID: 4086191
Dimitrov DS, Zhelev DV, Jain RK
Stability of membrane systems modeled as multilayered viscoelastic films.
J Theor Biol. 1985;113(2):353-77 - PMID: 3999781 - DOI: 10.1016/s0022-5193(85)80232-0
Ward-Hartley KA, Jain RK
Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.
Cancer Res. 1987;47(2):371-7 - PMID: 3791228
Dellian M, Helmlinger G, Yuan F, Jain RK
Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
Br J Cancer. 1996;74(8):1206-15 - PMID: 8883406 - PMCID: PMC2075944 - DOI: 10.1038/bjc.1996.518
Leunig M, Yuan F, Gerweck LE, Jain RK
Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice.
Int J Microcirc Clin Exp. 1997;17(1):1-9 - PMID: 9176719 - DOI: 10.1159/000179199
Baish JW, Netti PA, Jain RK
Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Microvasc Res. 1997;53(2):128-41 - PMID: 9143544 - DOI: 10.1006/mvre.1996.2005
Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK
Geometric resistance and microvascular network architecture of human colorectal carcinoma.
Microcirculation. 1997;4(1):25-33 - PMID: 9110281 - DOI: 10.3109/10739689709148315
Jain RK
The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Microcirculation. 1997;4(1):1-23 - PMID: 9110280 - DOI: 10.3109/10739689709148314
Lichtenbeld HC, Yuan F, Michel CC, Jain RK
Perfusion of single tumor microvessels: application to vascular permeability measurement.
Microcirculation. 1996;3(4):349-57 - PMID: 9086446 - DOI: 10.3109/10739689609148307
Briscoe DM, Ganz P, Alexander SI, Melder RJ, Jain RK, Cotran RS, Lichtman AH
The problem of chronic rejection: influence of leukocyte-endothelial interactions.
Kidney Int Suppl. 1997;58:S22-7 - PMID: 9067938
Berk DA, Yuan F, Leunig M, Jain RK
Direct in vivo measurement of targeted binding in a human tumor xenograft.
Proc Natl Acad Sci U S A. 1997;94(5):1785-90 - PMID: 9050856 - PMCID: PMC19994 - DOI: 10.1073/pnas.94.5.1785
Helmlinger G, Yuan F, Dellian M, Jain RK
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nat Med. 1997;3(2):177-82 - PMID: 9018236 - DOI: 10.1038/nm0297-177
Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK
Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Microvasc Res. 1996;51(3):327-46 - PMID: 8992232 - DOI: 10.1006/mvre.1996.0031
Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Proc Natl Acad Sci U S A. 1996;93(25):14765-70 - PMID: 8962129 - PMCID: PMC26210 - DOI: 10.1073/pnas.93.25.14765
Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS
Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Biophys J. 1996;71(5):2656-68 - PMID: 8913603 - PMCID: PMC1233752 - DOI: 10.1016/S0006-3495(96)79457-2
Traykov TT, Jain RK
Effect of glucose and galactose on red blood cell membrane deformability.
Int J Microcirc Clin Exp. 1987;6(1):35-44 - PMID: 3583577
Jain RK
1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Ann Biomed Eng. 1996;24(4):457-73 - PMID: 8841721 - DOI: 10.1007/BF02648108
Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK
Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.
Acta Orthop Scand. 1996;67(4):383-8 - PMID: 8792744 - DOI: 10.3109/17453679609002336
Zhu H, Melder RJ, Baxter LT, Jain RK
Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Cancer Res. 1996;56(16):3771-81 - PMID: 8706023
Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK
Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.
Am J Pathol. 1996;149(1):59-71 - PMID: 8686763 - PMCID: PMC1865247
Nozue M, Lee I, Manning JM, Manning LR, Jain RK
Oxygenation in tumors by modified hemoglobins.
J Surg Oncol. 1996;62(2):109-14 - PMID: 8649036 - DOI: 10.1002/(SICI)1096-9098(199606)62:2<109::AID-JSO6>3.0.CO;2-C
Jain RK
Delivery of molecular medicine to solid tumors.
Science. 1996;271(5252):1079-80 - PMID: 8599082 - DOI: 10.1126/science.271.5252.1079
Leunig M, Yuan F, Gerweck LE, Berk DA, Jain RK
Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.
Res Exp Med (Berl). 1996;195(5):275-88 - PMID: 8578003 - DOI: 10.1007/BF02576798
Eskey CJ, Koretsky AP, Domach MM, Jain RK
Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Proc Natl Acad Sci U S A. 1993;90(7):2646-50 - PMID: 8464871 - PMCID: PMC46152 - DOI: 10.1073/pnas.90.7.2646
Yuan F, Leunig M, Berk DA, Jain RK
Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Microvasc Res. 1993;45(3):269-89 - PMID: 8321142 - DOI: 10.1006/mvre.1993.1024
Berk DA, Yuan F, Leunig M, Jain RK
Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Biophys J. 1993;65(6):2428-36 - PMID: 8312481 - PMCID: PMC1225983 - DOI: 10.1016/S0006-3495(93)81326-2
Fidler IJ, Singh RK, Yoneda J, Kumar R, Xu L, Dong Z, Bielenberg DR, McCarty M, Ellis LM
Critical determinants of neoplastic angiogenesis
The Cancer Journal. 2000;6 Suppl 3:S225-36 - PMID: 10874492
Kaufman EN, Jain RK
Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.
Cancer Res. 1992;52(15):4157-67 - PMID: 1638531
Gutmann R, Leunig M, Feyh J, Goetz AE, Messmer K, Kastenbauer E, Jain RK
Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.
Cancer Res. 1992;52(7):1993-5 - PMID: 1551128
Eskey CJ, Koretsky AP, Domach MM, Jain RK
2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.
Cancer Res. 1992;52(21):6010-9 - PMID: 1394226
Baxter LT, Yuan F, Jain RK
Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Cancer Res. 1992;52(20):5838-44 - PMID: 1394212
Kaufman EN, Jain RK
In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching.
J Immunol Methods. 1992;155(1):1-17 - PMID: 1383343 - DOI: 10.1016/0022-1759(92)90265-u
Melder RJ, Jain RK
Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells.
Cell Biophys. 1994;20(2-3):161-76 - PMID: 1285298 - DOI: 10.1007/BF02823656
Weissbrod JM, Jain RK, Sirotnak FM
Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.
J Pharmacokinet Biopharm. 1978;6(6):487-503 - PMID: 731413 - DOI: 10.1007/BF01062105
Herrera CA, Xu L, Bucana CD, Silva el VG, Hess KR, Gershenson DM, Fidler IJ
Expression of metastasis-related genes in human epithelial ovarian tumors.
Int J Oncol. 2002;20(1):5-13 - PMID: 11743636
Xu L, Czito BG, Willett CG
Epigenetic markers in rectal cancer.
Clin Cancer Res. 2010;16(10):2699-701 - PMID: 20460492 - DOI: 10.1158/1078-0432.CCR-10-0559
Fidler IJ, Yoneda J, Herrera C, Wood J, Xu L
Specific Keynote: Molecular determinants of angiogenesis in ovarian cancer
Gynecologic Oncology. 2003;88:S290S36
Fidler IJ, Bielenberg DR, Slaton J, Xu L, Dinney CPN, Dong Z
Interferon-mediated antiangiogenic therapy
Journal of National Cancer Institute. 2000;1092:4-12
Jain RK
Haemodynamic and transport barriers to the treatment of solid tumours.
Int J Radiat Biol. 1991;60(1-2):85-100 - PMID: 1678003 - DOI: 10.1080/09553009114551621
Xu L, Fidler IJ
Interleukin 8: an autocrine growth factor for human ovarian cancer.
Oncol Res. 2000;12(2):97-106 - PMID: 11132928 - DOI: 10.3727/096504001108747567
Xu L, Yoneda J, Herrera C, Wood J, Killion JJ, Fidler IJ
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
Int J Oncol. 2000;16(3):445-54 - PMID: 10675474 - DOI: 10.3892/ijo.16.3.445
Xu L, Fidler IJ
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells.
Cancer Res. 2000;60(16):4610-6 - PMID: 10969814
Xu L, Xie K, Mukaida N, Matsushima K, Fidler IJ
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
Cancer Res. 1999;59(22):5822-9 - PMID: 10582705
Xu L, Xie K, Fidler IJ
Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase.
Hum Gene Ther. 1998;9(18):2699-708 - PMID: 9874268 - DOI: 10.1089/hum.1998.9.18-2699
Juang SH, Xie K, Xu L, Shi Q, Wang Y, Yoneda J, Fidler IJ
Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene.
Hum Gene Ther. 1998;9(6):845-54 - PMID: 9581907 - DOI: 10.1089/hum.1998.9.6-845
Juang SH, Xie K, Xu L, Wang Y, Yoneda J, Fidler IJ
Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma.
Cancer Biother Radiopharm. 1997;12(3):167-75 - PMID: 10851463 - DOI: 10.1089/cbr.1997.12.167
Xie K, Bielenberg D, Huang S, Xu L, Salas T, Juang SH, Dong Z, Fidler IJ
Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.
Clin Cancer Res. 1997;3(12 Pt 1):2283-94 - PMID: 9815626
Xie K, Wang Y, Huang S, Xu L, Bielenberg D, Salas T, McConkey DJ, Jiang W, Fidler IJ
Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene. 1997;15(7):771-9 - PMID: 9266963 - DOI: 10.1038/sj.onc.1201239
Jain RK
Delivery of molecular and cellular medicine to solid tumors.
Adv Drug Deliv Rev. 2012;64(Suppl):353-365 - PMID: 24511174 - PMCID: PMC3914635 - DOI: 10.1016/j.addr.2012.09.011
Clauss MA, Jain RK
Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer Res. 1990;50(12):3487-92 - PMID: 2340499
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