Sort by:
Reset
Lei PJ, Fraser C, Jones D, Ubellacker JM, Padera TP
Lymphatic system regulation of anti-cancer immunity and metastasis.
Front Immunol. 2024;15:1449291 - PMID: 39211044 - PMCID: PMC11357954 - DOI: 10.3389/fimmu.2024.1449291
Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LK, Singh A, Fu J, Waterton SK, Cheng YC, Roberge S, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA
Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer.
bioRxiv. 2024;:ePub - PMID: 39257788 - PMCID: PMC11383995 - DOI: 10.1101/2024.08.28.609802
Mohamed YI, Lee SS, Demir T, Chamseddine S, Hu ZI, Xiao L, Elsayes K, Morris JS, Wolff RA, Hiatia R, Qayyum A, Rashid A, Duda DG, Yao JC, LaPelusa M, Koay EJ, Mahvash A, Al Azzam A, Dumbrava EE, Hassan M, Amin HM, Kaseb AO
Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab.
Cancer Biomark. 2024;41(1):83-91 - PMID: 39269823 - PMCID: PMC11491993 - DOI: 10.3233/CBM-230431
Ho AY, Shiao S, Kobald SA, Chen J, Duda DG, Ly A, Bossuyt V, Cho HL, Arnold B, Knott S, Gupta GP, McAndrew P, Karlan S, Tighiouart M, Muzikansky A, Basho R, McArthur H
PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer.
J Clin Oncol. 2024;:JCO2400003 - PMID: 39298718 - DOI: 10.1200/JCO.24.00003
Banerjee S, Booth CM, Bruera E, Büchler MW, Drilon A, Fry TJ, Ghobrial IM, Gianni L, Jain RK, Kroemer G, Llovet JM, Long GV, Pantel K, Pritchard-Jones K, Scher HI, Tabernero J, Weichselbaum RR, Weller M, Wu YL
Two decades of advances in clinical oncology - lessons learned and future directions.
Nat Rev Clin Oncol. 2024;21(11):771-780 - PMID: 39354161 - DOI: 10.1038/s41571-024-00945-4
Liu Z, Ma K, Jia Q, Yang Y, Fan P, Wang Y, Wang J, Sun J, Sun L, Shi H, Sun L, Zhu B, Xu W, Zhang L, Jain RK, Qin S, Huang Y
Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer
10.1136/bmjonc-2024-000473. 2024;3:e000473 - DOI: 10.1136/bmjonc-2024-000473
Sun Y, Yin Z, Li S, Wu L, Zhang Y, Zhao Y, Gomes Dos Santos IL, Subudhi S, Lei P, Muzikansky A, Yuan Z, Rueda BR, Jain RK, Xu L
Losartan rewires the tumor-immune microenvironment and suppresses IGF-1 to overcome resistance to chemo-immunotherapy in ovarian cancer.
Br J Cancer. 2024;131(10):1683-1693 - PMID: 39369055 - PMCID: PMC11554678 - DOI: 10.1038/s41416-024-02863-9
Linke JA, Munn LL, Jain RK
Compressive stresses in cancer: characterization and implications for tumour progression and treatment.
Nat Rev Cancer. 2024;24(11):768-791 - PMID: 39390249 - DOI: 10.1038/s41568-024-00745-z
Park RJ, Parikh M, Pappas L, Sade-Feldman M, Kulkarni AS, Bi L, LaSalle TJ, Galway A, Kuhlman C, Blaszkowsky LS, Meyerhardt JA, Enzinger PC, Biller L, Allen JN, Kagey MH, Baum J, Sirard C, Duda DG, Zhu AX, Abrams TA, Hacohen N, Ting DT, Mehta A, Goyal L
Characterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab.
medRxiv. 2024;:ePub - PMID: 39417106 - PMCID: PMC11483019 - DOI: 10.1101/2024.10.08.24315092
Wu B, Tapadar S, Ruan Z, Sun CQ, Arnold RS, Johnston A, Olugbami JO, Arunsi U, Gaul DA, Petros JA, Kobayashi T, Duda DG, Oyelere AK
A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy.
ACS Pharmacol Transl Sci. 2024;7(10):3155-3169 - PMID: 39416967 - PMCID: PMC11475281 - DOI: 10.1021/acsptsci.4c00358
LaPelusa M, Chamseddine S, Tran Cao HS, Xiao L, Hasanov E, Bhosale P, Amin HM, Mohamed YI, Gok Yavuz B, Sakr Y, Xu L, Hu I, Lee SS, Sakamuri D, Jindal S, Nguyen V, Curran MA, Sun R, Rashid A, Duda DG, Sharma P, Qayyum A, Kaseb AO
Tissue and imaging biomarkers of response to neoadjuvant nivolumab or nivolumab plus ipilimumab in patients with resectable hepatocellular carcinoma.
Oncology. 2024;:1-8 - PMID: 39427654 - DOI: 10.1159/000541250
Kunz LV, Bosque JJ, Nikmaneshi M, Chamseddine I, Munn LL, Schuemann J, Paganetti H, Bertolet A
AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response.
Bull Math Biol. 2024;86(12):139 - PMID: 39460828 - DOI: 10.1007/s11538-024-01371-4
Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Honeder SE, Kumar AS, Ramesh DL, Wu M, Hansen JA, Sivanand S, Riedmayr LM, Duquette M, Ali A, Henning N, Shevzov-Zebrun A, Gourgue F, Barbeau AM, Waite M, Kunchok T, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG
Site of breast cancer metastasis is independent of single nutrient levels.
bioRxiv. 2024;:ePub - PMID: 39484531 - PMCID: PMC11527034 - DOI: 10.1101/2024.10.24.616714
Pal R, Krishnamoorthy M, Matsui A, Kang H, Morita S, Taniguchi H, Kobayashi T, Morita A, Choi HS, Duda DG, Kumar ATN
Fluorescence Lifetime Imaging Enables In vivo Quantification of PD-L1 Expression and Inter-tumoral Heterogeneity.
Cancer Res. 2024;:ePub - PMID: 39514403 - DOI: 10.1158/0008-5472.CAN-24-0880
Morita S, Lei PJ, Shigeta K, Ando T, Kobayashi T, Kikuchi H, Matsui A, Huang P, Pittet MJ, Duda DG
Combination CXCR4 and PD1 blockade enhances intratumoral dendritic cell activation and immune responses against hepatocellular carcinoma.
Cancer Immunol Res. 2024;:ePub - PMID: 39514263 - DOI: 10.1158/2326-6066.CIR-24-0324
Chamseddine S, Yavuz BG, Mohamed YI, Lee SS, Yao JC, Hu ZI, LaPelusa M, Xiao L, Sun R, Morris JS, Hatia RI, Hassan M, Duda DG, Diab M, Mohamed A, Nassar A, Amin HM, Kaseb AO
Circulating Galectin-3: A Prognostic Biomarker in Hepatocellular Carcinoma.
J Immunother Precis Oncol. 2024;7(4):255-262 - PMID: 39524465 - PMCID: PMC11541930 - DOI: 10.36401/JIPO-24-6
Martin JD, Mpekris F, Chauhan VP, Martin MR, Walsh ME, Stuber MD, McDonald DM, Yuan F, Stylianopoulos T, Jain RK
Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport.
Drug Deliv. 2024;31(1):2430528 - PMID: 39568143 - DOI: 10.1080/10717544.2024.2430528
Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model.
Neoplasia. 2002;4(1):3-8 - PMID: 11922388 - PMCID: PMC1503314 - DOI: 10.1038/sj/neo/7900209
Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK
Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors.
Cancer Res. 2000;60(22):6248-52 - PMID: 11103778
Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer Res. 2001;61(1):39-44 - PMID: 11196192
Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proc Natl Acad Sci U S A. 2001;98(8):4628-33 - PMID: 11274375 - PMCID: PMC31885 - DOI: 10.1073/pnas.081626898
Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
Cancer Res. 2001;61(6):2404-8 - PMID: 11289105
Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher Y
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvasc Res. 2001;62(1):26-42 - PMID: 11421658 - DOI: 10.1006/mvre.2001.2311
Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.
Nat Med. 2001;7(7):864-8 - PMID: 11433354 - DOI: 10.1038/89997
Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.
Cancer Res. 2001;61(16):6020-4 - PMID: 11507045
Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D
Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation.
Lab Invest. 2001;81(10):1439-51 - PMID: 11598156 - DOI: 10.1038/labinvest.3780357
Xu L, Fukumura D, Jain RK
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.
J Biol Chem. 2002;277(13):11368-74 - PMID: 11741977 - DOI: 10.1074/jbc.M108347200
Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
Am J Pathol. 2002;160(3):985-1000 - PMID: 11891196 - PMCID: PMC1867175 - DOI: 10.1016/S0002-9440(10)64920-6
Jain RK, Fenton BT
Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
J Natl Cancer Inst. 2002;94(6):417-21 - PMID: 11904313 - DOI: 10.1093/jnci/94.6.417
Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK
Tumour biology: herceptin acts as an anti-angiogenic cocktail.
Nature. 2002;416(6878):279-80 - PMID: 11907566 - DOI: 10.1038/416279b
Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer Res. 2000;60(19):5565-70 - PMID: 11034104
Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK
Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy.
Cancer Res. 2002;62(7):2151-6 - PMID: 11929837
Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK
Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.
Clin Cancer Res. 2002;8(4):1008-13 - PMID: 11948107
Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism.
Clin Cancer Res. 2002;8(4):1284-91 - PMID: 11948144
Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK
Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
Br J Cancer. 2002;86(6):947-53 - PMID: 11953828 - PMCID: PMC2364140 - DOI: 10.1038/sj.bjc.6600158
Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK
Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420
Jain RK, Munn LL, Fukumura D
Dissecting tumour pathophysiology using intravital microscopy.
Nat Rev Cancer. 2002;2(4):266-76 - PMID: 12001988 - DOI: 10.1038/nrc778
Jain RK, Padera TP
Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy.
J Natl Cancer Inst. 2002;94(11):785-7 - PMID: 12048260 - DOI: 10.1093/jnci/94.11.785
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett. 2002;524(1-3):163-71 - PMID: 12135761 - DOI: 10.1016/s0014-5793(02)03049-1
Hoshida T, Sunamura M, Duda DG, Egawa S, Miyazaki S, Shineha R, Hamada H, Ohtani H, Satomi S, Matsuno S
Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor.
Pancreas. 2002;25(2):111-21 - PMID: 12142732 - DOI: 10.1097/00006676-200208000-00001
Dolmans DE, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D
Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy.
Cancer Res. 2002;62(15):4289-94 - PMID: 12154031
Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Biophys J. 2002;83(3):1650-60 - PMID: 12202388 - PMCID: PMC1302261 - DOI: 10.1016/S0006-3495(02)73933-7
Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK
Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Proc Natl Acad Sci U S A. 1999;96(6):3137-42 - PMID: 10077650 - PMCID: PMC15908 - DOI: 10.1073/pnas.96.6.3137
Horie Y, Kato S, Ohki E, Hamamatsu H, Fukumura D, Kurose I, Suzuki H, Suematsu M, Miura S, Ishii H
Effect of lipopolysaccharides on erythrocyte flow velocity in rat liver.
J Gastroenterol. 1997;32(6):783-90 - PMID: 9430017 - DOI: 10.1007/BF02936955
Garkavtsev I, Grigorian IA, Ossovskaya VS, Chernov MV, Chumakov PM, Gudkov AV
The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.
Nature. 1998;391(6664):295-8 - PMID: 9440695 - DOI: 10.1038/34675
Garkavtsev I, Boland D, Mai J, Wilson H, Veillette C, Riabowol K
Specific monoclonal antibody raised against the p33ING1 tumor suppressor.
Hybridoma. 1997;16(6):537-40 - PMID: 9455706 - DOI: 10.1089/hyb.1997.16.537
Garkavtsev I, Hull C, Riabowol K
Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence.
Exp Gerontol. 1998;33(1-2):81-94 - PMID: 9467719 - DOI: 10.1016/s0531-5565(97)00086-7
Fukumura D, Jain RK
Role of nitric oxide in angiogenesis and microcirculation in tumors.
Cancer Metastasis Rev. 1998;17(1):77-89 - PMID: 9544424 - DOI: 10.1023/a:1005908805527
Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK
Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice.
J Invest Dermatol. 1998;111(1):1-6 - PMID: 9665379 - DOI: 10.1046/j.1523-1747.1998.00262.x
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E, Keshet E
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
Nature. 1998;394(6692):485-90 - PMID: 9697772 - DOI: 10.1038/28867
1144