Sort by:
Reset
Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK
Targeted therapy in rectal cancer.
Oncology (Williston Park). 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim - PMID: 17910311 - PMCID: PMC2686129
Jain RK, Xu L
alphaPlGF: a new kid on the antiangiogenesis block.
Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023
Mok W, Boucher Y, Jain RK
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107
Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT
Antiangiogenic agents for the treatment of glioblastoma.
Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895
Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK
Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643
Au P, Tam J, Fukumura D, Jain RK
Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11
Jain RK
Transport of macromolecules in tumor microcirculation.
Biotechnol Prog. 1985;1(2):81-94 - PMID: 20568145 - DOI: 10.1002/btpr.5420010205
Jain RK, Finn AV, Kolodgie FD, Gold HK, Virmani R
Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization.
Nat Clin Pract Cardiovasc Med. 2007;4(9):491-502 - PMID: 17712362 - DOI: 10.1038/ncpcardio0979
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT
Angiogenesis in brain tumours.
Nat Rev Neurosci. 2007;8(8):610-22 - PMID: 17643088 - DOI: 10.1038/nrn2175
Duda DG
American Association for Cancer Research 98th Annual Meeting. Angiogenesis and anti-angiogenesis in cancer.
IDrugs. 2007;10(6):366-9 - PMID: 17641996
Fukumura D, Jain RK
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
Microvasc Res. 2007;74(2-3):72-84 - PMID: 17560615 - PMCID: PMC2100036 - DOI: 10.1016/j.mvr.2007.05.003
Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE
Influence of tumor cell and stroma sensitivity on tumor response to radiation.
Cancer Res. 2007;67(9):4016-21 - PMID: 17483312 - DOI: 10.1158/0008-5472.CAN-06-4498
Bockhorn M, Jain RK, Munn LL
Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Lancet Oncol. 2007;8(5):444-8 - PMID: 17466902 - PMCID: PMC2712886 - DOI: 10.1016/S1470-2045(07)70140-7
Duda DG, Cohen KS, Scadden DT, Jain RK
A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.
Nat Protoc. 2007;2(4):805-10 - PMID: 17446880 - PMCID: PMC2686125 - DOI: 10.1038/nprot.2007.111
Jain RK, Tong RT, Munn LL
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model.
Cancer Res. 2007;67(6):2729-35 - PMID: 17363594 - PMCID: PMC3022341 - DOI: 10.1158/0008-5472.CAN-06-4102
Tyrrell JA, di Tomaso E, Fuja D, Tong R, Kozak K, Jain RK, Roysam B
Robust 3-D modeling of vasculature imagery using superellipsoids.
IEEE Trans Med Imaging. 2007;26(2):223-37 - PMID: 17304736 - DOI: 10.1109/TMI.2006.889722
Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Cancer Cell. 2007;11(1):83-95 - PMID: 17222792 - PMCID: PMC2748664 - DOI: 10.1016/j.ccr.2006.11.021
Fukumura D, Jain RK
Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize.
J Cell Biochem. 2007;101(4):937-49 - PMID: 17171643 - DOI: 10.1002/jcb.21187
Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK
Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Semin Oncol. 2006;33(5 Suppl 10):S35-40 - PMID: 17145523 - PMCID: PMC2686124 - DOI: 10.1053/j.seminoncol.2006.08.007
Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH
Platelet-derived growth factor receptor-beta in Gorham's disease.
Nat Clin Pract Oncol. 2006;3(12):693-7 - PMID: 17139320 - PMCID: PMC2693369 - DOI: 10.1038/ncponc0660
Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK
Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications.
Cancer Res. 2006;66(16):8065-75 - PMID: 16912183 - DOI: 10.1158/0008-5472.CAN-06-1392
Cochran DM, Fukumura D, Ancukiewicz M, Carmeliet P, Jain RK
Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells.
Ann Biomed Eng. 2006;34(8):1247-58 - PMID: 16832606 - DOI: 10.1007/s10439-006-9134-4
Fukumura D, Kashiwagi S, Jain RK
The role of nitric oxide in tumour progression.
Nat Rev Cancer. 2006;6(7):521-34 - PMID: 16794635 - DOI: 10.1038/nrc1910
Hoon DS, Kitago M, Kim J, Mori T, Piris A, Szyfelbein K, Mihm MC, Nathanson SD, Padera TP, Chambers AF, Vantyghem SA, MacDonald IC, Shivers SC, Alsarraj M, Reintgen DS, Passlick B, Sienel W, Pantel K
Molecular mechanisms of metastasis.
Cancer Metastasis Rev. 2006;25(2):203-20 - PMID: 16770533 - DOI: 10.1007/s10555-006-8500-x
Reddy ST, Berk DA, Jain RK, Swartz MA
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles.
J Appl Physiol. 2006;101(4):1162-9 - PMID: 16763103 - DOI: 10.1152/japplphysiol.00389.2006
Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D
Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models.
Cancer Res. 2006;66(8):3971-7 - PMID: 16618713 - DOI: 10.1158/0008-5472.CAN-04-3085
Duda DG
Antiangiogenesis and drug delivery to tumors: bench to bedside and back.
Cancer Res. 2006;66(8):3967-70 - PMID: 16618712 - DOI: 10.1158/0008-5472.CAN-05-4536
Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK
Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Cancer Res. 2006;66(7):3360-4 - PMID: 16585153 - DOI: 10.1158/0008-5472.CAN-05-2655
Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK
Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.
J Clin Oncol. 2006;24(9):1449-53 - PMID: 16549839 - PMCID: PMC2718681 - DOI: 10.1200/JCO.2005.04.2861
McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Cancer Res. 2006;66(5):2509-13 - PMID: 16510565 - DOI: 10.1158/0008-5472.CAN-05-2242
Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Proc Natl Acad Sci U S A. 2006;103(4):855-60 - PMID: 16418262 - PMCID: PMC1348013 - DOI: 10.1073/pnas.0510412103
Jain RK, Duda DG, Clark JW, Loeffler JS
Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Nat Clin Pract Oncol. 2006;3(1):24-40 - PMID: 16407877 - DOI: 10.1038/ncponc0403
Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.
Blood. 2006;107(7):2774-6 - PMID: 16339405 - PMCID: PMC1895376 - DOI: 10.1182/blood-2005-08-3210
Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
J Clin Oncol. 2005;23(31):8136-9 - PMID: 16258121 - DOI: 10.1200/JCO.2005.02.5635
Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B
A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.
Microvasc Res. 2005;70(3):165-78 - PMID: 16239015 - DOI: 10.1016/j.mvr.2005.08.005
Hagendoorn J, Padera TP, Fukumura D, Jain RK
Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Trends Cardiovasc Med. 2005;15(5):169-73 - PMID: 16165013 - DOI: 10.1016/j.tcm.2005.06.003
Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Héligon C, Terclavers S, Ciesiolka M, Kälin R, Man WY, Senn I, Wyns S, Lupu F, Brändli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nat Med. 2005;11(9):998-1004 - PMID: 16116431 - DOI: 10.1038/nm1285
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P
Genetic evidence for a tumor suppressor role of HIF-2alpha.
Cancer Cell. 2005;8(2):131-41 - PMID: 16098466 - DOI: 10.1016/j.ccr.2005.07.003
Huang P, McKee TD, Jain RK, Fukumura D
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse.
Comp Med. 2005;55(3):236-43 - PMID: 16089171
Jain RK, Au P, Tam J, Duda DG, Fukumura D
Engineering vascularized tissue.
Nat Biotechnol. 2005;23(7):821-3 - PMID: 16003365 - DOI: 10.1038/nbt0705-821
di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL
Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
Cancer Res. 2005;65(13):5740-9 - PMID: 15994949 - DOI: 10.1158/0008-5472.CAN-04-4552
Xu L, Tong R, Cochran DM, Jain RK
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Cancer Res. 2005;65(13):5711-9 - PMID: 15994946 - DOI: 10.1158/0008-5472.CAN-04-4313
Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682
Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels.
J Clin Invest. 2005;115(7):1816-27 - PMID: 15951843 - PMCID: PMC1143589 - DOI: 10.1172/JCI24015
Jain RK
Antiangiogenic therapy for cancer: current and emerging concepts.
Oncology (Williston Park). 2005;19(4 Suppl 3):7-16 - PMID: 15934498
Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.
Nat Med. 2005;11(6):678-82 - PMID: 15880117 - PMCID: PMC2686110 - DOI: 10.1038/nm1247
Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
J Clin Oncol. 2005;23(9):1951-61 - PMID: 15774788 - DOI: 10.1200/JCO.2005.08.119
Duda DG, Jain RK
Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow.
J Clin Invest. 2005;115(3):596-8 - PMID: 15765145 - PMCID: PMC1052004 - DOI: 10.1172/JCI24511
Garkavtsev I, Boucher Y
An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol.
Cancer Biol Ther. 2005;4(1):48-9 - PMID: 15711122 - DOI: 10.4161/cbt.4.1.1572
Shevkoplyas SS, Yoshida T, Munn LL, Bitensky MW
Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device.
Anal Chem. 2005;77(3):933-7 - PMID: 15679363 - PMCID: PMC3022340 - DOI: 10.1021/ac049037i
546