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Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK
CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636
Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK
Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 2011;108(9):3725-30 - PMID: 21321210 - PMCID: PMC3048115 - DOI: 10.1073/pnas.1100446108
Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proc Natl Acad Sci U S A. 2011;108(7):2909-14 - PMID: 21282607 - PMCID: PMC3041115 - DOI: 10.1073/pnas.1018892108
Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L
TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
Clin Cancer Res. 2011;17(6):1415-24 - PMID: 21278244 - PMCID: PMC3060297 - DOI: 10.1158/1078-0432.CCR-10-2429
Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D
Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Proc Natl Acad Sci U S A. 2011;108(6):2426-31 - PMID: 21245339 - PMCID: PMC3038705 - DOI: 10.1073/pnas.1018382108
Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK
Scaling rules for diffusive drug delivery in tumor and normal tissues.
Proc Natl Acad Sci U S A. 2011;108(5):1799-803 - PMID: 21224417 - PMCID: PMC3033252 - DOI: 10.1073/pnas.1018154108
Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc Natl Acad Sci U S A. 2011;108(1):302-7 - PMID: 21173223 - PMCID: PMC3017172 - DOI: 10.1073/pnas.1016917108
Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK
Malignant cells facilitate lung metastasis by bringing their own soil.
Proc Natl Acad Sci U S A. 2010;107(50):21677-82 - PMID: 21098274 - PMCID: PMC3003109 - DOI: 10.1073/pnas.1016234107
Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK
Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Biophys J. 2010;99(10):3119-28 - PMID: 21081058 - PMCID: PMC2980743 - DOI: 10.1016/j.bpj.2010.08.065
Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG
A nanoparticle size series for in vivo fluorescence imaging.
Angew Chem Int Ed Engl. 2010;49(46):8649-52 - PMID: 20886481 - PMCID: PMC3035057 - DOI: 10.1002/anie.201003142
Zhu AX, Duda DG, Ancukiewicz M, di Tomaso E, Clark JW, Miksad R, Fuchs CS, Ryan DP, Jain RK
Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
Clin Cancer Res. 2011;17(4):918-27 - PMID: 20843836 - PMCID: PMC3023846 - DOI: 10.1158/1078-0432.CCR-10-0515
Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK
Dehydro-alpha-lapachone, a plant product with antivascular activity.
Proc Natl Acad Sci U S A. 2011;108(28):11596-601 - PMID: 21709229 - PMCID: PMC3136298 - DOI: 10.1073/pnas.1104225108
Wang E, Feng Y, Zhang M, Zou L, Li Y, Buys ES, Huang P, Brouckaert P, Chao W
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.
Anesthesiology. 2011;114(3):603-13 - PMID: 21270629 - PMCID: PMC3044772 - DOI: 10.1097/ALN.0b013e31820a4d5b
Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT
Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
J Neurooncol. 2011;103(2):325-32 - PMID: 20821342 - PMCID: PMC4090923 - DOI: 10.1007/s11060-010-0390-7
Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK
Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Biophys J. 2010;99(5):1342-9 - PMID: 20816045 - PMCID: PMC2931749 - DOI: 10.1016/j.bpj.2010.06.016
Brown E, Munn LL, Fukumura D, Jain RK
In vivo imaging of tumors.
Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452
Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL
Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Nat Methods. 2010;7(8):655-60 - PMID: 20581828 - PMCID: PMC2921873 - DOI: 10.1038/nmeth.1475
Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D
Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073
Fukumura D, Duda DG, Munn LL, Jain RK
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x
Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH
In vivo wide-area cellular imaging by side-view endomicroscopy.
Nat Methods. 2010;7(4):303-5 - PMID: 20228814 - PMCID: PMC2849759 - DOI: 10.1038/nmeth.1440
Choi B, Bouma B, Fukumura D, Jain RK
Optical methods in vascular biology and medicine.
J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696
Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG
Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
J Am Chem Soc. 2010;132(2):472-83 - PMID: 20025223 - PMCID: PMC2871316 - DOI: 10.1021/ja908137d
Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG
InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
J Am Chem Soc. 2010;132(2):470-1 - PMID: 20025222 - PMCID: PMC2862004 - DOI: 10.1021/ja908250r
Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK
Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
PLoS One. 2009;4(12):e8316 - PMID: 20016816 - PMCID: PMC2789383 - DOI: 10.1371/journal.pone.0008316
Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK
Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Cancer Res. 2009;69(20):7905-10 - PMID: 19826039 - PMCID: PMC2859041 - DOI: 10.1158/0008-5472.CAN-09-2099
Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK
VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
PLoS One. 2009;4(9):e6525 - PMID: 19763275 - PMCID: PMC2744279 - DOI: 10.1371/journal.pone.0006525
Dawson MR, Duda DG, Fukumura D, Jain RK
VEGFR1-activity-independent metastasis formation.
Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254
Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971
Jain RK, Munn LL, Fukumura D, Melder RJ
In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553
Less JR, Skalak TC, Sevick EM, Jain RK
Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Cancer Res. 1991;51(1):265-73 - PMID: 1988088
Ohkubo C, Bigos D, Jain RK
Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Cancer Res. 1991;51(5):1561-3 - PMID: 1997196
Sevick EM, Jain RK
Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Cancer Res. 1991;51(10):2727-30 - PMID: 2021951
Yuan F, Baxter LT, Jain RK
Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Cancer Res. 1991;51(12):3119-30 - PMID: 2039991
Baxter LT, Jain RK
Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Microvasc Res. 1990;40(2):246-63 - PMID: 2250603 - DOI: 10.1016/0026-2862(90)90023-k
Jain RK, Stock RJ, Chary SR, Rueter M
Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Microvasc Res. 1990;39(1):77-93 - PMID: 2314308 - DOI: 10.1016/0026-2862(90)90060-5
Boucher Y, Baxter LT, Jain RK
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer Res. 1990;50(15):4478-84 - PMID: 2369726
Gerlowski LE, Jain RK
Microvascular permeability of normal and neoplastic tissues.
Microvasc Res. 1986;31(3):288-305 - PMID: 2423854 - DOI: 10.1016/0026-2862(86)90018-x
Sasaki A, Jain RK, Maghazachi AA, Goldfarb RH, Herberman RB
Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Cancer Res. 1989;49(14):3742-6 - PMID: 2500233
Sevick EM, Jain RK
Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.
Cancer Res. 1989;49(13):3513-9 - PMID: 2731173
Baxter LT, Jain RK
Vascular permeability and interstitial diffusion in superfused tissues: a two-dimensional model.
Microvasc Res. 1988;36(1):108-15 - PMID: 3185299 - DOI: 10.1016/0026-2862(88)90043-x
Jain RK, Baxter LT
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.
Cancer Res. 1988;48(24 Pt 1):7022-32 - PMID: 3191477
Sevick EM, Jain RK
Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.
Cancer Res. 1988;48(5):1201-7 - PMID: 3342400
DiPette DJ, Ward KA, Jain RK, Kerr NE, Schwarzenberger K
Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1988;48(6):1476-80 - PMID: 3345521
Jain RK
Transport of molecules in the tumor interstitium: a review.
Cancer Res. 1987;47(12):3039-51 - PMID: 3555767
Jain RK, Ward-Hartley KA
Dynamics of cancer cell interactions with microvasculature and interstitium.
Biorheology. 1987;24(2):117-25 - PMID: 3651585 - DOI: 10.3233/bir-1987-24205
DiPette DJ, Ward-Hartley KA, Jain RK
Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1986;46(12 Pt 1):6299-304 - PMID: 3779648
Nugent LJ, Jain RK
Two-compartment model for plasma pharmacokinetics in individual blood vessels.
J Pharmacokinet Biopharm. 1984;12(4):451-61 - PMID: 6084709 - DOI: 10.1007/BF01062668
Nugent LJ, Jain RK
Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues.
Microvasc Res. 1984;28(2):270-4 - PMID: 6209533 - DOI: 10.1016/0026-2862(84)90022-0
Jain RK, Shah SA, Finney PL
Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia.
J Natl Cancer Inst. 1984;73(2):429-36 - PMID: 6589435 - DOI: 10.1093/jnci/73.2.429
Jain RK, Weissbrod JM, Wei J
Mass transport in tumors: characterization and applications to chemotherapy.
Adv Cancer Res. 1981;33:251-310 - PMID: 7006335 - DOI: 10.1016/s0065-230x(08)60672-7
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