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Kikuchi H, Matsui A, Morita S, Amoozgar Z, Inoue K, Ruan Z, Staiculescu D, Wong JS, Huang P, Yau T, Jain RK, Duda DG

Increased CD8+ T-Cell Infiltration and Efficacy for Multikinase Inhibitors after PD-1 Blockade in Hepatocellular Carcinoma.
J Natl Cancer Inst. 2022;114(9):1301-1305 - PMID: 35288743 - PMCID: PMC9468280 - DOI: 10.1093/jnci/djac051

Baish JW, Padera TP, Munn LL

The effects of gravity and compression on interstitial fluid transport in the lower limb.
Sci Rep. 2022;12(1):4890 - PMID: 35318426 - PMCID: PMC8941011 - DOI: 10.1038/s41598-022-09028-9

Agrud A, Subburaju S, Goel P, Ren J, Kumar AS, Caldarone BJ, Dai W, Chavez J, Fukumura D, Jain RK, Kloner RA, Vasudevan A

Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.
Sci Rep. 2022;12(1):4922 - PMID: 35318369 - PMCID: PMC8941104 - DOI: 10.1038/s41598-022-08806-9

Zhao F, Chen Y, Li SW, Zhang J, Zhang S, Zhao XB, Yang ZJ, Wang B, He QY, Wang LM, Xu L, Liu PN

Novel patient-derived xenograft and cell line models for therapeutic screening in NF2-associated schwannoma.
J Pathol. 2022;257(5):620-634 - PMID: 35394061 - DOI: 10.1002/path.5908

Pu Z, Duda DG, Zhu Y, Pei S, Wang X, Huang Y, Yi P, Huang Z, Peng F, Hu X, Fan X

VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
J Transl Med. 2022;20(1):212 - PMID: 35562734 - PMCID: PMC9102726 - DOI: 10.1186/s12967-022-03416-5

Jones D, Wang Z, Chen I, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, Van Wijnbergen JW, Pereira E, Vakoc B, Huang P, Nia H, Padera T

Solid stress impairs lymphocyte infiltration into lymph node metastases.
FASEB J. 2022;36 Suppl 1:ePub - PMID: 35557097 - DOI: 10.1096/fasebj.2022.36.S1.R4616

Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK

Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.
Clin Cancer Res. 2022;28(14):3076-3090 - PMID: 35584239 - PMCID: PMC9355624 - DOI: 10.1158/1078-0432.CCR-22-0486

van den Bent L, Frenkel NC, Poghosyan S, Molenaar IQ, Padera TP, Kranenburg O, Borel Rinkes IHM, Hagendoorn J

Liver lymphatic drainage patterns follow segmental anatomy.
Br J Surg. 2022;109(6):559-560 - PMID: 35576376 - PMCID: PMC10364678 - DOI: 10.1093/bjs/znac076

Nuzzo PV, Adib E, Weise N, Curran C, Stewart T, Freeman D, Nassar AH, Abou Alaiwi S, Bakouny Z, McGregor BA, Choueiri TK, Jain RK, McKay RR, Sonpavde G

Impact of renin-angiotensin system inhibitors on outcomes in patients with metastatic renal cell carcinoma treated with immune-checkpoint inhibitors
Clin Genitourin Cancer. 2022;20(4):301-306 - PMID: 35614012 - PMCID: PMC10013974 - DOI: 10.1016/j.clgc.2022.04.012

Morita S, Duda DG

Refining genetic and molecular classifications to facilitate breakthrough treatments in intrahepatic cholangiocarcinoma: are we there yet?
Gut. 2022;72(4):608-610 - PMID: 35772925 - PMCID: PMC10435277 - DOI: 10.1136/gutjnl-2022-327782

Ho WW, Pittet MJ, Fukumura D, Jain RK

The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy.
Cancer Cell. 2022;40(7):701-702 - PMID: 35714604 - PMCID: PMC10894502 - DOI: 10.1016/j.ccell.2022.05.016

Saulnier Sholler G, Duda DG, Bergendahl G, Ebb D, Snuderl M, Laetsch TW, Michlitsch J, Hanson D, Isakoff MS, Bielamowicz K, Kraveka JM, Ferguson W, Carmeliet P, De Deene A, Gijsen L, Jain RK

A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.
Clin Cancer Res. 2022;28(18):3950-3957 - PMID: 35833850 - PMCID: PMC9481695 - DOI: 10.1158/1078-0432.CCR-22-1169

How J, Ren S, Lombardi-Story J, Bergeron M, Foster J, Amrein PC, Brunner AM, Fathi AT, Hock H, Khachatryan A, Kikuchi H, Ng MR, Moran J, Narayan R, Neuberg D, Ramos A, Som T, Vartanian M, Chen YB, Duda DG, Hobbs GS

A nonrandomized phase I and biomarker trial of regorafenib in advanced myeloid malignancies.
EJHaem. 2022;3(2):434-442 - PMID: 35846042 - PMCID: PMC9175677 - DOI: 10.1002/jha2.408

Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - PMCID: PMC10290535 - DOI: 10.1038/s41588-022-01134-8

Patel SA, Nilsson MB, Le X, Cascone T, Jain RK, Heymach JV

Molecular Mechanisms and Future Implications of VEGF/VEGFR in Cancer Therapy.
Clin Cancer Res. 2023;29(1):30-39 - PMID: 35969170 - PMCID: PMC10274152 - DOI: 10.1158/1078-0432.CCR-22-1366

Munoz NM, Dupuis C, Williams M, Dixon K, McWatters A, Zhang J, Pavuluri S, Rao A, Duda DG, Kaseb A, Sheth RA

Immune modulation by molecularly targeted photothermal ablation in a mouse model of advanced hepatocellular carcinoma and cirrhosis.
Sci Rep. 2022;12(1):14449 - PMID: 36002545 - PMCID: PMC9402568 - DOI: 10.1038/s41598-022-15948-3

Dima SO, Dumitraşcu T, Popescu I, Duda DG

Using Molecular Subtyping of Pancreatic Ductal Adenocarcinoma for Multimodal Treatment Selection in Resectable Disease.
Chirurgia (Bucur). 2022;117(4):407-414 - PMID: 36049097 - DOI: 10.21614/chirurgia.2772

Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S

Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy.
FASEB J. 2022;36(10):e22521 - PMID: 36052742 - PMCID: PMC9574655 - DOI: 10.1096/fj.202200033R

Nagalo BM, Zhou Y, Loeuillard EJ, Dumbauld C, Barro O, Elliott NM, Baker AT, Arora M, Bogenberger JM, Meurice N, Petit J, Uson Junior PLS, Aslam F, Raupach E, Gabere M, Basnakian A, Simoes CC, Cannon MJ, Post SR, Buetow K, Chamcheu JC, Barrett MT, Duda DG, Jacobs B, Vile R, Barry MA, Roberts LR, Ilyas S, Borad MJ

Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver Cancers.
Hepatology. 2022;77(6):1943-1957 - PMID: 36052732 - DOI: 10.1002/hep.32769

Duda DG, Jain RK

Revisiting Antiangiogenic Multikinase Inhibitors in the Era of Immune Checkpoint Blockade: The Case of Sorafenib.
Cancer Res. 2022;82(20):3665-3667 - PMID: 36245248 - PMCID: PMC11823948 - DOI: 10.1158/0008-5472.CAN-22-2639

Sasaki T, Shigeta K, Kitahara S, Suzuki Y, Matsui S, Seishima R, Okabayashi K, Duda DG, Kitagawa Y

Inhibition of STAT3 Promotes Effector T Cell Infiltration But also Immunosuppression in the HCC Tumor Microenvironment.
Anticancer Res. 2022;42(11):5205-5215 - PMID: 36288859 - DOI: 10.21873/anticanres.16027

Mohamed YI, Duda DG, Awiwi MO, Lee SS, Altameemi L, Xiao L, Morris JS, Wolff RA, Elsayes KM, Hatia RI, Qayyum A, Chamseddine SM, Rashid A, Yao JC, Mahvash A, Hassan MM, Amin HM, Kaseb AO

Plasma growth hormone is a potential biomarker of response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients.
Oncotarget. 2022;13:1314-1321 - PMID: 36473155 - PMCID: PMC9726202 - DOI: 10.18632/oncotarget.28322

Chen S, Huang C, Liao G, Sun H, Xie Y, Liao C, Wang J, He M, Hu H, Dai Z, Ren X, Zeng X, Lin Z, Zhang GP, Xie W, Shen S, Li S, Peng S, Kuang DM, Zhao Q, Duda DG, Kuang M

Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences.
Gut. 2023;72(6):1196-1210 - PMID: 36596711 - DOI: 10.1136/gutjnl-2022-328428

Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RK

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2.
Proc Natl Acad Sci U S A. 2023;120(3):e2211132120 - PMID: 36623200 - PMCID: PMC9934028 - DOI: 10.1073/pnas.2211132120

Li H, Wei H, Padera TP, Baish JW, Munn LL

Computational simulations of the effects of gravity on lymphatic transport.
PNAS Nexus. 2022;1(5):pgac237 - PMID: 36712369 - PMCID: PMC9802413 - DOI: 10.1093/pnasnexus/pgac237

Li Z, Huang S, He Y, van Wijnbergen JW, Zhang Y, Cottrell RD, Smith SG, Hammond PT, Chen DZ, Padera TP, Belcher AM

A new label-free optical imaging method for the lymphatic system enhanced by deep learning.
bioRxiv. 2023;:ePub - PMID: 36711668 - PMCID: PMC9882203 - DOI: 10.1101/2023.01.13.523938

Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, Dong X, Speranza MC, Neagu MR, Iorgulescu JB, Huang RY, Youssef G, Reardon DA, Sharpe AH, Freeman GJ, Suvà ML, Xu L, Jain RK

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models.
Proc Natl Acad Sci U S A. 2023;120(6):e2219199120 - PMID: 36724255 - PMCID: PMC9963691 - DOI: 10.1073/pnas.2219199120

Zhang Q, Gerweck LE, Cascio EW, Yang Q, Huang P, Niemierko A, Bertolet A, Nesteruk KP, McNamara AL, Schuemann J

Proton FLASH effects on mouse skin at different oxygen tensions.
Phys Med Biol. 2023;68(5):ePub - PMID: 36731139 - PMCID: PMC11164666 - DOI: 10.1088/1361-6560/acb888

Chamseddine I, Kim Y, De B, Naqa IE, Duda DG, Wolfgang JA, Pursley J, Wo JY, Hong TS, Paganetti H, Koay EJ, Grassberger C

Predictive Model of Liver Toxicity to Aid the Personalized Selection of Proton vs Photon Therapy in Hepatocellular Carcinoma.
Int J Radiat Oncol Biol Phys. 2023;116(5):1234-1243 - PMID: 36739920 - PMCID: PMC12273456 - DOI: 10.1016/j.ijrobp.2023.01.055

Boucher Y, Posada JM, Subudhi S, Kumar AS, Rosario SR, Gu L, Kumra H, Mino-Kenudson M, Talele NP, Duda DG, Fukumura D, Wo JY, Clark JW, Ryan DP, Fernandez-Del Castillo C, Hong TS, Pittet MJ, Jain RK

Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer.
Clin Cancer Res. 2023;29(8):1605-1619 - PMID: 36749873 - PMCID: PMC10106451 - DOI: 10.1158/1078-0432.CCR-22-1630

Chen J, Amoozgar Z, Liu X, Aoki S, Liu Z, Shin S, Matsui A, Pu Z, Lei PJ, Datta M, Zhu L, Ruan Z, Shi L, Staiculescu D, Inoue K, Munn LL, Fukumura D, Huang P, Bardeesy N, Ho WJ, Jain RK, Duda DG

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy.
bioRxiv. 2023;:ePub - PMID: 36747853 - PMCID: PMC9901023 - DOI: 10.1101/2023.01.26.525680

Yin Z, Wu L, Zhang Y, Sun Y, Chen JW, Subudhi S, Ho W, Lee GY, Wang A, Gao X, Ren J, Zhu C, Zhang N, Ferraro GB, Muzikansky A, Zhang L, Stemmer-Rachamimov A, Mao J, Plotkin SR, Xu L

Co-Targeting IL-6 and EGFR signaling for the treatment of schwannomatosis and associated pain.
bioRxiv. 2023;:ePub - PMID: 36798353 - PMCID: PMC9934519 - DOI: 10.1101/2023.02.06.527377

Singhal D, BörnerK, Chaikof EL, Detmar M, Hollmén M, Iliff JJ, Itkin M, Makinen T, Oliver G, Padera TP, Quardokus EM, Radtke AJ, Suami H, Weber GM, Rovira II, Muratoglu SC, Galis ZS

Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium.
Front Physiol. 2023;14:1099403 - PMID: 36814475 - PMCID: PMC9939837 - DOI: 10.3389/fphys.2023.1099403

Gupta N, Ochiai H, Hoshino Y, Klein S, Zustin J, Ramjiawan RR, Kitahara S, Maimon N, Bazou D, Chiang S, Li S, Schanne DH, Jain RK, Munn LL, Huang P, Kozin SV, Duda DG

Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models.
Cancers (Basel). 2023;15(4):ePub - PMID: 36831366 - PMCID: PMC9954510 - DOI: 10.3390/cancers15041021

Gkika E, Firat E, Adebahr S, Graf E, Popp I, Radicioni G, Lo SS, Nestle U, Nicolay NH, Niedermann G, Duda DG, Grosu AL

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer.
NPJ Precis Oncol. 2023;7(1):24 - PMID: 36864234 - PMCID: PMC9981559 - DOI: 10.1038/s41698-023-00358-z

Wang Y, Drum DL, Sun R, Zhang Y, Yu L, Jia L, Isakoff SJ, Kehlmann AM, Dal AE, Dotti G, Zheng H, Ferrone CR, Taghian AG, DeLeo AB, Zhang H, Jounaidi Y, Fan S, Huang P, Wang C, Yang J, Boland GM, Sadreyev RI, Wong L, Ferrone S, Wang X

Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and tumor microenvironment, overcoming multiple obstacles of CAR T therapy for solid tumors.
Res Sq. 2023;:ePub - PMID: 36865255 - PMCID: PMC9980213 - DOI: 10.21203/rs.3.rs-2595410/v1

McCullum L, Shin J, Xing S, Beekman C, Schuemann J, Hong T, Duda D, Mohan R, Lin S, Correa-Alfonso CM, Domal S, Withrow J, Bolch W, Paganetti H, Grassberger C

Predicting Severity of Radiation Induced Lymphopenia in Individual Proton Therapy Patients for Varying Dose Rate and Fractionation Using Dynamic 4D Blood Flow Simulations.
Int J Radiat Oncol Biol Phys. 2023;116(5):1226-1233 - PMID: 36739919 - PMCID: PMC10363211 - DOI: 10.1016/j.ijrobp.2023.01.054

Botezatu A, Bleotu C, Nastase A, Anton G, Bacalbasa N, Duda D, Dima SO, Popescu I

Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma.
Cancer Genomics Proteomics. 2015;12(1):21-30 - PMID: 25560641

Dong X, Ren J, Amoozgar Z, Lee S, Datta M, Roberge S, Duquette M, Fukumura D, Jain RK

Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice.
J Immunother Cancer. 2023;11(3):ePub - PMID: 36898734 - PMCID: PMC10008211 - DOI: 10.1136/jitc-2022-005583

Plotkin SR, Allen J, Dhall G, Campian JL, Clapp DW, Fisher MJ, Jain RK, Tonsgard J, Ullrich NJ, Thomas C, Edwards LJ, Korf B, Packer R, Karajannis MA, Blakeley JO

Multicenter, prospective, phase 2 study of maintenance bevacizumab for children and adults with NF2-related schwannomatosis and progressive vestibular schwannoma.
Neuro Oncol. 2023;25(8):1498-1506 - PMID: 37010875 - PMCID: PMC10398799 - DOI: 10.1093/neuonc/noad066

Wang X, Shen Y, Shang M, Liu X, Munn LL

Endothelial mechanobiology in atherosclerosis.
Cardiovasc Res. 2023;119(8):1656-1675 - PMID: 37163659 - PMCID: PMC10325702 - DOI: 10.1093/cvr/cvad076

Zhang Q, Gerweck LE, Cascio E, Gu L, Yang Q, Dong X, Huang P, Bertolet A, Nesteruk KP, Sung W, McNamara AL, Schuemann J

Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine.
Cancers (Basel). 2023;15(8):ePub - PMID: 37190197 - PMCID: PMC10137009 - DOI: 10.3390/cancers15082269

Munn LL, Bazou D

A Self-Assembly Method for Creating Vascularized Tumor Explants Using Biomaterials for 3D Culture.
Methods Mol Biol. 2023;2645:211-220 - PMID: 37202621 - PMCID: PMC11110101 - DOI: 10.1007/978-1-0716-3056-3_12

Nikmaneshi MR, Jain RK, Munn LL

Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization.
PLoS Comput Biol. 2023;19(6):e1011131 - PMID: 37289729 - PMCID: PMC10249820 - DOI: 10.1371/journal.pcbi.1011131

Jana S, Li W, Lei PJ, Wang Z, Huang P, Jones D

"Isolation and characterization of a novel hormone receptor positive mammary adenocarcinoma MCa-P1362 with stromal drivers of tumor growth, metastasis, and drug resistance".
bioRxiv. 2023;:ePub - PMID: 37333242 - PMCID: PMC10274631 - DOI: 10.1101/2023.06.02.543434

Lei PJ, Pereira ER, Andersson P, Amoozgar Z, Van Wijnbergen JW, O'Melia MJ, Zhou H, Chatterjee S, Ho WW, Posada JM, Kumar AS, Morita S, Menzel L, Chung C, Ergin I, Jones D, Huang P, Beyaz S, Padera TP

Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes.
J Exp Med. 2023;220(9):ePub - PMID: 37341991 - PMCID: PMC10286805 - DOI: 10.1084/jem.20221847

Chamseddine S, Mohamed YI, Lee SS, Yao JC, Hu ZI, Tran Cao HS, Xiao L, Sun R, Morris JS, Hatia RI, Hassan M, Duda DG, Diab M, Mohamed A, Nassar A, Datar S, Amin HM, Kaseb AO

Clinical and Prognostic Biomarker Value of Blood Circulating Inflammatory Cytokines in Hepatocellular Carcinoma.
Oncology. 2023;101(11):730-737 - PMID: 37467732 - PMCID: PMC10614568 - DOI: 10.1159/000531870

Chivu-Economescu M, Herlea V, Dima S, Sorop A, Pechianu C, Procop A, Kitahara S, Necula L, Matei L, Dragu D, Neagu AI, Bleotu C, Diaconu CC, Popescu I, Duda DG

Soluble PD-L1 as a diagnostic and prognostic biomarker in resectable gastric cancer patients.
Gastric Cancer. 2023;26(6):934-946 - PMID: 37668884 - PMCID: PMC12316475 - DOI: 10.1007/s10120-023-01429-7

Kashiwagi R, Funayama R, Aoki S, Matsui A, Klein S, Sato Y, Suzuki T, Murakami K, Inoue K, Iseki M, Masuda K, Mizuma M, Naito H, Duda DG, Unno M, Nakayama K

Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment.
Cancer Sci. 2023;114(11):4286-4298 - PMID: 37688308 - PMCID: PMC10637054 - DOI: 10.1111/cas.15952

Franses JW, Duda DG

Scirrhous HCC: Another 'omic thread in the HCC tapestry.
Hepatology. 2023;79(4):747-748 - PMID: 37725712 - DOI: 10.1097/HEP.0000000000000609
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