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Martin JD, Mpekris F, Chauhan VP, Martin MR, Walsh ME, Stuber MD, McDonald DM, Yuan F, Stylianopoulos T, Jain RK

Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport.
Drug Deliv. 2024;31(1):2430528 - PMID: 39568143 - PMCID: PMC11583359 - DOI: 10.1080/10717544.2024.2430528

Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK

Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
medRxiv. 2024;:ePub - PMID: 39677483 - PMCID: PMC11643154 - DOI: 10.1101/2024.11.28.24318104

Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Razavi MS, Zhou H, Menzel L, Huang L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Kurpios NA, Ubellacker JM, Padera TP

Aging-induced changes in lymphatic muscle cell transcriptomes are associated with reduced pumping of peripheral collecting lymphatic vessels in mice.
Dev Cell. 2024;60(7):1118-1133.e5 - PMID: 39731913 - PMCID: PMC11981864 - DOI: 10.1016/j.devcel.2024.12.010

Tesfay MZ, Zhang Y, Ferdous KU, Taylor MA, Cios A, Shelton RS, Simoes CC, Watters CR, Barro O, Elliott NM, Mustafa B, Chamcheu JC, Graham AL, Washam CL, Alkam D, Gies A, Byrum SD, Giorgakis E, Post SR, Kelly T, Ying J, Moaven O, Chabu CY, Fernandez-Zapico ME, Duda DG, Roberts LR, Govindarajan R, Borad MJ, Cannon MJ, Basnakian AG, Nagalo BM

Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade.
Mol Ther Oncol. 2024;32(4):200913 - PMID: 39758249 - PMCID: PMC11697550 - DOI: 10.1016/j.omton.2024.200913

Lu S, Yin Z, Wu L, Sun Y, Chen J, Wu LMN, Oblinger JL, Blake DC, Landegger LD, Seist R, Ho W, Xiu B, Jones AP, Muzikansky A, Stankovic KM, Plotkin SR, Chang LS, Xu L

Enhanced Tumor Control and Hearing Loss Prevention Achieved with Combined Immune Checkpoint Inhibitor and Anti-VEGF Therapy in Vestibular Schwannoma Model.
bioRxiv. 2024;:ePub - PMID: 39763968 - PMCID: PMC11703165 - DOI: 10.1101/2024.12.29.630658

Nia HT, Munn LL, Jain RK

Probing the physical hallmarks of cancer.
Nat Methods. 2025;22(9):1800-1818 - PMID: 39815103 - DOI: 10.1038/s41592-024-02564-4

Ren J, Amoozgar Z, Uccello TP, Lei PJ, Zhao Y, Ho WW, Huang P, Kardian A, Mack SC, Duda DG, Xu L, Jain RK

Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma.
Proc Natl Acad Sci U S A. 2025;122(4):e2319474122 - PMID: 39841145 - PMCID: PMC11789170 - DOI: 10.1073/pnas.2319474122

Yan J, Jiang Z, Zhang S, Yu Q, Lu Y, Miao R, Tang Z, Fan J, Wu L, Duda DG, Zhou J, Yang X

Spatial-temporal heterogeneities of liver cancer and the discovery of the invasive zone.
Clin Transl Med. 2025;15(2):e70224 - PMID: 39924620 - PMCID: PMC11807767 - DOI: 10.1002/ctm2.70224

Harkos C, Hadjigeorgiou AG, Voutouri C, Kumar AS, Stylianopoulos T, Jain RK

Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer.
Nat Rev Cancer. 2025;25(5):324-340 - PMID: 39972158 - DOI: 10.1038/s41568-025-00796-w

Menzel L, Zschummel M, O'Melia MJ, Zhou H, Lei PJ, Liu L, Sen DR, Munn LL, Padera TP

Lymph nodes link sex-biased immune aging to compromised antigen recognition.
bioRxiv. 2025;:ePub - PMID: 39990447 - PMCID: PMC11844512 - DOI: 10.1101/2025.02.11.637693

Westcott GP, Emont MP, Gulko A, Zhou Z, Kim C, Varma G, Tsai LL, O'Donnell E, Loureiro ZY, Liang W, Jacobs C, Tsai LT, Padera TP, Singhal D, Rosen ED

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population.
bioRxiv. 2025;:ePub - PMID: 40027673 - PMCID: PMC11870541 - DOI: 10.1101/2025.02.18.638907

Roh K, Li H, Freeman RN, Zazzeron L, Lee A, Zhou C, Shen S, Xia P, Guerra JRB, Sheffield C, Padera TP, Zhou Y, Kim S, Aguirre A, Houstis N, Roh JD, Ichinose F, Malhotra R, Rosenzweig A, Rhee J

Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart.
Aging Cell. 2025;24(6):e70043 - PMID: 40083143 - PMCID: PMC12151892 - DOI: 10.1111/acel.70043

Liu X, Liu Z, Kobayashi T, Lei PJ, Shi Y, Yuan D, Wang J, Li M, Matsui A, Mafra K, Huang P, Kuang M, Bod L, Duda DG

Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma.
bioRxiv. 2025;:ePub - PMID: 40093175 - PMCID: PMC11908210 - DOI: 10.1101/2025.03.04.641494

Saeed A, Colby S, Oberstein PE, Duda DG, Park R, Agarwal R, Figueroa-Moseley C, Vaidya R, Unger JM, Guthrie KA, Rocha FG, Senthil M, Safyan RA, Wainberg ZA, Iqbal S, Chiorean EG, Philip PA

S2303: phase II/III trial of paclitaxel + ramucirumab +/- nivolumab in gastric and esophageal adenocarcinoma (PARAMUNE)
Future Oncol. 2025;21(11):1325-1331 - PMID: 40155326 - PMCID: PMC12051544 - DOI: 10.1080/14796694.2025.2485020

Gkika E, Firat E, Adebahr S, Graf E, Popp I, Eichhorst A, Radicioni G, Lo SS, Spohn SKB, Nestle U, Nicolay NH, Niedermann G, Grosu AL, Duda DG

A prospective study of immune responses in patients with lung metastases treated with stereotactic body radiotherapy with or without concurrent systemic treatment.
Radiother Oncol. 2025;207:110889 - PMID: 40209858 - DOI: 10.1016/j.radonc.2025.110889

Duda D, Liu X, Liu Z, Kobayashi T, Lei PJ, Shi Y, Yuan D, Wang J, Li M, Matsui A, Mafra K, Huang P, Kuang M, Bod L

Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma.
Res Sq. 2025;:ePub - PMID: 40321752 - PMCID: PMC12047993 - DOI: 10.21203/rs.3.rs-6355345/v1

Talele NP, Kumra H, Gomes-Santos IL, Ho WW, Andersson P, Siwicki M, Huang P, Duda DG, Pittet MJ, Fukumura D, Jain RK

IL-1β blockade prevents cardiotoxicity and improves the efficacy of immune checkpoint blockers and chemotherapy against pancreatic cancer in mice with obesity.
J Immunother Cancer. 2025;13(5):ePub - PMID: 40413022 - PMCID: PMC12104899 - DOI: 10.1136/jitc-2024-011404

Munn LL

The cellular dance that splits vessels.
Proc Natl Acad Sci U S A. 2025;122(22):e2508260122 - PMID: 40424133 - PMCID: PMC12146740 - DOI: 10.1073/pnas.2508260122

Nakhate V, Ly I, Muzikansky A, Rapalino O, Allen JC, Blakeley JO, Campian JL, Clapp DW, Dhall G, Jain RK, Karajannis MA, Packer RJ, Tonsgard J, Ullrich NJ, Korf BR, Fisher MJ, Plotkin SR, Neurofibromatosis Clinical Trials Consortium

Effect of bevacizumab on non-target intracranial meningiomas and non-vestibular schwannomas in NF2-related schwannomatosis: NF104.
J Neurooncol. 2025;173(3):751-757 - PMID: 40434540 - DOI: 10.1007/s11060-025-05020-1

Hadjigeorgiou AG, Harkos C, Mishra AK, Morad G, Johnson SB, Ajami NJ, Wargo JA, Munn LL, Stylianopoulos T, Jain RK

Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy.
Cancer Res. 2025;85(16):3139-3155 - PMID: 40439571 - PMCID: PMC12355177 - DOI: 10.1158/0008-5472.CAN-24-2232

Nia HT, Datta M, Kumar AS, Siri S, Ferraro GB, Chatterjee S, McHugh JM, Ng PR, West TR, Rapalino O, Choi BD, Nahed BV, Munn LL, Jain RK

Solid stress estimations via intraoperative 3D navigation in patients with brain tumors.
Clin Cancer Res. 2025;31(16):3571-3580 - PMID: 40495423 - PMCID: PMC12351280 - DOI: 10.1158/1078-0432.CCR-24-4159

Voutouri C, Munn LL, Stylianopoulos T, Jain RK

Biomarkers of mRNA vaccine efficacy derived from mechanistic modeling of tumor-immune interactions.
PLoS Comput Biol. 2025;21(6):e1013163 - PMID: 40504865 - PMCID: PMC12201673 - DOI: 10.1371/journal.pcbi.1013163

Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LH, Singh A, Fu J, Waterton SK, Cheng YC, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA

Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.
Immunity. 2025;58(7):1688-1705.e9 - PMID: 40592342 - PMCID: PMC12233199 - DOI: 10.1016/j.immuni.2025.06.005

Razavi MS, Ruscic KJ, Korn EG, Marquez M, Houle TT, Singhal D, Munn LL, Padera TP

A multiresolution approach with method-informed statistical analysis for quantifying lymphatic pumping dynamics.
Npj Imaging. 2025;3(1):2 - PMID: 40604254 - PMCID: PMC12091688 - DOI: 10.1038/s44303-024-00061-z

Hale AT, Kalailingam P, Kundishora AJ, Reeves BC, Brastianos PK, Shih HA, Jain RK, Ning M, Stapleton CJ, Patel AB, Smith ER, Chapman PH, Rabinov JD, Kleinstiver BP, Musolino PL, Kahle KT

An opportune time for targeted brain arteriovenous malformation therapy.
J Neurosurg. 2025;:1-4 - PMID: 40644723 - PMCID: PMC12477702 - DOI: 10.3171/2025.4.JNS25260

Mahfoud S, Padera TP

S1PR1, an endothelial-immune influencer.
J Exp Med. 2025;222(9):ePub - PMID: 40663043 - DOI: 10.1084/jem.20251056

Munn LL, Jain RK

Challenges and opportunities for the next generation of computational tumor models.
PLoS Biol. 2025;23(7):e3003269 - PMID: 40700394 - PMCID: PMC12286354 - DOI: 10.1371/journal.pbio.3003269

Lei PJ, Padera TP

Closing in on pacemaker cells.
Elife. 2025;14:ePub - PMID: 40693539 - PMCID: PMC12283070 - DOI: 10.7554/eLife.108102

Fanning JE, Tsai LL, Amore MA, Crescenzi R, De Paepe KN, Donohoe KJ, Maki JH, Padera TP, Pieper CC, Reynolds HM, Suami H, Singhal D

Bringing to Light the Invisible Lymphatic Anatomy of the Upper Extremity: Report From the 2024 Harvard Radcliffe Institute Accelerator Workshop.
Ann Surg. 2025;:ePub - PMID: 40767571 - DOI: 10.1097/SLA.0000000000006893

Duda DG, Javle M

A GOLP rush in biliary tract cancer: early promise in the quest for curative surgery.
Lancet Oncol. 2025;26(10):1265-1267 - PMID: 40889501 - DOI: 10.1016/S1470-2045(25)00427-9
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