Boucher Lab
Boucher Y, Posada JM, Subudhi S, Kumar AS, Rosario SR, Gu L, Kumra H, Mino-Kenudson M, Talele NP, Duda DG, Fukumura D, Wo JY, Clark JW, Ryan DP, Fernandez-Del Castillo C, Hong TS, Pittet MJ, Jain RK
Addition of losartan to FOLFIRINOX and chemoradiation reduces immunosuppression-associated genes, Tregs and FOXP3+ cancer cells in locally advanced pancreatic cancer.
Clin Cancer Res. 2023;29(8):1605-1619 - PMID: 36749873 - PMCID: PMC10106451 - DOI: 10.1158/1078-0432.CCR-22-1630
Boucher Y, Kumar AS, Posada JM, Gjini E, Pfaff K, Lipschitz M, Lako A, Duda DG, Rodig SJ, Hodi FS, Jain RK
Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients
NPJ Precis Oncol. 2021;5(1):62 - PMID: 34188163 - PMCID: PMC8242049 - DOI: 10.1038/s41698-021-00197-w
Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, Allen JN, Corcoran RB, Ting DT, Faris JE, Zhu AX, Goyal L, Berger DL, Qadan M, Lillemoe KD, Talele N, Jain RK, DeLaney TF, Duda DG, Boucher Y, Fernández-Del Castillo C, Hong TS
Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial.
JAMA Oncol. 2019;5(7):1020-1027 - PMID: 31145418 - PMCID: PMC6547247 - DOI: 10.1001/jamaoncol.2019.0892
Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK
Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy.
Proc Natl Acad Sci U S A. 2019;116(22):10674-10680 - PMID: 31040208 - PMCID: PMC6561160 - DOI: 10.1073/pnas.1819889116
Cleary JM, Horick NK, McCleary NJ, Abrams TA, Yurgelun MB, Azzoli CG, Rubinson DA, Brooks GA, Chan JA, Blaszkowsky LS, Clark JW, Goyal L, Meyerhardt JA, Ng K, Schrag D, Savarese DMF, Graham C, Fitzpatrick B, Gibb KA, Boucher Y, Duda DG, Jain RK, Fuchs CS, Enzinger PC
FOLFOX plus ziv-aflibercept or placebo in first-line metastatic esophagogastric adenocarcinoma: A double-blind, randomized, multicenter phase 2 trial.
Cancer. 2019;125(13):2213-2221 - PMID: 30913304 - PMCID: PMC6763367 - DOI: 10.1002/cncr.32029
David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram Shankaraiah, Z. Alexander Cao, Rakesh R. Ramjiawan, Divya Bezwada, Bhushankumar Patel, Yongchul Song, Carlotta Costa, Kamila Naxerova, Christina S. F. Wong, Jonas Kloepper, Rita Das, Angela Tam, Jantima Tanboon, Dan G. Duda, C. Ryan Miller, Marni B. Siegel, Carey K. Anders, Melinda Sanders, Monica V. Estrada, Robert Schlegel, Carlos L. Arteaga, Elena Brachtel, Alan Huang, Dai Fukumura, Jeffrey A. Engelman, Rakesh K. Jain
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Science Translational Medicine. 2017;9(391):eaal4682
Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK
Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27908927 - PMCID: PMC5131752 - DOI: 10.1101/cshperspect.a031195
Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR
Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma.
Transl Oncol. 2016;9(5):431-437 - PMID: 27751347 - PMCID: PMC5067928 - DOI: 10.1016/j.tranon.2016.07.004
Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.
Sci Transl Med. 2016;8(360):360ra135 - PMID: 27733559 - PMCID: PMC5457741 - DOI: 10.1126/scitranslmed.aaf5219
Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK
Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.
Cold Spring Harb Perspect Med. 2016;6(12):ePub - PMID: 27663981 - PMCID: PMC5131751 - DOI: 10.1101/cshperspect.a027094
Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, Winer EP, Krop IE, Jain RK
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.
Proc Natl Acad Sci U S A. 2015;112(46):14325-14330 - PMID: 26578779 - PMCID: PMC4655544 - DOI: 10.1073/pnas.1518808112
Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.
J Natl Cancer Inst. 2015;107(4):ePub - PMID: 25710962 - PMCID: PMC4402365 - DOI: 10.1093/jnci/djv017
Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK
Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure.
Cancer Cell. 2014;26(1):14-15 - PMID: 25026209 - PMCID: PMC4381566 - DOI: 10.1016/j.ccr.2014.06.003
Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA
Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Proc Natl Acad Sci U S A. 2014;111(30):E3091-100 - PMID: 25024225 - PMCID: PMC4121834 - DOI: 10.1073/pnas.1411679111
Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-Del Castillo C, Duda DG
A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma.
Int J Radiat Oncol Biol Phys. 2014;89(4):830-8 - PMID: 24867540 - PMCID: PMC4791180 - DOI: 10.1016/j.ijrobp.2014.03.034
Schwabl P, Payer BA, Grahovac J, Klein S, Horvatits T, Mitterhauser M, Stift J, Boucher Y, Trebicka J, Trauner M, Angermayr B, Fuhrmann V, Reiberger T, Peck-Radosavljevic M
Pioglitazone decreases portosystemic shunting by modulating inflammation and angiogenesis in cirrhotic and non-cirrhotic portal hypertensive rats.
J Hepatol. 2014;60(6):1135-42 - PMID: 24530596 - DOI: 10.1016/j.jhep.2014.01.025
Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels.
Nat Commun. 2013;4:2516 - PMID: 24084631 - PMCID: PMC3806395 - DOI: 10.1038/ncomms3516
Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK
Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Annu Rev Chem Biomol Eng. 2012;2:281-98 - PMID: 22432620 - DOI: 10.1146/annurev-chembioeng-061010-114300
Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L
TGF-? blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma.
Proc Natl Acad Sci U S A. 2012;109(41):16618-23 - PMID: 22996328 - PMCID: PMC3478596 - DOI: 10.1073/pnas.1117610109
Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors.
Proc Natl Acad Sci U S A. 2012;109(38):15101-8 - PMID: 22932871 - PMCID: PMC3458380 - DOI: 10.1073/pnas.1213353109
Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK
Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
PLoS One. 2012;7(2):e26331 - PMID: 22347360 - PMCID: PMC3274514 - DOI: 10.1371/journal.pone.0026331
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK
Normalization of the vasculature for treatment of cancer and other diseases.
Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010
Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK
Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proc Natl Acad Sci U S A. 2011;108(7):2909-14 - PMID: 21282607 - PMCID: PMC3041115 - DOI: 10.1073/pnas.1018892108
Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer Res. 2011;71(13):4527-38 - PMID: 21571860 - DOI: 10.1158/0008-5472.CAN-10-4376
Horowitz NS, Penson RT, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Cohen KS, Berlin S, Krasner CN, Moses MA, Jain RK
Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Clin Ovarian Cancer Other Gynecol Malig. 2011;4(1):26-33 - PMID: 21833345 - PMCID: PMC3151740 - DOI: 10.1016/j.cloc.2011.04.003
Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study.
J Clin Oncol. 2009;27(18):3020-6 - PMID: 19470921 - PMCID: PMC2702234 - DOI: 10.1200/JCO.2008.21.1771
Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK
Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.
Biophys J. 2009;97(1):330-6 - PMID: 19580771 - PMCID: PMC2711376 - DOI: 10.1016/j.bpj.2009.03.064
Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295
Mok W, Stylianopoulos T, Boucher Y, Jain RK
Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Clin Cancer Res. 2009;15(7):2352-60 - PMID: 19318482 - PMCID: PMC2872130 - DOI: 10.1158/1078-0432.CCR-08-2082
Willett CG, Duda DG, Xu L, diTomaso E, Boucher Y, Czito B, Ancukiewicz M, Clark J, Carroll M, Lauwers G, Jain RK
Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC).
J Clin Oncol. 2008;26(15_suppl):4096 - PMID: 27949464
Nagano S, Perentes JY, Jain RK, Boucher Y
Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193
Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE
Influence of tumor cell and stroma sensitivity on tumor response to radiation.
Cancer Res. 2007;67(9):4016-21 - PMID: 17483312 - DOI: 10.1158/0008-5472.CAN-06-4498
Mok W, Boucher Y, Jain RK
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107
Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK
Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer.
Nat Clin Pract Oncol. 2007;4(5):316-21 - PMID: 17464339 - PMCID: PMC2686127 - DOI: 10.1038/ncponc0813
Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB
Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma.
J Soc Integr Oncol. 2007;5(1):11-7 - PMID: 17309809 - DOI: 10.2310/7200.2006.033
Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y
Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors.
Cancer Res. 2007;67(11):5076-82 - PMID: 17545583 - DOI: 10.1158/0008-5472.CAN-06-3664
McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector.
Cancer Res. 2006;66(5):2509-13 - PMID: 16510565 - DOI: 10.1158/0008-5472.CAN-05-2242
Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK
Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice.
Semin Oncol. 2006;33(5 Suppl 10):S35-40 - PMID: 17145523 - PMCID: PMC2686124 - DOI: 10.1053/j.seminoncol.2006.08.007
Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
J Clin Oncol. 2005;23(9):1951-61 - PMID: 15774788 - DOI: 10.1200/JCO.2005.08.119
Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.
J Clin Oncol. 2005;23(31):8136-9 - PMID: 16258121 - DOI: 10.1200/JCO.2005.02.5635
Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line.
Cancer Res. 2005;65(13):5674-82 - PMID: 15994941 - DOI: 10.1158/0008-5472.CAN-04-1682
Garkavtsev I, Boucher Y
An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol.
Cancer Biol Ther. 2005;4(1):48-9 - PMID: 15711122 - DOI: 10.4161/cbt.4.1.1572
Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Nat Med. 2004;10(2):203-7 - PMID: 14716306 - DOI: 10.1038/nm981
Brown EB, Boucher Y, Nasser S, Jain RK
Measurement of macromolecular diffusion coefficients in human tumors.
Microvasc Res. 2004;67(3):231-6 - PMID: 15121448 - DOI: 10.1016/j.mvr.2004.02.001
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.
Nat Med. 2004;10(2):145-7 - PMID: 14745444 - PMCID: PMC2693485 - DOI: 10.1038/nm988
Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors.
Cancer Res. 2004;64(11):3731-6 - PMID: 15172975 - DOI: 10.1158/0008-5472.CAN-04-0074
Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.
Nat Med. 2003;9(6):796-800 - PMID: 12754503 - DOI: 10.1038/nm879
Roose T, Netti PA, Munn LL, Boucher Y, Jain RK
Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled.
Microvasc Res. 2003;66(3):204-12 - PMID: 14609526 - DOI: 10.1016/s0026-2862(03)00057-8
Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.
Clin Cancer Res. 2003;9(15):5508-13 - PMID: 14654530
Padera TP, Boucher Y, Jain RK
Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003.
Cancer Res. 2003;63(23):8555-6; author reply 8558 - PMID: 14679026
Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK
Solid stress facilitates spheroid formation: potential involvement of hyaluronan.
Br J Cancer. 2002;86(6):947-53 - PMID: 11953828 - PMCID: PMC2364140 - DOI: 10.1038/sj.bjc.6600158
Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK
Lymphatic metastasis in the absence of functional intratumor lymphatics.
Science. 2002;296(5574):1883-6 - PMID: 11976409 - DOI: 10.1126/science.1071420
Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Biophys J. 2002;83(3):1650-60 - PMID: 12202388 - PMCID: PMC1302261 - DOI: 10.1016/S0006-3495(02)73933-7
Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher Y
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1.
Microvasc Res. 2001;62(1):26-42 - PMID: 11421658 - DOI: 10.1006/mvre.2001.2311
Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
Cancer Res. 2001;61(1):39-44 - PMID: 11196192
Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.
Proc Natl Acad Sci U S A. 2001;98(8):4628-33 - PMID: 11274375 - PMCID: PMC31885 - DOI: 10.1073/pnas.081626898
Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK
LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.
Cancer Res. 2001;61(22):8079-84 - PMID: 11719431
Stohrer M, Boucher Y, Stangassinger M, Jain RK
Oncotic pressure in solid tumors is elevated.
Cancer Res. 2000;60(15):4251-5 - PMID: 10945638
Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer Res. 2000;60(19):5565-70 - PMID: 11034104
Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK
Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules.
Proc Natl Acad Sci U S A. 1999;96(6):3137-42 - PMID: 10077650 - PMCID: PMC15908 - DOI: 10.1073/pnas.96.6.3137
Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK
Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation.
J Biomech. 1999;32(12):1297-307 - PMID: 10569708 - DOI: 10.1016/s0021-9290(99)00125-6
Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK
Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.
Cancer Res. 1999;59(15):3776-82 - PMID: 10446995
Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK
Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1.
Nat Med. 1999;5(10):1203-8 - PMID: 10502827 - DOI: 10.1038/13524
Boucher Y, Brekken C, Netti PA, Baxter LT, Jain RK
Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents.
Br J Cancer. 1998;78(11):1442-8 - PMID: 9836476 - PMCID: PMC2063228 - DOI: 10.1038/bjc.1998.705
Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK
Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors
AIChE Journal. 1997;43:818-834
Griffon-Etienne G, Boucher Y, Jain RK, Suit HD
Effects of needle insertion in tumors on interstitial fluid pressure.
Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037
Boucher Y, Salehi H, Witwer B, Harsh GR, Jain RK
Interstitial fluid pressure in intracranial tumours in patients and in rodents.
Br J Cancer. 1997;75(6):829-36 - PMID: 9062403 - PMCID: PMC2063404 - DOI: 10.1038/bjc.1997.148
Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK
Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer Res. 1996;56(5):964-68 - PMID: 8640786
Kristensen CA, Nozue M, Boucher Y, Jain RK
Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
Br J Cancer. 1996;74(4):533-6 - PMID: 8761366 - PMCID: PMC2074665 - DOI: 10.1038/bjc.1996.397
Boucher Y, Leunig M, Jain RK
Tumor angiogenesis and interstitial hypertension.
Cancer Res. 1996;56(18):4264-6 - PMID: 8797602
Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK
Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Microvasc Res. 1996;52(1):27-46 - PMID: 8812751 - DOI: 10.1006/mvre.1996.0041
Boucher Y, Lee I, Jain RK
Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Microvasc Res. 1995;50(2):175-82 - PMID: 8538498 - DOI: 10.1006/mvre.1995.1051
Zlotecki RA, Baxter LT, Boucher Y, Jain RK
Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Microvasc Res. 1995;50(3):429-43 - PMID: 8583955 - DOI: 10.1006/mvre.1995.1069
Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK
Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer Res. 1995;55(22):5451-8 - PMID: 7585615
Lee I, Boucher Y, Demhartner TJ, Jain RK
Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline.
Br J Cancer. 1994;69(3):492-6 - PMID: 8123479 - PMCID: PMC1968875 - DOI: 10.1038/bjc.1994.89
Lee I, Demhartner TJ, Boucher Y, Jain RK, Intaglietta M
Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation.
Microvasc Res. 1994;48(1):1-12 - PMID: 7990716 - DOI: 10.1006/mvre.1994.1034
Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK
Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.
Cancer Res. 1994;54(17):4564-8 - PMID: 8062241
Zlotecki RA, Boucher Y, Lee I, Baxter LT, Jain RK
Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure.
Cancer Res. 1993;53(11):2466-8 - PMID: 8495405
Boucher Y, Pollin B, Azérad J
Microinfusions of excitatory amino acid antagonists into the trigeminal sensory complex antagonize the jaw opening reflex in freely moving rats.
Brain Res. 1993;614(1-2):155-63 - PMID: 8102311 - DOI: 10.1016/0006-8993(93)91029-r
Kristjansen PE, Boucher Y, Jain RK
Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.
Cancer Res. 1993;53(20):4764-6 - PMID: 8402656
Lee I, Boucher Y, Jain RK
Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Cancer Res. 1992;52(11):3237-40 - PMID: 1534273
Boucher Y, Jain RK
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.
Cancer Res. 1992;52(18):5110-4 - PMID: 1516068
Less JR, Posner MC, Boucher Y, Borochovitz D, Wolmark N, Jain RK
Interstitial hypertension in human breast and colorectal tumors.
Cancer Res. 1992;52(22):6371-4 - PMID: 1423283
Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, Jain RK
Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
Cancer Res. 1992;52(23):6553-60 - PMID: 1384965
Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK
Interstitial hypertension in superficial metastatic melanomas in humans.
Cancer Res. 1991;51(24):6691-4 - PMID: 1742743
Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK
Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.
Cancer Res. 1991;51(24):6695-8 - PMID: 1742744
Boucher Y, Baxter LT, Jain RK
Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer Res. 1990;50(15):4478-84 - PMID: 2369726
Boucher Y, Roberge S, Roy PE
Ultrastructural comparative study on lymphatic capillaries of the subendocardium, myocardium, and subepicardium of the heart left ventricle.
Microvasc Res. 1985;29(3):305-19 - PMID: 3999989 - DOI: 10.1016/0026-2862(85)90021-4
Roberge S, Boucher Y, Roy PE
Transient ultrastructural variations of pulmonary lymphatic capillaries during the respiratory cycle of the rat lung.
Anat Rec. 1985;213(4):551-9 - PMID: 4083535 - DOI: 10.1002/ar.1092130411
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