Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.

Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.

Vascular and interstitial barriers to delivery of therapeutic agents in tumors.

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.

Tumor physiology and antibody delivery.

Microcirculatory flow changes during tissue growth.

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.

Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.

Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation.

Measurement of capillary filtration coefficient in a solid tumor.

Therapeutic implications of tumor physiology.

Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.

Haemodynamic and transport barriers to the treatment of solid tumours.

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays.

Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma.

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.

In vivo evaluation of the early events associated with liver metastasis of circulating cancer cells

Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice.

The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft.

Spontaneous metastasis, proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenografts.

Spontaneous osteosarcoma in a severe combined immunodeficient (SCID/Sed) mouse.

Use of the comet assay for assessment of drug resistance and its modulation in vivo.

Inter- and intramouse heterogeneity of radiation response for a growing paired organ.

Endothelial cell-based therapy for hematopoiesis

Gene therapy for pancreatic cancer based on genetic characterization of the disease.

Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.

The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice.

Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12.

Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus.

The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice.

Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies.

Analysis of lymphocyte aggregation using digital image analysis.

Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes.

Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry.

Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis.

During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.

Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation.

Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions.

Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.

Effect of local anti-VEGF antibody treatment on tumor microvessel permeability.

Leaky vessels? Call Ang1!

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.

Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma.

Physiologically based pharmacokinetic modeling: principles and applications.