Reset

Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP

Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells.
Angiogenesis. 2014;17(2):419-27 - PMID: 24201897 - PMCID: PMC3981926 - DOI: 10.1007/s10456-013-9400-7

Willett CG, Duda DG, Czito BG, Bendell JC, Clark JW, Jain RK

Targeted therapy in rectal cancer.
Oncology (Williston Park). 2007;21(9):1055-65; discussion 1065, 1070, 1075 passim - PMID: 17910311 - PMCID: PMC2686129

Jain RK, Xu L

alphaPlGF: a new kid on the antiangiogenesis block.
Cell. 2007;131(3):443-5 - PMID: 17981110 - DOI: 10.1016/j.cell.2007.10.023

Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK

Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.
Blood. 2008;111(3):1302-5 - PMID: 17993613 - PMCID: PMC2214740 - DOI: 10.1182/blood-2007-06-094318

Mok W, Boucher Y, Jain RK

Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Cancer Res. 2007;67(22):10664-8 - PMID: 18006807 - DOI: 10.1158/0008-5472.CAN-07-3107

Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT

Antiangiogenic agents for the treatment of glioblastoma.
Expert Opin Investig Drugs. 2007;16(12):1895-908 - PMID: 18041999 - DOI: 10.1517/13543784.16.12.1895

Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK

Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.
Neoplasia. 2007;9(12):1038-45 - PMID: 18084611 - PMCID: PMC2137938 - DOI: 10.1593/neo.07643

Au P, Tam J, Fukumura D, Jain RK

Small blood vessel engineering.
Methods Mol Med. 2007;140:183-95 - PMID: 18085210 - DOI: 10.1007/978-1-59745-443-8_11

Munn LL, Dupin MM

Blood cell interactions and segregation in flow.
Ann Biomed Eng. 2008;36(4):534-44 - PMID: 18188702 - PMCID: PMC2752714 - DOI: 10.1007/s10439-007-9429-0

Jain RK

Taming vessels to treat cancer.
Sci Am. 2008;298(1):56-63 - PMID: 18225696 - DOI: 10.1038/scientificamerican0108-56

Au P, Tam J, Fukumura D, Jain RK

Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature.
Blood. 2008;111(9):4551-8 - PMID: 18256324 - PMCID: PMC2343592 - DOI: 10.1182/blood-2007-10-118273

Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D

Perivascular nitric oxide gradients normalize tumor vasculature.
Nat Med. 2008;14(3):255-7 - PMID: 18278052 - DOI: 10.1038/nm1730

Jones RC, Capen D, Petersen B, Jain RK, Duda DG

A protocol for a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):378-87 - PMID: 18323809 - PMCID: PMC2676330 - DOI: 10.1038/nprot.2007.536

Jones RC, Capen DE, Cohen KS, Munn LL, Jain RK, Duda DG

A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents.
Nat Protoc. 2008;3(3):388-97 - PMID: 18323810 - PMCID: PMC2676340 - DOI: 10.1038/nprot.2007.537

Jain RK

Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer.
Nat Rev Cancer. 2008;8(4):309-16 - PMID: 18337733 - DOI: 10.1038/nrc2346

Nagano S, Perentes JY, Jain RK, Boucher Y

Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors.
Cancer Res. 2008;68(10):3795-802 - PMID: 18483263 - PMCID: PMC2871708 - DOI: 10.1158/0008-5472.CAN-07-6193

Huang P, Duda DG, Jain RK, Fukumura D

Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice.
Comp Med. 2008;58(3):253-63 - PMID: 18589867 - PMCID: PMC2693079

Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib.
Mol Cancer Ther. 2008;7(8):2272-9 - PMID: 18687659 - PMCID: PMC2664998 - DOI: 10.1158/1535-7163.MCT-08-0182

Padera TP, Jain RK

VEGFR3: a new target for antiangiogenesis therapy?
Dev Cell. 2008;15(2):178-9 - PMID: 18694556 - PMCID: PMC4790102 - DOI: 10.1016/j.devcel.2008.07.014

Sorensen AG, Batchelor TT, Wen PY, Zhang WT, Jain RK

Response criteria for glioma.
Nat Clin Pract Oncol. 2008;5(11):634-44 - PMID: 18711427 - PMCID: PMC4795821 - DOI: 10.1038/ncponc1204

Fukumura D, Jain RK

Imaging angiogenesis and the microenvironment.
APMIS. 2008;116(7-8):695-715 - PMID: 18834413 - PMCID: PMC2859845 - DOI: 10.1111/j.1600-0463.2008.01148.x

Gerstner ER, Sorensen AG, Jain RK, Batchelor TT

Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas.
Curr Opin Neurol. 2008;21(6):728-35 - PMID: 18989120 - DOI: 10.1097/WCO.0b013e328318402a

Tam J, Fukumura D, Jain RK

A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight.
Cell Metab. 2009;9(1):52-63 - PMID: 19117546 - PMCID: PMC2643084 - DOI: 10.1016/j.cmet.2008.11.005

Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts.
Nat Methods. 2009;6(2):143-5 - PMID: 19151720 - PMCID: PMC2877598 - DOI: 10.1038/nmeth.1295

Mok W, Stylianopoulos T, Boucher Y, Jain RK

Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.
Clin Cancer Res. 2009;15(7):2352-60 - PMID: 19318482 - PMCID: PMC2872130 - DOI: 10.1158/1078-0432.CCR-08-2082

Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT

VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer.
Nat Rev Clin Oncol. 2009;6(4):229-36 - PMID: 19333229 - PMCID: PMC4793889 - DOI: 10.1038/nrclinonc.2009.14

Sun C, Munn LL

Lattice Boltzmann simulation of blood flow in digitized vessel networks.
Comput Math Appl. 2008;55(7):1594-1600 - PMID: 19343080 - PMCID: PMC2390865 - DOI: 10.1016/j.camwa.2007.08.019

Jones R, Capen DE, Jacobson M, Cohen KS, Scadden DT, Duda DG

VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).
J Cell Mol Med. 2009;13(9B):3720-9 - PMID: 19426150 - PMCID: PMC2832073 - DOI: 10.1111/j.1582-4934.2009.00785.x

Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
J Clin Oncol. 2009;27(18):3027-35 - PMID: 19470923 - PMCID: PMC2702235 - DOI: 10.1200/JCO.2008.20.9908

Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK

Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo.
Am J Pathol. 2009;175(1):294-302 - PMID: 19477947 - PMCID: PMC2708815 - DOI: 10.2353/ajpath.2009.080887

Chi AS, Sorensen AG, Jain RK, Batchelor TT

Angiogenesis as a therapeutic target in malignant gliomas.
Oncologist. 2009;14(6):621-36 - PMID: 19487335 - PMCID: PMC4790121 - DOI: 10.1634/theoncologist.2008-0272

Zhu AX, Duda DG, Sahani DV, Jain RK

Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies.
Cancer J. 2009;15(4):263-8 - PMID: 19672141 - PMCID: PMC4792519 - DOI: 10.1097/PPO.0b013e3181af5e35

Finn AV, Jain RK

Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization?
JACC Cardiovasc Imaging. 2010;3(1):41-4 - PMID: 20129529 - PMCID: PMC2842010 - DOI: 10.1016/j.jcmg.2009.11.001

Gerstner ER, Chen PJ, Wen PY, Jain RK, Batchelor TT, Sorensen G

Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib.
Neuro Oncol. 2010;12(5):466-72 - PMID: 20406897 - PMCID: PMC2940624 - DOI: 10.1093/neuonc/nop051

Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E

Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.
Cancer Res. 2010;70(9):3483-93 - PMID: 20406973 - PMCID: PMC4785015 - DOI: 10.1158/0008-5472.CAN-09-3107

Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK

Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
J Clin Oncol. 2010;28(17):2817-23 - PMID: 20458050 - PMCID: PMC2903316 - DOI: 10.1200/JCO.2009.26.3988

Jain RK

Transport of macromolecules in tumor microcirculation.
Biotechnol Prog. 1985;1(2):81-94 - PMID: 20568145 - DOI: 10.1002/btpr.5420010205

Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG

Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation.
Cancer Res. 2010;70(14):5679-85 - PMID: 20631066 - PMCID: PMC2918387 - DOI: 10.1158/0008-5472.CAN-09-4446

di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK

Glioblastoma recurrence after cediranib therapy in patients: lack of rebound revascularization as mode of escape.
Cancer Res. 2011;71(1):19-28 - PMID: 21199795 - PMCID: PMC3074948 - DOI: 10.1158/0008-5472.CAN-10-2602

Huang Y, Snuderl M, Jain RK

Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity.
Cancer Cell. 2011;19(1):1-2 - PMID: 21251607 - PMCID: PMC3037265 - DOI: 10.1016/j.ccr.2011.01.005

Jain A, Munn LL

Biomimetic postcapillary expansions for enhancing rare blood cell separation on a microfluidic chip.
Lab Chip. 2011;11(17):2941-7 - PMID: 21773633 - PMCID: PMC3743538 - DOI: 10.1039/c1lc20401g

Stylianopoulos T, Soteriou K, Fukumura D, Jain RK

Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model.
Ann Biomed Eng. 2013;41(1):68-77 - PMID: 22855118 - PMCID: PMC3886728 - DOI: 10.1007/s10439-012-0630-4

Dima SO, Tanase C, Albulescu R, Herlea V, Chivu-Economescu M, Purnichescu-Purtan R, Dumitrascu T, Duda DG, Popescu I

An Exploratory Study of Inflammatory Cytokines as Prognostic Biomarkers in Patients With Ductal Pancreatic Adenocarcinoma.
Pancreas. 2012;41(7):1001-7 - PMID: 22722257 - DOI: 10.1097/MPA.0b013e3182546e13

Meyerhardt JA, Ancukiewicz M, Abrams TA, Schrag D, Enzinger PC, Chan JA, Kulke MH, Wolpin BM, Goldstein M, Blaszkowsky L, Zhu AX, Elliott M, Regan E, Jain RK, Duda DG

Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer.
PLoS One. 2012;7(6):e38231 - PMID: 22701615 - PMCID: PMC3373492 - DOI: 10.1371/journal.pone.0038231

Jain RK, Carmeliet P

SnapShot: Tumor angiogenesis.
Cell. 2012;149(6):1408-1408.e1 - PMID: 22682256 - DOI: 10.1016/j.cell.2012.05.025

Song JW, Bazou D, Munn LL

Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis.
Integr Biol (Camb). 2012;4(8):857-62 - PMID: 22673771 - PMCID: PMC3759296 - DOI: 10.1039/c2ib20061a

Plotkin SR, Bredella MA, Cai W, Kassarjian A, Harris GJ, Esparza S, Merker VL, Munn LL, Muzikansky A, Askenazi M, Nguyen R, Wenzel R, Mautner VF

Quantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis.
PLoS One. 2012;7(4):e35711 - PMID: 22558206 - PMCID: PMC3338705 - DOI: 10.1371/journal.pone.0035711

Goel S, Wong AH, Jain RK

Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.
Cold Spring Harb Perspect Med. 2012;2(3):a006486 - PMID: 22393532 - PMCID: PMC3282493 - DOI: 10.1101/cshperspect.a006486

Faber AC, Corcoran RB, Ebi H, Sequist LV, Waltman BA, Chung E, Incio J, Digumarthy SR, Pollack SF, Song Y, Muzikansky A, Lifshits E, Roberge S, Coffman EJ, Benes CH, Gómez HL, Baselga J, Arteaga CL, Rivera MN, Dias-Santagata D, Jain RK, Engelman JA

BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Cancer Discov. 2011;1(4):352-65 - PMID: 22145099 - PMCID: PMC3229203 - DOI: 10.1158/2159-8290.CD-11-0106

Sorensen AG, Emblem KE, Polaskova P, Jennings D, Kim H, Ancukiewicz M, Wang M, Wen PY, Ivy P, Batchelor TT, Jain RK

Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.
Cancer Res. 2012;72(2):402-7 - PMID: 22127927 - PMCID: PMC3261301 - DOI: 10.1158/0008-5472.CAN-11-2464
1180