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Abdel-Wahab R, Hassan MM, George B, Carmagnani Pestana R, Xiao L, Lacin S, Yalcin S, Shalaby AS, Al-Shamsi HO, Raghav K, Wolff RA, Yao JC, Girard L, Haque A, Duda DG, Dima S, Popescu I, Elghazaly HA, Vauthey JN, Aloia TA, Tzeng CW, Chun YS, Rashid A, Morris JS, Amin HM, Kaseb AO

Impact of Integrating Insulin-Like Growth Factor 1 Levels into Model for End-Stage Liver Disease Score for Survival Prediction in Hepatocellular Carcinoma Patients.
Oncology. 2020;98(12):836-846 - PMID: 33027788 - PMCID: PMC7704605 - DOI: 10.1159/000502482

Subburaju S, Kaye S, Choi YK, Baruah J, Datta D, Ren J, Kumar AS, Szabo G, Fukumura D, Jain RK, Elkhal A, Vasudevan A

NAD+-mediated rescue of prenatal forebrain angiogenesis restores postnatal behavior.
Sci Adv. 2020;6(41):ePub - PMID: 33036972 - PMCID: PMC7546698 - DOI: 10.1126/sciadv.abb9766

Pinter M, Jain RK, Duda DG

The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review.
JAMA Oncol. 2021;7(1):113-123 - PMID: 33090190 - PMCID: PMC8265820 - DOI: 10.1001/jamaoncol.2020.3381

Nia HT, Munn LL, Jain RK

Physical traits of cancer.
Science. 2020;370(6516):ePub - PMID: 33122355 - PMCID: PMC8274378 - DOI: 10.1126/science.aaz0868

Rowlands CJ, Bruns OT, Franke D, Fukamura D, Jain RK, Bawendi MG, So PTC

Increasing the penetration depth of temporal focusing multiphoton microscopy for neurobiological applications.
J Phys D Appl Phys. 2019;52(26):264001 - PMID: 33191950 - PMCID: PMC7655118 - DOI: 10.1088/1361-6463/ab16b4

Nayak L, Molinaro AM, Peters KB, Clarke JL, Jordan JT, de Groot JF, Nghiemphu PL, Kaley TJ, Colman H, McCluskey C, Gaffey S, Smith T, Cote DJ, Severgnini M, Yearley JH, Zhao Q, Blumenschein WM, Duda DG, Muzikansky A, Jain RK, Wen PY, Reardon DA

Randomized phase II and biomarker study of pembrolizumab plus bevacizumab versus pembrolizumab alone for recurrent glioblastoma patients.
Clin Cancer Res. 2021;27(4):1048-1057 - PMID: 33199490 - PMCID: PMC8284901 - DOI: 10.1158/1078-0432.CCR-20-2500

Saif M, Kwanten WJ, Carr JA, Chen IX, Posada JM, Srivastava A, Zhang J, Zheng Y, Pinter M, Chatterjee S, Softic S, Kahn CR, van Leyen K, Bruns OT, Jain RK, Bawendi MG

Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Nat Biomed Eng. 2020;4(12):1222 - PMID: 33235308 - PMCID: PMC8328147 - DOI: 10.1038/s41551-020-00664-y

Shigeta K, Matsui A, Kikuchi H, Klein S, Mamessier E, Chen IX, Aoki S, Kitahara S, Inoue K, Shigeta A, Hato T, Ramjiawan RR, Staiculescu D, Zopf D, Fiebig L, Hobbs GS, Quaas A, Dima S, Popescu I, Huang P, Munn LL, Cobbold M, Goyal L, Zhu AX, Jain RK, Duda DG

Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
J Immunother Cancer. 2020;8(2):ePub - PMID: 33234602 - PMCID: PMC7689089 - DOI: 10.1136/jitc-2020-001435

Jin X, Demere Z, Nair K, Ali A, Ferraro GB, Natoli T, Deik A, Petronio L, Tang AA, Zhu C, Wang L, Rosenberg D, Mangena V, Roth J, Chung K, Jain RK, Clish CB, Vander Heiden MG, Golub TR

A metastasis map of human cancer cell lines.
Nature. 2020;588(7837):331-336 - PMID: 33299191 - PMCID: PMC8439149 - DOI: 10.1038/s41586-020-2969-2

Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK

In silico dynamics of COVID-19 phenotypes for optimizing clinical management.
Proc Natl Acad Sci U S A. 2021;118(3):ePub - PMID: 33402434 - PMCID: PMC7826337 - DOI: 10.1073/pnas.2021642118

Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, Shigeta K, Kikuchi H, Ramjiawan RR, Schmidt TC, Iwasaki M, Yau T, Hong TS, Quaas A, Plum PS, Dima S, Popescu I, Bardeesy N, Munn LL, Borad MJ, Sassi S, Jain RK, Zhu AX, Duda DG

Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma.
Gut. 2021;71(1):185-193 - PMID: 33431577 - PMCID: PMC8666816 - DOI: 10.1136/gutjnl-2020-322493

Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT

Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients.
Neurooncol Adv. 2020;2(1):vdaa157 - PMID: 33392506 - PMCID: PMC7764510 - DOI: 10.1093/noajnl/vdaa157

Krishnan S, Amoozgar Z, Fukumura D, Jain RK

Implications of a granulocyte-high glioblastoma microenvironment in immune suppression and therapy resistance†.
J Pathol. 2021;254(2):105-108 - PMID: 33534142 - PMCID: PMC8262382 - DOI: 10.1002/path.5637

Li W, Li S, Chen IX, Liu Y, Ramjiawan RR, Leung CH, Gerweck LE, Fukumura D, Loeffler JS, Jain RK, Duda DG, Huang P

Combining losartan with radiotherapy increases tumor control and inhibits lung metastases from a HER2/neu-positive orthotopic breast cancer model.
Radiat Oncol. 2021;16(1):48 - PMID: 33663521 - PMCID: PMC7934382 - DOI: 10.1186/s13014-021-01775-9

Munn LL, Stylianopoulos T, Jain NK, Hardin CC, Khandekar MJ, Jain RK

Vascular normalization to improve treatment of COVID-19: Lessons from treatment of cancer.
Clin Cancer Res. 2021;27(10):2706-2711 - PMID: 33648989 - PMCID: PMC8127351 - DOI: 10.1158/1078-0432.CCR-20-4750

Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M

NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Nature. 2021;592(7854):450-456 - PMID: 33762733 - PMCID: PMC8046670 - DOI: 10.1038/s41586-021-03362-0

Ajdari A, Xie Y, Richter C, Niyazi M, Duda DG, Hong TS, Bortfeld T

Toward Personalized Radiation Therapy of Liver Metastasis: Importance of Serial Blood Biomarkers.
JCO Clin Cancer Inform. 2021;5:315-325 - PMID: 33764817 - PMCID: PMC8462658 - DOI: 10.1200/CCI.20.00118

Zhou H, Lei PJ, Padera TP

Progression of Metastasis through Lymphatic System.
Cells. 2021;10(3):ePub - PMID: 33808959 - PMCID: PMC7999434 - DOI: 10.3390/cells10030627

Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, Chen IX, Naxerova K, Ng C, Westermark AM, Duquette M, Roberge S, Lindeman NI, Lyssiotis CA, Nielsen J, Housman DE, Duda DG, Brachtel E, Golub TR, Cantley LC, Asara JM, Davidson SM, Fukumura D, Dartois VA, Clish CB, Jain, RK, Vander Heiden MG

Fatty acid synthesis is required for breast cancer brain metastasis
Nature Cancer. 2021;:ePub

Gomes-Santos IL, Amoozgar Z, Kumar AS, Ho WW, Roh K, Talele NP, Curtis H, Kawaguchi K, Jain RK, Fukumura D

Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade.
Cancer Immunol Res. 2021;9(7):765-778 - PMID: 33839688 - PMCID: PMC8295193 - DOI: 10.1158/2326-6066.CIR-20-0499

Hauth F, Ho AY, Ferrone S, Duda DG

Radiotherapy to Enhance Chimeric Antigen Receptor T-Cell Therapeutic Efficacy in Solid Tumors: A Narrative Review.
JAMA Oncol. 2021;7(7):1051-1059 - PMID: 33885725 - PMCID: PMC8668197 - DOI: 10.1001/jamaoncol.2021.0168

Mohamed YI, Lee S, Xiao L, Hassan MM, Qayyum A, Hiatia R, Pestana RC, Haque A, George B, Rashid A, Duda DG, Elghazaly H, Wolff RA, Morris JS, Yao J, Amin HM, Kaseb AO

Insulin-like growth factor 1/Child-Turcotte-Pugh composite score as a predictor of treatment outcomes in patients with advanced hepatocellular carcinoma treated with sorafenib.
Oncotarget. 2021;12(8):756-766 - PMID: 33889299 - PMCID: PMC8057275 - DOI: 10.18632/oncotarget.27924

Nathanson SD, Detmar M, Padera TP, Yates LR, Welch DR, Beadnell TC, Scheid AD, Wrenn ED, Cheung K

Mechanisms of breast cancer metastasis.
Clin Exp Metastasis. 2021;39(1):117-137 - PMID: 33950409 - PMCID: PMC8568733 - DOI: 10.1007/s10585-021-10090-2

Amoozgar Z, Kloepper J, Ren J, Tay RE, Kazer SW, Kiner E, Krishnan S, Posada JM, Ghosh M, Mamessier E, Wong C, Ferraro GB, Batista A, Wang N, Badeaux M, Roberge S, Xu L, Huang P, Shalek AK, Fukumura D, Kim HJ, Jain RK

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Nat Commun. 2021;12(1):2582 - PMID: 33976133 - PMCID: PMC8113440 - DOI: 10.1038/s41467-021-22885-8

Jain RK, Skelton Iv WP, Pond GR, Naqvi M, Kim Y, Curran C, Freeman D, Nuzzo PV, Alaiwi SA, Nassar AH, Jain RK, Sonpavde G

Angiotensin Blockade Modulates the Activity of PD1/L1 Inhibitors in Metastatic Urothelial Carcinoma.
Clin Genitourin Cancer. 2021;19(6):540-546 - PMID: 34011489 - PMCID: PMC8526625 - DOI: 10.1016/j.clgc.2021.04.002

Subudhi S, Verma A, Patel AB, Hardin CC, Khandekar MJ, Lee H, McEvoy D, Stylianopoulos T, Munn LL, Dutta S, Jain RK

Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19.
NPJ Digit Med. 2021;4(1):87 - PMID: 34021235 - PMCID: PMC8140139 - DOI: 10.1038/s41746-021-00456-x

Ng MR, Jain RK

Hypoxia-induced DNA hypermethylation: another reason to normalize tumor vessels
Translational Cancer Research. 2016;5:7

Boucher Y, Kumar AS, Posada JM, Gjini E, Pfaff K, Lipschitz M, Lako A, Duda DG, Rodig SJ, Hodi FS, Jain RK

Bevacizumab improves tumor infiltration of mature dendritic cells and effector T-cells in triple-negative breast cancer patients
NPJ Precis Oncol. 2021;5(1):62 - PMID: 34188163 - PMCID: PMC8242049 - DOI: 10.1038/s41698-021-00197-w

Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.
Sci Immunol. 2021;6(61):ePub - PMID: 34215680 - PMCID: PMC8845079 - DOI: 10.1126/sciimmunol.abi7083

Wu L, Vasilijic S, Sun Y, Chen J, Landegger LD, Zhang Y, Zhou W, Ren J, Early S, Yin Z, Ho WW, Zhang N, Gao X, Lee GY, Datta M, Sagers JE, Brown A, Muzikansky A, Stemmer-Rachamimov A, Zhang L, Plotkin SR, Jain RK, Stankovic KM, Xu L

Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models.
Sci Transl Med. 2021;13(602):ePub - PMID: 34261799 - PMCID: PMC8409338 - DOI: 10.1126/scitranslmed.abd4816

Jain RK

1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Ann Biomed Eng. 1996;24(4):457-73 - PMID: 8841721 - DOI: 10.1007/BF02648108

Dellian M, Helmlinger G, Yuan F, Jain RK

Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients.
Br J Cancer. 1996;74(8):1206-15 - PMID: 8883406 - PMCID: PMC2075944 - DOI: 10.1038/bjc.1996.518

Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS

Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems.
Biophys J. 1996;71(5):2656-68 - PMID: 8913603 - PMCID: PMC1233752 - DOI: 10.1016/S0006-3495(96)79457-2

Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody.
Proc Natl Acad Sci U S A. 1996;93(25):14765-70 - PMID: 8962129 - PMCID: PMC26210 - DOI: 10.1073/pnas.93.25.14765

Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK

Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model.
Microvasc Res. 1996;51(3):327-46 - PMID: 8992232 - DOI: 10.1006/mvre.1996.0031

Helmlinger G, Yuan F, Dellian M, Jain RK

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation.
Nat Med. 1997;3(2):177-82 - PMID: 9018236 - DOI: 10.1038/nm0297-177

Berk DA, Yuan F, Leunig M, Jain RK

Direct in vivo measurement of targeted binding in a human tumor xenograft.
Proc Natl Acad Sci U S A. 1997;94(5):1785-90 - PMID: 9050856 - PMCID: PMC19994 - DOI: 10.1073/pnas.94.5.1785

Briscoe DM, Ganz P, Alexander SI, Melder RJ, Jain RK, Cotran RS, Lichtman AH

The problem of chronic rejection: influence of leukocyte-endothelial interactions.
Kidney Int Suppl. 1997;58:S22-7 - PMID: 9067938

Lichtenbeld HC, Yuan F, Michel CC, Jain RK

Perfusion of single tumor microvessels: application to vascular permeability measurement.
Microcirculation. 1996;3(4):349-57 - PMID: 9086446 - DOI: 10.3109/10739689609148307

Jain RK

The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors.
Microcirculation. 1997;4(1):1-23 - PMID: 9110280 - DOI: 10.3109/10739689709148314

Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK

Geometric resistance and microvascular network architecture of human colorectal carcinoma.
Microcirculation. 1997;4(1):25-33 - PMID: 9110281 - DOI: 10.3109/10739689709148315

Baish JW, Netti PA, Jain RK

Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors.
Microvasc Res. 1997;53(2):128-41 - PMID: 9143544 - DOI: 10.1006/mvre.1996.2005

Leunig M, Yuan F, Gerweck LE, Jain RK

Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice.
Int J Microcirc Clin Exp. 1997;17(1):1-9 - PMID: 9176719 - DOI: 10.1159/000179199

Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK

Solid stress inhibits the growth of multicellular tumor spheroids.
Nat Biotechnol. 1997;15(8):778-83 - PMID: 9255794 - DOI: 10.1038/nbt0897-778

Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CG, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, Suit HD

Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.
J Surg Oncol. 1997;66(1):30-8 - PMID: 9290690 - DOI: 10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o

Griffon-Etienne G, Boucher Y, Jain RK, Suit HD

Effects of needle insertion in tumors on interstitial fluid pressure.
Microvasc Res. 1997;54(2):174-7 - PMID: 9327388 - DOI: 10.1006/mvre.1997.2037

Jain RK, Schlenger K, Höckel M, Yuan F

Quantitative angiogenesis assays: progress and problems.
Nat Med. 1997;3(11):1203-8 - PMID: 9359693 - DOI: 10.1038/nm1197-1203

Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK

Fractal characteristics of tumor vascular architecture during tumor growth and regression.
Microcirculation. 1997;4(4):395-402 - PMID: 9431507 - DOI: 10.3109/10739689709146803

Zhu H, Jain RK, Baxter LT

Tumor pretargeting for radioimmunodetection and radioimmunotherapy.
J Nucl Med. 1998;39(1):65-76 - PMID: 9443740

Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK

Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
Proc Natl Acad Sci U S A. 1998;95(8):4607-12 - PMID: 9539785 - PMCID: PMC22537 - DOI: 10.1073/pnas.95.8.4607
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