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Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice.
Lab Invest. 1994;71(2):300-7 - PMID: 7521447

Jain RK

Determinants of tumor blood flow: a review.
Cancer Res. 1988;48(10):2641-58 - PMID: 3282647

Chary SR, Jain RK

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.
Proc Natl Acad Sci U S A. 1989;86(14):5385-9 - PMID: 2748592 - PMCID: PMC297627 - DOI: 10.1073/pnas.86.14.5385

Sevick EM, Jain RK

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.
Cancer Res. 1989;49(13):3506-12 - PMID: 2731172

Jain RK

Delivery of novel therapeutic agents in tumors: physiological barriers and strategies.
J Natl Cancer Inst. 1989;81(8):570-6 - PMID: 2649688 - DOI: 10.1093/jnci/81.8.570

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Microvasc Res. 1989;37(1):77-104 - PMID: 2646512 - DOI: 10.1016/0026-2862(89)90074-5

Baxter LT, Jain RK, Svensjö E

Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs.
Microvasc Res. 1987;34(3):336-48 - PMID: 2448593 - DOI: 10.1016/0026-2862(87)90066-5

Jain RK

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.
Cancer Res. 1990;50(3 Suppl):814s-819s - PMID: 2404582

Clauss MA, Jain RK

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.
Cancer Res. 1990;50(12):3487-92 - PMID: 2340499

Jain RK

Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
Cancer Metastasis Rev. 1990;9(3):253-66 - PMID: 2292138 - DOI: 10.1007/BF00046364

Kaufman EN, Jain RK

Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications.
Biophys J. 1990;58(4):873-85 - PMID: 2248992 - PMCID: PMC1281033 - DOI: 10.1016/S0006-3495(90)82432-2

Jain RK

Tumor physiology and antibody delivery.
Front Radiat Ther Oncol. 1990;24:32-46; discussion 64-8 - PMID: 2187763

Martin GR, Jain RK

Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues.
Microvasc Res. 1993;46(2):216-30 - PMID: 8246820 - DOI: 10.1006/mvre.1993.1048

Leunig M, Yuan F, Berk DA, Gerweck LE, Jain RK

Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice.
Acta Orthop Scand. 1996;67(4):383-8 - PMID: 8792744 - DOI: 10.3109/17453679609002336

Zhu H, Melder RJ, Baxter LT, Jain RK

Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy.
Cancer Res. 1996;56(16):3771-81 - PMID: 8706023

Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.
Am J Pathol. 1996;149(1):59-71 - PMID: 8686763 - PMCID: PMC1865247

Nozue M, Lee I, Manning JM, Manning LR, Jain RK

Oxygenation in tumors by modified hemoglobins.
J Surg Oncol. 1996;62(2):109-14 - PMID: 8649036 - DOI: 10.1002/(SICI)1096-9098(199606)62:2<109::AID-JSO6>3.0.CO;2-C

Jain RK

Delivery of molecular medicine to solid tumors.
Science. 1996;271(5252):1079-80 - PMID: 8599082 - DOI: 10.1126/science.271.5252.1079

Leunig M, Yuan F, Gerweck LE, Berk DA, Jain RK

Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach.
Res Exp Med (Berl). 1996;195(5):275-88 - PMID: 8578003 - DOI: 10.1007/BF02576798

Eskey CJ, Koretsky AP, Domach MM, Jain RK

Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR.
Proc Natl Acad Sci U S A. 1993;90(7):2646-50 - PMID: 8464871 - PMCID: PMC46152 - DOI: 10.1073/pnas.90.7.2646

Yuan F, Leunig M, Berk DA, Jain RK

Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice.
Microvasc Res. 1993;45(3):269-89 - PMID: 8321142 - DOI: 10.1006/mvre.1993.1024

Berk DA, Yuan F, Leunig M, Jain RK

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media.
Biophys J. 1993;65(6):2428-36 - PMID: 8312481 - PMCID: PMC1225983 - DOI: 10.1016/S0006-3495(93)81326-2

Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK

Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster.
Br J Cancer. 1994;69(1):101-3 - PMID: 8286189 - PMCID: PMC1968758 - DOI: 10.1038/bjc.1994.15

Melder RJ, Brownell AL, Shoup TM, Brownell GL, Jain RK

Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors.
Cancer Res. 1993;53(24):5867-71 - PMID: 8261395

Ward KA, DiPette DJ, Held TN, Jain RK

Effect of intravenous versus intraperitoneal glucose injection on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.
Cancer Res. 1991;51(13):3612-6 - PMID: 2054796

Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK

Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement.
J Natl Cancer Inst. 1994;86(4):293-9 - PMID: 8158684 - DOI: 10.1093/jnci/86.4.293

Baxter LT, Zhu H, Mackensen DG, Jain RK

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Cancer Res. 1994;54(6):1517-28 - PMID: 8137258

Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK

Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice.
Proc Natl Acad Sci U S A. 1994;91(6):2081-5 - PMID: 8134352 - PMCID: PMC43313 - DOI: 10.1073/pnas.91.6.2081

Jain RK

Barriers to drug delivery in solid tumors.
Sci Am. 1994;271(1):58-65 - PMID: 8066425 - DOI: 10.1038/scientificamerican0794-58

Yuan F, Leunig M, Huang SK, Berk DA, Papahadjopoulos D, Jain RK

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.
Cancer Res. 1994;54(13):3352-6 - PMID: 8012948

Hamberg LM, Kristjansen PE, Hunter GJ, Wolf GL, Jain RK

Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution.
Cancer Res. 1994;54(23):6032-6 - PMID: 7954440

Leu AJ, Berk DA, Yuan F, Jain RK

Flow velocity in the superficial lymphatic network of the mouse tail.
Am J Physiol. 1994;267(4 Pt 2):H1507-13 - PMID: 7943396 - DOI: 10.1152/ajpheart.1994.267.4.H1507

Melder RJ, Elmaleh D, Brownell AL, Brownell GL, Jain RK

A method for labeling cells for positron emission tomography (PET) studies.
J Immunol Methods. 1994;175(1):79-87 - PMID: 7930641 - DOI: 10.1016/0022-1759(94)90333-6

Melder RJ, Jain RK

Reduction of rigidity in human activated natural killer cells by thioglycollate treatment.
J Immunol Methods. 1994;175(1):69-77 - PMID: 7930640 - DOI: 10.1016/0022-1759(94)90332-8

Martin GR, Jain RK

Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.
Cancer Res. 1994;54(21):5670-4 - PMID: 7923215

Kristjansen PE, Roberge S, Lee I, Jain RK

Tissue-isolated human tumor xenografts in athymic nude mice.
Microvasc Res. 1994;48(3):389-402 - PMID: 7731400 - DOI: 10.1006/mvre.1994.1063

Xie K, Bielenberg D, Huang S, Xu L, Salas T, Juang SH, Dong Z, Fidler IJ

Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.
Clin Cancer Res. 1997;3(12 Pt 1):2283-94 - PMID: 9815626

Xu L, Czito BG, Willett CG

Epigenetic markers in rectal cancer.
Clin Cancer Res. 2010;16(10):2699-701 - PMID: 20460492 - DOI: 10.1158/1078-0432.CCR-10-0559

Fidler IJ, Yoneda J, Herrera C, Wood J, Xu L

Specific Keynote: Molecular determinants of angiogenesis in ovarian cancer
Gynecologic Oncology. 2003;88:S290S36

Fidler IJ, Bielenberg DR, Slaton J, Xu L, Dinney CPN, Dong Z

Interferon-mediated antiangiogenic therapy
Journal of National Cancer Institute. 2000;1092:4-12

Fidler IJ, Singh RK, Yoneda J, Kumar R, Xu L, Dong Z, Bielenberg DR, McCarty M, Ellis LM

Critical determinants of neoplastic angiogenesis
The Cancer Journal. 2000;6 Suppl 3:S225-36 - PMID: 10874492

Xu L, Fidler IJ

Interleukin 8: an autocrine growth factor for human ovarian cancer.
Oncol Res. 2000;12(2):97-106 - PMID: 11132928 - DOI: 10.3727/096504001108747567

Xu L, Yoneda J, Herrera C, Wood J, Killion JJ, Fidler IJ

Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
Int J Oncol. 2000;16(3):445-54 - PMID: 10675474 - DOI: 10.3892/ijo.16.3.445

Xu L, Fidler IJ

Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells.
Cancer Res. 2000;60(16):4610-6 - PMID: 10969814

Xu L, Xie K, Mukaida N, Matsushima K, Fidler IJ

Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
Cancer Res. 1999;59(22):5822-9 - PMID: 10582705

Xu L, Xie K, Fidler IJ

Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase.
Hum Gene Ther. 1998;9(18):2699-708 - PMID: 9874268 - DOI: 10.1089/hum.1998.9.18-2699

Juang SH, Xie K, Xu L, Shi Q, Wang Y, Yoneda J, Fidler IJ

Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene.
Hum Gene Ther. 1998;9(6):845-54 - PMID: 9581907 - DOI: 10.1089/hum.1998.9.6-845

Juang SH, Xie K, Xu L, Wang Y, Yoneda J, Fidler IJ

Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma.
Cancer Biother Radiopharm. 1997;12(3):167-75 - PMID: 10851463 - DOI: 10.1089/cbr.1997.12.167

Herrera CA, Xu L, Bucana CD, Silva el VG, Hess KR, Gershenson DM, Fidler IJ

Expression of metastasis-related genes in human epithelial ovarian tumors.
Int J Oncol. 2002;20(1):5-13 - PMID: 11743636

Xie K, Wang Y, Huang S, Xu L, Bielenberg D, Salas T, McConkey DJ, Jiang W, Fidler IJ

Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene. 1997;15(7):771-9 - PMID: 9266963 - DOI: 10.1038/sj.onc.1201239
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