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Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK

Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity.
Microvasc Res. 1996;52(1):27-46 - PMID: 8812751 - DOI: 10.1006/mvre.1996.0041

Kristensen CA, Nozue M, Boucher Y, Jain RK

Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts.
Br J Cancer. 1996;74(4):533-6 - PMID: 8761366 - PMCID: PMC2074665 - DOI: 10.1038/bjc.1996.397

Miura S, Fukumura D, Kurose I, Higuchi H, Kimura H, Tsuzuki Y, Shigematsu T, Han JY, Tsuchiya M, Ishii H

Roles of ET-1 in endotoxin-induced microcirculatory disturbance in rat small intestine.
Am J Physiol. 1996;271(3 Pt 1):G461-9 - PMID: 8843771 - DOI: 10.1152/ajpgi.1996.271.3.G461

Boucher Y, Leunig M, Jain RK

Tumor angiogenesis and interstitial hypertension.
Cancer Res. 1996;56(18):4264-6 - PMID: 8797602

Kurose I, Higuchi H, Yonei Y, Ebinuma H, Watanabe N, Hokari R, Fukumura D, Miura S, Takaishi M, Saito H, Nakatsumi RC, Ishii H

Rat Kupffer cell-derived nitric oxide suppresses proliferation and induces apoptosis of syngeneic hepatoma cells.
Gastroenterology. 1996;111(4):1058-70 - PMID: 8831602 - DOI: 10.1016/s0016-5085(96)70075-6

Kurose I, Miura S, Higuchi H, Watanabe N, Kamegaya Y, Takaishi M, Tomita K, Fukumura D, Kato S, Ishii H

Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles for tumor necrosis factor alpha.
Hepatology. 1996;24(5):1185-92 - PMID: 8903396 - DOI: 10.1002/hep.510240534

Garkavtsev I, Kazarov A, Gudkov A, Riabowol K

Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation.
Nat Genet. 1996;14(4):415-20 - PMID: 8944021 - DOI: 10.1038/ng1296-415

Fukumura D, Miura S, Kurose I, Higuchi H, Suzuki H, Ebinuma H, Han JY, Watanabe N, Wakabayashi G, Kitajima M, Ishii H

IL-1 is an important mediator for microcirculatory changes in endotoxin-induced intestinal mucosal damage.
Dig Dis Sci. 1996;41(12):2482-92 - PMID: 9011462 - DOI: 10.1007/BF02100147

Fukumura D, Yonei Y, Kurose I, Saito H, Ohishi T, Higuchi H, Miura S, Kato S, Kimura H, Ebinuma H, Ishi H

Role in nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicity in vitro and ex vivo.
Hepatology. 1996;24(1):141-9 - PMID: 8707254 - DOI: 10.1053/jhep.1996.v24.pm0008707254

Garkavtsev I, Demetrick D, Riabowol K

Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1).
Cytogenet Cell Genet. 1997;76(3-4):176-8 - PMID: 9186514 - DOI: 10.1159/000134539

Fukumura D, Yuan F, Endo M, Jain RK

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.
Am J Pathol. 1997;150(2):713-25 - PMID: 9033284 - PMCID: PMC1858293

Tanaka S, Miura S, Kimura H, Ohkubo N, Tsuzuki Y, Fukumura D, Serizawa H, Kurose I, Mori M, Ishii H

Amelioration of chronic inflammation by ingestion of elemental diet in a rat model of granulomatous enteritis.
Dig Dis Sci. 1997;42(2):408-19 - PMID: 9052527 - DOI: 10.1023/a:1018890624384

Helbing CC, Veillette C, Riabowol K, Johnston RN, Garkavtsev I

A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.
Cancer Res. 1997;57(7):1255-8 - PMID: 9102209

Garkavtsev I, Riabowol K

Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor.
Mol Cell Biol. 1997;17(4):2014-9 - PMID: 9121449 - PMCID: PMC232048 - DOI: 10.1128/mcb.17.4.2014

Higuchi H, Kurose I, Fukumura D, Yan HJ, Saito H, Miura S, Hokari R, Watanabe N, Zeki S, Yoshida M, Kitajima M, Granger DN, Ishii H

Active oxidants mediate IFN-alpha-induced microvascular alterations in rat mesentery.
J Immunol. 1997;158(10):4893-900 - PMID: 9144506

Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
Science. 1997;276(5317):1423-5 - PMID: 9162011 - DOI: 10.1126/science.276.5317.1423

Garkavtsev I, Mizukami T

Integrated map of the Schizosaccharomyces pombe genome.
Chromosoma. 1997;106(4):254-65 - PMID: 9254727 - DOI: 10.1007/s004120050246

Miura S, Fukumura D, Shiozaki H, Suzuki M, Kurose I, Suematsu M, Tsuchiya M, Ishii H

Bile acid-induced depolarization of mitochondrial membrane potential preceding cell injury in cultured gastric mucosal cells.
J Gastroenterol Hepatol. 1996;10(6):621-6 - PMID: 8580403 - DOI: 10.1111/j.1440-1746.1995.tb01360.x

Suzuki M, Miura S, Mori M, Kai A, Suzuki H, Fukumura D, Suematsu M, Tsuchiya M

Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants.
Gut. 1994;35(10):1375-8 - PMID: 7959190 - PMCID: PMC1375008 - DOI: 10.1136/gut.35.10.1375

Miura S, Fukumura D, Kurose I, Kimura H, Suzuki M, Morishita T, Nagata H, Tsuchiya M, Ishii H

Spatial heterogeneity of mucosal blood flow during ischemia-reperfusion injury of rat stomach investigated by laser Doppler perfusion imaging.
J Gastroenterol. 1995;30(3):279-86 - PMID: 7647892 - DOI: 10.1007/BF02347500

Yoshida M, Fukumura D, Wakabayashi G, Otani Y, Oshima A, Shimazu M, Kubota T, Kumai K, Kurose I, Miura S

Gastric microcirculatory disturbance and behaviour of leucocytes after thermal injury: intravital observation of arteriovenous shunting channels in the gastric submucosal layer.
J Gastroenterol Hepatol. 1996;10(4):365-70 - PMID: 8527699 - DOI: 10.1111/j.1440-1746.1995.tb01585.x

Atadja P, Wong H, Garkavtsev I, Veillette C, Riabowol K

Increased activity of p53 in senescing fibroblasts.
Proc Natl Acad Sci U S A. 1995;92(18):8348-52 - PMID: 7667293 - PMCID: PMC41154 - DOI: 10.1073/pnas.92.18.8348

Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Cancer Res. 1995;55(17):3752-6 - PMID: 7641188

Boucher Y, Lee I, Jain RK

Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors.
Microvasc Res. 1995;50(2):175-82 - PMID: 8538498 - DOI: 10.1006/mvre.1995.1051

Miura S, Tsuzuki Y, Fukumura D, Serizawa H, Suematsu M, Kurose I, Imaeda H, Kimura H, Nagata H, Tsuchiya M

Intravital demonstration of sequential migration process of lymphocyte subpopulations in rat Peyer's patches.
Gastroenterology. 1995;109(4):1113-23 - PMID: 7557076 - DOI: 10.1016/0016-5085(95)90569-3

Fukumura D, Kurose I, Miura S, Tsuchiya M, Ishii H

Oxidative stress in gastric mucosal injury: role of platelet-activating factor-activated granulocytes.
J Gastroenterol. 1995;30(5):565-71 - PMID: 8574326 - DOI: 10.1007/BF02367780

Fukumura D, Salehi HA, Witwer B, Tuma RF, Melder RJ, Jain RK

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.
Cancer Res. 1995;55(21):4824-9 - PMID: 7585514

Fukumura D, Yuan F, Monsky WL, Chen Y, Jain RK

Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.
Am J Pathol. 1997;151(3):679-88 - PMID: 9284816 - PMCID: PMC1857859

Zlotecki RA, Baxter LT, Boucher Y, Jain RK

Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation.
Microvasc Res. 1995;50(3):429-43 - PMID: 8583955 - DOI: 10.1006/mvre.1995.1069

Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK

Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.
Cancer Res. 1995;55(22):5451-8 - PMID: 7585615

Kurose I, Miura S, Saito H, Tada S, Fukumura D, Higuchi H, Ishii H

Rat Kupffer cell-derived nitric oxide modulates induction of lymphokine-activated killer cell.
Gastroenterology. 1995;109(6):1958-68 - PMID: 7498662 - DOI: 10.1016/0016-5085(95)90764-5

Suzuki H, Miura S, Imaeda H, Suzuki M, Han JY, Mori M, Fukumura D, Tsuchiya M, Ishii H

Enhanced levels of chemiluminescence and platelet activating factor in urease-positive gastric ulcers.
Free Radic Biol Med. 1996;20(3):449-54 - PMID: 8720917 - DOI: 10.1016/0891-5849(96)02048-5

Suzuki M, Mori M, Miura S, Suematsu M, Fukumura D, Kimura H, Ishii H

Omeprazole attenuates oxygen-derived free radical production from human neutrophils.
Free Radic Biol Med. 1997;21(5):727-31 - PMID: 8891677 - DOI: 10.1016/0891-5849(96)00180-3

Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK

Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft.
Cancer Res. 1996;56(5):964-68 - PMID: 8640786

Fukumura D, Kurose I, Miura S, Serizawa H, Sekizuka E, Nagata H, Tsuchiya M, Ishii H

Role of endothelin-1 in repeated electrical stimulation-induced microcirculatory disturbance and mucosal damage in rat stomach.
J Gastroenterol Hepatol. 1996;11(3):279-85 - PMID: 8742927 - DOI: 10.1111/j.1440-1746.1996.tb00076.x

Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ

Leukocyte-endothelial adhesion and angiogenesis in tumors.
Cancer Metastasis Rev. 1996;15(2):195-204 - PMID: 8842491 - DOI: 10.1007/BF00437472

Kozin SV, Duda DG, Munn LL, Jain RK

Neovascularization After Irradiation: What is the Source of Newly Formed Vessels in Recurring Tumors?
J Natl Cancer Inst. 2012;104(12):899-905 - PMID: 22572994 - PMCID: PMC3379722 - DOI: 10.1093/jnci/djs239

Goel S, Fukumura D, Jain RK

Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology.
Proc Natl Acad Sci U S A. 2012;109(20):E1214 - PMID: 22550180 - PMCID: PMC3356659 - DOI: 10.1073/pnas.1203794109

Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner.
Nat Nanotechnol. 2012;7(6):383-8 - PMID: 22484912 - PMCID: PMC3370066 - DOI: 10.1038/nnano.2012.45

Vakoc BJ, Fukumura D, Jain RK, Bouma BE

Cancer imaging by optical coherence tomography: preclinical progress and clinical potential.
Nat Rev Cancer. 2012;12(5):363-8 - PMID: 22475930 - PMCID: PMC3560400 - DOI: 10.1038/nrc3235

Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D

Multistage nanoparticles for improved delivery into tumor tissue.
Methods Enzymol. 2012;508:109-30 - PMID: 22449923 - PMCID: PMC3774840 - DOI: 10.1016/B978-0-12-391860-4.00006-9

Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D

A transient parabiosis skin transplantation model in mice.
Nat Protoc. 2012;7(4):763-70 - PMID: 22441295 - PMCID: PMC3375333 - DOI: 10.1038/nprot.2012.032

Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG

Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice.
Nat Protoc. 2012;7(4):756-62 - PMID: 22441294 - PMCID: PMC3380105 - DOI: 10.1038/nprot.2012.031

Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK

An isolated tumor perfusion model in mice.
Nat Protoc. 2012;7(4):749-55 - PMID: 22441293 - PMCID: PMC3375334 - DOI: 10.1038/nprot.2012.030

Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK

Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948).
PLoS One. 2012;7(2):e26331 - PMID: 22347360 - PMCID: PMC3274514 - DOI: 10.1371/journal.pone.0026331

Saylor PJ, Kozak KR, Smith MR, Ancukiewicz MA, Efstathiou JA, Zietman AL, Jain RK, Duda DG

Changes in biomarkers of inflammation and angiogenesis during androgen deprivation therapy for prostate cancer.
Oncologist. 2012;17(2):212-9 - PMID: 22302227 - PMCID: PMC3286170 - DOI: 10.1634/theoncologist.2011-0321

Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LL

Mechanical compression drives cancer cells toward invasive phenotype.
Proc Natl Acad Sci U S A. 2012;109(3):911-6 - PMID: 22203958 - PMCID: PMC3271885 - DOI: 10.1073/pnas.1118910109

Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK

Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration.
Angew Chem Int Ed Engl. 2011;50(48):11417-20 - PMID: 22113800 - PMCID: PMC3260125 - DOI: 10.1002/anie.201104449

Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP

Impaired lymphatic contraction associated with immunosuppression.
Proc Natl Acad Sci U S A. 2011;108(46):18784-9 - PMID: 22065738 - PMCID: PMC3219138 - DOI: 10.1073/pnas.1116152108

Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL

Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis.
Blood. 2011;118(17):4740-9 - PMID: 21835951 - PMCID: PMC3208287 - DOI: 10.1182/blood-2011-02-338426
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