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Horowitz NS, Penson RT, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Cohen KS, Berlin S, Krasner CN, Moses MA, Jain RK

Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma.
Clin Ovarian Cancer Other Gynecol Malig. 2011;4(1):26-33 - PMID: 21833345 - PMCID: PMC3151740 - DOI: 10.1016/j.cloc.2011.04.003

Dawson MR, Chae SS, Jain RK, Duda DG

Direct evidence for lineage-dependent effects of bone marrow stromal cells on tumor progression.
Am J Cancer Res. 2011;1(2):144-54 - PMID: 21822499 - PMCID: PMC3150110

Huang P, Westmoreland SV, Jain RK, Fukumura D

Spontaneous nonthymic tumors in SCID mice.
Comp Med. 2011;61(3):227-34 - PMID: 21819692 - PMCID: PMC3123755

Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK

Normalization of the vasculature for treatment of cancer and other diseases.
Physiol Rev. 2011;91(3):1071-121 - PMID: 21742796 - PMCID: PMC3258432 - DOI: 10.1152/physrev.00038.2010

Kozin SV, Duda DG, Munn LL, Jain RK

Is vasculogenesis crucial for the regrowth of irradiated tumours?
Nat Rev Cancer. 2011;11(7):532 - PMID: 21701514 - PMCID: PMC4790119 - DOI: 10.1038/nrc2007-c1

Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y

Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer Res. 2011;71(13):4527-38 - PMID: 21571860 - DOI: 10.1158/0008-5472.CAN-10-4376

Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK

The biology of brain metastases-translation to new therapies.
Nat Rev Clin Oncol. 2011;8(6):344-56 - PMID: 21487419 - PMCID: PMC3259742 - DOI: 10.1038/nrclinonc.2011.58

Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L

PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.
Clin Cancer Res. 2011;17(11):3638-48 - PMID: 21459800 - PMCID: PMC3107920 - DOI: 10.1158/1078-0432.CCR-10-2456

Zhu AX, Duda DG, Sahani DV, Jain RK

HCC and angiogenesis: possible targets and future directions.
Nat Rev Clin Oncol. 2011;8(5):292-301 - PMID: 21386818 - PMCID: PMC3266719 - DOI: 10.1038/nrclinonc.2011.30

Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK

CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Clin Cancer Res. 2011;17(8):2074-80 - PMID: 21349998 - PMCID: PMC3079023 - DOI: 10.1158/1078-0432.CCR-10-2636

Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A. 2011;108(9):3725-30 - PMID: 21321210 - PMCID: PMC3048115 - DOI: 10.1073/pnas.1100446108

Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors.
Proc Natl Acad Sci U S A. 2011;108(7):2909-14 - PMID: 21282607 - PMCID: PMC3041115 - DOI: 10.1073/pnas.1018892108

Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L

TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models.
Clin Cancer Res. 2011;17(6):1415-24 - PMID: 21278244 - PMCID: PMC3060297 - DOI: 10.1158/1078-0432.CCR-10-2429

Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D

Multistage nanoparticle delivery system for deep penetration into tumor tissue.
Proc Natl Acad Sci U S A. 2011;108(6):2426-31 - PMID: 21245339 - PMCID: PMC3038705 - DOI: 10.1073/pnas.1018382108

Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK

Scaling rules for diffusive drug delivery in tumor and normal tissues.
Proc Natl Acad Sci U S A. 2011;108(5):1799-803 - PMID: 21224417 - PMCID: PMC3033252 - DOI: 10.1073/pnas.1018154108

Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK

Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies.
Annu Rev Chem Biomol Eng. 2012;2:281-98 - PMID: 22432620 - DOI: 10.1146/annurev-chembioeng-061010-114300

Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK

C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc Natl Acad Sci U S A. 2011;108(1):302-7 - PMID: 21173223 - PMCID: PMC3017172 - DOI: 10.1073/pnas.1016917108

Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK

Malignant cells facilitate lung metastasis by bringing their own soil.
Proc Natl Acad Sci U S A. 2010;107(50):21677-82 - PMID: 21098274 - PMCID: PMC3003109 - DOI: 10.1073/pnas.1016234107

Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK

Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation.
Biophys J. 2010;99(10):3119-28 - PMID: 21081058 - PMCID: PMC2980743 - DOI: 10.1016/j.bpj.2010.08.065

Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG

A nanoparticle size series for in vivo fluorescence imaging.
Angew Chem Int Ed Engl. 2010;49(46):8649-52 - PMID: 20886481 - PMCID: PMC3035057 - DOI: 10.1002/anie.201003142

Zhu AX, Duda DG, Ancukiewicz M, di Tomaso E, Clark JW, Miksad R, Fuchs CS, Ryan DP, Jain RK

Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: kinetics and potential biomarker value.
Clin Cancer Res. 2011;17(4):918-27 - PMID: 20843836 - PMCID: PMC3023846 - DOI: 10.1158/1078-0432.CCR-10-0515

Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK

Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.
Neoplasia. 2012;14(2):84-94 - PMID: 22431917 - PMCID: PMC3306254 - DOI: 10.1593/neo.111600

Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK

Dehydro-alpha-lapachone, a plant product with antivascular activity.
Proc Natl Acad Sci U S A. 2011;108(28):11596-601 - PMID: 21709229 - PMCID: PMC3136298 - DOI: 10.1073/pnas.1104225108

Wang E, Feng Y, Zhang M, Zou L, Li Y, Buys ES, Huang P, Brouckaert P, Chao W

Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.
Anesthesiology. 2011;114(3):603-13 - PMID: 21270629 - PMCID: PMC3044772 - DOI: 10.1097/ALN.0b013e31820a4d5b

Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT

Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide.
J Neurooncol. 2011;103(2):325-32 - PMID: 20821342 - PMCID: PMC4090923 - DOI: 10.1007/s11060-010-0390-7

Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK

Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions.
Biophys J. 2010;99(5):1342-9 - PMID: 20816045 - PMCID: PMC2931749 - DOI: 10.1016/j.bpj.2010.06.016

Brown E, Munn LL, Fukumura D, Jain RK

In vivo imaging of tumors.
Cold Spring Harb Protoc. 2010;2010(7):pdb.prot5452 - PMID: 20647356 - PMCID: PMC3891051 - DOI: 10.1101/pdb.prot5452

Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks.
Nat Methods. 2010;7(8):655-60 - PMID: 20581828 - PMCID: PMC2921873 - DOI: 10.1038/nmeth.1475

Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D

Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas.
Clin Cancer Res. 2010;16(14):3618-27 - PMID: 20501615 - PMCID: PMC2905497 - DOI: 10.1158/1078-0432.CCR-09-3073

Fukumura D, Duda DG, Munn LL, Jain RK

Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models.
Microcirculation. 2010;17(3):206-25 - PMID: 20374484 - PMCID: PMC2859831 - DOI: 10.1111/j.1549-8719.2010.00029.x

Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH

In vivo wide-area cellular imaging by side-view endomicroscopy.
Nat Methods. 2010;7(4):303-5 - PMID: 20228814 - PMCID: PMC2849759 - DOI: 10.1038/nmeth.1440

Choi B, Bouma B, Fukumura D, Jain RK

Optical methods in vascular biology and medicine.
J Biomed Opt. 2010;15(1):011001 - PMID: 20210426 - DOI: 10.1117/1.3338696

Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG

Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand.
J Am Chem Soc. 2010;132(2):472-83 - PMID: 20025223 - PMCID: PMC2871316 - DOI: 10.1021/ja908137d

Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG

InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared.
J Am Chem Soc. 2010;132(2):470-1 - PMID: 20025222 - PMCID: PMC2862004 - DOI: 10.1021/ja908250r

Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK

Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.
PLoS One. 2009;4(12):e8316 - PMID: 20016816 - PMCID: PMC2789383 - DOI: 10.1371/journal.pone.0008316

Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK

Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Cancer Res. 2009;69(20):7905-10 - PMID: 19826039 - PMCID: PMC2859041 - DOI: 10.1158/0008-5472.CAN-09-2099

Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK

VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.
PLoS One. 2009;4(9):e6525 - PMID: 19763275 - PMCID: PMC2744279 - DOI: 10.1371/journal.pone.0006525

Dawson MR, Duda DG, Fukumura D, Jain RK

VEGFR1-activity-independent metastasis formation.
Nature. 2009;461(7262):E4; discussion E5 - PMID: 19759568 - PMCID: PMC3065241 - DOI: 10.1038/nature08254

Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Nat Med. 2009;15(10):1219-23 - PMID: 19749772 - PMCID: PMC2759417 - DOI: 10.1038/nm.1971

Jain RK, Munn LL, Fukumura D, Melder RJ

In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium.
Methods Mol Med. 2011;18:553-75 - PMID: 21370203 - DOI: 10.1385/0-89603-516-6:553

Jain RK, Munn LL, Fukumura D

Rabbit ear chambers.
Cold Spring Harb Protoc. 2012;2012(7):813-14 - PMID: 22753607 - DOI: 10.1101/pdb.prot070045

Less JR, Skalak TC, Sevick EM, Jain RK

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
Cancer Res. 1991;51(1):265-73 - PMID: 1988088

Ohkubo C, Bigos D, Jain RK

Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome.
Cancer Res. 1991;51(5):1561-3 - PMID: 1997196

Sevick EM, Jain RK

Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.
Cancer Res. 1991;51(10):2727-30 - PMID: 2021951

Yuan F, Baxter LT, Jain RK

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
Cancer Res. 1991;51(12):3119-30 - PMID: 2039991

Baxter LT, Jain RK

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Microvasc Res. 1990;40(2):246-63 - PMID: 2250603 - DOI: 10.1016/0026-2862(90)90023-k

Jain RK, Stock RJ, Chary SR, Rueter M

Convection and diffusion measurements using fluorescence recovery after photobleaching and video image analysis: in vitro calibration and assessment.
Microvasc Res. 1990;39(1):77-93 - PMID: 2314308 - DOI: 10.1016/0026-2862(90)90060-5

Boucher Y, Baxter LT, Jain RK

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.
Cancer Res. 1990;50(15):4478-84 - PMID: 2369726

Gerlowski LE, Jain RK

Microvascular permeability of normal and neoplastic tissues.
Microvasc Res. 1986;31(3):288-305 - PMID: 2423854 - DOI: 10.1016/0026-2862(86)90018-x

Sasaki A, Jain RK, Maghazachi AA, Goldfarb RH, Herberman RB

Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution.
Cancer Res. 1989;49(14):3742-6 - PMID: 2500233
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