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Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.
Nat Genet. 2022;54(8):1178-1191 - PMID: 35902743 - DOI: 10.1038/s41588-022-01134-8
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A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.
Clin Cancer Res. 2022;:ePub - PMID: 35833850 - DOI: 10.1158/1078-0432.CCR-22-1169
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The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy.
Cancer Cell. 2022;40(7):701-702 - PMID: 35714604 - DOI: 10.1016/j.ccell.2022.05.016
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Impact of renin-angiotensin system inhibitors on outcomes in patients with metastatic renal cell carcinoma treated with immune-checkpoint inhibitors
Clin Genitourin Cancer. 2022;20(4):301-306 - PMID: 35614012 - DOI: 10.1016/j.clgc.2022.04.012
Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK
Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.
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Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.
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Increased CD8+ T-Cell Infiltration and Efficacy for Multikinase Inhibitors after PD-1 Blockade in Hepatocellular Carcinoma.
J Natl Cancer Inst. 2022;:ePub - PMID: 35288743 - DOI: 10.1093/jnci/djac051
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Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy
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Renin–angiotensin–aldosterone system inhibitors and survival in patients with hypertension treated with immune checkpoint inhibitors
European Journal of Cancer. 2022;163:108-118 - PMID: 35065368 - DOI: 10.1016/j.ejca.2021.12.024
Subudhi S, Voutouri C, Hardin CC, Nikmaneshi MR, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Jain RK, Munn LL
Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling
EBioMedicine. 2022;75:103809 - PMID: 35033853 - PMCID: PMC8757652 - DOI: 10.1016/j.ebiom.2021.103809
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